Gene/Proteome Database (LMPD)
Proteins
| flotillin-1 | |
|---|---|
| Refseq ID | NP_032053 |
| Protein GI | 6679809 |
| UniProt ID | O08917 |
| mRNA ID | NM_008027 |
| Length | 428 |
| RefSeq Status | PROVISIONAL |
| MFFTCGPNEAMVVSGFCRSPPVMVAGGRVFVLPCIQQIQRISLNTLTLNVKSEKVYTRHGVPISVTGIAQVKIQGQNKEMLAAACQMFLGKTEAEIAHIALETLEGHQRAIMAHMTVEEIYKDRQKFSEQVFKVASSDLVNMGISVVSYTLKDIHDDQDYLHSLGKARTAQVQKDARIGEAEAKRDAGIREAKAKQEKVSAQCLSEIEMAKAQRDYELKKATYDIEVNTRRAQADLAYQLQVAKTKQQIEEQRVQVQVVERAQQVAVQEQEIARREKELEARVRKPAEAERYRLERLAEAEKAQLIMQAEAEAESVRMRGEAEAFAIGARARAEAEQMAKKAEAFQMYQEAAQLDMLLEKLPQVAEEISGPLTSANKITLVSSGSGTMGAAKVTGEVLDILSRLPESVERLTGVSISQVNHNKPLRTA | |
Gene Information
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0008180 | IEA:Ensembl | C | COP9 signalosome |
| GO:0005901 | IDA:MGI | C | caveola |
| GO:0034451 | IEA:Ensembl | C | centriolar satellite |
| GO:0005768 | ISS:UniProtKB | C | endosome |
| GO:0070062 | IEA:Ensembl | C | extracellular vesicular exosome |
| GO:0016600 | IDA:BHF-UCL | C | flotillin complex |
| GO:0005765 | IEA:Ensembl | C | lysosomal membrane |
| GO:0016020 | IDA:MGI | C | membrane |
| GO:0045121 | IDA:MGI | C | membrane raft |
| GO:0005886 | IDA:MGI | C | plasma membrane |
| GO:0042383 | IDA:MGI | C | sarcolemma |
| GO:0007409 | IMP:MGI | P | axonogenesis |
| GO:0022617 | IEA:Ensembl | P | extracellular matrix disassembly |
| GO:0072659 | IMP:MGI | P | protein localization to plasma membrane |
| GO:0035023 | IMP:MGI | P | regulation of Rho protein signal transduction |
KEGG Pathway Links
Domain Information
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Function | May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. |
| Miscellaneous | Expression increases at least 10-fold as 3T3-L1 cells differentiate into adipocytes. |
| Similarity | Belongs to the band 7/mec-2 family. Flotillin subfamily. {ECO:0000305}. |
| Subcellular Location | Cell membrane; Peripheral membrane protein. Membrane, caveola; Peripheral membrane protein. Melanosome {ECO:0000250}. Endosome {ECO:0000250}. Note=Membrane-associated protein of caveolae. |
| Subunit | Heterooligomeric complex of flotillin-1 and flotillin-2 and caveolin-1 and caveolin-2. Interacts with ECM29 (By similarity). {ECO:0000250}. |
| Tissue Specificity | High expression in brain, white adipose tissue, heart muscle, skeletal muscle and lung. Low expression in spleen, liver and testis. |
Identical and Related Proteins
Unique RefSeq proteins for LMP000024 (as displayed in Record Overview)
Identical Sequences to LMP000024 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:6679809 | DBBJ | BAE29889.1 | 428 | unnamed protein product [Mus musculus] |
| GI:6679809 | GenBank | EDL23235.1 | 428 | flotillin 1 [Mus musculus] |
| GI:6679809 | RefSeq | XP_003505936.1 | 428 | PREDICTED: flotillin-1 isoform X2 [Cricetulus griseus] |
| GI:6679809 | RefSeq | XP_006523719.1 | 428 | PREDICTED: flotillin-1 isoform X1 [Mus musculus] |
| GI:6679809 | RefSeq | XP_006536579.1 | 428 | PREDICTED: flotillin-1 isoform X1 [Mus musculus] |
| GI:6679809 | RefSeq | XP_006537312.1 | 428 | PREDICTED: flotillin-1 isoform X1 [Mus musculus] |
Related Sequences to LMP000024 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:6679809 | DBBJ | BAE39425.1 | 428 | unnamed protein product [Mus musculus] |
| GI:6679809 | GenBank | AAC98705.1 | 428 | RAREG-2.1 [Rattus norvegicus] |
| GI:6679809 | GenBank | EDL86740.1 | 428 | flotillin 1, isoform CRA_a [Rattus norvegicus] |
| GI:6679809 | RefSeq | NP_073192.2 | 428 | flotillin-1 [Rattus norvegicus] |
| GI:6679809 | RefSeq | XP_006256086.1 | 428 | PREDICTED: flotillin-1 isoform X1 [Rattus norvegicus] |
| GI:6679809 | SwissProt | Q9Z1E1.2 | 428 | RecName: Full=Flotillin-1; AltName: Full=Reggie-2; Short=REG-2 [Rattus norvegicus] |