Gene/Proteome Database (LMPD)

LMPD ID
LMP000025
Gene ID
21390
Species
Mus musculus (Mouse)
Gene Name
thromboxane A2 receptor
Gene Symbol
Tbxa2r
Synonyms
TP; TXA2-R
Alternate Names
thromboxane A2 receptor; TXA2 receptor; prostanoid TP receptor; thromboxane prostanoid
Chromosome
10
Map Location
10 C1|10 39.72 cM
Summary
This gene encodes a multi-pass membrane protein that functions as a G-protein coupled receptor. The encoded protein binds thromboxane A2, resulting in the aggregation of platelets and constriction of blood vessels. Alternative splicing results in multiple transcript variants for this gene. [provided by RefSeq, Mar 2013]
Orthologs
View orthologs and multiple alignments for Tbxa2r

Proteins

thromboxane A2 receptor
Refseq ID NP_001264194
Protein GI 471270254
UniProt ID P30987
mRNA ID NM_001277265
Length 341
RefSeq Status REVIEWED
MWPNGTSLGACFRPVNITLQERRAIASPWFAASFCALGLGSNLLALSVLAGARPGAGPRSSFLALLCGLVLTDFLGLLVTGAIVASQHAALLDWRATDPSCRLCYFMGVAMVFFGLCPLLLGAAMASERFVGITRPFSRPTATSRRAWATVGLVWVAAGALGLLPLLGLGRYSVQYPGSWCFLTLGTQRGDVVFGLIFALLGSASVGLSLLLNTVSVATLCRVYHTREATQRPRDCEVEMMVQLVGIMVVATVCWMPLLVFIMQTLLQTPPVMSFSGQLLRATEHQLLIYLRVATWNQILDPWVYILFRRSVLRRLHPRFSSQLQAVSLRRPPAQAMLSGP
thromboxane A2 receptor
Refseq ID NP_033351
Protein GI 6678233
UniProt ID P30987
mRNA ID NM_009325
Length 341
RefSeq Status REVIEWED
Protein sequence is identical to GI:471270254 (mRNA isoform)

Gene Information

Entrez Gene ID
21390
Gene Name
thromboxane A2 receptor
Gene Symbol
Tbxa2r
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0001669 IEA:Ensembl C acrosomal vesicle
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0005886 IEA:UniProtKB-KW C plasma membrane
GO:0004960 IDA:MGI F thromboxane receptor activity
GO:0006954 IMP:MGI P inflammatory response
GO:0045766 IEA:Ensembl P positive regulation of angiogenesis
GO:0045777 IEA:Ensembl P positive regulation of blood pressure
GO:0007204 IEA:Ensembl P positive regulation of cytosolic calcium ion concentration
GO:0045987 IDA:MGI P positive regulation of smooth muscle contraction
GO:0045907 IEA:Ensembl P positive regulation of vasoconstriction
GO:0019229 IGI:MGI P regulation of vasoconstriction
GO:0042493 IEA:Ensembl P response to drug
GO:0032496 IMP:MGI P response to lipopolysaccharide
GO:0007584 IEA:Ensembl P response to nutrient
GO:0019932 IDA:MGI P second-messenger-mediated signaling

KEGG Pathway Links

KEGG Pathway ID Description
mmu04020 Calcium signaling pathway
mmu04611 Platelet activation

Domain Information

InterPro Annotations

Accession Description
IPR000276 G protein-coupled receptor, rhodopsin-like
IPR017452 GPCR, rhodopsin-like, 7TM
IPR008365 Prostanoid receptor
IPR001105 Thromboxane receptor

UniProt Annotations

Entry Information

Gene Name
thromboxane A2 receptor
Protein Entry
TA2R_MOUSE
UniProt ID
P30987
Species
Mouse

Comments

Comment Type Description
Function Receptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. In the kidney, the binding of TXA2 to glomerular TP receptors causes intense vasoconstriction. Activates phospholipase C and adenylyl cyclase.
Similarity Belongs to the G-protein coupled receptor 1 family. {ECO:0000255|PROSITE-ProRule:PRU00521}.
Subcellular Location Cell membrane; Multi-pass membrane protein.
Subunit Interacts with RPGRIP1L. Interacts with GNB2L1/RACK1; the interaction regulates TBXA2R cell surface expression (By similarity). {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP000025 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
471270254 RefSeq NP_001264194 341 thromboxane A2 receptor

Identical Sequences to LMP000025 proteins

Reference Database Accession Length Protein Name
GI:471270254 DBBJ BAE34532.1 341 unnamed protein product [Mus musculus]
GI:471270254 DBBJ BAF82013.1 341 thromboxane A2 receptor [Mus musculus]
GI:471270254 GenBank EDL31427.1 341 thromboxane A2 receptor [Mus musculus]
GI:471270254 GenBank AAI38886.1 341 Thromboxane A2 receptor [Mus musculus]
GI:471270254 GenBank AAI38887.1 341 Thromboxane A2 receptor [Mus musculus]
GI:471270254 RefSeq XP_006513523.1 341 PREDICTED: thromboxane A2 receptor isoform X1 [Mus musculus]

Related Sequences to LMP000025 proteins

Reference Database Accession Length Protein Name
GI:471270254 GenBank EDL89163.1 341 thromboxane A2 receptor, isoform CRA_a [Rattus norvegicus]
GI:471270254 GenBank EDL89164.1 341 thromboxane A2 receptor, isoform CRA_a [Rattus norvegicus]
GI:471270254 GenBank EDL89165.1 341 thromboxane A2 receptor, isoform CRA_a [Rattus norvegicus]
GI:471270254 GenBank AED45127.1 354 Sequence 201 from patent US 7892730
GI:471270254 RefSeq XP_006240908.1 341 PREDICTED: thromboxane A2 receptor isoform X1 [Rattus norvegicus]
GI:471270254 SwissProt P34978.1 341 RecName: Full=Thromboxane A2 receptor; Short=TXA2-R; AltName: Full=Prostanoid TP receptor; AltName: Full=TXR2 [Rattus norvegicus]