Gene/Proteome Database (LMPD)

LMPD ID
LMP000042
Gene ID
224
Species
Homo sapiens (Human)
Gene Name
aldehyde dehydrogenase 3 family, member A2
Gene Symbol
ALDH3A2
Synonyms
ALDH10; FALDH; SLS
Alternate Names
fatty aldehyde dehydrogenase; aldehyde dehydrogenase 10; microsomal aldehyde dehydrogenase; aldehyde dehydrogenase family 3 member A2
Chromosome
17
Map Location
17p11.2
EC Number
1.2.1.3
Summary
Aldehyde dehydrogenase isozymes are thought to play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. This gene product catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acid. Mutations in the gene cause Sjogren-Larsson syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Orthologs
View orthologs and multiple alignments for ALDH3A2

Proteins

fatty aldehyde dehydrogenase isoform 1
Refseq ID NP_001026976
Protein GI 73466520
UniProt ID P51648
mRNA ID NM_001031806
Length 508
RefSeq Status REVIEWED
MELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEVITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQYLDQDLYIVINGGVEETTELLKQRFDHIFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEFYGENIKESPDYERIINLRHFKRILSLLEGQKIAFGGETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFSHQRPCLLKSLKREGANKLRYPPNSQSKVDWGKFFLLKRFNKEKLGLLLLTFLGIVAAVLVKKYQAVLRRKALLIFLVVHRLRWSSKQR
fatty aldehyde dehydrogenase isoform 2
Refseq ID NP_000373
Protein GI 4557303
UniProt ID P51648
mRNA ID NM_000382
Length 485
RefSeq Status REVIEWED
MELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEVITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQYLDQDLYIVINGGVEETTELLKQRFDHIFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEFYGENIKESPDYERIINLRHFKRILSLLEGQKIAFGGETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFSHQRPCLLKSLKREGANKLRYPPNSQSKVDWGKFFLLKRFNKEKLGLLLLTFLGIVAAVLVKAEYY

Gene Information

Entrez Gene ID
224
Gene Name
aldehyde dehydrogenase 3 family, member A2
Gene Symbol
ALDH3A2
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IEA:UniProtKB-KW C endoplasmic reticulum
GO:0070062 IDA:UniProt C extracellular vesicular exosome
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0043231 IDA:UniProtKB C intracellular membrane-bounded organelle
GO:0005743 IEA:Ensembl C mitochondrial inner membrane
GO:0005777 IDA:UniProtKB C peroxisome
GO:0004029 IDA:UniProtKB F aldehyde dehydrogenase (NAD) activity
GO:0004030 IEA:InterPro F aldehyde dehydrogenase [NAD(P)+] activity
GO:0046577 IDA:UniProtKB F long-chain-alcohol oxidase activity
GO:0050061 IDA:UniProtKB F long-chain-aldehyde dehydrogenase activity
GO:0052814 IDA:UniProtKB F medium-chain-aldehyde dehydrogenase activity
GO:0006081 IDA:UniProtKB P cellular aldehyde metabolic process
GO:0007417 IMP:UniProtKB P central nervous system development
GO:0008544 IMP:UniProtKB P epidermis development
GO:0055114 IDA:GOC P oxidation-reduction process
GO:0007422 IMP:UniProtKB P peripheral nervous system development
GO:0033306 IMP:UniProtKB P phytol metabolic process
GO:0006714 IDA:UniProtKB P sesquiterpenoid metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
hsa00010 Glycolysis / Gluconeogenesis

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY66-388 fatty acid alpha-oxidation III
PWY-6342 noradrenaline and adrenaline degradation
PWY-6313 serotonin degradation

Domain Information

InterPro Annotations

Accession Description
IPR016162 Aldehyde dehydrogenase N-terminal domain
IPR012394 Aldehyde dehydrogenase NAD(P)-dependent
IPR015590 Aldehyde dehydrogenase domain
IPR016163 Aldehyde dehydrogenase, C-terminal
IPR016160 Aldehyde dehydrogenase, cysteine active site
IPR029510 Aldehyde dehydrogenase, glutamic acid active site
IPR016161 Aldehyde/histidinol dehydrogenase

UniProt Annotations

Entry Information

Gene Name
aldehyde dehydrogenase 3 family, member A2
Protein Entry
AL3A2_HUMAN
UniProt ID
P51648
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P51648-1; Sequence=Displayed; Name=2; IsoId=P51648-2; Sequence=VSP_001283;
Catalytic Activity An aldehyde + NAD(+) + H(2)O = a carboxylate + NADH.
Disease Sjoegren-Larsson syndrome (SLS) [MIM
Function Catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acids. Active on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length. Responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid.
Similarity Belongs to the aldehyde dehydrogenase family.
Subcellular Location Endoplasmic reticulum membrane; Single-pass membrane protein; Cytoplasmic side.

Identical and Related Proteins

Unique RefSeq proteins for LMP000042 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
73466520 RefSeq NP_001026976 508 fatty aldehyde dehydrogenase isoform 1
4557303 RefSeq NP_000373 485 fatty aldehyde dehydrogenase isoform 2

Identical Sequences to LMP000042 proteins

Reference Database Accession Length Protein Name
GI:4557303 DBBJ BAF85070.1 485 unnamed protein product [Homo sapiens]
GI:4557303 DBBJ BAG37560.1 485 unnamed protein product [Homo sapiens]
GI:4557303 EMBL CAG33703.1 485 ALDH3A2 [Homo sapiens]
GI:4557303 GenBank AAC51121.1 485 aldehyde dehydrogenase [Homo sapiens]
GI:73466520 GenBank AAH02430.1 508 Aldehyde dehydrogenase 3 family, member A2 [Homo sapiens]
GI:4557303 GenBank EAW50898.1 485 aldehyde dehydrogenase 3 family, member A2, isoform CRA_a [Homo sapiens]
GI:73466520 GenBank EAW50899.1 508 aldehyde dehydrogenase 3 family, member A2, isoform CRA_b [Homo sapiens]
GI:73466520 GenBank ABM86806.1 508 aldehyde dehydrogenase 3 family, member A2, partial [synthetic construct]
GI:73466520 GenBank ABW03828.1 508 aldehyde dehydrogenase 3 family, member A2 [synthetic construct]
GI:4557303 GenBank AHD69366.1 485 Sequence 380 from patent US 8586006
GI:73466520 GenBank AHD69367.1 508 Sequence 381 from patent US 8586006
GI:73466520 GenBank AIC48249.1 508 ALDH3A2, partial [synthetic construct]

Related Sequences to LMP000042 proteins

Reference Database Accession Length Protein Name
GI:4557303 EMBL CAH89597.1 485 hypothetical protein [Pongo abelii]
GI:73466520 GenBank AAP36923.1 509 Homo sapiens aldehyde dehydrogenase 3 family, member A2, partial [synthetic construct]
GI:73466520 GenBank AAX43795.1 509 aldehyde dehydrogenase 3 family member A2, partial [synthetic construct]
GI:4557303 GenBank ACM84301.1 578 Sequence 9799 from patent US 6812339
GI:73466520 GenBank JAA38734.1 508 aldehyde dehydrogenase 3 family, member A2 [Pan troglodytes]
GI:4557303 RefSeq NP_001124709.1 485 fatty aldehyde dehydrogenase [Pongo abelii]
GI:4557303 RefSeq XP_003807325.1 485 PREDICTED: fatty aldehyde dehydrogenase isoform X2 [Pan paniscus]
GI:73466520 RefSeq XP_003807326.1 508 PREDICTED: fatty aldehyde dehydrogenase isoform X1 [Pan paniscus]
GI:4557303 RefSeq XP_004042166.1 485 PREDICTED: fatty aldehyde dehydrogenase isoform 1 [Gorilla gorilla gorilla]
GI:73466520 RefSeq XP_004042167.1 508 PREDICTED: fatty aldehyde dehydrogenase isoform 2 [Gorilla gorilla gorilla]
GI:73466520 RefSeq XP_009234797.1 508 PREDICTED: fatty aldehyde dehydrogenase isoform X1 [Pongo abelii]
GI:4557303 SwissProt Q5RF60.1 485 RecName: Full=Fatty aldehyde dehydrogenase; AltName: Full=Aldehyde dehydrogenase family 3 member A2 [Pongo abelii]