Gene/Proteome Database (LMPD)
LMPD ID
LMP000051
Gene ID
Species
Homo sapiens (Human)
Gene Name
lysophosphatidic acid receptor 3
Gene Symbol
Synonyms
EDG7; Edg-7; GPCR; HOFNH30; LP-A3; LPA3; RP4-678I3
Alternate Names
lysophosphatidic acid receptor 3; LPA-3; LPA receptor 3; LPA receptor EDG7; lysophosphatidic acid receptor Edg-7; endothelial cell differentiation gene 7; calcium-mobilizing lysophosphatidic acid receptor LP-A3; endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 7
Chromosome
1
Map Location
1p22.3
Summary
This gene encodes a member of the G protein-coupled receptor family, as well as the EDG family of proteins. This protein functions as a cellular receptor for lysophosphatidic acid and mediates lysophosphatidic acid-evoked calcium mobilization. This receptor couples predominantly to G(q/11) alpha proteins. [provided by RefSeq, Jul 2008]
Orthologs
Proteins
| lysophosphatidic acid receptor 3 | |
|---|---|
| Refseq ID | NP_036284 |
| Protein GI | 6912348 |
| UniProt ID | Q9UBY5 |
| mRNA ID | NM_012152 |
| Length | 353 |
| RefSeq Status | REVIEWED |
| MNECHYDKHMDFFYNRSNTDTVDDWTGTKLVIVLCVGTFFCLFIFFSNSLVIAAVIKNRKFHFPFYYLLANLAAADFFAGIAYVFLMFNTGPVSKTLTVNRWFLRQGLLDSSLTASLTNLLVIAVERHMSIMRMRVHSNLTKKRVTLLILLVWAIAIFMGAVPTLGWNCLCNISACSSLAPIYSRSYLVFWTVSNLMAFLIMVVVYLRIYVYVKRKTNVLSPHTSGSISRRRTPMKLMKTVMTVLGAFVVCWTPGLVVLLLDGLNCRQCGVQHVKRWFLLLALLNSVVNPIIYSYKDEDMYGTMKKMICCFSQENPERRPSRIPSTVLSRSDTGSQYIEDSISQGAVCNKSTS | |
Gene Information
Entrez Gene ID
Gene Name
lysophosphatidic acid receptor 3
Gene Symbol
Species
Homo sapiens
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0030424 | IEA:Ensembl | C | axon |
| GO:0005887 | TAS:ProtInc | C | integral component of plasma membrane |
| GO:0005886 | TAS:Reactome | C | plasma membrane |
| GO:0004930 | TAS:ProtInc | F | G-protein coupled receptor activity |
| GO:0008289 | TAS:ProtInc | F | lipid binding |
| GO:0070915 | IEA:InterPro | F | lysophosphatidic acid receptor activity |
| GO:0005543 | IEA:Ensembl | F | phospholipid binding |
| GO:0000187 | IEA:Ensembl | P | activation of MAPK activity |
| GO:0032060 | IEA:Ensembl | P | bleb assembly |
| GO:0007187 | TAS:ProtInc | P | G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger |
| GO:0051928 | IEA:Ensembl | P | positive regulation of calcium ion transport |
| GO:0048672 | IEA:Ensembl | P | positive regulation of collateral sprouting |
| GO:0007204 | TAS:ProtInc | P | positive regulation of cytosolic calcium ion concentration |
| GO:0051482 | IEA:Ensembl | P | positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway |
| GO:0007268 | TAS:ProtInc | P | synaptic transmission |
KEGG Pathway Links
REACTOME Pathway Links
| REACTOME Pathway ID | Description |
|---|---|
| REACT_19231 | G alpha (i) signalling events |
| REACT_18365 | Lysosphingolipid and LPA receptors |
Domain Information
UniProt Annotations
Entry Information
Gene Name
lysophosphatidic acid receptor 3
Protein Entry
LPAR3_HUMAN
UniProt ID
Species
Human
Comments
| Comment Type | Description |
|---|---|
| Function | Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. May play a role in the development of ovarian cancer. Seems to be coupled to the G(i)/G(o) and G(q) families of heteromeric G proteins. |
| Similarity | Belongs to the G-protein coupled receptor 1 family. |
| Subcellular Location | Cell membrane; Multi-pass membrane protein. |
| Tissue Specificity | Most abundantly expressed in prostate, testes, pancreas, and heart, with moderate levels in lung and ovary. No detectable expression in brain, placenta, liver, skeletal muscle, kidney, spleen, thymus, small intestine, colon, or peripheral blood leukocytes. |
Identical and Related Proteins
Unique RefSeq proteins for LMP000051 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 6912348 | RefSeq | NP_036284 | 353 | lysophosphatidic acid receptor 3 |
Identical Sequences to LMP000051 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:6912348 | EMBL | CCV20023.1 | 353 | unnamed protein product [Homo sapiens] |
| GI:6912348 | GenBank | ABL56032.1 | 353 | Sequence 4 from patent US 7141383 |
| GI:6912348 | GenBank | EAW73222.1 | 353 | endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 7 [Homo sapiens] |
| GI:6912348 | GenBank | ACH09755.1 | 353 | Sequence 19 from patent US 7396663 |
| GI:6912348 | GenBank | ACR85434.1 | 353 | Sequence 11 from patent US 7521192 |
| GI:6912348 | RefSeq | XP_006710605.1 | 353 | PREDICTED: lysophosphatidic acid receptor 3 isoform X1 [Homo sapiens] |
Related Sequences to LMP000051 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:6912348 | GenBank | ACM82363.1 | 359 | Sequence 7861 from patent US 6812339 |
| GI:6912348 | GenBank | JAA12938.1 | 353 | lysophosphatidic acid receptor 3 [Pan troglodytes] |
| GI:6912348 | GenBank | JAA38994.1 | 353 | lysophosphatidic acid receptor 3 [Pan troglodytes] |
| GI:6912348 | GenBank | AIC56075.1 | 353 | LPAR3, partial [synthetic construct] |
| GI:6912348 | RefSeq | XP_001139887.1 | 353 | PREDICTED: lysophosphatidic acid receptor 3 [Pan troglodytes] |
| GI:6912348 | RefSeq | XP_009422624.1 | 353 | PREDICTED: lysophosphatidic acid receptor 3 [Pan troglodytes] |