Gene/Proteome Database (LMPD)

LMPD ID
LMP000057
Gene ID
15485
Species
Mus musculus (Mouse)
Gene Name
hydroxysteroid (17-beta) dehydrogenase 1
Gene Symbol
Hsd17b1
Synonyms
17HSDB1; 17beta-HSD; E2DH; Hsd17ba
Alternate Names
estradiol 17-beta-dehydrogenase 1; 17-beta-HSD 1; 17-beta-hydroxysteroid dehydrogenase type 1
Chromosome
11
Map Location
11 D|11 64.17 cM
EC Number
1.1.1.62

Proteins

estradiol 17-beta-dehydrogenase 1
Refseq ID NP_034605
Protein GI 6754248
UniProt ID P51656
mRNA ID NM_010475
Length 344
RefSeq Status PROVISIONAL
MDPTVVLITGCSSGIGMHLAVRLASDRSQSFKVYATLRDLKAQGPLLEAARTQGCPPGSLEILELDVRDSKSVAAAQACVTEGRVDVLVCNAGRGLFGPLEAHELNAVGAVLDVNVLGTIRMLQAFLPDMKRRHSGRVLVTASVGGLMGLPFHEVYCASKFALEGLCESLAILLPLFGVHVSLIECGAVHTAFYEKLVGGPGGALERADAQTRHLFAHYLRGYEQALSEAQDPEEVTELFLTAMRAPQPALRYFSTNRFLPLARMRTEDPSGSSYVAAMHQEAFSNLQTQENAKAGAQVPGVSDTASSALICLPECAIPRVASELGWSASDKPGQDNSCYQQKI

Gene Information

Entrez Gene ID
15485
Gene Name
hydroxysteroid (17-beta) dehydrogenase 1
Gene Symbol
Hsd17b1
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005829 IEA:Ensembl C cytosol
GO:0031965 IEA:Ensembl C nuclear membrane
GO:0004303 IEA:UniProtKB-EC F estradiol 17-beta-dehydrogenase activity
GO:0060348 IEA:Ensembl P bone development
GO:0071248 IEA:Ensembl P cellular response to metal ion
GO:0006703 IEA:UniProtKB-UniPathway P estrogen biosynthetic process
GO:0061370 IEA:Ensembl P testosterone biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
ko04913 Ovarian steroidogenesis
mmu04913 Ovarian steroidogenesis
mmu00140 Steroid hormone biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR011348 17beta-dehydrogenase
IPR002347 Glucose/ribitol dehydrogenase
IPR016040 NAD(P)-binding domain
IPR020904 Short-chain dehydrogenase/reductase, conserved site
IPR002198 Short-chain dehydrogenase/reductase SDR

UniProt Annotations

Entry Information

Gene Name
hydroxysteroid (17-beta) dehydrogenase 1
Protein Entry
DHB1_MOUSE
UniProt ID
P51656
Species
Mouse

Comments

Comment Type Description
Catalytic Activity 17-beta-estradiol + NAD(P)(+) = estrone + NAD(P)H.
Function Favors the reduction of estrogens and androgens. Uses preferentially NADH.
Pathway Steroid biosynthesis; estrogen biosynthesis.
Similarity Belongs to the short-chain dehydrogenases/reductases (SDR) family. {ECO:0000305}.
Subcellular Location Cytoplasm.
Subunit Homodimer. {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP000057 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6754248 RefSeq NP_034605 344 estradiol 17-beta-dehydrogenase 1

Identical Sequences to LMP000057 proteins

Reference Database Accession Length Protein Name
GI:6754248 EMBL CAA61770.1 344 estradiol 17 beta-dehydrogenase [Mus musculus]
GI:6754248 GenBank AAM21195.1 344 17-beta-hydroxysteroid dehydrogenase [Mus musculus]
GI:6754248 GenBank AAI25658.1 344 Hydroxysteroid (17-beta) dehydrogenase 1 [Mus musculus]
GI:6754248 GenBank AAI25660.1 344 Hydroxysteroid (17-beta) dehydrogenase 1 [Mus musculus]
GI:6754248 GenBank EDL03877.1 344 hydroxysteroid (17-beta) dehydrogenase 1 [Mus musculus]
GI:6754248 SwissProt P51656.1 344 RecName: Full=Estradiol 17-beta-dehydrogenase 1; AltName: Full=17-beta-hydroxysteroid dehydrogenase type 1; Short=17-beta-HSD 1 [Mus musculus]

Related Sequences to LMP000057 proteins

Reference Database Accession Length Protein Name
GI:6754248 DBBJ BAE25350.1 337 unnamed protein product, partial [Mus musculus]
GI:6754248 EMBL CAA66349.1 344 17-beta-hydroxysteroid dehydrogenase type I [Rattus norvegicus]
GI:6754248 EMBL CAA66657.1 344 17 beta hydroxysteroid dehydrogenase type I [Rattus norvegicus]
GI:6754248 GenBank EDM06082.1 344 hydroxysteroid (17-beta) dehydrogenase 1 [Rattus norvegicus]
GI:6754248 RefSeq NP_036983.1 344 estradiol 17-beta-dehydrogenase 1 [Rattus norvegicus]
GI:6754248 SwissProt P51657.1 344 RecName: Full=Estradiol 17-beta-dehydrogenase 1; AltName: Full=17-beta-hydroxysteroid dehydrogenase type 1; Short=17-beta-HSD 1 [Rattus norvegicus]