Gene/Proteome Database (LMPD)

LMPD ID
LMP000059
Gene ID
237542
Species
Mus musculus (Mouse)
Gene Name
oxysterol binding protein-like 8
Gene Symbol
Osbpl8
Synonyms
AA536976; AA536995; C730029P18Rik; D330025H14Rik; ORP-8
Chromosome
10
Map Location
10 D1|10
Summary
This gene encodes a member of the oxysterol-binding protein (Osbp) family, a group of intracellular lipid receptors. Like most members, the encoded protein contains an N-terminal pleckstrin homology domain and a highly conserved C-terminal Osbp-like sterol-binding domain. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Orthologs
View orthologs and multiple alignments for Osbpl8

Proteins

oxysterol-binding protein-like protein 8 isoform a
Refseq ID NP_780698
Protein GI 51243034
UniProt ID B9EJ86
mRNA ID NM_175489
Length 889
RefSeq Status REVIEWED
MEAALADGEPDRSSLLGDSKDVLGPSTVVANSDEPQHLTPGKMSQRQGRDANPTPTRDLPQPSLSPASLHSQGFERGKEDISQNKDDSSLSMSKSKSESKLYNGSEKDSSTSSKLTKKESLKVQKKNYREEKKRATKELLSTITDPSVIVMADWLKIRGTLKSWTKLWCVLKPGVLLIYKTQKNGQWVGTVLLNACEIIERPSKKDGFCFKLFHPLEQSIWAVKGPKGEAVGSITQPLPSSYLIIRATSESDGRCWMDALELALKCSSLLKRTMVREGKEHDLSISSDSTHVTLYGLLRANNLHSGDNFQLNDSEIERQHFKDQDLYSDKSDKENDPEHDESDNEVLGKSEESDTDTSERQDDSYIDPEPVEPLKETTYMEQSHEELGEAGEASQTETVSEENKSLIWTLLKQVRPGMDLSRVVLPTFILEPRSFLDKLSDYYYHADFLSEAALEENPYFRLKKVVKWYLSGFYKKPKGLKKPYNPILGETFRCLWIHPRTNSKTFYIAEQVSHHPPISAFYVSNRKDGFCLSGSILAKSKFYGNSLSAILEGEARLTFLNRGEDYVMTMPYAHCKGILYGTMTLELGGTVNITCQKTGYSAILEFKLKPFLGSSDYVNQISGKLKLGKEVLATLEGHWDSEVFINDKKTDNSEIFWNPTPDIKQWRLIRHTVKFEEQDDFESEKLWQRVTKAINAKDQTEATQEKYVLEEAQRQAARDRKTKTQEWVCKLFELDPLTGEWHYKFSDTRPWDPLNDMIQFEKDGVIQTKVKHRTPMVSVPKMKHKPTRQQKKVVKGYSSPEPDIQDSSGSEAQSVKPSTRRKKGIDLGDIQSSIESIKQTQEEIKRNIMALRNHLLSSTPATDYFLQQKDYFVIFLLILLQVIINFIFK
oxysterol-binding protein-like protein 8 isoform b
Refseq ID NP_001003717
Protein GI 51243036
UniProt ID G3X9N6
mRNA ID NM_001003717
Length 847
RefSeq Status REVIEWED
MSQRQGRDANPTPTRDLPQPSLSPASLHSQGFERGKEDISQNKDDSSLSMSKSKSESKLYNGSEKDSSTSSKLTKKESLKVQKKNYREEKKRATKELLSTITDPSVIVMADWLKIRGTLKSWTKLWCVLKPGVLLIYKTQKNGQWVGTVLLNACEIIERPSKKDGFCFKLFHPLEQSIWAVKGPKGEAVGSITQPLPSSYLIIRATSESDGRCWMDALELALKCSSLLKRTMVREGKEHDLSISSDSTHVTLYGLLRANNLHSGDNFQLNDSEIERQHFKDQDLYSDKSDKENDPEHDESDNEVLGKSEESDTDTSERQDDSYIDPEPVEPLKETTYMEQSHEELGEAGEASQTETVSEENKSLIWTLLKQVRPGMDLSRVVLPTFILEPRSFLDKLSDYYYHADFLSEAALEENPYFRLKKVVKWYLSGFYKKPKGLKKPYNPILGETFRCLWIHPRTNSKTFYIAEQVSHHPPISAFYVSNRKDGFCLSGSILAKSKFYGNSLSAILEGEARLTFLNRGEDYVMTMPYAHCKGILYGTMTLELGGTVNITCQKTGYSAILEFKLKPFLGSSDYVNQISGKLKLGKEVLATLEGHWDSEVFINDKKTDNSEIFWNPTPDIKQWRLIRHTVKFEEQDDFESEKLWQRVTKAINAKDQTEATQEKYVLEEAQRQAARDRKTKTQEWVCKLFELDPLTGEWHYKFSDTRPWDPLNDMIQFEKDGVIQTKVKHRTPMVSVPKMKHKPTRQQKKVVKGYSSPEPDIQDSSGSEAQSVKPSTRRKKGIDLGDIQSSIESIKQTQEEIKRNIMALRNHLLSSTPATDYFLQQKDYFVIFLLILLQVIINFIFK

Gene Information

Entrez Gene ID
237542
Gene Name
oxysterol binding protein-like 8
Gene Symbol
Osbpl8
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0031965 IMP:MGI C nuclear membrane
GO:0015485 IEA:Ensembl F cholesterol binding
GO:0045444 IEA:Ensembl P fat cell differentiation
GO:0006869 IEA:UniProtKB-KW P lipid transport
GO:0030336 IMP:MGI P negative regulation of cell migration
GO:0010891 IEA:Ensembl P negative regulation of sequestering of triglyceride
GO:0046628 IMP:MGI P positive regulation of insulin receptor signaling pathway
GO:0051897 IMP:MGI P positive regulation of protein kinase B signaling
GO:0090204 IMP:MGI P protein localization to nuclear pore

Domain Information

InterPro Annotations

Accession Description
IPR000648 Oxysterol-binding protein
IPR018494 Oxysterol-binding protein, conserved site
IPR001849 Pleckstrin homology domain
IPR011993 Pleckstrin homology-like domain

UniProt Annotations

Entry Information

Gene Name
oxysterol binding protein-like 8
Protein Entry
G3X9N6_MOUSE
UniProt ID
G3X9N6
Species
Mouse

Comments

Comment Type Description
Similarity Belongs to the OSBP family.
Similarity Contains 1 PH domain.

Identical and Related Proteins

Unique RefSeq proteins for LMP000059 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
51243034 RefSeq NP_780698 889 oxysterol-binding protein-like protein 8 isoform a
51243036 RefSeq NP_001003717 847 oxysterol-binding protein-like protein 8 isoform b

Identical Sequences to LMP000059 proteins

Reference Database Accession Length Protein Name
GI:51243034 GenBank EDL21721.1 889 oxysterol binding protein-like 8, isoform CRA_a [Mus musculus]
GI:51243036 GenBank EDL21722.1 847 oxysterol binding protein-like 8, isoform CRA_b [Mus musculus]
GI:51243034 GenBank AAI41384.1 889 Oxysterol binding protein-like 8 [Mus musculus]
GI:51243036 RefSeq XP_006513702.1 847 PREDICTED: oxysterol binding protein-like 8 isoform X3 [Mus musculus]

Related Sequences to LMP000059 proteins

Reference Database Accession Length Protein Name
GI:51243036 GenBank EDL21721.1 889 oxysterol binding protein-like 8, isoform CRA_a [Mus musculus]
GI:51243034 GenBank EDM16738.1 888 similar to oxysterol-binding protein-like protein 8 isoform a (predicted), isoform CRA_b [Rattus norvegicus]
GI:51243036 GenBank AAI41384.1 889 Oxysterol binding protein-like 8 [Mus musculus]
GI:51243036 RefSeq NP_780698.2 889 oxysterol-binding protein-like protein 8 isoform a [Mus musculus]
GI:51243034 RefSeq XP_003754332.1 888 PREDICTED: oxysterol-binding protein-related protein 8 isoform X2 [Rattus norvegicus]
GI:51243036 RefSeq XP_003754332.1 888 PREDICTED: oxysterol-binding protein-related protein 8 isoform X2 [Rattus norvegicus]
GI:51243034 RefSeq XP_003750367.1 888 PREDICTED: oxysterol-binding protein-related protein 8 isoform X2 [Rattus norvegicus]
GI:51243036 RefSeq XP_003750367.1 888 PREDICTED: oxysterol-binding protein-related protein 8 isoform X2 [Rattus norvegicus]
GI:51243034 RefSeq XP_005358132.1 889 PREDICTED: oxysterol-binding protein-related protein 8 isoform X1 [Microtus ochrogaster]
GI:51243034 RefSeq XP_006241386.1 875 PREDICTED: oxysterol-binding protein-related protein 8 isoform X3 [Rattus norvegicus]
GI:51243036 RefSeq XP_006513700.1 886 PREDICTED: oxysterol binding protein-like 8 isoform X1 [Mus musculus]
GI:51243034 RefSeq XP_006513700.1 886 PREDICTED: oxysterol binding protein-like 8 isoform X1 [Mus musculus]