Gene/Proteome Database (LMPD)

LMPD ID
LMP000061
Gene ID
15486
Species
Mus musculus (Mouse)
Gene Name
hydroxysteroid (17-beta) dehydrogenase 2
Gene Symbol
Hsd17b2
Synonyms
AI194836; AI194967; AI255511
Alternate Names
estradiol 17-beta-dehydrogenase 2; 17 HSD type 2; 17-beta-HSD 2; testosterone 17-beta-dehydrogenase; 17-beta-hydroxysteroid dehydrogenase 2; 17-beta-hydroxysteroid dehydrogenase type 2
Chromosome
8
Map Location
8 E1|8
EC Number
1.1.1.62

Proteins

estradiol 17-beta-dehydrogenase 2
Refseq ID NP_032316
Protein GI 123173870
UniProt ID P51658
mRNA ID NM_008290
Length 381
RefSeq Status VALIDATED
MSPFASESAWLCLAAAAVLGGTLLCGCRSGRQLRSQAVCLAGLWGGACLLSLSLLCTLFLLSVACFLLLYMSSSDQDLLPVDQKAVLVTGADSGFGHGLAKHLDKLGFTVFAGVLDKEGPGAEELRKHCSERLSVLQMDVTKPEQIKDAHSKVTEKIQDKGLWAVVNNAGVFHLPIDGELIPMSIYRKCMAVNFFGTVEVTKAFLPLLRKSKGRLVNVSSMGGTVPLQMTSAYAATKAALTMFSTIIRQELDKWGVKVVTIKPGGFKTNITGSQDIWDKMEKEILDHFSKDIQENYGQDYVHTQKLIIPTLKERSNPDITPVLRDIQHAISARNPSSFYYPGRMAYLWVCLAAYCPTSLLDYVIKKGFYPQPTPRALRTVH

Gene Information

Entrez Gene ID
15486
Gene Name
hydroxysteroid (17-beta) dehydrogenase 2
Gene Symbol
Hsd17b2
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0004303 IEA:UniProtKB-EC F estradiol 17-beta-dehydrogenase activity
GO:0047035 IEA:UniProtKB-EC F testosterone dehydrogenase (NAD+) activity
GO:0001701 IMP:MGI P in utero embryonic development
GO:0001890 IMP:MGI P placenta development
GO:0032526 IEA:Ensembl P response to retinoic acid
GO:0006694 IEA:UniProtKB-KW P steroid biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
ko04913 Ovarian steroidogenesis
mmu04913 Ovarian steroidogenesis
mmu00140 Steroid hormone biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR002347 Glucose/ribitol dehydrogenase
IPR016040 NAD(P)-binding domain
IPR002198 Short-chain dehydrogenase/reductase SDR
IPR020904 Short-chain dehydrogenase/reductase, conserved site

UniProt Annotations

Entry Information

Gene Name
hydroxysteroid (17-beta) dehydrogenase 2
Protein Entry
DHB2_MOUSE
UniProt ID
P51658
Species
Mouse

Comments

Comment Type Description
Catalytic Activity 17-beta-estradiol + NAD(P)(+) = estrone + NAD(P)H.
Catalytic Activity Testosterone + NAD(+) = androstenedione + NADH.
Function Capable of catalyzing the interconversion of testosterone and androstenedione, as well as estradiol and estrone. Also has 20-alpha-HSD activity. Uses NADH while EDH17B3 uses NADPH (By similarity). {ECO:0000250}.
Similarity Belongs to the short-chain dehydrogenases/reductases (SDR) family. {ECO:0000305}.
Subcellular Location Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.

Identical and Related Proteins

Unique RefSeq proteins for LMP000061 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
123173870 RefSeq NP_032316 381 estradiol 17-beta-dehydrogenase 2

Identical Sequences to LMP000061 proteins

Reference Database Accession Length Protein Name
GI:123173870 EMBL CAA70706.1 381 17-beta-hydroxysteroid dehydrogenase type II [Mus musculus]
GI:123173870 SwissProt P51658.2 381 RecName: Full=Estradiol 17-beta-dehydrogenase 2; AltName: Full=17-beta-hydroxysteroid dehydrogenase type 2; Short=17-beta-HSD 2; AltName: Full=Testosterone 17-beta-dehydrogenase [Mus musculus]

Related Sequences to LMP000061 proteins

Reference Database Accession Length Protein Name
GI:123173870 EMBL CAA64982.1 358 17-beta-hydroxysteroid dehydrogenase type II [Mus musculus]
GI:123173870 EMBL CAA62617.1 381 17-beta hydroxysteroid dehydrogenase type 2 [Rattus norvegicus]
GI:123173870 GenBank EDL11587.1 358 hydroxysteroid (17-beta) dehydrogenase 2, partial [Mus musculus]
GI:123173870 GenBank AEK13592.1 381 Sequence 4 from patent US 7972785
GI:123173870 RefSeq NP_077367.1 381 estradiol 17-beta-dehydrogenase 2 [Rattus norvegicus]
GI:123173870 SwissProt Q62730.1 381 RecName: Full=Estradiol 17-beta-dehydrogenase 2; AltName: Full=17-beta-hydroxysteroid dehydrogenase type 2; Short=17-beta-HSD 2; AltName: Full=Testosterone 17-beta-dehydrogenase [Rattus norvegicus]