Gene/Proteome Database (LMPD)

LMPD ID
LMP000064
Gene ID
18784
Species
Mus musculus (Mouse)
Gene Name
phospholipase A2, group V
Gene Symbol
Pla2g5
Synonyms
PLA2; sPLA2
Alternate Names
calcium-dependent phospholipase A2; PLA2-10; group V phospholipase A2; phosphatidylcholine 2-acylhydrolase 5
Chromosome
4
Map Location
4 D3|4 70.57 cM
EC Number
3.1.1.4

Proteins

calcium-dependent phospholipase A2 precursor
Refseq ID NP_001116426
Protein GI 171906563
UniProt ID P97391
mRNA ID NM_001122954
Length 137
RefSeq Status VALIDATED
MKGLLTLAWFLACSVPAVPGGLLELKSMIEKVTRKNAFKNYGFYGCYCGWGGRGTPKDGTDWCCQMHDRCYGQLEEKDCAIRTQSYDYRYTNGLVICEHDSFCPMRLCACDRKLVYCLRRNLWTYNPLYQYYPNFLC
calcium-dependent phospholipase A2 precursor
Refseq ID NP_035240
Protein GI 171906565
UniProt ID P97391
mRNA ID NM_011110
Length 137
RefSeq Status VALIDATED
Protein sequence is identical to GI:171906563 (mRNA isoform)
sig_peptide: 1..20 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2075 peptide sequence: MKGLLTLAWFLACSVPAVPG mat_peptide: 21..137 product: Calcium-dependent phospholipase A2 experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (P97391.2) calculated_mol_wt: 13902 peptide sequence: GLLELKSMIEKVTRKNAFKNYGFYGCYCGWGGRGTPKDGTDWCCQMHDRCYGQLEEKDCAIRTQSYDYRYTNGLVICEHDSFCPMRLCACDRKLVYCLRRNLWTYNPLYQYYPNFLC sig_peptide: 1..20 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2075 peptide sequence: MKGLLTLAWFLACSVPAVPG mat_peptide: 21..137 product: Calcium-dependent phospholipase A2 experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (P97391.2) calculated_mol_wt: 13902 peptide sequence: GLLELKSMIEKVTRKNAFKNYGFYGCYCGWGGRGTPKDGTDWCCQMHDRCYGQLEEKDCAIRTQSYDYRYTNGLVICEHDSFCPMRLCACDRKLVYCLRRNLWTYNPLYQYYPNFLC

Gene Information

Entrez Gene ID
18784
Gene Name
phospholipase A2, group V
Gene Symbol
Pla2g5
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0009986 IDA:MGI C cell surface
GO:0005576 IEA:UniProtKB-KW C extracellular region
GO:0016020 IEA:UniProtKB-KW C membrane
GO:0005509 IEA:InterPro F calcium ion binding
GO:0004623 IDA:UniProtKB F phospholipase A2 activity
GO:0005102 IPI:UniProtKB F receptor binding
GO:0050482 IDA:UniProtKB P arachidonic acid secretion
GO:0016042 IEA:UniProtKB-KW P lipid catabolic process
GO:0006644 IDA:UniProtKB P phospholipid metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
mmu04975 Fat digestion and absorption
mmu04014 Ras signaling pathway

Domain Information

InterPro Annotations

Accession Description
IPR001211 Phospholipase A2
IPR013090 Phospholipase A2, active site
IPR016090 Phospholipase A2 domain

UniProt Annotations

Entry Information

Gene Name
phospholipase A2, group V
Protein Entry
PA2G5_MOUSE
UniProt ID
P97391
Species
Mouse

Comments

Comment Type Description
Catalytic Activity Phosphatidylcholine + H(2)O = 1- acylglycerophosphocholine + a carboxylate. {ECO:0000255|PROSITE- ProRule:PRU10035, ECO:0000255|PROSITE-ProRule:PRU10036}.
Cofactor Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000250}; Note=Binds 1 Ca(2+) ion per subunit. {ECO:0000250};
Function PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. This isozyme hydrolyzes L- alpha-palmitoyl-2-oleoyl phosphatidylcholine more efficiently than L-alpha-1-palmitoyl-2-arachidonyl phosphatidylcholine, L-alpha-1- palmitoyl-2-arachidonyl phosphatidylethanolamine or L-alpha-1- stearoyl-2-arachidonyl phosphatidylinositol (By similarity). {ECO:0000250}.
Ptm This enzyme lacks one of the seven disulfide bonds found in similar PA2 proteins.
Similarity Belongs to the phospholipase A2 family. {ECO:0000305}.
Subcellular Location Secreted {ECO:0000269|PubMed:10531350}. Membrane {ECO:0000269|PubMed:10531350}. Note=Also associated with various membranous organelles including the Golgi apparatus, nuclear envelope, and plasma membrane.

Identical and Related Proteins

Unique RefSeq proteins for LMP000064 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
171906563 RefSeq NP_001116426 137 calcium-dependent phospholipase A2 precursor

Identical Sequences to LMP000064 proteins

Reference Database Accession Length Protein Name
GI:171906563 DBBJ BAE34019.1 137 unnamed protein product [Mus musculus]
GI:171906563 GenBank EDL13281.1 137 phospholipase A2, group V, isoform CRA_c [Mus musculus]
GI:171906563 RefSeq NP_035240.3 137 calcium-dependent phospholipase A2 precursor [Mus musculus]
GI:171906563 RefSeq XP_006538722.1 137 PREDICTED: calcium-dependent phospholipase A2 isoform X2 [Mus musculus]
GI:171906563 RefSeq XP_006538723.1 137 PREDICTED: calcium-dependent phospholipase A2 isoform X3 [Mus musculus]
GI:171906563 RefSeq XP_006538724.1 137 PREDICTED: calcium-dependent phospholipase A2 isoform X4 [Mus musculus]

Related Sequences to LMP000064 proteins

Reference Database Accession Length Protein Name
GI:171906563 GenBank AAD45807.1 137 group V phospholipase A2 [Mus musculus]
GI:171906563 GenBank ABK42327.1 137 phospholipase A2 group V [synthetic construct]
GI:171906563 GenBank EDL13282.1 154 phospholipase A2, group V, isoform CRA_d, partial [Mus musculus]
GI:171906563 GenBank AEU43290.1 137 Sequence 39 from patent US 8052970
GI:171906563 RefSeq XP_006538721.1 314 PREDICTED: calcium-dependent phospholipase A2 isoform X1 [Mus musculus]
GI:171906563 SwissProt P97391.2 137 RecName: Full=Calcium-dependent phospholipase A2; AltName: Full=Group V phospholipase A2; AltName: Full=PLA2-10; AltName: Full=Phosphatidylcholine 2-acylhydrolase 5; Flags: Precursor [Mus musculus]