Gene/Proteome Database (LMPD)

LMPD ID
LMP000071
Gene ID
10170
Species
Homo sapiens (Human)
Gene Name
dehydrogenase/reductase (SDR family) member 9
Gene Symbol
DHRS9
Synonyms
3-alpha-HSD; 3ALPHA-HSD; RDH-E2; RDH-TBE; RDH15; RDHL; RDHTBE; RETSDR8; SDR9C4
Alternate Names
dehydrogenase/reductase SDR family member 9; retinol dehydrogenase homolog; 3-alpha hydroxysteroid dehydrogenase; short-chain dehydrogenase/reductase retSDR8; NADP-dependent retinol dehydrogenase/reductase; short chain dehydrogenase/reductase family 9C, member 4; tracheobronchial epithelial cell-specific retinol dehydrogenase
Chromosome
2
Map Location
2q31.1
EC Number
1.1.-.-
Summary
This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. This protein demonstrates oxidoreductase activity toward hydroxysteroids and is able to convert 3-alpha-tetrahydroprogesterone to dihydroxyprogesterone and 3-alpha-androstanediol to dihydroxyprogesterone in the cytoplasm, and may additionally function as a transcriptional repressor in the nucleus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Orthologs
View orthologs and multiple alignments for DHRS9

Proteins

dehydrogenase/reductase SDR family member 9 isoform 1 precursor
Refseq ID NP_001135742
Protein GI 214010156
UniProt ID Q9BPW9
mRNA ID NM_001142270
Length 319
RefSeq Status REVIEWED
MLFWVLGLLILCGFLWTRKGKLKIEDITDKYIFITGCDSGFGNLAARTFDKKGFHVIAACLTESGSTALKAETSERLRTVLLDVTDPENVKRTAQWVKNQVGEKGLWGLINNAGVPGVLAPTDWLTLEDYREPIEVNLFGLISVTLNMLPLVKKAQGRVINVSSVGGRLAIVGGGYTPSKYAVEGFNDSLRRDMKAFGVHVSCIEPGLFKTNLADPVKVIEKKLAIWEQLSPDIKQQYGEGYIEKSLDKLKGNKSYVNMDLSPVVECMDHALTSLFPKTHYAAGKDAKIFWIPLSHMPAALQDFLLLKQKAELANPKAV
dehydrogenase/reductase SDR family member 9 isoform 1 precursor
Refseq ID NP_001135743
Protein GI 214010158
UniProt ID Q9BPW9
mRNA ID NM_001142271
Length 319
RefSeq Status REVIEWED
Protein sequence is identical to GI:214010156 (mRNA isoform)
dehydrogenase/reductase SDR family member 9 isoform 1 precursor
Refseq ID NP_954674
Protein GI 40548397
UniProt ID Q9BPW9
mRNA ID NM_199204
Length 319
RefSeq Status REVIEWED
Protein sequence is identical to GI:214010156 (mRNA isoform)
sig_peptide: 1..17 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2026 peptide sequence: MLFWVLGLLILCGFLWT mat_peptide: 18..319 product: Dehydrogenase/reductase SDR family member 9 experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q9BPW9.1) calculated_mol_wt: 33220 peptide sequence: RKGKLKIEDITDKYIFITGCDSGFGNLAARTFDKKGFHVIAACLTESGSTALKAETSERLRTVLLDVTDPENVKRTAQWVKNQVGEKGLWGLINNAGVPGVLAPTDWLTLEDYREPIEVNLFGLISVTLNMLPLVKKAQGRVINVSSVGGRLAIVGGGYTPSKYAVEGFNDSLRRDMKAFGVHVSCIEPGLFKTNLADPVKVIEKKLAIWEQLSPDIKQQYGEGYIEKSLDKLKGNKSYVNMDLSPVVECMDHALTSLFPKTHYAAGKDAKIFWIPLSHMPAALQDFLLLKQKAELANPKAV sig_peptide: 1..17 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2026 peptide sequence: MLFWVLGLLILCGFLWT mat_peptide: 18..319 product: Dehydrogenase/reductase SDR family member 9 experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q9BPW9.1) calculated_mol_wt: 33220 peptide sequence: RKGKLKIEDITDKYIFITGCDSGFGNLAARTFDKKGFHVIAACLTESGSTALKAETSERLRTVLLDVTDPENVKRTAQWVKNQVGEKGLWGLINNAGVPGVLAPTDWLTLEDYREPIEVNLFGLISVTLNMLPLVKKAQGRVINVSSVGGRLAIVGGGYTPSKYAVEGFNDSLRRDMKAFGVHVSCIEPGLFKTNLADPVKVIEKKLAIWEQLSPDIKQQYGEGYIEKSLDKLKGNKSYVNMDLSPVVECMDHALTSLFPKTHYAAGKDAKIFWIPLSHMPAALQDFLLLKQKAELANPKAV sig_peptide: 1..17 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2026 peptide sequence: MLFWVLGLLILCGFLWT mat_peptide: 18..319 product: Dehydrogenase/reductase SDR family member 9 experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q9BPW9.1) calculated_mol_wt: 33220 peptide sequence: RKGKLKIEDITDKYIFITGCDSGFGNLAARTFDKKGFHVIAACLTESGSTALKAETSERLRTVLLDVTDPENVKRTAQWVKNQVGEKGLWGLINNAGVPGVLAPTDWLTLEDYREPIEVNLFGLISVTLNMLPLVKKAQGRVINVSSVGGRLAIVGGGYTPSKYAVEGFNDSLRRDMKAFGVHVSCIEPGLFKTNLADPVKVIEKKLAIWEQLSPDIKQQYGEGYIEKSLDKLKGNKSYVNMDLSPVVECMDHALTSLFPKTHYAAGKDAKIFWIPLSHMPAALQDFLLLKQKAELANPKAV
dehydrogenase/reductase SDR family member 9 isoform 2
Refseq ID NP_001276692
Protein GI 576796343
UniProt ID Q9BPW9
mRNA ID NM_001289763
Length 379
RefSeq Status REVIEWED
MPEGRSHCACSITSLTLLVSLTRVTLDILQKLDPPQPAHWRHHLLVLYKKGVYLSHTGGKMLFWVLGLLILCGFLWTRKGKLKIEDITDKYIFITGCDSGFGNLAARTFDKKGFHVIAACLTESGSTALKAETSERLRTVLLDVTDPENVKRTAQWVKNQVGEKGLWGLINNAGVPGVLAPTDWLTLEDYREPIEVNLFGLISVTLNMLPLVKKAQGRVINVSSVGGRLAIVGGGYTPSKYAVEGFNDSLRRDMKAFGVHVSCIEPGLFKTNLADPVKVIEKKLAIWEQLSPDIKQQYGEGYIEKSLDKLKGNKSYVNMDLSPVVECMDHALTSLFPKTHYAAGKDAKIFWIPLSHMPAALQDFLLLKQKAELANPKAV

Gene Information

Entrez Gene ID
10170
Gene Name
dehydrogenase/reductase (SDR family) member 9
Gene Symbol
DHRS9
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0030176 IDA:UniProtKB C integral component of endoplasmic reticulum membrane
GO:0004022 IDA:UniProtKB F alcohol dehydrogenase (NAD) activity
GO:0016854 NAS:UniProtKB F racemase and epimerase activity
GO:0004745 IDA:UniProtKB F retinol dehydrogenase activity
GO:0047035 IDA:UniProtKB F testosterone dehydrogenase (NAD+) activity
GO:0042904 IDA:UniProtKB P 9-cis-retinoic acid biosynthetic process
GO:0008209 IDA:UniProtKB P androgen metabolic process
GO:0030855 NAS:UniProtKB P epithelial cell differentiation
GO:0042448 IDA:UniProtKB P progesterone metabolic process
GO:0042572 NAS:UniProtKB P retinol metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
hsa01100 Metabolic pathways
hsa00830 Retinol metabolism

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_160156 The canonical retinoid cycle in rods (twilight vision)
REACT_160125 Visual phototransduction

Domain Information

InterPro Annotations

Accession Description
IPR002347 Glucose/ribitol dehydrogenase
IPR016040 NAD(P)-binding domain
IPR002198 Short-chain dehydrogenase/reductase SDR

UniProt Annotations

Entry Information

Gene Name
dehydrogenase/reductase (SDR family) member 9
Protein Entry
DHRS9_HUMAN
UniProt ID
Q9BPW9
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q9BPW9-1; Sequence=Displayed; Name=2; Synonyms=Retinol dehydrogenase homolog isoform-2; IsoId=Q9BPW9-2; Sequence=VSP_015875; Note=No experimental confirmation available.; Name=3; Synonyms=Retinol dehydrogenase homolog isoform-1; IsoId=Q9BPW9-3; Sequence=VSP_015876; Note=No experimental confirmation available.; Name=4; IsoId=Q9BPW9-4; Sequence=VSP_054357; Note=No experimental confirmation available.;
Biophysicochemical Properties Kinetic parameters: KM=9 uM for NADH ; KM=72 uM for NAD ; KM=5 uM for allopregnanolone ; KM=7.5 uM for 3-alpha-androstanediol ; KM=24 uM for androsterone ; KM=12 uM for dihydrotestosterone ;
Function 3-alpha-hydroxysteroid dehydrogenase that converts 3- alpha-tetrahydroprogesterone (allopregnanolone) to dihydroxyprogesterone and 3-alpha-androstanediol to dihydroxyprogesterone. May play a role in the biosynthesis of retinoic acid from retinaldehyde, but seems to have low activity with retinoids. Can utilize both NADH and NADPH. {ECO
Similarity Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Subcellular Location Microsome membrane {ECO
Subunit Homotetramer.
Tissue Specificity Highly expressed in trachea and epidermis. Detected at lower levels in spinal cord, bone marrow, brain, tongue, esophagus, heart, colon, testis, placenta, lung, skeletal muscle and lymph node. {ECO

Identical and Related Proteins

Unique RefSeq proteins for LMP000071 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
214010156 RefSeq NP_001135742 319 dehydrogenase/reductase SDR family member 9 isoform 1 precursor
576796343 RefSeq NP_001276692 379 dehydrogenase/reductase SDR family member 9 isoform 2

Identical Sequences to LMP000071 proteins

Reference Database Accession Length Protein Name
GI:576796343 DBBJ BAH12402.1 379 unnamed protein product [Homo sapiens]
GI:214010156 GenBank AHE02613.1 319 Sequence 62701 from patent US 8586006
GI:214010156 GenBank AHE03474.1 319 Sequence 65282 from patent US 8586006
GI:214010156 GenBank AIC50529.1 319 DHRS9, partial [synthetic construct]
GI:214010156 RefSeq XP_004032794.1 319 PREDICTED: dehydrogenase/reductase SDR family member 9 isoform 1 [Gorilla gorilla gorilla]
GI:214010156 RefSeq XP_004032796.1 319 PREDICTED: dehydrogenase/reductase SDR family member 9 isoform 3 [Gorilla gorilla gorilla]
GI:214010156 RefSeq XP_004032797.1 319 PREDICTED: dehydrogenase/reductase SDR family member 9 isoform 4 [Gorilla gorilla gorilla]

Related Sequences to LMP000071 proteins

Reference Database Accession Length Protein Name
GI:214010156 DBBJ BAG36032.1 319 unnamed protein product [Homo sapiens]
GI:214010156 DBBJ BAH12402.1 379 unnamed protein product [Homo sapiens]
GI:576796343 GenBank ABP15908.1 319 Sequence 10 from patent US 7189530
GI:576796343 GenBank ABP16053.1 319 Sequence 20 from patent US 7189532
GI:576796343 GenBank ABP16946.1 319 Sequence 20 from patent US 7189563
GI:214010156 RefSeq XP_002812609.1 378 PREDICTED: dehydrogenase/reductase SDR family member 9 isoform X1 [Pongo abelii]
GI:576796343 RefSeq XP_002812609.1 378 PREDICTED: dehydrogenase/reductase SDR family member 9 isoform X1 [Pongo abelii]
GI:214010156 RefSeq XP_002812611.1 319 PREDICTED: dehydrogenase/reductase SDR family member 9 isoform X2 [Pongo abelii]
GI:576796343 RefSeq XP_003309347.1 379 PREDICTED: dehydrogenase/reductase SDR family member 9 isoform X2 [Pan troglodytes]
GI:214010156 RefSeq XP_004032795.1 379 PREDICTED: dehydrogenase/reductase SDR family member 9 isoform 2 [Gorilla gorilla gorilla]
GI:576796343 RefSeq XP_004032795.1 379 PREDICTED: dehydrogenase/reductase SDR family member 9 isoform 2 [Gorilla gorilla gorilla]
GI:214010156 RefSeq NP_001276692.1 379 dehydrogenase/reductase SDR family member 9 isoform 2 [Homo sapiens]