Gene/Proteome Database (LMPD)
LMPD ID
LMP000074
Gene ID
Species
Mus musculus (Mouse)
Gene Name
hydroxysteroid (17-beta) dehydrogenase 4
Gene Symbol
Synonyms
17-beta-HSD; 17[b]-HSD; 4; DBP; MFE-2; MFP2; MPF-2; Mfp-2; perMFE-2
Alternate Names
peroxisomal multifunctional enzyme type 2; 17-beta-HSD 4; D-bifunctional protein; multifunctional protein 2; 17-beta-hydroxysteroid dehydrogenase 4
Chromosome
18
Map Location
18 D1|18
EC Number
1.1.1.n12
Proteins
| peroxisomal multifunctional enzyme type 2 | |
|---|---|
| Refseq ID | NP_032318 |
| Protein GI | 31982273 |
| UniProt ID | P51660 |
| mRNA ID | NM_008292 |
| Length | 735 |
| RefSeq Status | VALIDATED |
| MASPLRFDGRVVLVTGAGGGLGRAYALAFAERGALVIVNDLGGDFKGIGKGSSAADKVVAEIRRKGGKAVANYDSVEAGEKLVKTALDTFGRIDVVVNNAGILRDRSFSRISDEDWDIIHRVHLRGSFQVTRAAWDHMKKQNYGRILMTSSASGIYGNFGQANYSAAKLGILGLCNTLAIEGRKNNIHCNTIAPNAGSRMTETVLPEDLVEALKPEYVAPLVLWLCHESCEENGGLFEVGAGWIGKLRWERTLGAIVRKRNQPMTPEAVRDNWEKICDFSNASKPQTIQESTGGIVEVLHKVDSEGISPNRTSHAAPAATSGFVGAVGHKLPSFSSSYTELQSIMYALGVGASVKNPKDLKFVYEGSADFSCLPTFGVIVAQKSMMNGGLAEVPGLSFNFAKALHGEQYLELYKPLPRSGELKCEAVIADILDKGSGVVIVMDVYSYSGKELICYNQFSVFVVGSGGFGGKRTSEKLKAAVAVPNRPPDAVLRDATSLNQAALYRLSGDWNPLHIDPDFASVAGFEKPILHGLCTFGFSARHVLQQFADNDVSRFKAIKVRFAKPVYPGQTLQTEMWKEGNRIHFQTKVHETGDVVISNAYVDLVPASGVSTQTPSEGGELQSALVFGEIGRRLKSVGREVVKKANAVFEWHITKGGTVAAKWTIDLKSGSGEVYQGPAKGSADVTIIISDEDFMEVVFGKLDPQKAFFSGRLKARGNIMLSQKLQMILKDYAKL | |
| mat_peptide: 1..311 product: (3R)-hydroxyacyl-CoA dehydrogenase experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (P51660.3) calculated_mol_wt: 33724 peptide sequence: MASPLRFDGRVVLVTGAGGGLGRAYALAFAERGALVIVNDLGGDFKGIGKGSSAADKVVAEIRRKGGKAVANYDSVEAGEKLVKTALDTFGRIDVVVNNAGILRDRSFSRISDEDWDIIHRVHLRGSFQVTRAAWDHMKKQNYGRILMTSSASGIYGNFGQANYSAAKLGILGLCNTLAIEGRKNNIHCNTIAPNAGSRMTETVLPEDLVEALKPEYVAPLVLWLCHESCEENGGLFEVGAGWIGKLRWERTLGAIVRKRNQPMTPEAVRDNWEKICDFSNASKPQTIQESTGGIVEVLHKVDSEGISPNR mat_peptide: 312..735 product: Enoyl-CoA hydratase 2 experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (P51660.3) calculated_mol_wt: 45777 peptide sequence: TSHAAPAATSGFVGAVGHKLPSFSSSYTELQSIMYALGVGASVKNPKDLKFVYEGSADFSCLPTFGVIVAQKSMMNGGLAEVPGLSFNFAKALHGEQYLELYKPLPRSGELKCEAVIADILDKGSGVVIVMDVYSYSGKELICYNQFSVFVVGSGGFGGKRTSEKLKAAVAVPNRPPDAVLRDATSLNQAALYRLSGDWNPLHIDPDFASVAGFEKPILHGLCTFGFSARHVLQQFADNDVSRFKAIKVRFAKPVYPGQTLQTEMWKEGNRIHFQTKVHETGDVVISNAYVDLVPASGVSTQTPSEGGELQSALVFGEIGRRLKSVGREVVKKANAVFEWHITKGGTVAAKWTIDLKSGSGEVYQGPAKGSADVTIIISDEDFMEVVFGKLDPQKAFFSGRLKARGNIMLSQKLQMILKDYAKL | |
Gene Information
Entrez Gene ID
Gene Name
hydroxysteroid (17-beta) dehydrogenase 4
Gene Symbol
Species
Mus musculus
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005739 | IDA:MGI | C | mitochondrion |
| GO:0005778 | IEA:Ensembl | C | peroxisomal membrane |
| GO:0005777 | IDA:MGI | C | peroxisome |
| GO:0044594 | IEA:Ensembl | F | 17-beta-hydroxysteroid dehydrogenase (NAD+) activity |
| GO:0003857 | IEA:Ensembl | F | 3-hydroxyacyl-CoA dehydrogenase activity |
| GO:0033989 | IEA:UniProtKB-EC | F | 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity |
| GO:0016853 | IEA:UniProtKB-KW | F | isomerase activity |
| GO:0016508 | IEA:Ensembl | F | long-chain-enoyl-CoA hydratase activity |
| GO:0060009 | IMP:MGI | P | Sertoli cell development |
| GO:0008209 | IEA:Ensembl | P | androgen metabolic process |
| GO:0008210 | IEA:Ensembl | P | estrogen metabolic process |
| GO:0006635 | IMP:MGI | P | fatty acid beta-oxidation |
| GO:0036112 | IEA:Ensembl | P | medium-chain fatty-acyl-CoA metabolic process |
| GO:0001649 | IEA:Ensembl | P | osteoblast differentiation |
| GO:0000038 | IMP:MGI | P | very long-chain fatty acid metabolic process |
| GO:0036111 | IEA:Ensembl | P | very long-chain fatty-acyl-CoA metabolic process |
KEGG Pathway Links
REACTOME Pathway Links
Domain Information
InterPro Annotations
UniProt Annotations
Entry Information
Gene Name
hydroxysteroid (17-beta) dehydrogenase 4
Protein Entry
DHB4_MOUSE
UniProt ID
Species
Mouse
Comments
| Comment Type | Description |
|---|---|
| Catalytic Activity | (24R,25R)-3-alpha,7-alpha,12-alpha,24- tetrahydroxy-5-beta-cholestanoyl-CoA = (24E)-3-alpha,7-alpha,12- alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA + H(2)O. |
| Catalytic Activity | (3R)-3-hydroxyacyl-CoA = (2E)-2-enoyl-CoA + H(2)O. |
| Catalytic Activity | (R)-3-hydroxyacyl-CoA + NAD(+) = 3-oxoacyl-CoA + NADH. |
| Function | Bifunctional enzyme acting on the peroxisomal beta- oxidation pathway for fatty acids. Catalyzes the formation of 3- ketoacyl-CoA intermediates from both straight-chain and 2-methyl- branched-chain fatty acids (By similarity). {ECO:0000250}. |
| Miscellaneous | The protein is found both as a full length peptide and in a cleaved version. {ECO:0000250}. |
| Pathway | Lipid metabolism; fatty acid beta-oxidation. |
| Similarity | Belongs to the short-chain dehydrogenases/reductases (SDR) family. {ECO:0000305}. |
| Similarity | Contains 1 MaoC-like domain. {ECO:0000305}. |
| Similarity | Contains 1 SCP2 domain. {ECO:0000305}. |
| Subcellular Location | Peroxisome {ECO:0000250}. |
| Subunit | Homodimer. {ECO:0000250}. |
| Tissue Specificity | Present in many tissues with highest concentrations in liver and kidney. |
Identical and Related Proteins
Unique RefSeq proteins for LMP000074 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 31982273 | RefSeq | NP_032318 | 735 | peroxisomal multifunctional enzyme type 2 |
Identical Sequences to LMP000074 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:31982273 | DBBJ | BAC40317.1 | 735 | unnamed protein product [Mus musculus] |
| GI:31982273 | DBBJ | BAE40862.1 | 735 | unnamed protein product [Mus musculus] |
| GI:31982273 | DBBJ | BAE39029.1 | 735 | unnamed protein product [Mus musculus] |
| GI:31982273 | DBBJ | BAE39222.1 | 735 | unnamed protein product [Mus musculus] |
| GI:31982273 | GenBank | EDL09936.1 | 735 | hydroxysteroid (17-beta) dehydrogenase 4, isoform CRA_d [Mus musculus] |
| GI:31982273 | SwissProt | P51660.3 | 735 | RecName: Full=Peroxisomal multifunctional enzyme type 2; Short=MFE-2; AltName: Full=17-beta-hydroxysteroid dehydrogenase 4; Short=17-beta-HSD 4; AltName: Full=D-bifunctional protein; Short=DBP; AltName: Full=Multifunctional protein 2; Short=MPF-2; Contains: RecName: Full=(3R)-hydroxyacyl-CoA dehydrogenase; Contains: RecName: Full=Enoyl-CoA hydratase 2; AltName: Full=3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase [Mus musculus] |
Related Sequences to LMP000074 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:31982273 | DBBJ | BAE36514.1 | 735 | unnamed protein product [Mus musculus] |
| GI:31982273 | DBBJ | BAE27744.1 | 735 | unnamed protein product [Mus musculus] |
| GI:31982273 | EMBL | CAA62015.1 | 735 | 17beta-hydroxysteroid dehydrogenase IV [Mus musculus] |
| GI:31982273 | GenBank | AAB49519.1 | 735 | 17 beta-hydroxysteroid dehydrogenase type IV [Rattus sp.] |
| GI:31982273 | GenBank | EDL09934.1 | 733 | hydroxysteroid (17-beta) dehydrogenase 4, isoform CRA_b [Mus musculus] |
| GI:31982273 | SwissProt | P97852.3 | 735 | RecName: Full=Peroxisomal multifunctional enzyme type 2; Short=MFE-2; AltName: Full=17-beta-hydroxysteroid dehydrogenase 4; Short=17-beta-HSD 4; AltName: Full=D-bifunctional protein; Short=DBP; AltName: Full=Multifunctional protein 2; Short=MPF-2; Contains: RecName: Full=(3R)-hydroxyacyl-CoA dehydrogenase; Contains: RecName: Full=Enoyl-CoA hydratase 2; AltName: Full=3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase [Rattus norvegicus] |