Gene/Proteome Database (LMPD)
LMPD ID
LMP000078
Gene ID
Species
Homo sapiens (Human)
Gene Name
phospholipase C, eta 2
Gene Symbol
Synonyms
PLC-eta2; PLCL4; PLCeta2
Alternate Names
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2; PLC-L4; RP3-395M20.1; phospholipase C-eta2; phospholipase C-eta-2; phospholipase C-like 4; phospholipase C-like protein 4; phosphoinositide phospholipase C-eta-2; phosphoinositide phospholipase C-like 4; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase eta-2
Chromosome
1
Map Location
1p36.32
EC Number
3.1.4.11
Summary
PLCH2 is a member of the PLC-eta family of the phosphoinositide-specific phospholipase C (PLC) superfamily of enzymes that cleave PtdIns(4,5) P2 to generate second messengers inositol 1,4,5-trisphosphate and diacylglycerol (Zhou et al., 2005 [PubMed 16107206]).[supplied by OMIM, Jun 2009]
Orthologs
Proteins
| 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 | |
|---|---|
| Refseq ID | NP_055453 |
| Protein GI | 78499633 |
| UniProt ID | O75038 |
| mRNA ID | NM_014638 |
| Length | 1416 |
| RefSeq Status | PROVISIONAL |
| MSGPWPSPDSRTKGTVAWLAEVLLWVGGSVVLSSEWQLGPLVERCMGAMQEGMQMVKLRGGSKGLVRFYYLDEHRSCIRWRPSRKNEKAKISIDSIQEVSEGRQSEVFQRYPDGSFDPNCCFSIYHGSHRESLDLVSTSSEVARTWVTGLRYLMAGISDEDSLARRQRTRDQWLKQTFDEADKNGDGSLSIGEVLQLLHKLNVNLPRQRVKQMFREADTDDHQGTLGFEEFCAFYKMMSTRRDLYLLMLTYSNHKDHLDAASLQRFLQVEQKMAGVTLESCQDIIEQFEPCPENKSKGLLGIDGFTNYTRSPAGDIFNPEHHHVHQDMTQPLSHYFITSSHNTYLVGDQLMSQSRVDMYAWVLQAGCRCVEVDCWDGPDGEPIVHHGYTLTSKILFKDVIETINKYAFIKNEYPVILSIENHCSVIQQKKMAQYLTDILGDKLDLSSVSSEDATTLPSPQMLKGKILVKGKKLPANISEDAEEGEVSDEDSADEIDDDCKLLNGDASTNRKRVENTAKRKLDSLIKESKIRDCEDPNNFSVSTLSPSGKLGRKSKAEEDVESGEDAGASRRNGRLVVGSFSRRKKKGSKLKKAASVEEGDEGQDSPGGQSRGATRQKKTMKLSRALSDLVKYTKSVATHDIEMEAASSWQVSSFSETKAHQILQQKPAQYLRFNQQQLSRIYPSSYRVDSSNYNPQPFWNAGCQMVALNYQSEGRMLQLNRAKFSANGGCGYVLKPGCMCQGVFNPNSEDPLPGQLKKQLVLRIISGQQLPKPRDSMLGDRGEIIDPFVEVEIIGLPVDCSREQTRVVDDNGFNPTWEETLVFMVHMPEIALVRFLVWDHDPIGRDFIGQRTLAFSSMMPGYRHVYLEGMEEASIFVHVAVSDISGKVKQALGLKGLFLRGPKPGSLDSHAAGRPPARPSVSQRILRRTASAPTKSQKPGRRGFPELVLGTRDTGSKGVADDVVPPGPGPAPEAPAQEGPGSGSPRDTRPLSTQRPLPPLCSLETIAEEPAPGPGPPPPAAVPTSSSQGRPPYPTGPGANVASPLEDTEEPRDSRPRPCNGEGAGGAYERAPGSQTDGRSQPRTLGHLPVIRRVKSEGQVPTEPLGGWRPLAAPFPAPAVYSDATGSDPLWQRLEPCGHRDSVSSSSSMSSSDTVIDLSLPSLGLGRSRENLAGAHMGRLPPRPHSASAARPDLPPVTKSKSNPNLRATGQRPPIPDELQPRSLAPRMAGLPFRPPWGCLSLVGVQDCPVAAKSKSLGDLTADDFAPSFEGGSRRLSHSLGLPGGTRRVSGPGVRRDTLTEQLRWLTVFQQAGDITSPTSLGPAGEGVAGGPGFVRRSSSRSHSRVRAIASRARQAQERQQRLQGLGRQGPPEEERGTPEGACSVGHEGSVDAPAPSKGALGPASAAAENLVLLRL | |
Gene Information
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005737 | IEA:UniProtKB-KW | C | cytoplasm |
| GO:0005886 | TAS:Reactome | C | plasma membrane |
| GO:0005509 | IEA:InterPro | F | calcium ion binding |
| GO:0004435 | IEA:UniProtKB-EC | F | phosphatidylinositol phospholipase C activity |
| GO:0004871 | IEA:UniProtKB-KW | F | signal transducer activity |
| GO:0043647 | TAS:Reactome | P | inositol phosphate metabolic process |
| GO:0035556 | IEA:InterPro | P | intracellular signal transduction |
| GO:0016042 | IEA:UniProtKB-KW | P | lipid catabolic process |
| GO:0046488 | IEA:Ensembl | P | phosphatidylinositol metabolic process |
| GO:0044281 | TAS:Reactome | P | small molecule metabolic process |
REACTOME Pathway Links
| REACTOME Pathway ID | Description |
|---|---|
| REACT_150154 | Inositol phosphate metabolism |
| REACT_111217 | Metabolism |
| REACT_150312 | Synthesis of IP3 and IP4 in the cytosol |
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR028393 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 |
| IPR000008 | C2 domain |
| IPR018247 | EF-Hand 1, calcium-binding site |
| IPR002048 | EF-hand domain |
| IPR011992 | EF-hand domain pair |
| IPR017946 | PLC-like phosphodiesterase, TIM beta/alpha-barrel domain |
| IPR001192 | Phosphoinositide phospholipase C family |
| IPR000909 | Phospholipase C, phosphatidylinositol-specific , X domain |
| IPR001711 | Phospholipase C, phosphatidylinositol-specific, Y domain |
| IPR015359 | Phospholipase C, phosphoinositol-specific, EF-hand-like |
| IPR001849 | Pleckstrin homology domain |
| IPR011993 | Pleckstrin homology-like domain |
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Alternative Products | Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=O75038-1; Sequence=Displayed; Name=2; IsoId=O75038-2; Sequence=VSP_029068, VSP_029072, VSP_029073; Name=3; IsoId=O75038-3; Sequence=VSP_029070; Note=No experimental confirmation available.; Name=4; IsoId=O75038-4; Sequence=VSP_029071, VSP_029074; Note=No experimental confirmation available. Ref.2 (BAB84975) sequence is in conflict in position: 1004:P->L. ; Name=5; IsoId=O75038-5; Sequence=VSP_029067, VSP_029069, VSP_029071, VSP_029074; Note=No experimental confirmation available. Ref.2 (BAC56932) sequence is in conflict in position: 209:Q->L. ; |
| Catalytic Activity | 1-phosphatidyl-1D-myo-inositol 4,5- bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol. |
| Cofactor | Name=Ca(2+); Xref=ChEBI |
| Function | The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. This phospholipase activity is very sensitive to calcium. May be important for formation and maintenance of the neuronal network in the postnatal brain (By similarity). |
| Sequence Caution | Sequence=AAH43358.1; Type=Frameshift; Positions=172; Evidence= ; Sequence=BAA32295.3; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence= ; Sequence=BAC56932.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence= ; |
| Similarity | Contains 1 C2 domain. {ECO |
| Similarity | Contains 1 PH domain. {ECO |
| Similarity | Contains 1 PI-PLC X-box domain. {ECO |
| Similarity | Contains 1 PI-PLC Y-box domain. {ECO |
| Similarity | Contains 2 EF-hand domains. {ECO |
| Subcellular Location | Cytoplasm. Cell membrane. Note=Localized predominantly at the plasma membrane. |
| Tissue Specificity | Expressed in retina and kidney. |
Identical and Related Proteins
Unique RefSeq proteins for LMP000078 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 78499633 | RefSeq | NP_055453 | 1416 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 |
Identical Sequences to LMP000078 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:78499633 | GenBank | ABA12209.1 | 1416 | phospholipase C-eta2 [Homo sapiens] |
| GI:78499633 | SwissProt | O75038.3 | 1416 | RecName: Full=1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2; AltName: Full=Phosphoinositide phospholipase C-eta-2; AltName: Full=Phosphoinositide phospholipase C-like 4; Short=PLC-L4; Short=Phospholipase C-like protein 4; AltName: Full=Phospholipase C-eta-2; Short=PLC-eta2 [Homo sapiens] |
Related Sequences to LMP000078 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:78499633 | RefSeq | XP_004024563.1 | 1387 | PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 isoform 1 [Gorilla gorilla gorilla] |
| GI:78499633 | RefSeq | XP_004024564.1 | 1419 | PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 isoform 2 [Gorilla gorilla gorilla] |
| GI:78499633 | RefSeq | XP_005545067.1 | 1416 | PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 isoform X1 [Macaca fascicularis] |
| GI:78499633 | RefSeq | XP_006711117.1 | 1413 | PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 isoform X1 [Homo sapiens] |
| GI:78499633 | RefSeq | XP_006725012.1 | 1388 | PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 isoform X1 [Homo sapiens] |
| GI:78499633 | RefSeq | XP_006725013.1 | 1389 | PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 isoform X2 [Homo sapiens] |