Gene/Proteome Database (LMPD)

LMPD ID
LMP000085
Gene ID
80908
Species
Mus musculus (Mouse)
Gene Name
ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase, transferase B, alpha 1-3-galactosyltransferase)
Gene Symbol
Abo
Synonyms
NAGAT
Alternate Names
histo-blood group ABO system transferase; cis-AB transferase; histo-blood group A transferase; histo-blood group B transferase; fucosylglycoprotein 3-alpha-galactosyltransferase; fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase; glycoprotein-fucosylgalactoside alpha-galactosyltransferase; glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase
Chromosome
2
Map Location
2 A3|2
EC Number
2.4.1.40

Proteins

histo-blood group ABO system transferase isoform a
Refseq ID NP_109643
Protein GI 224967118
UniProt ID P38649
mRNA ID NM_030718
Length 332
RefSeq Status VALIDATED
MNLRGRPKCNFLHLGILPFAVFVLVFFGYLFLSFRSQNLGHPGAVTRNAYLQPRVLKPTRKDVLVLTPWLAPIIWEGTFNIDILNEQFRIRNTTIGLTVFAIKKYVVFLKLFLETAEQHFMVGHKVIYYVFTDRPADVPQVILGAGRQLVVLTVRNYTRWQDVSMHRMEMISHFSERRFLREVDYLVCADADMKFSDHVGVEILSTFFGTLHPGFYSSSREAFTYERRPQSQAYIPWDRGDFYYGGAFFGGSVLEVYHLTKACHEAMMEDKANGIEPVWHDESYLNKYLLYHKPTKVLSPEYLWDQQLLGWPSIMKKLRYVAVPKDHQAIRN
histo-blood group ABO system transferase isoform b
Refseq ID NP_001277373
Protein GI 594190889
UniProt ID P38649
mRNA ID NM_001290444
Length 287
RefSeq Status VALIDATED
MNLRGRPKCNFLHLGILPFAVFVLVFFGYLFLSFRSQNLGHPGAVTRNAYLQPRVLKPTYVVFLKLFLETAEQHFMVGHKVIYYVFTDRPADVPQVILGAGRQLVVLTVRNYTRWQDVSMHRMEMISHFSERRFLREVDYLVCADADMKFSDHVGVEILSTFFGTLHPGFYSSSREAFTYERRPQSQAYIPWDRGDFYYGGAFFGGSVLEVYHLTKACHEAMMEDKANGIEPVWHDESYLNKYLLYHKPTKVLSPEYLWDQQLLGWPSIMKKLRYVAVPKDHQAIRN

Gene Information

Entrez Gene ID
80908
Gene Name
ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase, transferase B, alpha 1-3-galactosyltransferase)
Gene Symbol
Abo
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005576 IEA:UniProtKB-KW C extracellular region
GO:0005794 IEA:UniProtKB-KW C Golgi apparatus
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0004381 IDA:MGI F fucosylgalactoside 3-alpha-galactosyltransferase activity
GO:0004380 IDA:MGI F glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity
GO:0046872 IEA:UniProtKB-KW F metal ion binding
GO:0006486 IEA:UniProtKB-UniPathway P protein glycosylation

KEGG Pathway Links

KEGG Pathway ID Description
ko00601 Glycosphingolipid biosynthesis - lacto and neolacto series
mmu00601 Glycosphingolipid biosynthesis - lacto and neolacto series
mmu01100 Metabolic pathways

Domain Information

InterPro Annotations

Accession Description
IPR005076 Glycosyl transferase, family 6
IPR029044 Nucleotide-diphospho-sugar transferases

UniProt Annotations

Entry Information

Gene Name
ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase, transferase B, alpha 1-3-galactosyltransferase)
Protein Entry
BGAT_MOUSE
UniProt ID
P38649
Species
Mouse

Comments

Comment Type Description
Catalytic Activity UDP-alpha-D-galactose + alpha-L-fucosyl- (1->2)-D-galactosyl-R = UDP + alpha-D-galactosyl-(1->3)-(alpha-L- fucosyl-(1->2))-D-galactosyl-R.
Catalytic Activity UDP-N-acetyl-alpha-beta-D-galactosamine + glycoprotein-alpha-L-fucosyl-(1->2)-D-galactose = UDP + glycoprotein-N-acetyl-alpha-D-galactosaminyl-(1->3)-(alpha-L- fucosyl-(1->2))-beta-D-galactose.
Cofactor Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250}; Note=Binds 1 Mn(2+) ion per subunit. {ECO:0000250};
Domain The conserved DXD motif is involved in cofactor binding. The manganese ion interacts with the beta-phosphate group of UDP and may also have a role in catalysis.
Pathway Protein modification; protein glycosylation.
Sequence Caution Sequence=CAM23695.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Similarity Belongs to the glycosyltransferase 6 family. {ECO:0000305}.
Subcellular Location Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Secreted. Note=Membrane- bound form in trans cisternae of Golgi. Secreted into the body fluid (By similarity). {ECO:0000250}.
Tissue Specificity Submaxillary glands (at protein level). {ECO:0000269|PubMed:11278752}.

Identical and Related Proteins

Unique RefSeq proteins for LMP000085 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
224967118 RefSeq NP_109643 332 histo-blood group ABO system transferase isoform a
594190889 RefSeq NP_001277373 287 histo-blood group ABO system transferase isoform b

Identical Sequences to LMP000085 proteins

Reference Database Accession Length Protein Name
GI:224967118 DBBJ BAB20560.1 332 cis-AB transferase [Mus musculus]
GI:224967118 GenBank AAI16762.1 332 ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase, transferase B, alpha 1-3-galactosyltransferase) [Mus musculus]
GI:224967118 GenBank AAI16760.1 332 ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase, transferase B, alpha 1-3-galactosyltransferase) [Mus musculus]
GI:224967118 GenBank EDL08332.1 332 ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase, transferase B, alpha 1-3-galactosyltransferase) [Mus musculus]
GI:224967118 SwissProt P38649.2 332 RecName: Full=Histo-blood group ABO system transferase; AltName: Full=Cis-AB transferase; AltName: Full=Fucosylglycoprotein 3-alpha-galactosyltransferase; AltName: Full=Fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase; AltName: Full=Glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase; AltName: Full=Glycoprotein-fucosylgalactoside alpha-galactosyltransferase; AltName: Full=Histo-blood group A transferase; Short=A transferase; AltName: Full=Histo-blood group B transferase; Short=B transferase; AltName: Full=NAGAT [Mus musculus]

Related Sequences to LMP000085 proteins

Reference Database Accession Length Protein Name
GI:224967118 DBBJ BAB20559.1 327 cis-AB transferase, partial [Mus musculus]
GI:594190889 DBBJ BAB20560.1 332 cis-AB transferase [Mus musculus]
GI:224967118 DBBJ BAC28473.1 332 unnamed protein product [Mus musculus]
GI:224967118 DBBJ BAC29005.1 332 unnamed protein product [Mus musculus]
GI:594190889 GenBank AAI16762.1 332 ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase, transferase B, alpha 1-3-galactosyltransferase) [Mus musculus]
GI:594190889 GenBank AAI16760.1 332 ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase, transferase B, alpha 1-3-galactosyltransferase) [Mus musculus]
GI:594190889 GenBank EDL08332.1 332 ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase, transferase B, alpha 1-3-galactosyltransferase) [Mus musculus]
GI:594190889 RefSeq NP_109643.3 332 histo-blood group ABO system transferase isoform a [Mus musculus]
GI:224967118 RefSeq XP_006498519.1 389 PREDICTED: histo-blood group ABO system transferase isoform X1 [Mus musculus]
GI:224967118 RefSeq XP_006498520.1 334 PREDICTED: histo-blood group ABO system transferase isoform X2 [Mus musculus]
GI:224967118 RefSeq XP_006981163.1 360 PREDICTED: histo-blood group ABO system transferase-like [Peromyscus maniculatus bairdii]
GI:594190889 SwissProt P38649.2 332 RecName: Full=Histo-blood group ABO system transferase; AltName: Full=Cis-AB transferase; AltName: Full=Fucosylglycoprotein 3-alpha-galactosyltransferase; AltName: Full=Fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase; AltName: Full=Glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase; AltName: Full=Glycoprotein-fucosylgalactoside alpha-galactosyltransferase; AltName: Full=Histo-blood group A transferase; Short=A transferase; AltName: Full=Histo-blood group B transferase; Short=B transferase; AltName: Full=NAGAT [Mus musculus]