Gene/Proteome Database (LMPD)

LMPD ID
LMP000087
Gene ID
26875
Species
Mus musculus (Mouse)
Gene Name
piccolo (presynaptic cytomatrix protein)
Gene Symbol
Pclo
Synonyms
Acz; Pico
Chromosome
5
Map Location
5 A2|5

Proteins

protein piccolo isoform 1
Refseq ID NP_036125
Protein GI 160707976
UniProt ID Q9QYX7
mRNA ID NM_011995
Length 5068
RefSeq Status VALIDATED
MGNEASLEGEGLPEGLAAAAGGAGGSGSALHPGIPAGMEADLSQLSEEERRQIAAVMSRAQGLPKGSVPAAAAESPSMHRKQELDSSQAPQQPGKPPDPGRPPQHGLSKSRTTDTFRSEQKLPGRSPSTISLKESKSRTDFKEEYKSSMMPGFFSDVNPLSAVSSVVNKFNPFDLISDSEAVQEETTKKQKVAQKDQGKSEGITKPSLQQPSPKLIPKQQGPGKEVIPQDIPSKSVSSQQAEKTKPQAPGTAKPSQQSPAQTPAQQAKPVAQQPGPAKATVQQPGPAKSPAQPAGTGKSPAQPPVTAKPPAQQAGLEKTSLQQPGPKSLAQTPGQGKVPPGPAKSPAQQPGTAKLPAQQPGPQTAAKVPGPTKTPAQLSGPGKTPAQQPGPTKPSPQQPIPAKPQPQQPVATKPQPQQPAPAKPQPQHPTPAKPQPQHPTPAKPQPQQPTPAKPQPQQPTPAKPQPQQPTPAKPQPQHPTPAKPQPQQPGLGKPSAQQPSKSISQTVTGRPLQAPPTSAAQAPAQGLSKTICPLCNTTELLLHTPEKANFNTCTECQSTVCSLCGFNPNPHLTEIKEWLCLNCQMQRALGGELAAIPSSPQPTPKAASVQPATASKSPVPSQQASPKKELPSKQDSPKAPESKKPPPLVKQPTLHGPTPATAPQPPVAEALPKPAPPKKPSAALPEQAKAPVADVEPKQPKTTETLTDSPSSAAATSKPAILSSQVQAQAQVTTAPPLKTDSAKTSQSFPPTGDTITPLDSKAMPRPASDSKIVSHPGPTSESKDPVQKKEEPKKAQTKVTPKPDTKPVPKGSPTPSGTRPTTGQATPQSQQPPKPPEQSRRFSLNLGGIADAPKSQPTTPQETVTGKLFGFGASIFSQASNLISTAGQQAPHPQTGPAAPSKQAPPPSQTLAAQGPPKSTGPHPSAPAKTTAVKKETKGPAAENLEAKPVQAPTVKKAEKDKKPPPGKVSKPPPTEPEKAVLAQKPDKTTKPKPACPLCRTELNVGSQDPPNFNTCTECKNQVCNLCGFNPTPHLTEIQEWLCLNCQTQRAISGQLGDMDKMPPASSGPKASPVPAPAEPPPQKTPTAAHAKGKKKETEVKAETEKQIPEKETPSIEKTPPAVATDQKLEESEVTKSLVSVLPEKKPSEEEKALPADKKEKKPPAAEAPPLEEKKPIPDDQKLPPDAKPSASEGEEKRDLLKAHVQIPEEGPIGKVASLACEGEQQPDTRPEDLPGATPQTLPKDRQKESRDVTQPQAEGTAKEGRGEPSKDRTEKEEDKSDTSSSQQPKSPQGLSDTGYSSDGISGSLGEIPSLIPSDEKDLLKGLKKDSFSQESSPSSPSDLAKLESTVLSILEAQASTLVGEKAEKKTQPQKVSPEQPQDQQKTQTPSETRDISISEEEIKESQEKKVTSKKDSAQGFPSRKEHKENPELVDDLSPRRASYDSVEDSSESENSPVARRKRRTSIGSSSSEEYKQEDSQGSGEDEDFIRKQIIEMSADEDASGSEDEEFIRSQLKEIGGVTESQKREETKGKGKSPAGKHRRLTRKSSTSFDDDAGRRHSWHDEDDETFDESPELKFRETKSQESEELVVAGGGGLRRFKTIELNSTVTDKYSAESSQKKTTLYFDEEPELEMESLTDSPEDRSRGEGSSSLHASSFTPGTSPTSVSSLDEDSDSSPSHKKGESKQQRKARHRSHGPLLPTIEDSSEEEELREEEELLKEQEKQRELEQQQRKSSSKKSKKDKDELRAQRRRERPKTPPSNLSPIEDASPTEELRQAAEMEELHRSSCSEYSPSIESDPEGFEISPEKIIEVQKVYKLPTAVSLYSPTDEQSVMQKEGAQKALKSAEEMYEEMMHKPHKYKAFPAANERDEVFEKEPLYGGMLIEDYIYESLVEDTYNGSVDGSLLTRQDEQNGFMQQRGREQKIRLQEQIYDDPMQKITDLQKEFYELESLHSIVPQEDIVSSSYIIPESHEIVDLGSMVTSTSEEKKLLDADAAYEELMKRQQMQVTDGSSLIQTTMGDDMAESTLDFDRVQDASLTSSILSGASLTDSTSSATLSIPDVKITQHFSTEEFEDEYVTDYTREIQEIIAHESLILTYSEPSESATSVPPSDTPSLTSSISSVCTTDSSSPVTTLDSLTTVYTEPADVITKFKDSEEISSTYFPGSVIDYPEDIGVSLDRTITPESRTNADQIMISFPGIAPSITESVATKPERPQADTISTDLPISEKELIKGKKETGDGIILEVLDAYKDKREESEAELTKISLPETGLAPTPSSQTKEQPGSPHSVSGEILGQEKPTYRSPSGGLPVSTHPSKSHPFFRSSSLDISAQPPPPPPPPPPPPPPPPPPPPPPLPPATSPKPPTYPKRKLAAAAPVAPTAIVTAHADAIPTVEATAARRSNGLPATKICAAAPPPVPPKPSSIPTGLVFTHRPEASKPPIAPKPAVPEIPVTTQKTTDTCPKPTGLPLTSNMSLNLVTSADYKLPSPTSPLSPHSNKSSPRYSKSLMETYVVITLPSEPGTPTDSSAAQAITSWPLGSPPKDLVSLETVFSVVPPMTSTEIPSASQPTLYTSGALGTFSVTPAVTASLFQTVPTSLTQFLPAEASKPEVSAVSSAVPSVAPRSVSIPIPPEPLALDRHQYKENGKLPLIGDAIDLRTIPKSEVKVTEKCMDLSASAMDVKRQTTANEVYRRQISAVQPSIINLSAASSLGTPVTMDSKTVAVVTCTDTTIYTTGTESQVGIEHAVTSPLQLTTSKHTELQYRKPSSQAFPMIRDEAPINLSLGPSTQAVTLAVTKPVTVPPVGVTNGWTDSTISQGITDGEVVDLSTSKSHRTVVTMDESTSNVVTKIIEDEEKPVDLTAGRRAVCCDMVYKLPFGRSCTAQQPATTLPEDRFGYRDDHYQYDRSGPYGYRGIGGMKPSMSDTNLAEAGHFFYKSKNAFDYSGGTEAAVDLTSGRVSTGEVMDYSSKTTGPYPETRQVISGVGISTPQYSTARMTPPPGPQYGVGSVLRSSNGVVYSSVATPIPSTFAITTQPGSIFSTTVRDLSGIHTTDAITSLSALHQSQPMPRSYFITTGASETDISVTSIDINASLQTITMETLPAETMDSVPTLTTASEVFSEVVGEESTLLIVPDEDKQQQQLDLERELLELEKIKQQRFAEELEWERQEIQRFREQEKIMVQKKLEELQSMKQHLLYQQEEERQAQFMMRQETLAQQQLQLEQIQQLQQQLHQQLEEQKLRQIYQYNYEPSGTASPQTTTEQAILEGQYVATEGSQFWATEDATTTASTVVAIEIPQSQGWYTVQSDGVTQYIAPPGILSTVSEIPLTDVVVKEEKQPKKRSSGAKVRGQYDEMGESMADDPRNLKKIVDSGVQTDDEETADRTYASRRRRTKKSVDTSVQTDDEDQDEWDMPSRSRRKARTGKYGDSTAEGDKTKPPSKVSSVAVQTVAEISVQTEPLGTIRTPSIRARVDAKVEIIKHISAPEKTYKGGSLGCQTETDPDTQSPPYMGATSPPKDKKRPTPLEIGYSSSHLRADPTVQLAPSPPKSPKVLYSPISPLSPGHALEPAFVPYEKPLPDDISPQKVLHPDMAKVPPASPKTAKMMQRSMSDPKPLSPTADESSRAPFQYSEGFTAKGSQTTSGTQKKVKRTLPNPPPEEASTGTQSTYSTMGTASRRRMCRTNTMARAKILQDIDRELDLVERESAKLRKKQAELDEEEKEIDAKLRYLEMGINRRKEALLKEREKRERAYLQGVAEDRDYMSDSEVSSTRPSRVESQHGIERPRTAPQTEFSQFIPPQTQTEAQLVPPTSPYTQYQYSSPALPTQAPTPYTQQSHFQQQTLYHQQVSPYQTQPTFQAVATMSFTPQAQPTPTPQPSYQLPSQMMVIQQKPRQTTLYLEPKITSTYEVIRNQPLMIAPVSTDNTYAVSHLGSKYNSLDLRIGLEERSSMASSPISSISADSFYADIDHHTSRNYVLIDDIGDITKGTAALSSAFSLHEKDLSKTDRLLRTTETRRSQEVTDFLAPLQTSSRLHSYVKAEEDSMEDPYELKLLKHQIKQEFRRGTESLDHLAGLSHYYHADTSYRHFPKSEKYSISRLTLEKQAAKQLPAAILYQKQSKHKKALIDPKMSKFSPIQESRDLEPDYPTYLSSSTSSIGGISSRARLLQDDITFGLRKNITDQQKFMGSSLGSGLGTLGNTIRSALQDEADKPYSSGSRSRPSSRPSSVYGLDLSIKRDSSSSSLRLKAQEAEALDVSFGHSSSSARTKPTSLPISQSRGRIPIVAQNSEEESPLSPVGQPMGMARAAAGPLPPISADTRDQFGSSHSLPEVQQHMREESRTRGYDRDIAFIMDDFQHAMSDSEAYHLRREETDWFDKPRESRLENGHGLDRKLPERLVHSRPLSQHQEQILQMNGKTMHYIFPHARIKITRDSKDHTVSGNGLGIRIVGGKEIPGHSGEIGAYIAKILPGGSAEHSGKLIEGMQVLEWNGIPLTSKTYEEVQSIINQQSGEAEICVRLDLNMLSDSENPQHLELHEPPKVVDKAKSPGVDPKQLAAELQKVSLQQSPLVMSSVVEKGAHAHSGPTSAGSSSVPSPGQPGSPSVSKKKHGGSKPTDVSKTASHPITGEIQLQINYDLGNLIIHILQARNLVPRDNNGYSDPFVKVYLLPGRGQVMVVQNASVEYKRRTKYVQKSLNPEWNQTVIYKSISMEQLMKKTLEVTVWDYDRFSSNDFLGEVLIDLSSTSHLDNTPRWYPLKEQTESIEHGKSHSSQNSQQSPKPSVIKSRSHGIFPDPSKDMQVPTIEKSHSSPGSSKSSSEGHLRSHGPSRSQSKTSVAQTHLEDAGAAIAAAEAAVQQLRIQPTKPTNHRPAETSVSTGSSGSSVGSGYSVDSEGSSCVAGEPNLLPIPRIGKMGQNGQDPVKQPGMGAADTEAKTQVMGEIKLALKKEMKTDGEQLIVEILQCRNITYKFKSPDHLPDLYVKIYVINIATQKKVIKKKTRVCRHDREPSFNETFRFSLSPAGHSLQILLFSNGGKFMKKTLIGEACIWLDKVDLRKRIVNWHKLLMSPTQTH
protein piccolo isoform 2
Refseq ID NP_001104266
Protein GI 160707978
UniProt ID Q9QYX7
mRNA ID NM_001110796
Length 4863
RefSeq Status VALIDATED
MGNEASLEGEGLPEGLAAAAGGAGGSGSALHPGIPAGMEADLSQLSEEERRQIAAVMSRAQGLPKGSVPAAAAESPSMHRKQELDSSQAPQQPGKPPDPGRPPQHGLSKSRTTDTFRSEQKLPGRSPSTISLKESKSRTDFKEEYKSSMMPGFFSDVNPLSAVSSVVNKFNPFDLISDSEAVQEETTKKQKVAQKDQGKSEGITKPSLQQPSPKLIPKQQGPGKEVIPQDIPSKSVSSQQAEKTKPQAPGTAKPSQQSPAQTPAQQAKPVAQQPGPAKATVQQPGPAKSPAQPAGTGKSPAQPPVTAKPPAQQAGLEKTSLQQPGPKSLAQTPGQGKVPPGPAKSPAQQPGTAKLPAQQPGPQTAAKVPGPTKTPAQLSGPGKTPAQQPGPTKPSPQQPIPAKPQPQQPVATKPQPQQPAPAKPQPQHPTPAKPQPQHPTPAKPQPQQPTPAKPQPQQPTPAKPQPQQPTPAKPQPQHPTPAKPQPQQPGLGKPSAQQPSKSISQTVTGRPLQAPPTSAAQAPAQGLSKTICPLCNTTELLLHTPEKANFNTCTECQSTVCSLCGFNPNPHLTEIKEWLCLNCQMQRALGGELAAIPSSPQPTPKAASVQPATASKSPVPSQQASPKKELPSKQDSPKAPESKKPPPLVKQPTLHGPTPATAPQPPVAEALPKPAPPKKPSAALPEQAKAPVADVEPKQPKTTETLTDSPSSAAATSKPAILSSQVQAQAQVTTAPPLKTDSAKTSQSFPPTGDTITPLDSKAMPRPASDSKIVSHPGPTSESKDPVQKKEEPKKAQTKVTPKPDTKPVPKGSPTPSGTRPTTGQATPQSQQPPKPPEQSRRFSLNLGGIADAPKSQPTTPQETVTGKLFGFGASIFSQASNLISTAGQQAPHPQTGPAAPSKQAPPPSQTLAAQGPPKSTGPHPSAPAKTTAVKKETKGPAAENLEAKPVQAPTVKKAEKDKKPPPGKVSKPPPTEPEKAVLAQKPDKTTKPKPACPLCRTELNVGSQDPPNFNTCTECKNQVCNLCGFNPTPHLTEIQEWLCLNCQTQRAISGQLGDMDKMPPASSGPKASPVPAPAEPPPQKTPTAAHAKGKKKETEVKAETEKQIPEKETPSIEKTPPAVATDQKLEESEVTKSLVSVLPEKKPSEEEKALPADKKEKKPPAAEAPPLEEKKPIPDDQKLPPDAKPSASEGEEKRDLLKAHVQIPEEGPIGKVASLACEGEQQPDTRPEDLPGATPQTLPKDRQKESRDVTQPQAEGTAKEGRGEPSKDRTEKEEDKSDTSSSQQPKSPQGLSDTGYSSDGISGSLGEIPSLIPSDEKDLLKGLKKDSFSQESSPSSPSDLAKLESTVLSILEAQASTLVGEKAEKKTQPQKVSPEQPQDQQKTQTPSETRDISISEEEIKESQEKKVTSKKDSAQGFPSRKEHKENPELVDDLSPRRASYDSVEDSSESENSPVARRKRRTSIGSSSSEEYKQEDSQGSGEDEDFIRKQIIEMSADEDASGSEDEEFIRSQLKEIGGVTESQKREETKGKGKSPAGKHRRLTRKSSTSFDDDAGRRHSWHDEDDETFDESPELKFRETKSQESEELVVAGGGGLRRFKTIELNSTVTDKYSAESSQKKTTLYFDEEPELEMESLTDSPEDRSRGEGSSSLHASSFTPGTSPTSVSSLDEDSDSSPSHKKGESKQQRKARHRSHGPLLPTIEDSSEEEELREEEELLKEQEKQRELEQQQRKSSSKKSKKDKDELRAQRRRERPKTPPSNLSPIEDASPTEELRQAAEMEELHRSSCSEYSPSIESDPEGFEISPEKIIEVQKVYKLPTAVSLYSPTDEQSVMQKEGAQKALKSAEEMYEEMMHKPHKYKAFPAANERDEVFEKEPLYGGMLIEDYIYESLVEDTYNGSVDGSLLTRQDEQNGFMQQRGREQKIRLQEQIYDDPMQKITDLQKEFYELESLHSIVPQEDIVSSSYIIPESHEIVDLGSMVTSTSEEKKLLDADAAYEELMKRQQMQVTDGSSLIQTTMGDDMAESTLDFDRVQDASLTSSILSGASLTDSTSSATLSIPDVKITQHFSTEEFEDEYVTDYTREIQEIIAHESLILTYSEPSESATSVPPSDTPSLTSSISSVCTTDSSSPVTTLDSLTTVYTEPADVITKFKDSEEISSTYFPGSVIDYPEDIGVSLDRTITPESRTNADQIMISFPGIAPSITESVATKPERPQADTISTDLPISEKELIKGKKETGDGIILEVLDAYKDKREESEAELTKISLPETGLAPTPSSQTKEQPGSPHSVSGEILGQEKPTYRSPSGGLPVSTHPSKSHPFFRSSSLDISAQPPPPPPPPPPPPPPPPPPPPPPLPPATSPKPPTYPKRKLAAAAPVAPTAIVTAHADAIPTVEATAARRSNGLPATKICAAAPPPVPPKPSSIPTGLVFTHRPEASKPPIAPKPAVPEIPVTTQKTTDTCPKPTGLPLTSNMSLNLVTSADYKLPSPTSPLSPHSNKSSPRYSKSLMETYVVITLPSEPGTPTDSSAAQAITSWPLGSPPKDLVSLETVFSVVPPMTSTEIPSASQPTLYTSGALGTFSVTPAVTASLFQTVPTSLTQFLPAEASKPEVSAVSSAVPSVAPRSVSIPIPPEPLALDRHQYKENGKLPLIGDAIDLRTIPKSEVKVTEKCMDLSASAMDVKRQTTANEVYRRQISAVQPSIINLSAASSLGTPVTMDSKTVAVVTCTDTTIYTTGTESQVGIEHAVTSPLQLTTSKHTELQYRKPSSQAFPMIRDEAPINLSLGPSTQAVTLAVTKPVTVPPVGVTNGWTDSTISQGITDGEVVDLSTSKSHRTVVTMDESTSNVVTKIIEDEEKPVDLTAGRRAVCCDMVYKLPFGRSCTAQQPATTLPEDRFGYRDDHYQYDRSGPYGYRGIGGMKPSMSDTNLAEAGHFFYKSKNAFDYSGGTEAAVDLTSGRVSTGEVMDYSSKTTGPYPETRQVISGVGISTPQYSTARMTPPPGPQYGVGSVLRSSNGVVYSSVATPIPSTFAITTQPGSIFSTTVRDLSGIHTTDAITSLSALHQSQPMPRSYFITTGASETDISVTSIDINASLQTITMETLPAETMDSVPTLTTASEVFSEVVGEESTLLIVPDEDKQQQQLDLERELLELEKIKQQRFAEELEWERQEIQRFREQEKIMVQKKLEELQSMKQHLLYQQEEERQAQFMMRQETLAQQQLQLEQIQQLQQQLHQQLEEQKLRQIYQYNYEPSGTASPQTTTEQAILEGQYVATEGSQFWATEDATTTASTVVAIEIPQSQGWYTVQSDGVTQYIAPPGILSTVSEIPLTDVVVKEEKQPKKRSSGAKVRGQYDEMGESMADDPRNLKKIVDSGVQTDDEETADRTYASRRRRTKKSVDTSVQTDDEDQDEWDMPSRSRRKARTGKYGDSTAEGDKTKPPSKVSSVAVQTVAEISVQTEPLGTIRTPSIRARVDAKVEIIKHISAPEKTYKGGSLGCQTETDPDTQSPPYMGATSPPKDKKRPTPLEIGYSSSHLRADPTVQLAPSPPKSPKVLYSPISPLSPGHALEPAFVPYEKPLPDDISPQKVLHPDMAKVPPASPKTAKMMQRSMSDPKPLSPTADESSRAPFQYSEGFTAKGSQTTSGTQKKVKRTLPNPPPEEASTGTQSTYSTMGTASRRRMCRTNTMARAKILQDIDRELDLVERESAKLRKKQAELDEEEKEIDAKLRYLEMGINRRKEALLKEREKRERAYLQGVAEDRDYMSDSEVSSTRPSRVESQHGIERPRTAPQTEFSQFIPPQTQTEAQLVPPTSPYTQYQYSSPALPTQAPTPYTQQSHFQQQTLYHQQVSPYQTQPTFQAVATMSFTPQAQPTPTPQPSYQLPSQMMVIQQKPRQTTLYLEPKITSTYEVIRNQPLMIAPVSTDNTYAVSHLGSKYNSLDLRIGLEERSSMASSPISSISADSFYADIDHHTSRNYVLIDDIGDITKGTAALSSAFSLHEKDLSKTDRLLRTTETRRSQEVTDFLAPLQTSSRLHSYVKAEEDSMEDPYELKLLKHQIKQEFRRGTESLDHLAGLSHYYHADTSYRHFPKSEKYSISRLTLEKQAAKQLPAAILYQKQSKHKKALIDPKMSKFSPIQESRDLEPDYPTYLSSSTSSIGGISSRARLLQDDITFGLRKNITDQQKFMGSSLGSGLGTLGNTIRSALQDEADKPYSSGSRSRPSSRPSSVYGLDLSIKRDSSSSSLRLKAQEAEALDVSFGHSSSSARTKPTSLPISQSRGRIPIVAQNSEEESPLSPVGQPMGMARAAAGPLPPISADTRDQFGSSHSLPEVQQHMREESRTRGYDRDIAFIMDDFQHAMSDSEAYHLRREETDWFDKPRESRLENGHGLDRKLPERLVHSRPLSQHQEQILQMNGKTMHYIFPHARIKITRDSKDHTVSGNGLGIRIVGGKEIPGHSGEIGAYIAKILPGGSAEHSGKLIEGMQVLEWNGIPLTSKTYEEVQSIINQQSGEAEICVRLDLNMLSDSENPQHLELHEPPKVVDKAKSPGVDPKQLAAELQKVSLQQSPLVMSSVVEKGAHAHSGPTSAGSSSVPSPGQPGSPSVSKKKHGGSKPTDVSKTASHPITGEIQLQINYDLGNLIIHILQARNLVPRDNNGYSDPFVKVYLLPGRGQVMVVQNASVEYKRRTKYVQKSLNPEWNQTVIYKSISMEQLMKKTLEVTVWDYDRFSSNDFLGEVLIDLSSTSHLDNTPRWYPLKEQTESIEHGKSHSSQNSQQSPKPSVIKSRSHGIFPDPSKDMQVPTIEKSHSSPGSSKSSSEGHLRSHGPSRSQSKTSVAQTHLEDAGAAIAAAEAAVQQLRIQPSKRRK

Gene Information

Entrez Gene ID
26875
Gene Name
piccolo (presynaptic cytomatrix protein)
Gene Symbol
Pclo
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0030054 IEA:UniProtKB-KW C cell junction
GO:0014069 IDA:MGI C postsynaptic density
GO:0045202 IDA:UniProtKB C synapse
GO:0005509 ISS:UniProtKB F calcium ion binding
GO:0005544 ISS:UniProtKB F calcium-dependent phospholipid binding
GO:0005522 IDA:UniProtKB F profilin binding
GO:0019933 IDA:MGI P cAMP-mediated signaling
GO:0007010 IDA:MGI P cytoskeleton organization
GO:0030073 IDA:MGI P insulin secretion
GO:0017157 IDA:MGI P regulation of exocytosis
GO:0016080 NAS:UniProtKB P synaptic vesicle targeting

Domain Information

InterPro Annotations

Accession Description
IPR000008 C2 domain
IPR001478 PDZ domain
IPR011011 Zinc finger, FYVE/PHD-type
IPR013083 Zinc finger, RING/FYVE/PHD-type
IPR008899 Zinc finger, piccolo-type

UniProt Annotations

Entry Information

Gene Name
piccolo (presynaptic cytomatrix protein)
Protein Entry
Q9QYX7_MOUSE
UniProt ID
Q9QYX7
Species
Mouse

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=L; IsoId=Q9QYX7-1; Sequence=Displayed; Name=2; Synonyms=S; IsoId=Q9QYX7-2; Sequence=VSP_003928, VSP_003929;
Domain C2 domain 1 is involved in binding calcium and phospholipids. Calcium binds with low affinity but with high specificity and induces a large conformational change.
Function May act as a scaffolding protein involved in the organization of synaptic active zones and in synaptic vesicle trafficking.
Sequence Caution Sequence=BAC53723.1; Type=Miscellaneous discrepancy; Note=Unlikely isoform. Several sequence problems.; Evidence= ; Sequence=BAC53724.1; Type=Miscellaneous discrepancy; Note=Unlikely isoform. Several sequence problems.; Evidence= ; Sequence=CAB60731.2; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence= ; Sequence=CAB60732.2; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence= ;
Similarity Contains 1 PDZ (DHR) domain. {ECO:0000255|PROSITE- ProRule:PRU00143}.
Similarity Contains 2 C2 domains. {ECO:0000255|PROSITE- ProRule:PRU00041}.
Subcellular Location Cell junction, synapse . Note=Concentrated at the presynaptic side of synaptic junctions.
Subunit Interacts with RABAC1/PRA1, RIMS2 and profilin.
Tissue Specificity Highly expressed in brain. Moderately expressed in pituitary gland and pancreatic islets. Low levels found in stomach. {ECO:0000269|PubMed:10508862, ECO:0000269|PubMed:12401793}.

Identical and Related Proteins

Unique RefSeq proteins for LMP000087 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
160707976 RefSeq NP_036125 5068 protein piccolo isoform 1
160707978 RefSeq NP_001104266 4863 protein piccolo isoform 2

Identical Sequences to LMP000087 proteins

Reference Database Accession Length Protein Name
GI:160707976 SwissProt Q9QYX7.4 5068 RecName: Full=Protein piccolo; AltName: Full=Aczonin; AltName: Full=Brain-derived HLMN protein; AltName: Full=Multidomain presynaptic cytomatrix protein [Mus musculus]

Related Sequences to LMP000087 proteins

Reference Database Accession Length Protein Name
GI:160707976 EMBL CAB60731.2 5038 aczonin [Mus musculus]
GI:160707976 EMBL CAB60732.2 4833 aczonin [Mus musculus]
GI:160707978 EMBL CAB60732.2 4833 aczonin [Mus musculus]
GI:160707976 GenBank ADS25540.1 4833 Sequence 9 from patent US 7776538
GI:160707978 GenBank ADS25540.1 4833 Sequence 9 from patent US 7776538
GI:160707978 RefSeq NP_036125.4 5068 protein piccolo isoform 1 [Mus musculus]
GI:160707976 RefSeq NP_001104266.1 4863 protein piccolo isoform 2 [Mus musculus]
GI:160707976 RefSeq XP_006503645.1 5256 PREDICTED: protein piccolo isoform X1 [Mus musculus]
GI:160707978 RefSeq XP_006503645.1 5256 PREDICTED: protein piccolo isoform X1 [Mus musculus]
GI:160707976 RefSeq XP_006503646.1 5243 PREDICTED: protein piccolo isoform X2 [Mus musculus]
GI:160707978 RefSeq XP_006503646.1 5243 PREDICTED: protein piccolo isoform X2 [Mus musculus]
GI:160707978 SwissProt Q9QYX7.4 5068 RecName: Full=Protein piccolo; AltName: Full=Aczonin; AltName: Full=Brain-derived HLMN protein; AltName: Full=Multidomain presynaptic cytomatrix protein [Mus musculus]