Gene/Proteome Database (LMPD)

LMPD ID
LMP000091
Gene ID
65107
Species
Mus musculus (Mouse)
Gene Name
low-density lipoprotein receptor-related protein 10
Gene Symbol
Lrp10
Synonyms
Lrp9
Alternate Names
low-density lipoprotein receptor-related protein 10; LRP-10
Chromosome
14
Map Location
14 C2-C3|14

Proteins

low-density lipoprotein receptor-related protein 10 precursor
Refseq ID NP_075369
Protein GI 31981254
UniProt ID Q7TQH7
mRNA ID NM_022993
Length 713
RefSeq Status VALIDATED
MLSALPLLFLLLGGALARPDRITFPRSACEAPPAVLSEVQGTLQRPLGRDSRSSPANCTWVILGSKDQTVTVRFQKLHLACGSEHLILHSPLQPPISLCEAPSGPLQLPGGNVTITYSYAGARAPMGQGFLLTYSQDWLLCLQEEFQCLNHRCIPAAQRCDGIDACGDGSDEAGCSSDPFPNLNPAPAPTLACNLTLEDFYGVFSSPGYSHLASVSHPQSCLWLLDPHDGRRLAVRFTALDLSYGDAVHVYDGAGPPETPRLLRSLTHFSNGKAVTVETLSGQAVVSYHTVAWSSGRGFNATYHVRGYCLPWDRPCGLGSGLGASENLGERCYSEAQRCDGSWDCADGTDEEGCPGCPPGHFPCGAAGTPGATACYLPADRCNYQTFCADGADERRCRHCQPGNFRCRDEKCVYETWVCDGQPDCTDGSDEWDCSYALPRKVITAAVIGSLVCGLLLVIALGCTCKLYAIRTQEYSIFAPLSRMEAEIVQQQAPPSYGQLIAQGAIPPVEDFPTENPNDNSVLGNLRSLLQILRQDMTPGGTSGGRRRQRGRSIRRLVRRLRRWGLLPRTNTPARAPETRSQVTPSVPSEALDDSTGQACEGGAVGGQDGEQAPPLPIKTPIPTPSTLPALATVSEPPGPLPSVPVESSLLSGVVQVLRGRLLPSLWSPGPTWTQTGTHTTVLSPEDEDDVLLLPLAEPEVWVVEAEDEPLLA
sig_peptide: 1..17 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 1713 peptide sequence: MLSALPLLFLLLGGALA mat_peptide: 18..713 product: low-density lipoprotein receptor-related protein 10 calculated_mol_wt: 74767 peptide sequence: RPDRITFPRSACEAPPAVLSEVQGTLQRPLGRDSRSSPANCTWVILGSKDQTVTVRFQKLHLACGSEHLILHSPLQPPISLCEAPSGPLQLPGGNVTITYSYAGARAPMGQGFLLTYSQDWLLCLQEEFQCLNHRCIPAAQRCDGIDACGDGSDEAGCSSDPFPNLNPAPAPTLACNLTLEDFYGVFSSPGYSHLASVSHPQSCLWLLDPHDGRRLAVRFTALDLSYGDAVHVYDGAGPPETPRLLRSLTHFSNGKAVTVETLSGQAVVSYHTVAWSSGRGFNATYHVRGYCLPWDRPCGLGSGLGASENLGERCYSEAQRCDGSWDCADGTDEEGCPGCPPGHFPCGAAGTPGATACYLPADRCNYQTFCADGADERRCRHCQPGNFRCRDEKCVYETWVCDGQPDCTDGSDEWDCSYALPRKVITAAVIGSLVCGLLLVIALGCTCKLYAIRTQEYSIFAPLSRMEAEIVQQQAPPSYGQLIAQGAIPPVEDFPTENPNDNSVLGNLRSLLQILRQDMTPGGTSGGRRRQRGRSIRRLVRRLRRWGLLPRTNTPARAPETRSQVTPSVPSEALDDSTGQACEGGAVGGQDGEQAPPLPIKTPIPTPSTLPALATVSEPPGPLPSVPVESSLLSGVVQVLRGRLLPSLWSPGPTWTQTGTHTTVLSPEDEDDVLLLPLAEPEVWVVEAEDEPLLA

Gene Information

Entrez Gene ID
65107
Gene Name
low-density lipoprotein receptor-related protein 10
Gene Symbol
Lrp10
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005905 IEA:UniProtKB-KW C coated pit
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0006897 IEA:UniProtKB-KW P endocytosis

Domain Information

InterPro Annotations

Accession Description
IPR000859 CUB domain
IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
IPR023415 Low-density lipoprotein (LDL) receptor class A, conserved site

UniProt Annotations

Entry Information

Gene Name
low-density lipoprotein receptor-related protein 10
Protein Entry
LRP10_MOUSE
UniProt ID
Q7TQH7
Species
Mouse

Comments

Comment Type Description
Function Probable receptor, which is involved in the internalization of lipophilic molecules and/or signal transduction. May be involved in the uptake of lipoprotein APOE in liver. {ECO:0000269|PubMed:11123907}.
Sequence Caution Sequence=AAH11058.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Similarity Belongs to the LDLR family. {ECO:0000305}.
Similarity Contains 2 CUB domains. {ECO:0000255|PROSITE- ProRule:PRU00059}.
Similarity Contains 4 LDL-receptor class A domains. {ECO:0000255|PROSITE-ProRule:PRU00124}.
Subcellular Location Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Membrane, coated pit {ECO:0000250}.
Tissue Specificity Highly expressed in heart, lung, liver and liver. Expressed at low level in brain and spleen. Weakly or not expressed in testis and skeletal muscle. In liver, it is expressed in hepatocytes and at higher level in sinusoidal lining. In the kidney, it is expressed in peritubular capillaries. In brain, it is expressed in the epithelium of the choroid plexus ependymal cells of the third ventricle pia matter, and to lesser extent in hippocampal fields CA2 and CA3. {ECO:0000269|PubMed:11123907}.

Identical and Related Proteins

Unique RefSeq proteins for LMP000091 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
31981254 RefSeq NP_075369 713 low-density lipoprotein receptor-related protein 10 precursor

Identical Sequences to LMP000091 proteins

Reference Database Accession Length Protein Name
GI:31981254 DBBJ BAE25667.1 713 unnamed protein product [Mus musculus]
GI:31981254 GenBank AAH52378.1 713 Low-density lipoprotein receptor-related protein 10 [Mus musculus]
GI:31981254 GenBank AEJ67032.1 713 Sequence 88 from patent US 7968301
GI:31981254 GenBank AFL31427.1 713 Sequence 88 from patent US 8173125
GI:31981254 SwissProt Q7TQH7.2 713 RecName: Full=Low-density lipoprotein receptor-related protein 10; Short=LRP-10; Flags: Precursor [Mus musculus]

Related Sequences to LMP000091 proteins

Reference Database Accession Length Protein Name
GI:31981254 DBBJ BAE21008.1 713 unnamed protein product [Mus musculus]
GI:31981254 DBBJ BAE41719.1 713 unnamed protein product [Mus musculus]
GI:31981254 GenBank AAH54447.1 713 Low-density lipoprotein receptor-related protein 10 [Mus musculus]
GI:31981254 GenBank EDL36347.1 713 low-density lipoprotein receptor-related protein 10 [Mus musculus]
GI:31981254 GenBank AEJ67031.1 713 Sequence 87 from patent US 7968301
GI:31981254 GenBank AFL31426.1 713 Sequence 87 from patent US 8173125