Gene/Proteome Database (LMPD)

LMPD ID
LMP000093
Gene ID
20652
Species
Mus musculus (Mouse)
Gene Name
sterol O-acyltransferase 1
Gene Symbol
Soat1
Synonyms
8430426K15Rik; ACAT-1; AW550831; Acact; ald; hid
Alternate Names
sterol O-acyltransferase 1; cholesterol acyltransferase 1; adrenocortical lipid depletion; acyl coenzyme A:cholesterol acyltransferase 1; acyl-coenzyme A:cholesterol acyltransferase 1
Chromosome
1
Map Location
1 G3|1 67.71 cM
EC Number
2.3.1.26

Proteins

sterol O-acyltransferase 1
Refseq ID NP_033256
Protein GI 84619697
UniProt ID Q61263
mRNA ID NM_009230
Length 540
RefSeq Status VALIDATED
MSLRNRLSKSGENPEQDEAQKNFMDTYRNGHITMKQLIAKKRLLAAEAEELKPLFMKEVGCHFDDFVTNLIEKSASLDNGGCALTTFSILEEMKKNHRAKDLRAPPEQGKIFISRQSLLDELFEVDHIRTIYHMFIALLILFVLSTIVVDYIDEGRLVLEFNLLAYAFGKFPTVIWTWWAMFLSTLSIPYFLFQRWAHGYSKSSHPLIYSLVHGLLFLVFQLGVLGFVPTYVVLAYTLPPASRFILILEQIRLIMKAHSFVRENIPRVLNAAKEKSSKDPLPTVNQYLYFLFAPTLIYRDNYPRTPTVRWGYVAMQFLQVFGCLFYVYYIFERLCAPLFRNIKQEPFSARVLVLCVFNSILPGVLILFLSFFAFLHCWLNAFAEMLRFGDRMFYKDWWNSTSYSNYYRTWNVVVHDWLYYYVYKDLLWFFSKRFKSAAMLAVFALSAVVHEYALAICLSYFYPVLFVLFMFFGMAFNFIVNDSRKRPIWNIMVWASLFLGYGLILCFYSQEWYARQHCPLKNPTFLDYVRPRTWTCRYVF

Gene Information

Entrez Gene ID
20652
Gene Name
sterol O-acyltransferase 1
Gene Symbol
Soat1
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IEA:UniProtKB-KW C endoplasmic reticulum
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0034736 IEA:UniProtKB-EC F cholesterol O-acyltransferase activity
GO:0004772 IDA:MGI F sterol O-acyltransferase activity
GO:0008203 IDA:MGI P cholesterol metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
ko00100 Steroid biosynthesis
mmu00100 Steroid biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR004299 Membrane bound O-acyl transferase, MBOAT
IPR014371 Sterol O-acyltransferase, ACAT/DAG/ARE types

UniProt Annotations

Entry Information

Gene Name
sterol O-acyltransferase 1
Protein Entry
SOAT1_MOUSE
UniProt ID
Q61263
Species
Mouse

Comments

Comment Type Description
Catalytic Activity Acyl-CoA + cholesterol = CoA + cholesterol ester.
Function Catalyzes the formation of fatty acid-cholesterol esters, which are less soluble in membranes than cholesterol. Plays a role in lipoprotein assembly and dietary cholesterol absorption.
Similarity Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily. {ECO:0000305}.
Subcellular Location Endoplasmic reticulum membrane; Multi-pass membrane protein {ECO:0000269|PubMed:11071899}.
Subunit May form homo- or heterodimers. Interacts with UBIAD1 (By similarity). {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP000093 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
84619697 RefSeq NP_033256 540 sterol O-acyltransferase 1

Identical Sequences to LMP000093 proteins

Reference Database Accession Length Protein Name
GI:84619697 DBBJ BAE35047.1 540 unnamed protein product [Mus musculus]
GI:84619697 DBBJ BAE35158.1 540 unnamed protein product [Mus musculus]
GI:84619697 DBBJ BAE25081.1 540 unnamed protein product [Mus musculus]
GI:84619697 DBBJ BAE35563.1 540 unnamed protein product [Mus musculus]
GI:84619697 GenBank AAH83092.1 540 Sterol O-acyltransferase 1 [Mus musculus]
GI:84619697 SwissProt Q61263.2 540 RecName: Full=Sterol O-acyltransferase 1; AltName: Full=Acyl-coenzyme A:cholesterol acyltransferase 1; Short=ACAT-1; AltName: Full=Cholesterol acyltransferase 1 [Mus musculus]

Related Sequences to LMP000093 proteins

Reference Database Accession Length Protein Name
GI:84619697 GenBank AAC42075.1 540 acyl-coenzyme A: cholesterol acyltransferase [Mus musculus]
GI:84619697 GenBank ABI81497.1 540 sterol O-acyltransferase 1 [Mus musculus]
GI:84619697 GenBank EDM09484.1 545 sterol O-acyltransferase 1, isoform CRA_a [Rattus norvegicus]
GI:84619697 PRF - 540 acyl-CoA/cholesterol acyltransferase [Mus musculus]
GI:84619697 RefSeq XP_005363965.1 546 PREDICTED: sterol O-acyltransferase 1 [Microtus ochrogaster]
GI:84619697 RefSeq XP_006973857.1 546 PREDICTED: sterol O-acyltransferase 1 [Peromyscus maniculatus bairdii]