Gene/Proteome Database (LMPD)

LMPD ID
LMP000094
Gene ID
134526
Species
Homo sapiens (Human)
Gene Name
acyl-CoA thioesterase 12
Gene Symbol
ACOT12
Synonyms
CACH-1; Cach; STARD15; THEAL
Alternate Names
acyl-coenzyme A thioesterase 12; hCACH-1; cytosolic acetyl-CoA hydrolase; acyl-CoA thioester hydrolase 12; START domain-containing protein 15; cytoplasmic acetyl-CoA hydrolase 1; StAR-related lipid transfer (START) domain containing 15
Chromosome
5
Map Location
5q14.1
EC Number
3.1.2.1

Proteins

acyl-coenzyme A thioesterase 12
Refseq ID NP_570123
Protein GI 18640736
UniProt ID Q8WYK0
mRNA ID NM_130767
Length 555
RefSeq Status VALIDATED
MERPAPGEVVMSQAIQPAHATARGELSAGQLLKWIDTTACLAAEKHAGVSCVTASVDDIQFEETARVGQVITIKAKVTRAFSTSMEISIKVMVQDMLTGIEKLVSVAFSTFVAKPVGKEKIHLKPVTLLTEQDHVEHNLAAERRKVRLQHEDTFNNLMKESSKFDDLIFDEEEGAVSTRGTSVQSIELVLPPHANHHGNTFGGQIMAWMETVATISASRLCWAHPFLKSVDMFKFRGPSTVGDRLVFTAIVNNTFQTCVEVGVRVEAFDCQEWAEGRGRHINSAFLIYNAADDKENLITFPRIQPISKDDFRRYRGAIARKRIRLGRKYVISHKEEVPLCIHWDISKQASLSDSNVEALKKLAAKRGWEVTSTVEKIKIYTLEEHDVLSVWVEKHVGSPAHLAYRLLSDFTKRPLWDPHFVSCEVIDWVSEDDQLYHITCPILNDDKPKDLVVLVSRRKPLKDGNTYTVAVKSVILPSVPPSPQYIRSEIICAGFLIHAIDSNSCIVSYFNHMSASILPYFAGNLGGWSKSIEETAASCIQFLENPPDDGFVSTF

Gene Information

Entrez Gene ID
134526
Gene Name
acyl-CoA thioesterase 12
Gene Symbol
ACOT12
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005829 ISS:HGNC C cytosol
GO:0005524 IEA:Ensembl F ATP binding
GO:0003986 ISS:HGNC F acetyl-CoA hydrolase activity
GO:0052689 IEA:UniProtKB-KW F carboxylic ester hydrolase activity
GO:0008289 IEA:InterPro F lipid binding
GO:0006084 IEA:Ensembl P acetyl-CoA metabolic process
GO:0006637 ISS:HGNC P acyl-CoA metabolic process
GO:0006631 IEA:UniProtKB-KW P fatty acid metabolic process
GO:0006090 IEA:UniProtKB-UniPathway P pyruvate metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
hsa00620 Pyruvate metabolism
ko00620 Pyruvate metabolism

Domain Information

InterPro Annotations

Accession Description
IPR029069 HotDog domain
IPR023393 START-like domain
IPR002913 START_lipid-bd_dom
IPR006683 Thioesterase superfamily

UniProt Annotations

Entry Information

Gene Name
acyl-CoA thioesterase 12
Protein Entry
ACO12_HUMAN
UniProt ID
Q8WYK0
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8WYK0-1; Sequence=Displayed; Name=2; IsoId=Q8WYK0-2; Sequence=VSP_055785, VSP_055786; Note=No experimental confirmation available.;
Catalytic Activity Acetyl-CoA + H(2)O = CoA + acetate.
Enzyme Regulation Inhibited by ADP. Active in the presence of ATP.
Function Hydrolyzes acetyl-CoA to acetate and CoA.
Pathway Carbohydrate metabolism; pyruvate metabolism.
Similarity Contains 1 START domain. {ECO
Similarity Contains 2 acyl coenzyme A hydrolase domains.
Subcellular Location Cytoplasm .
Subunit Homodimer or homotetramer.

Identical and Related Proteins

Unique RefSeq proteins for LMP000094 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
18640736 RefSeq NP_570123 555 acyl-coenzyme A thioesterase 12

Identical Sequences to LMP000094 proteins

Reference Database Accession Length Protein Name
GI:18640736 DBBJ BAG53821.1 555 unnamed protein product [Homo sapiens]
GI:18640736 GenBank AAH75010.1 555 Acyl-CoA thioesterase 12 [Homo sapiens]
GI:18640736 GenBank EAW95875.1 555 acyl-CoA thioesterase 12, isoform CRA_b [Homo sapiens]
GI:18640736 GenBank ADA53451.1 555 Sequence 1281 from patent US 7625699
GI:18640736 GenBank AHE01094.1 555 Sequence 56010 from patent US 8586006
GI:18640736 GenBank AIC53081.1 555 ACOT12, partial [synthetic construct]

Related Sequences to LMP000094 proteins

Reference Database Accession Length Protein Name
GI:18640736 RefSeq XP_517670.2 555 PREDICTED: acyl-coenzyme A thioesterase 12 isoform X1 [Pan troglodytes]
GI:18640736 RefSeq XP_003822307.1 555 PREDICTED: acyl-coenzyme A thioesterase 12 isoform X1 [Pan paniscus]
GI:18640736 RefSeq XP_003899931.1 555 PREDICTED: acyl-coenzyme A thioesterase 12 isoform X2 [Papio anubis]
GI:18640736 RefSeq XP_004042278.1 555 PREDICTED: acyl-coenzyme A thioesterase 12 [Gorilla gorilla gorilla]
GI:18640736 RefSeq XP_005557354.1 555 PREDICTED: acyl-coenzyme A thioesterase 12 [Macaca fascicularis]
GI:18640736 RefSeq XP_007975202.1 555 PREDICTED: acyl-coenzyme A thioesterase 12 [Chlorocebus sabaeus]