Gene/Proteome Database (LMPD)

LMPD ID
LMP000101
Gene ID
13070
Species
Mus musculus (Mouse)
Gene Name
cytochrome P450, family 11, subfamily a, polypeptide 1
Gene Symbol
Cyp11a1
Synonyms
Cyp11a; Cypxia1; D9Ertd411e; P450scc; Scc; cscc
Alternate Names
cholesterol side-chain cleavage enzyme, mitochondrial; cytochrome P450 11A1; cytochrome P450(scc); cholesterol desmolase; cholesterol side chain cleavage; cytochrome P450 side-chain cleavage enzyme; cytochrome P450, 11a, cholesterol side-chain cleavage
Chromosome
9
Map Location
9 B|9 31.63 cM
EC Number
1.14.15.6

Proteins

cholesterol side-chain cleavage enzyme, mitochondrial precursor
Refseq ID NP_062753
Protein GI 148747566
UniProt ID Q9QZ82
mRNA ID NM_019779
Length 526
RefSeq Status PROVISIONAL
MLAKGLSLRSVLVKGCQPFLSPTWQGPVLSTGKGAGTSTSSPRSFNEIPSPGDNGWLNLYHFWRESGTQKIHYHQMQSFQKYGPIYREKLGTLESVYIVDPKDASILFSCEGPNPERFLVPPWVAYHQYYQRPIGVLFKSSDAWKKDRIVLNQEVMAPGAIKNFVPLLEGVAQDFIKVLHRRIKQQNSGNFSGVISDDLFRFSFESISSVIFGERMGMLEEIVDPEAQRFINAVYQMFHTSVPMLNLPPDFFRLLRTKTWKDHAAAWDVIFNKADEYTQNFYWDLRQKRDFSQYPGVLYSLLGGNKLPFKNIQANITEMLAGGVDTTSMTLQWNLYEMAHNLKVQEMLRAEVLAARRQAQGDMAKMVQLVPLLKASIKETLRLHPISVTLQRYTVNDLVLRNYKIPAKTLVQVASFAMGRDPGFFPNPNKFDPTRWLEKSQNTTHFRYLGFGWGVRQCLGRRIAELEMTILLINLLENFRIEVQNLRDVGTKFSLILMPENPILFNFQPLKQDLGPAVTRKDNTVN
transit_peptide: 1..36 inference: non-experimental evidence, no additional details recorded note: Mitochondrion (By similarity); propagated from UniProtKB/Swiss-Prot (Q9QZ82.1) calculated_mol_wt: 3685 peptide sequence: MLAKGLSLRSVLVKGCQPFLSPTWQGPVLSTGKGAG mat_peptide: 37..526 product: Cholesterol side-chain cleavage enzyme, mitochondrial experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q9QZ82.1) calculated_mol_wt: 56648 peptide sequence: TSTSSPRSFNEIPSPGDNGWLNLYHFWRESGTQKIHYHQMQSFQKYGPIYREKLGTLESVYIVDPKDASILFSCEGPNPERFLVPPWVAYHQYYQRPIGVLFKSSDAWKKDRIVLNQEVMAPGAIKNFVPLLEGVAQDFIKVLHRRIKQQNSGNFSGVISDDLFRFSFESISSVIFGERMGMLEEIVDPEAQRFINAVYQMFHTSVPMLNLPPDFFRLLRTKTWKDHAAAWDVIFNKADEYTQNFYWDLRQKRDFSQYPGVLYSLLGGNKLPFKNIQANITEMLAGGVDTTSMTLQWNLYEMAHNLKVQEMLRAEVLAARRQAQGDMAKMVQLVPLLKASIKETLRLHPISVTLQRYTVNDLVLRNYKIPAKTLVQVASFAMGRDPGFFPNPNKFDPTRWLEKSQNTTHFRYLGFGWGVRQCLGRRIAELEMTILLINLLENFRIEVQNLRDVGTKFSLILMPENPILFNFQPLKQDLGPAVTRKDNTVN

Gene Information

Entrez Gene ID
13070
Gene Name
cytochrome P450, family 11, subfamily a, polypeptide 1
Gene Symbol
Cyp11a1
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0030061 IEA:Ensembl C mitochondrial crista
GO:0005739 IDA:MGI C mitochondrion
GO:0043204 IEA:Ensembl C perikaryon
GO:0015485 IEA:Ensembl F cholesterol binding
GO:0008386 IDA:MGI F cholesterol monooxygenase (side-chain-cleaving) activity
GO:0020037 ISS:UniProtKB F heme binding
GO:0005506 IEA:InterPro F iron ion binding
GO:0018879 IEA:Ensembl P biphenyl metabolic process
GO:0006700 IDA:MGI P C21-steroid hormone biosynthetic process
GO:0071236 IEA:Ensembl P cellular response to antibiotic
GO:0071276 IEA:Ensembl P cellular response to cadmium ion
GO:0071320 IEA:Ensembl P cellular response to cAMP
GO:0044344 IEA:Ensembl P cellular response to fibroblast growth factor stimulus
GO:0071372 IEA:Ensembl P cellular response to follicle-stimulating hormone stimulus
GO:0071347 IEA:Ensembl P cellular response to interleukin-1
GO:0071222 IEA:Ensembl P cellular response to lipopolysaccharide
GO:0071375 IEA:Ensembl P cellular response to peptide hormone stimulus
GO:0071560 IEA:Ensembl P cellular response to transforming growth factor beta stimulus
GO:0071356 IEA:Ensembl P cellular response to tumor necrosis factor
GO:0021549 IEA:Ensembl P cerebellum development
GO:0008203 ISS:UniProtKB P cholesterol metabolic process
GO:0018894 IEA:Ensembl P dibenzo-p-dioxin metabolic process
GO:0006703 IEA:Ensembl P estrogen biosynthetic process
GO:0050756 IEA:Ensembl P fractalkine metabolic process
GO:0060014 IEA:Ensembl P granulosa cell differentiation
GO:0021766 IEA:Ensembl P hippocampus development
GO:0033327 IEA:Ensembl P Leydig cell differentiation
GO:0060135 IEA:Ensembl P maternal process involved in female pregnancy
GO:0007617 IEA:Ensembl P mating behavior
GO:0018958 IEA:Ensembl P phenol-containing compound metabolic process
GO:0018963 IEA:Ensembl P phthalate metabolic process
GO:0006701 IEA:Ensembl P progesterone biosynthetic process
GO:0043279 IEA:Ensembl P response to alkaloid
GO:0051412 IEA:Ensembl P response to corticosterone
GO:0042493 IEA:Ensembl P response to drug
GO:0060992 IEA:Ensembl P response to fungicide
GO:0010332 IEA:Ensembl P response to gamma radiation
GO:0033595 IEA:Ensembl P response to genistein
GO:0042542 IEA:Ensembl P response to hydrogen peroxide
GO:0017085 IEA:Ensembl P response to insecticide
GO:0033591 IEA:Ensembl P response to L-ascorbic acid
GO:0009651 IEA:Ensembl P response to salt stress
GO:0033197 IEA:Ensembl P response to vitamin E
GO:0014037 IEA:Ensembl P Schwann cell differentiation
GO:0061370 IEA:Ensembl P testosterone biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
mmu04913 Ovarian steroidogenesis
mmu00140 Steroid hormone biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR001128 Cytochrome P450
IPR017972 Cytochrome P450, conserved site
IPR002401 Cytochrome P450, E-class, group I

UniProt Annotations

Entry Information

Gene Name
cytochrome P450, family 11, subfamily a, polypeptide 1
Protein Entry
CP11A_MOUSE
UniProt ID
Q9QZ82
Species
Mouse

Comments

Comment Type Description
Catalytic Activity Cholesterol + 6 reduced adrenodoxin + 3 O(2) + 6 H(+) = pregnenolone + 4-methylpentanal + 6 oxidized adrenodoxin + 4 H(2)O. {ECO:0000250|UniProtKB:P05108}.
Cofactor Name=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000250|UniProtKB:P05108};
Function Catalyzes the side-chain cleavage reaction of cholesterol to pregnenolone. {ECO:0000250|UniProtKB:P05108}.
Pathway Lipid metabolism; C21-steroid hormone metabolism.
Similarity Belongs to the cytochrome P450 family. {ECO:0000305}.
Subcellular Location Mitochondrion membrane.
Subunit Interacts with FDX1/adrenodoxin. {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP000101 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
148747566 RefSeq NP_062753 526 cholesterol side-chain cleavage enzyme, mitochondrial precursor

Identical Sequences to LMP000101 proteins

Reference Database Accession Length Protein Name
GI:148747566 GenBank AAF03897.1 526 cytochrome P450 side chain cleavage enzyme 11a1 [Mus musculus]
GI:148747566 GenBank EDL25930.1 526 cytochrome P450, family 11, subfamily a, polypeptide 1 [Mus musculus]
GI:148747566 SwissProt Q9QZ82.1 526 RecName: Full=Cholesterol side-chain cleavage enzyme, mitochondrial; AltName: Full=CYPXIA1; AltName: Full=Cholesterol desmolase; AltName: Full=Cytochrome P450 11A1; AltName: Full=Cytochrome P450(scc); Flags: Precursor [Mus musculus]

Related Sequences to LMP000101 proteins

Reference Database Accession Length Protein Name
GI:148747566 GenBank AAA40958.1 526 cytochrome P-450-scc [Rattus norvegicus]
GI:148747566 GenBank AAA40989.1 526 cholesterol side-chain cleavage enzyme precursor (EC 1.14.15.6) [Rattus norvegicus]
GI:148747566 GenBank AAH68264.1 526 Cytochrome P450, family 11, subfamily a, polypeptide 1 [Mus musculus]
GI:148747566 GenBank AAH89100.1 526 Cytochrome P450, family 11, subfamily a, polypeptide 1 [Rattus norvegicus]
GI:148747566 GenBank EDL95659.1 526 cytochrome P450, family 11, subfamily a, polypeptide 1 [Rattus norvegicus]
GI:148747566 SwissProt P14137.1 526 RecName: Full=Cholesterol side-chain cleavage enzyme, mitochondrial; AltName: Full=CYPXIA1; AltName: Full=Cholesterol desmolase; AltName: Full=Cytochrome P450 11A1; AltName: Full=Cytochrome P450(scc); Flags: Precursor [Rattus norvegicus]