Gene/Proteome Database (LMPD)

LMPD ID
LMP000101
Gene ID
13070
Species
Mus musculus (Mouse)
Gene Name
cytochrome P450, family 11, subfamily a, polypeptide 1
Gene Symbol
Cyp11a1
Synonyms
Cyp11a; Cypxia1; D9Ertd411e; P450scc; Scc; cscc
Alternate Names
cholesterol side-chain cleavage enzyme, mitochondrial; cytochrome P450 11A1; cytochrome P450(scc); cholesterol desmolase; cholesterol side chain cleavage; cytochrome P450 side-chain cleavage enzyme; cytochrome P450, 11a, cholesterol side-chain cleavage
Chromosome
9
Map Location
9 B|9 31.63 cM
EC Number
1.14.15.6

Proteins

cholesterol side-chain cleavage enzyme, mitochondrial precursor
Refseq ID NP_062753
Protein GI 148747566
UniProt ID Q9QZ82
mRNA ID NM_019779
Length 526
RefSeq Status PROVISIONAL
MLAKGLSLRSVLVKGCQPFLSPTWQGPVLSTGKGAGTSTSSPRSFNEIPSPGDNGWLNLYHFWRESGTQKIHYHQMQSFQKYGPIYREKLGTLESVYIVDPKDASILFSCEGPNPERFLVPPWVAYHQYYQRPIGVLFKSSDAWKKDRIVLNQEVMAPGAIKNFVPLLEGVAQDFIKVLHRRIKQQNSGNFSGVISDDLFRFSFESISSVIFGERMGMLEEIVDPEAQRFINAVYQMFHTSVPMLNLPPDFFRLLRTKTWKDHAAAWDVIFNKADEYTQNFYWDLRQKRDFSQYPGVLYSLLGGNKLPFKNIQANITEMLAGGVDTTSMTLQWNLYEMAHNLKVQEMLRAEVLAARRQAQGDMAKMVQLVPLLKASIKETLRLHPISVTLQRYTVNDLVLRNYKIPAKTLVQVASFAMGRDPGFFPNPNKFDPTRWLEKSQNTTHFRYLGFGWGVRQCLGRRIAELEMTILLINLLENFRIEVQNLRDVGTKFSLILMPENPILFNFQPLKQDLGPAVTRKDNTVN
transit_peptide: 1..36 inference: non-experimental evidence, no additional details recorded note: Mitochondrion (By similarity); propagated from UniProtKB/Swiss-Prot (Q9QZ82.1) calculated_mol_wt: 3685 peptide sequence: MLAKGLSLRSVLVKGCQPFLSPTWQGPVLSTGKGAG mat_peptide: 37..526 product: Cholesterol side-chain cleavage enzyme, mitochondrial experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q9QZ82.1) calculated_mol_wt: 56648 peptide sequence: TSTSSPRSFNEIPSPGDNGWLNLYHFWRESGTQKIHYHQMQSFQKYGPIYREKLGTLESVYIVDPKDASILFSCEGPNPERFLVPPWVAYHQYYQRPIGVLFKSSDAWKKDRIVLNQEVMAPGAIKNFVPLLEGVAQDFIKVLHRRIKQQNSGNFSGVISDDLFRFSFESISSVIFGERMGMLEEIVDPEAQRFINAVYQMFHTSVPMLNLPPDFFRLLRTKTWKDHAAAWDVIFNKADEYTQNFYWDLRQKRDFSQYPGVLYSLLGGNKLPFKNIQANITEMLAGGVDTTSMTLQWNLYEMAHNLKVQEMLRAEVLAARRQAQGDMAKMVQLVPLLKASIKETLRLHPISVTLQRYTVNDLVLRNYKIPAKTLVQVASFAMGRDPGFFPNPNKFDPTRWLEKSQNTTHFRYLGFGWGVRQCLGRRIAELEMTILLINLLENFRIEVQNLRDVGTKFSLILMPENPILFNFQPLKQDLGPAVTRKDNTVN

Gene Information

Entrez Gene ID
13070
Gene Name
cytochrome P450, family 11, subfamily a, polypeptide 1
Gene Symbol
Cyp11a1
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0030061 IEA:Ensembl C mitochondrial crista
GO:0005739 IDA:MGI C mitochondrion
GO:0043204 IEA:Ensembl C perikaryon
GO:0015485 IEA:Ensembl F cholesterol binding
GO:0008386 IDA:MGI F cholesterol monooxygenase (side-chain-cleaving) activity
GO:0020037 ISS:UniProtKB F heme binding
GO:0005506 IEA:InterPro F iron ion binding
GO:0006700 IDA:MGI P C21-steroid hormone biosynthetic process
GO:0033327 IEA:Ensembl P Leydig cell differentiation
GO:0014037 IEA:Ensembl P Schwann cell differentiation
GO:0018879 IEA:Ensembl P biphenyl metabolic process
GO:0071236 IEA:Ensembl P cellular response to antibiotic
GO:0071320 IEA:Ensembl P cellular response to cAMP
GO:0071276 IEA:Ensembl P cellular response to cadmium ion
GO:0044344 IEA:Ensembl P cellular response to fibroblast growth factor stimulus
GO:0071372 IEA:Ensembl P cellular response to follicle-stimulating hormone stimulus
GO:0071347 IEA:Ensembl P cellular response to interleukin-1
GO:0071222 IEA:Ensembl P cellular response to lipopolysaccharide
GO:0071375 IEA:Ensembl P cellular response to peptide hormone stimulus
GO:0071560 IEA:Ensembl P cellular response to transforming growth factor beta stimulus
GO:0071356 IEA:Ensembl P cellular response to tumor necrosis factor
GO:0021549 IEA:Ensembl P cerebellum development
GO:0008203 ISS:UniProtKB P cholesterol metabolic process
GO:0018894 IEA:Ensembl P dibenzo-p-dioxin metabolic process
GO:0006703 IEA:Ensembl P estrogen biosynthetic process
GO:0050756 IEA:Ensembl P fractalkine metabolic process
GO:0060014 IEA:Ensembl P granulosa cell differentiation
GO:0021766 IEA:Ensembl P hippocampus development
GO:0060135 IEA:Ensembl P maternal process involved in female pregnancy
GO:0007617 IEA:Ensembl P mating behavior
GO:0018958 IEA:Ensembl P phenol-containing compound metabolic process
GO:0018963 IEA:Ensembl P phthalate metabolic process
GO:0006701 IEA:Ensembl P progesterone biosynthetic process
GO:0033591 IEA:Ensembl P response to L-ascorbic acid
GO:0043279 IEA:Ensembl P response to alkaloid
GO:0051412 IEA:Ensembl P response to corticosterone
GO:0042493 IEA:Ensembl P response to drug
GO:0060992 IEA:Ensembl P response to fungicide
GO:0010332 IEA:Ensembl P response to gamma radiation
GO:0033595 IEA:Ensembl P response to genistein
GO:0042542 IEA:Ensembl P response to hydrogen peroxide
GO:0017085 IEA:Ensembl P response to insecticide
GO:0009651 IEA:Ensembl P response to salt stress
GO:0033197 IEA:Ensembl P response to vitamin E
GO:0061370 IEA:Ensembl P testosterone biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
mmu04913 Ovarian steroidogenesis
mmu00140 Steroid hormone biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR001128 Cytochrome P450
IPR002401 Cytochrome P450, E-class, group I
IPR017972 Cytochrome P450, conserved site

UniProt Annotations

Entry Information

Gene Name
cytochrome P450, family 11, subfamily a, polypeptide 1
Protein Entry
CP11A_MOUSE
UniProt ID
Q9QZ82
Species
Mouse

Comments

Comment Type Description
Catalytic Activity Cholesterol + 6 reduced adrenodoxin + 3 O(2) + 6 H(+) = pregnenolone + 4-methylpentanal + 6 oxidized adrenodoxin + 4 H(2)O. {ECO:0000250|UniProtKB:P05108}.
Cofactor Name=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000250|UniProtKB:P05108};
Function Catalyzes the side-chain cleavage reaction of cholesterol to pregnenolone. {ECO:0000250|UniProtKB:P05108}.
Pathway Lipid metabolism; C21-steroid hormone metabolism.
Similarity Belongs to the cytochrome P450 family. {ECO:0000305}.
Subcellular Location Mitochondrion membrane.
Subunit Interacts with FDX1/adrenodoxin. {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP000101 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
148747566 RefSeq NP_062753 526 cholesterol side-chain cleavage enzyme, mitochondrial precursor

Identical Sequences to LMP000101 proteins

Reference Database Accession Length Protein Name
GI:148747566 GenBank AAF03897.1 526 cytochrome P450 side chain cleavage enzyme 11a1 [Mus musculus]
GI:148747566 GenBank EDL25930.1 526 cytochrome P450, family 11, subfamily a, polypeptide 1 [Mus musculus]
GI:148747566 SwissProt Q9QZ82.1 526 RecName: Full=Cholesterol side-chain cleavage enzyme, mitochondrial; AltName: Full=CYPXIA1; AltName: Full=Cholesterol desmolase; AltName: Full=Cytochrome P450 11A1; AltName: Full=Cytochrome P450(scc); Flags: Precursor [Mus musculus]

Related Sequences to LMP000101 proteins

Reference Database Accession Length Protein Name
GI:148747566 GenBank AAA40958.1 526 cytochrome P-450-scc [Rattus norvegicus]
GI:148747566 GenBank AAA40989.1 526 cholesterol side-chain cleavage enzyme precursor (EC 1.14.15.6) [Rattus norvegicus]
GI:148747566 GenBank AAH68264.1 526 Cytochrome P450, family 11, subfamily a, polypeptide 1 [Mus musculus]
GI:148747566 GenBank AAH89100.1 526 Cytochrome P450, family 11, subfamily a, polypeptide 1 [Rattus norvegicus]
GI:148747566 GenBank EDL95659.1 526 cytochrome P450, family 11, subfamily a, polypeptide 1 [Rattus norvegicus]
GI:148747566 SwissProt P14137.1 526 RecName: Full=Cholesterol side-chain cleavage enzyme, mitochondrial; AltName: Full=CYPXIA1; AltName: Full=Cholesterol desmolase; AltName: Full=Cytochrome P450 11A1; AltName: Full=Cytochrome P450(scc); Flags: Precursor [Rattus norvegicus]