Gene/Proteome Database (LMPD)

LMPD ID
LMP000115
Gene ID
11685
Species
Mus musculus (Mouse)
Gene Name
arachidonate lipoxygenase, epidermal
Gene Symbol
Alox12e
Synonyms
8-LOX; AW259591; Alox12-ps1; Alox12-ps2; Aloxe; e-LOX1
Alternate Names
arachidonate 12-lipoxygenase, epidermal-type; 12-LOX; arachidonate 12-lipoxygenase, epidermal
Chromosome
11
Map Location
11 B3|11 42.99 cM
EC Number
1.13.11.31

Proteins

arachidonate 12-lipoxygenase, epidermal-type
Refseq ID NP_663717
Protein GI 21729795
UniProt ID P55249
mRNA ID NM_145684
Length 662
RefSeq Status PROVISIONAL
MVKYKILVATGDSVFAGSANLVHLWLVGEHGEADLGKQLRPLLGRKTELEVDVPLHLGRLLAVKLRKQKGLLDSDWFCKSITVQGPGTQGEAFFPCYSWVQGKETICLTEGTALKVTDDTQNLFRKYREQELENRRNVYRWGSWKEGLILPIAGSTERDLPRNQRFMKDKDLDFSLSLVKELKNFAIKGTLDFVSRVQKLEDYQKVFPHTKTALPERVRGSWKEDALFGYQFLNGANPMLLRRSMRLPARLVLPPGMEDVQTQLEKELKAGSLFEVDFSLLDGVKPNIIIFKQQYVTAPLVMLKLQPDGRLLPMVIQLQPPRHGCPPPLLFLPSDPPMAWLLAKIWVRSSDFQLHQLQSHLLRGHLMAEVISVATMRSLPSLHPIYKLLAPHFRYTMEINTLARNNLVSEWGIFDLVVSTGSGGHVDILQRATSCLTYRSFCPPDDLADRGLVGVKSSLYAQDALRLWEIISRYVERMVELFYRSDTDVKEDPELQVWCREVTEVGLLGAQDRGFPLSLESRAELCRFVAMCIFTCTGQHASTHLGQLDWYAWIPNGPCTMRKPPPISKDVTERDIVDSLPCLQQARMQITVTKFLGRRQPVMVALGQHKEEYFSGPRPRDVLKQFQEELAIMDKEIEVRNASLDLPYEYLRPSLVENSVTI

Gene Information

Entrez Gene ID
11685
Gene Name
arachidonate lipoxygenase, epidermal
Gene Symbol
Alox12e
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IEA:UniProtKB-KW C cytoplasm
GO:0004052 IEA:UniProtKB-EC F arachidonate 12-lipoxygenase activity
GO:0005506 IEA:InterPro F iron ion binding
GO:0019369 IMP:UniProtKB P arachidonic acid metabolic process
GO:0019372 IMP:UniProtKB P lipoxygenase pathway

KEGG Pathway Links

KEGG Pathway ID Description
mmu00590 Arachidonic acid metabolism
ko04750 Inflammatory mediator regulation of TRP channels
mmu04750 Inflammatory mediator regulation of TRP channels
mmu04726 Serotonergic synapse

Domain Information

InterPro Annotations

Accession Description
IPR008976 Lipase/lipooxygenase, PLAT/LH2
IPR000907 Lipoxygenase
IPR020834 Lipoxygenase, conserved site
IPR013819 Lipoxygenase, C-terminal
IPR020833 Lipoxygenase, iron binding site
IPR001885 Lipoxygenase, mammalian
IPR001024 PLAT/LH2 domain

UniProt Annotations

Entry Information

Gene Name
arachidonate lipoxygenase, epidermal
Protein Entry
LX12E_MOUSE
UniProt ID
P55249
Species
Mouse

Comments

Comment Type Description
Catalytic Activity Arachidonate + O(2) = (5Z,8Z,10E,14Z)-(12S)- 12-hydroperoxyicosa-5,8,10,14-tetraenoate.
Caution Was originally thought to be an arachidonate 8- lipoxygenase and was called LOX8. {ECO:0000305}.
Cofactor Name=Fe cation; Xref=ChEBI:CHEBI:24875; Evidence={ECO:0000255|PROSITE-ProRule:PRU00726}; Note=Binds 1 Fe cation per subunit. {ECO:0000255|PROSITE- ProRule:PRU00726};
Function Non-heme iron-containing dioxygenase that probably catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. May preferentially convert arachidonic acid to (12S)-hydroperoxyeicosatetraenoic acid/(12S)-HPETE. {ECO:0000269|PubMed:8798535, ECO:0000269|PubMed:9037187}.
Pathway Lipid metabolism; hydroperoxy eicosatetraenoic acid biosynthesis.
Similarity Belongs to the lipoxygenase family. {ECO:0000305}.
Similarity Contains 1 lipoxygenase domain. {ECO:0000255|PROSITE- ProRule:PRU00726}.
Similarity Contains 1 PLAT domain. {ECO:0000255|PROSITE- ProRule:PRU00152}.
Subcellular Location Cytoplasm {ECO:0000255|PROSITE- ProRule:PRU00726}.
Tissue Specificity Expressed in epidermis. {ECO:0000269|PubMed:8798535}.

Identical and Related Proteins

Unique RefSeq proteins for LMP000115 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
21729795 RefSeq NP_663717 662 arachidonate 12-lipoxygenase, epidermal-type

Identical Sequences to LMP000115 proteins

Reference Database Accession Length Protein Name
GI:21729795 DBBJ BAE23765.1 662 unnamed protein product [Mus musculus]
GI:21729795 EMBL CAA67625.1 662 arachidonate 12(S)-lipoxygenase [Mus musculus]
GI:21729795 GenBank AAC52869.1 662 12(S)-lipoxygenase [Mus musculus]
GI:21729795 GenBank EDL12553.1 662 arachidonate lipoxygenase, epidermal [Mus musculus]
GI:21729795 SwissProt P55249.1 662 RecName: Full=Arachidonate 12-lipoxygenase, epidermal-type; Short=12-LOX [Mus musculus]

Related Sequences to LMP000115 proteins

Reference Database Accession Length Protein Name
GI:21729795 GenBank AAC52324.1 662 arachidonate lipoxygenase [Mus musculus]
GI:21729795 GenBank AAH13751.1 662 Arachidonate lipoxygenase, epidermal [Mus musculus]
GI:21729795 GenBank AAH51047.1 662 Arachidonate lipoxygenase, epidermal [Mus musculus]
GI:21729795 RefSeq XP_006532097.1 695 PREDICTED: arachidonate 12-lipoxygenase, epidermal-type isoform X1 [Mus musculus]
GI:21729795 RefSeq XP_006537175.1 695 PREDICTED: arachidonate 12-lipoxygenase, epidermal-type isoform X1 [Mus musculus]
GI:21729795 RefSeq XP_006537176.1 694 PREDICTED: arachidonate 12-lipoxygenase, epidermal-type isoform X2 [Mus musculus]