Gene/Proteome Database (LMPD)
LMPD ID
LMP000122
Gene ID
Species
Mus musculus (Mouse)
Gene Name
fatty acid desaturase 2
Gene Symbol
Synonyms
2900042M13Rik; Fadsd2
Alternate Names
fatty acid desaturase 2; D6D; delta-6 desaturase; delta(6) desaturase; delta-6 fatty acid desaturase; delta(6) fatty acid desaturase
Chromosome
19
Map Location
19|19 B
EC Number
1.14.19.-
Proteins
| fatty acid desaturase 2 | |
|---|---|
| Refseq ID | NP_062673 |
| Protein GI | 9790071 |
| UniProt ID | Q9Z0R9 |
| mRNA ID | NM_019699 |
| Length | 444 |
| RefSeq Status | PROVISIONAL |
| MGKGGNQGEGSTERQAPMPTFRWEEIQKHNLRTDRWLVIDRKVYNVTKWSQRHPGGHRVIGHYSGEDATDAFRAFHLDLDFVGKFLKPLLIGELAPEEPSLDRGKSSQITEDFRALKKTAEDMNLFKTNHLFFFLLLSHIIVMESLAWFILSYFGTGWIPTLVTAFVLATSQAQAGWLQHDYGHLSVYKKSIWNHVVHKFVIGHLKGASANWWNHRHFQHHAKPNIFHKDPDIKSLHVFVLGEWQPLEYGKKKLKYLPYNHQHEYFFLIGPPLLIPMYFQYQIIMTMISRRDWVDLAWAISYYMRFFYTYIPFYGILGALVFLNFIRFLESHWFVWVTQMNHLVMEIDLDHYRDWFSSQLAATCNVEQSFFNDWFSGHLNFQIEHHLFPTMPRHNLHKIAPLVKSLCAKHGIEYQEKPLLRALIDIVSSLKKSGELWLDAYLHK | |
Gene Information
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005783 | IEA:UniProtKB-KW | C | endoplasmic reticulum |
| GO:0016021 | IEA:UniProtKB-KW | C | integral component of membrane |
| GO:0016020 | TAS:MGI | C | membrane |
| GO:0020037 | IEA:InterPro | F | heme binding |
| GO:0005506 | IEA:InterPro | F | iron ion binding |
| GO:0004768 | IDA:MGI | F | stearoyl-CoA 9-desaturase activity |
| GO:0006636 | IEA:UniProtKB-UniPathway | P | unsaturated fatty acid biosynthetic process |
KEGG Pathway Links
| KEGG Pathway ID | Description |
|---|---|
| mmu03320 | PPAR signaling pathway |
Domain Information
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Developmental Stage | Found in 13-day-old embryo heart. |
| Domain | The histidine box domains may contain the active site and/or be involved in metal ion binding. |
| Function | Component of a lipid metabolic pathway that catalyzes biosynthesis of highly unsaturated fatty acids (HUFA) from precursor essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3). Catalyzes the first and rate limiting step in this pathway which is the desaturation of LA (18:2n-6) and ALA (18:3n-3) into gamma- linoleic acid (GLA) (18:3n-6) and stearidonic acid (18:4n-3) respectively and other desaturation steps. Highly unsaturated fatty acids (HUFA) play pivotal roles in many biological functions (By similarity). {ECO:0000250}. |
| Induction | Induced by dietary PUFA-deficient diet. Induced by a fat-free diet and by a diet containing triolein (18:1n-9) as the only fat source. Down-regulated in liver by dietary PUFA. {ECO:0000269|PubMed:11792729, ECO:0000269|PubMed:9867867}. |
| Pathway | Lipid metabolism; polyunsaturated fatty acid biosynthesis. |
| Similarity | Belongs to the fatty acid desaturase family. {ECO:0000305}. |
| Similarity | Contains 1 cytochrome b5 heme-binding domain. {ECO:0000255|PROSITE-ProRule:PRU00279}. |
| Subcellular Location | Endoplasmic reticulum membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. |
| Tissue Specificity | Highly expressed in the adrenal gland, liver, brain, and testis, tissues where lipogenesis and steroidogenesis are active. Also detected in lung, heart, and skeletal muscle. {ECO:0000269|PubMed:11792729, ECO:0000269|PubMed:9867867}. |
Identical and Related Proteins
Unique RefSeq proteins for LMP000122 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 9790071 | RefSeq | NP_062673 | 444 | fatty acid desaturase 2 |
Identical Sequences to LMP000122 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:9790071 | GenBank | AEF65896.1 | 444 | Sequence 22 from patent US 7932438 |
| GI:9790071 | GenBank | AEW32725.1 | 444 | Sequence 22 from patent US 8071341 |
| GI:9790071 | GenBank | AFK97133.1 | 444 | Sequence 22 from patent US 8158392 |
| GI:9790071 | GenBank | AFL61026.1 | 444 | Sequence 22 from patent US 8106226 |
| GI:9790071 | GenBank | AGB67181.1 | 444 | Sequence 22 from patent US 8288572 |
| GI:9790071 | GenBank | AHE22359.1 | 444 | Sequence 22 from patent US 8575377 |
Related Sequences to LMP000122 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:9790071 | DBBJ | BAA75496.1 | 444 | delta-6 fatty acid desaturase [Rattus norvegicus] |
| GI:9790071 | GenBank | AAH81776.1 | 444 | Fatty acid desaturase 2 [Rattus norvegicus] |
| GI:9790071 | GenBank | EDM12790.1 | 444 | fatty acid desaturase 2 [Rattus norvegicus] |
| GI:9790071 | GenBank | AEX15918.1 | 444 | fatty acid desaturase 2 [Rattus norvegicus] |
| GI:9790071 | RefSeq | NP_112634.1 | 444 | fatty acid desaturase 2 [Rattus norvegicus] |
| GI:9790071 | SwissProt | Q9Z122.1 | 444 | RecName: Full=Fatty acid desaturase 2; AltName: Full=Delta(6) fatty acid desaturase; Short=D6D; Short=Delta(6) desaturase; Short=Delta-6 desaturase [Rattus norvegicus] |