Gene/Proteome Database (LMPD)

LMPD ID
LMP000135
Gene ID
237320
Species
Mus musculus (Mouse)
Gene Name
aldehyde dehydrogenase 8 family, member A1
Gene Symbol
Aldh8a1
Synonyms
Raldh4
Alternate Names
aldehyde dehydrogenase family 8 member A1; retinal dehydrogenase 4; retinal dehydrogenase type 4
Chromosome
10
Map Location
10 A3|10
EC Number
1.2.1.-

Proteins

aldehyde dehydrogenase family 8 member A1
Refseq ID NP_848828
Protein GI 30520135
UniProt ID Q8BH00
mRNA ID NM_178713
Length 487
RefSeq Status VALIDATED
MAGKRELLMLENFIGGKFLPCNSYIDSYDPSTGEVYCKVPNSGKEEIEAAVEAAREAFPAWSSRSPQERSLVLNRLADVLEQSLEELAQAESKDQGKTLTLARTMDIPRSVLNFRFFASSNLHHVSECTQMSHLGCMHYTVRTPVGIAGLISPWNLPLYLLTWKIAPAIAAGNTVIAKPSEMTSVTAWMFCKLLDKAGVPPGVINIVFGTGPRVGEALVSHPEVPLISFTGSQPTAERITQLSAPHCKKLSLELGGKNPAIIFEDANLEECIPATVRSSFANQGEICLCTSRIFVQRSIYSEFLKRFVEATRKWKVGVPSDPSANMGALISKAHLEKVRSYVLKAQTEGARILCGEGVDQLSLPLRNQAGYFMLPTVITDIKDESRCMTEEIFGPVTCVVPFDSEEEVITRANSVRYGLAATVWSKDVGRIHRVAKKLQSGLVWTNCWLIRELNLPFGGMKSSGIGREGAKDSYDFFTEIKTITIKY

Gene Information

Entrez Gene ID
237320
Gene Name
aldehyde dehydrogenase 8 family, member A1
Gene Symbol
Aldh8a1
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IEA:UniProtKB-KW C cytoplasm
GO:0070062 IEA:Ensembl C extracellular vesicular exosome
GO:0005622 ISS:UniProtKB C intracellular
GO:0001758 ISS:UniProtKB F retinal dehydrogenase activity
GO:0042904 IDA:MGI P 9-cis-retinoic acid biosynthetic process
GO:0042574 ISS:UniProtKB P retinal metabolic process
GO:0042573 ISS:UniProtKB P retinoic acid metabolic process

Domain Information

InterPro Annotations

Accession Description
IPR016163 Aldehyde dehydrogenase, C-terminal
IPR016160 Aldehyde dehydrogenase, cysteine active site
IPR015590 Aldehyde dehydrogenase domain
IPR029510 Aldehyde dehydrogenase, glutamic acid active site
IPR016162 Aldehyde dehydrogenase N-terminal domain
IPR016161 Aldehyde/histidinol dehydrogenase

UniProt Annotations

Entry Information

Gene Name
aldehyde dehydrogenase 8 family, member A1
Protein Entry
AL8A1_MOUSE
UniProt ID
Q8BH00
Species
Mouse

Comments

Comment Type Description
Biophysicochemical Properties Kinetic parameters: KM=2.3 uM for 9-cis-retinal {ECO:0000269|PubMed:12519776}; Vmax=3.4 nmol/min/mg enzyme {ECO:0000269|PubMed:12519776}; Note=Activity was measured with total soluble protein.;
Function Converts 9-cis-retinal to 9-cis-retinoic acid. Has lower activity towards 13-cis-retinal. Has much lower activity towards all-trans-retinal. Has a preference for NAD, but shows considerable activity with NADP (in vitro) (By similarity). {ECO:0000250}.
Similarity Belongs to the aldehyde dehydrogenase family. {ECO:0000305}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:12519776}.
Tissue Specificity Detected in hepatocytes and in proximal and distal convoluted tubules in kidney cortex (at protein level). Highly expressed in adult liver and in kidney cortex. First detected in embryonic liver after 15 days of development. {ECO:0000269|PubMed:12519776}.

Identical and Related Proteins

Unique RefSeq proteins for LMP000135 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
30520135 RefSeq NP_848828 487 aldehyde dehydrogenase family 8 member A1

Identical Sequences to LMP000135 proteins

Reference Database Accession Length Protein Name
GI:30520135 DBBJ BAC34173.1 487 unnamed protein product [Mus musculus]
GI:30520135 DBBJ BAE25524.1 487 unnamed protein product [Mus musculus]
GI:30520135 GenBank AAH38493.1 487 Aldh8a1 protein [Mus musculus]
GI:30520135 GenBank AAO64246.1 487 retinal dehydrogenase type 4 [Mus musculus]
GI:30520135 GenBank EDL03414.1 487 aldehyde dehydrogenase 8 family, member A1 [Mus musculus]
GI:30520135 SwissProt Q8BH00.1 487 RecName: Full=Aldehyde dehydrogenase family 8 member A1; AltName: Full=Retinal dehydrogenase 4 [Mus musculus]

Related Sequences to LMP000135 proteins

Reference Database Accession Length Protein Name
GI:30520135 GenBank ERE84135.1 1080 aldehyde dehydrogenase family 8 member A1-like protein [Cricetulus griseus]
GI:30520135 RefSeq NP_001178017.1 487 aldehyde dehydrogenase family 8 member A1 [Rattus norvegicus]
GI:30520135 RefSeq XP_005361003.1 503 PREDICTED: aldehyde dehydrogenase family 8 member A1 isoform X1 [Microtus ochrogaster]
GI:30520135 RefSeq XP_006227736.1 487 PREDICTED: aldehyde dehydrogenase family 8 member A1 isoform X1 [Rattus norvegicus]
GI:30520135 RefSeq XP_006980164.1 488 PREDICTED: aldehyde dehydrogenase family 8 member A1 isoform X1 [Peromyscus maniculatus bairdii]
GI:30520135 RefSeq XP_008820313.1 487 PREDICTED: aldehyde dehydrogenase family 8 member A1 isoform X1 [Nannospalax galili]