Gene/Proteome Database (LMPD)

LMPD ID
LMP000137
Gene ID
12401
Species
Mus musculus (Mouse)
Gene Name
serine (or cysteine) peptidase inhibitor, clade A, member 6
Gene Symbol
Serpina6
Synonyms
AI265318; AV104445; Cbg
Alternate Names
corticosteroid-binding globulin; serpin A6; transcortin; corticosteroid binding globulin; serine (or cysteine) proteinase inhibitor, clade A, member 6
Chromosome
12
Map Location
12 E|12 52.98 cM

Proteins

corticosteroid-binding globulin precursor
Refseq ID NP_031644
Protein GI 6680856
UniProt ID Q06770
mRNA ID NM_007618
Length 397
RefSeq Status PROVISIONAL
MSLALYTCLFWLCTSGLWTTQAVTDEDSSSHRDLAPTNVDFAFNLYKRLVALNSDKNTLISPVSISMALAMLSLSTRGSTQYLENLGFNMSKMSEAEIHQGFQYLNSLLQQSDTGLEMNMGNVMFLLQNLKLKDSFLADTKHYYESEALTIPSKDWTKAGEQINNHVKNKTQGKIEHVVSDLDSSATLILINYIFLKGIWKLPFSPENTREEDFYVNETSTVKVPMMVQSGNISYFRDSAIPCQMVQMNYVGNGTTFIILPDQGQMDTVVAALNRDTIDRWGKLMIPRQMNLYIPKFSMSDTYDLQDVLADVGIKDLFTNQSDFADTTKDTPLTLTVLHKAMLQLDEGNVLPAATNGPPVHLPSESFTLKYNRPFIFLAFDKYTWSSLMMSQVMNPA
sig_peptide: 1..22 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2510 peptide sequence: MSLALYTCLFWLCTSGLWTTQA mat_peptide: 23..397 product: Corticosteroid-binding globulin experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q06770.1) calculated_mol_wt: 42277 peptide sequence: VTDEDSSSHRDLAPTNVDFAFNLYKRLVALNSDKNTLISPVSISMALAMLSLSTRGSTQYLENLGFNMSKMSEAEIHQGFQYLNSLLQQSDTGLEMNMGNVMFLLQNLKLKDSFLADTKHYYESEALTIPSKDWTKAGEQINNHVKNKTQGKIEHVVSDLDSSATLILINYIFLKGIWKLPFSPENTREEDFYVNETSTVKVPMMVQSGNISYFRDSAIPCQMVQMNYVGNGTTFIILPDQGQMDTVVAALNRDTIDRWGKLMIPRQMNLYIPKFSMSDTYDLQDVLADVGIKDLFTNQSDFADTTKDTPLTLTVLHKAMLQLDEGNVLPAATNGPPVHLPSESFTLKYNRPFIFLAFDKYTWSSLMMSQVMNPA

Gene Information

Entrez Gene ID
12401
Gene Name
serine (or cysteine) peptidase inhibitor, clade A, member 6
Gene Symbol
Serpina6
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005615 IMP:MGI C extracellular space
GO:0070062 IEA:Ensembl C extracellular vesicular exosome
GO:0004867 IBA:RefGenome F serine-type endopeptidase inhibitor activity
GO:0005496 IDA:MGI F steroid binding
GO:0008211 IMP:MGI P glucocorticoid metabolic process
GO:0010951 IBA:RefGenome P negative regulation of endopeptidase activity
GO:0030162 IBA:RefGenome P regulation of proteolysis
GO:0006810 IEA:UniProtKB-KW P transport

Domain Information

InterPro Annotations

Accession Description
IPR023795 Serpin, conserved site
IPR023796 Serpin domain
IPR000215 Serpin family

UniProt Annotations

Entry Information

Gene Name
serine (or cysteine) peptidase inhibitor, clade A, member 6
Protein Entry
CBG_MOUSE
UniProt ID
Q06770
Species
Mouse

Comments

Comment Type Description
Domain Proteolytic cleavage leads to an important conformation change. This reduces the affinity for steroids (By similarity). {ECO:0000250}.
Function Major transport protein for glucocorticoids and progestins in the blood of almost all vertebrate species.
Similarity Belongs to the serpin family. {ECO:0000305}.
Subcellular Location Secreted.
Tissue Specificity Expressed by the liver; secreted in plasma.

Identical and Related Proteins

Unique RefSeq proteins for LMP000137 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6680856 RefSeq NP_031644 397 corticosteroid-binding globulin precursor

Identical Sequences to LMP000137 proteins

Reference Database Accession Length Protein Name
GI:6680856 EMBL CAA49934.1 397 corticosteroid-binding globulin [Mus musculus]
GI:6680856 GenBank EDL18821.1 397 serine (or cysteine) peptidase inhibitor, clade A, member 6 [Mus musculus]
GI:6680856 SwissProt Q06770.1 397 RecName: Full=Corticosteroid-binding globulin; Short=CBG; AltName: Full=Serpin A6; AltName: Full=Transcortin; Flags: Precursor [Mus musculus]

Related Sequences to LMP000137 proteins

Reference Database Accession Length Protein Name
GI:6680856 DBBJ BAE26690.1 397 unnamed protein product [Mus musculus]
GI:6680856 GenBank AAH13632.1 397 Serine (or cysteine) peptidase inhibitor, clade A, member 6 [Mus musculus]
GI:6680856 GenBank AAH88300.1 396 Serine (or cysteine) peptidase inhibitor, clade A, member 6 [Rattus norvegicus]
GI:6680856 GenBank EDL81783.1 396 serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6 (mapped) [Rattus norvegicus]
GI:6680856 RefSeq NP_001009663.1 396 corticosteroid-binding globulin precursor [Rattus norvegicus]
GI:6680856 SwissProt P31211.2 396 RecName: Full=Corticosteroid-binding globulin; Short=CBG; AltName: Full=Serpin A6; AltName: Full=Transcortin; Flags: Precursor [Rattus norvegicus]