Gene/Proteome Database (LMPD)

LMPD ID
LMP000150
Gene ID
50640
Species
Homo sapiens (Human)
Gene Name
patatin-like phospholipase domain containing 8
Gene Symbol
PNPLA8
Synonyms
IPLA2(GAMMA); IPLA2-2; IPLA2G; iPLA2gamma
Alternate Names
calcium-independent phospholipase A2-gamma; PNPLA-gamma; iPLA2 gamma; iPLA2-gamma; patatin-like phospholipase domain-containing protein 8; membrane-associated calcium-independent phospholipase A2 gamma; intracellular membrane-associated calcium-independent phospholipase A2 gamma
Chromosome
7
Map Location
7q31
EC Number
3.1.1.5
Summary
This gene encodes a member of the patatin-like phospholipase domain containing protein family. Members of this family are phospholipases which catalyze the cleavage of fatty acids from membrane phospholipids. The product of this gene is a calcium-independent phospholipase. A pseudogene of this gene is located on the X chromosome. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Orthologs
View orthologs and multiple alignments for PNPLA8

Proteins

calcium-independent phospholipase A2-gamma isoform 1
Refseq ID NP_001242936
Protein GI 365192573
UniProt ID Q9NP80
mRNA ID NM_001256007
Length 782
RefSeq Status VALIDATED
MSINLTVDIYIYLLSNARSVCGKQRSKQLYFLFSPKHYWRISHISLQRGFHTNIIRCKWTKSEAHSCSKHCYSPSNHGLHIGILKLSTSAPKGLTKVNICMSRIKSTLNSVSKAVFGNQNEMISRLAQFKPSSQILRKVSDSGWLKQKNIKQAIKSLKKYSDKSAEKSPFPEEKSHIIDKEEDIGKRSLFHYTSSITTKFGDSFYFLSNHINSYFKRKEKMSQQKENEHFRDKSELEDKKVEEGKLRSPDPGILAYKPGSESVHTVDKPTSPSAIPDVLQVSTKQSIANFLSRPTEGVQALVGGYIGGLVPKLKYDSKSQSEEQEEPAKTDQAVSKDRNAEEKKRLSLQREKIIARVSIDNRTRALVQALRRTTDPKLCITRVEELTFHLLEFPEGKGVAVKERIIPYLLRLRQIKDETLQAAVREILALIGYVDPVKGRGIRILSIDGGGTRGVVALQTLRKLVELTQKPVHQLFDYICGVSTGAILAFMLGLFHMPLDECEELYRKLGSDVFSQNVIVGTVKMSWSHAFYDSQTWENILKDRMGSALMIETARNPTCPKVAAVSTIVNRGITPKAFVFRNYGHFPGINSHYLGGCQYKMWQAIRASSAAPGYFAEYALGNDLHQDGGLLLNNPSALAMHECKCLWPDVPLECIVSLGTGRYESDVRNTVTYTSLKTKLSNVINSATDTEEVHIMLDGLLPPDTYFRFNPVMCENIPLDESRNEKLDQLQLEGLKYIERNEQKMKKVAKILSQEKTTLQKINDWIKLKTDMYEGLPFFSKL
calcium-independent phospholipase A2-gamma isoform 1
Refseq ID NP_001242937
Protein GI 365192575
UniProt ID Q9NP80
mRNA ID NM_001256008
Length 782
RefSeq Status VALIDATED
Protein sequence is identical to GI:365192573 (mRNA isoform)
calcium-independent phospholipase A2-gamma isoform 1
Refseq ID NP_056538
Protein GI 48525351
UniProt ID Q9NP80
mRNA ID NM_015723
Length 782
RefSeq Status VALIDATED
Protein sequence is identical to GI:365192573 (mRNA isoform)
calcium-independent phospholipase A2-gamma isoform 2
Refseq ID NP_001242938
Protein GI 365192577
UniProt ID Q9NP80
mRNA ID NM_001256009
Length 720
RefSeq Status VALIDATED
MSINLTVDIYIYLLSNARSVCGKQRSKQLYFLFSPKHYWRISHISLQRGFHTNIIRCKWTKSEAHSCSKHCYSPSNHGLHIGILKLSTSAPKGLTKVNICMSRIKSTLNSVSKAVFGNQNEMISRLAQFKPSSQILRKVSDSGWLKQKNIKQAIKSLKKYSDKSAEKSPFPEEKSHIIDKEEDIGKRSLFHYTSSITTKFGDSFYFLSNHINSYFKRKEKMSQQKENEHFRDKSELEDKKVEEGKLRSPDPGILAYKPGSESVHTVDKPTSPSAIPDVLQVSTKQSIANFLSRPTEGVQALVGGYIGGLVPKLKYDSKSQSEEQEEPAKTDQAVSKDRNAEEKKRLSLQREKIIARVSIDNRTRALVQALRRTTDPKLCITRVEELTFHLLEFPEGKGVAVKERIIPYLLRLRQIKDETLQAAVREILALIGYVDPVKGRGIRILSIDGGGTRGVVALQTLRKLVELTQKPVHQLFDYICGVSTGAILAFMLGLFHMPLDECEELYRKLGSDVFSQNVIVGTVKMSWSHAFYDSQTWENILKDRMGSALMIETARNPTCPKVAADGGLLLNNPSALAMHECKCLWPDVPLECIVSLGTGRYESDVRNTVTYTSLKTKLSNVINSATDTEEVHIMLDGLLPPDTYFRFNPVMCENIPLDESRNEKLDQLQLEGLKYIERNEQKMKKVAKILSQEKTTLQKINDWIKLKTDMYEGLPFFSKL
calcium-independent phospholipase A2-gamma isoform 3
Refseq ID NP_001242939
Protein GI 365192579
UniProt ID Q9NP80
mRNA ID NM_001256010
Length 682
RefSeq Status VALIDATED
MSRIKSTLNSVSKAVFGNQNEMISRLAQFKPSSQILRKVSDSGWLKQKNIKQAIKSLKKYSDKSAEKSPFPEEKSHIIDKEEDIGKRSLFHYTSSITTKFGDSFYFLSNHINSYFKRKEKMSQQKENEHFRDKSELEDKKVEEGKLRSPDPGILAYKPGSESVHTVDKPTSPSAIPDVLQVSTKQSIANFLSRPTEGVQALVGGYIGGLVPKLKYDSKSQSEEQEEPAKTDQAVSKDRNAEEKKRLSLQREKIIARVSIDNRTRALVQALRRTTDPKLCITRVEELTFHLLEFPEGKGVAVKERIIPYLLRLRQIKDETLQAAVREILALIGYVDPVKGRGIRILSIDGGGTRGVVALQTLRKLVELTQKPVHQLFDYICGVSTGAILAFMLGLFHMPLDECEELYRKLGSDVFSQNVIVGTVKMSWSHAFYDSQTWENILKDRMGSALMIETARNPTCPKVAAVSTIVNRGITPKAFVFRNYGHFPGINSHYLGGCQYKMWQAIRASSAAPGYFAEYALGNDLHQDGGLLLNNPSALAMHECKCLWPDVPLECIVSLGTGRYESDVRNTVTYTSLKTKLSNVINSATDTEEVHIMLDGLLPPDTYFRFNPVMCENIPLDESRNEKLDQLQLEGLKYIERNEQKMKKVAKILSQEKTTLQKINDWIKLKTDMYEGLPFFSKL
calcium-independent phospholipase A2-gamma isoform 3
Refseq ID NP_001242940
Protein GI 365192581
UniProt ID Q9NP80
mRNA ID NM_001256011
Length 682
RefSeq Status VALIDATED
Protein sequence is identical to GI:365192579 (mRNA isoform)

Gene Information

Entrez Gene ID
50640
Gene Name
patatin-like phospholipase domain containing 8
Gene Symbol
PNPLA8
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005794 IEA:UniProtKB-KW C Golgi apparatus
GO:0005789 TAS:Reactome C endoplasmic reticulum membrane
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0005622 IDA:UniProtKB C intracellular
GO:0016020 IDA:UniProtKB C membrane
GO:0005778 IDA:UniProtKB C peroxisomal membrane
GO:0005777 IDA:UniProtKB C peroxisome
GO:0005524 NAS:UniProtKB F ATP binding
GO:0047499 IDA:UniProtKB F calcium-independent phospholipase A2 activity
GO:0004622 IEA:UniProtKB-EC F lysophospholipase activity
GO:0019369 IDA:UniProtKB P arachidonic acid metabolic process
GO:0050482 IDA:UniProtKB P arachidonic acid secretion
GO:0008219 IDA:UniProtKB P cell death
GO:0006631 IDA:UniProtKB P fatty acid metabolic process
GO:0046474 TAS:Reactome P glycerophospholipid biosynthetic process
GO:0043651 IDA:UniProtKB P linoleic acid metabolic process
GO:0036151 TAS:Reactome P phosphatidylcholine acyl-chain remodeling
GO:0034638 IDA:UniProtKB P phosphatidylcholine catabolic process
GO:0036152 TAS:Reactome P phosphatidylethanolamine acyl-chain remodeling
GO:0046338 IDA:UniProtKB P phosphatidylethanolamine catabolic process
GO:0006644 TAS:Reactome P phospholipid metabolic process
GO:0001516 IDA:UniProtKB P prostaglandin biosynthetic process
GO:0044281 TAS:Reactome P small molecule metabolic process

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_120829 Acyl chain remodelling of PC
REACT_121369 Acyl chain remodelling of PE
REACT_121401 Glycerophospholipid biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase
IPR002641 Patatin/Phospholipase A2-related

UniProt Annotations

Entry Information

Gene Name
patatin-like phospholipase domain containing 8
Protein Entry
PLPL8_HUMAN
UniProt ID
Q9NP80
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9NP80-1; Sequence=Displayed; Name=2; IsoId=Q9NP80-2; Sequence=VSP_028005; Note=No experimental confirmation available.; Name=3; IsoId=Q9NP80-3; Sequence=VSP_045594; Note=No experimental confirmation available.;
Biophysicochemical Properties pH dependence: Optimum pH is 8.0.;
Catalytic Activity 2-lysophosphatidylcholine + H(2)O = glycerophosphocholine + a carboxylate.
Enzyme Regulation Inhibited by E-6-bromomethylene-3-1- naphthalenyl-2H-tetrahydropyran-2-one (BEL).
Function Calcium-independent phospholipase A2, which catalyzes the hydrolysis of the sn-2 position of glycerophospholipids, PtdSer and to a lower extent PtdCho. Cleaves membrane phospholipids. {ECO
Sequence Caution Sequence=AAF67630.1; Type=Erroneous initiation; Evidence= ; Sequence=BAA92090.1; Type=Erroneous initiation; Evidence= ; Sequence=EAL24384.1; Type=Erroneous gene model prediction; Evidence= ;
Similarity Contains 1 patatin domain.
Subcellular Location Endoplasmic reticulum membrane {ECO
Tissue Specificity Expressed in parenchymal tissues including heart, skeletal muscle, placenta, brain, liver and pancreas. Also expressed in bronchial epithelial cells and kidney. Highest expression is observed in skeletal muscle and heart. {ECO

Identical and Related Proteins

Unique RefSeq proteins for LMP000150 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
365192573 RefSeq NP_001242936 782 calcium-independent phospholipase A2-gamma isoform 1
365192577 RefSeq NP_001242938 720 calcium-independent phospholipase A2-gamma isoform 2
365192579 RefSeq NP_001242939 682 calcium-independent phospholipase A2-gamma isoform 3

Identical Sequences to LMP000150 proteins

Reference Database Accession Length Protein Name
GI:365192577 DBBJ BAG72674.1 720 patatin-like phospholipase domain containing 8, partial [synthetic construct]
GI:365192577 EMBL CAD38859.1 720 hypothetical protein [Homo sapiens]
GI:365192577 EMBL CAL37541.1 720 hypothetical protein, partial [synthetic construct]
GI:365192579 GenBank EAW83433.1 682 intracellular membrane-associated calcium-independent phospholipase A2 gamma, isoform CRA_b [Homo sapiens]
GI:365192579 GenBank AEU43426.1 682 Sequence 175 from patent US 8052970
GI:365192573 GenBank AEU43427.1 782 Sequence 176 from patent US 8052970
GI:365192573 GenBank AEU43458.1 782 Sequence 207 from patent US 8052970
GI:365192573 GenBank AEU43462.1 782 Sequence 211 from patent US 8052970
GI:365192573 GenBank AEU43463.1 782 Sequence 212 from patent US 8052970
GI:365192573 GenBank AHD69513.1 782 Sequence 527 from patent US 8586006
GI:365192573 RefSeq NP_001242937.1 782 calcium-independent phospholipase A2-gamma isoform 1 [Homo sapiens]
GI:365192579 RefSeq NP_001242940.1 682 calcium-independent phospholipase A2-gamma isoform 3 [Homo sapiens]
GI:365192577 RefSeq XP_005250453.1 720 PREDICTED: calcium-independent phospholipase A2-gamma isoform X2 [Homo sapiens]

Related Sequences to LMP000150 proteins

Reference Database Accession Length Protein Name
GI:365192573 DBBJ BAF84444.1 782 unnamed protein product [Homo sapiens]
GI:365192579 GenBank AAF75269.1 782 membrane-associated calcium-independent phospholipase A2 gamma [Homo sapiens]
GI:365192579 GenBank ABM81874.1 782 patatin-like phospholipase domain containing 8 [synthetic construct]
GI:365192579 GenBank ABM85037.1 782 patatin-like phospholipase domain containing 8, partial [synthetic construct]
GI:365192573 GenBank AEU43432.1 782 Sequence 181 from patent US 8052970
GI:365192573 GenBank AEU43433.1 782 Sequence 182 from patent US 8052970
GI:365192573 GenBank AEU43525.1 782 Sequence 274 from patent US 8052970
GI:365192573 GenBank JAA07173.1 782 patatin-like phospholipase domain containing 8 [Pan troglodytes]
GI:365192579 GenBank AHD69513.1 782 Sequence 527 from patent US 8586006
GI:365192577 RefSeq XP_001166237.1 720 PREDICTED: calcium-independent phospholipase A2-gamma isoform X4 [Pan troglodytes]
GI:365192579 RefSeq NP_001242936.1 782 calcium-independent phospholipase A2-gamma isoform 1 [Homo sapiens]
GI:365192577 RefSeq XP_003811264.1 720 PREDICTED: calcium-independent phospholipase A2-gamma isoform X4 [Pan paniscus]
GI:365192573 RefSeq XP_003951157.1 782 PREDICTED: calcium-independent phospholipase A2-gamma isoform X2 [Pan troglodytes]
GI:365192577 RefSeq XP_008961848.1 731 PREDICTED: calcium-independent phospholipase A2-gamma isoform X3 [Pan paniscus]
GI:365192577 RefSeq XP_009241410.1 729 PREDICTED: calcium-independent phospholipase A2-gamma isoform X3 [Pongo abelii]
GI:365192577 RefSeq XP_009241411.1 718 PREDICTED: calcium-independent phospholipase A2-gamma isoform X4 [Pongo abelii]
GI:365192577 RefSeq XP_009452255.1 731 PREDICTED: calcium-independent phospholipase A2-gamma isoform X3 [Pan troglodytes]
GI:365192579 SwissProt Q9NP80.1 782 RecName: Full=Calcium-independent phospholipase A2-gamma; AltName: Full=Intracellular membrane-associated calcium-independent phospholipase A2 gamma; Short=iPLA2-gamma; AltName: Full=PNPLA-gamma; AltName: Full=Patatin-like phospholipase domain-containing protein 8; AltName: Full=iPLA2-2 [Homo sapiens]