Gene/Proteome Database (LMPD)

LMPD ID
LMP000155
Gene ID
13617
Species
Mus musculus (Mouse)
Gene Name
endothelin receptor type A
Gene Symbol
Ednra
Synonyms
ET-AR; ETa; Gpcr10
Alternate Names
endothelin-1 receptor; ET-A; endothelin A receptor; G-protein coupled receptor 10
Chromosome
8
Map Location
8 C2|8

Proteins

endothelin-1 receptor precursor
Refseq ID NP_034462
Protein GI 45383740
UniProt ID Q61614
mRNA ID NM_010332
Length 427
RefSeq Status VALIDATED
MSIFCLAAYFWLTMVGGVMADNPERYSANLSSHMEDFTPFPGTEINFLGTTHRPPNLALPSNGSMHGYCPQQTKITTAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIASLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALSVDRYRAVASWSRVQGIGIPLITAIEIVSIWILSFILAIPEAIGFVMVPFEYKGELHRTCMLNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQRREVAKTVFCLVVIFALCWFPLHLSRILKKTVYDEMDKNRCELLSFLLLMDYIGINLATMNSCINPIALYFVSKKFKNCFQSCLCCCCHQSKSLMTSVPMNGTSIQWKNQEQNNHNTERSSHKDSMN
sig_peptide: 1..20 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2212 peptide sequence: MSIFCLAAYFWLTMVGGVMA mat_peptide: 21..427 product: Endothelin-1 receptor experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q61614.3) calculated_mol_wt: 46385 peptide sequence: DNPERYSANLSSHMEDFTPFPGTEINFLGTTHRPPNLALPSNGSMHGYCPQQTKITTAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIASLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALSVDRYRAVASWSRVQGIGIPLITAIEIVSIWILSFILAIPEAIGFVMVPFEYKGELHRTCMLNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQRREVAKTVFCLVVIFALCWFPLHLSRILKKTVYDEMDKNRCELLSFLLLMDYIGINLATMNSCINPIALYFVSKKFKNCFQSCLCCCCHQSKSLMTSVPMNGTSIQWKNQEQNNHNTERSSHKDSMN

Gene Information

Entrez Gene ID
13617
Gene Name
endothelin receptor type A
Gene Symbol
Ednra
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0030315 IEA:Ensembl C T-tubule
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0031965 IEA:Ensembl C nuclear membrane
GO:0004930 TAS:MGI F G-protein coupled receptor activity
GO:0004962 IMP:MGI F endothelin receptor activity
GO:0007186 TAS:MGI P G-protein coupled receptor signaling pathway
GO:0007266 IEA:Ensembl P Rho protein signal transduction
GO:0007568 IEA:Ensembl P aging
GO:0014824 IEA:Ensembl P artery smooth muscle contraction
GO:0071260 IEA:Ensembl P cellular response to mechanical stimulus
GO:0086100 IMP:GOC P endothelin receptor signaling pathway
GO:0048484 IEA:InterPro P enteric nervous system development
GO:0048144 IEA:Ensembl P fibroblast proliferation
GO:0003094 IEA:Ensembl P glomerular filtration
GO:0015758 IDA:MGI P glucose transport
GO:0060322 IMP:MGI P head development
GO:0007507 IGI:MGI P heart development
GO:0001821 IEA:Ensembl P histamine secretion
GO:0001701 IMP:MGI P in utero embryonic development
GO:0060137 IEA:Ensembl P maternal process involved in parturition
GO:0043066 IEA:Ensembl P negative regulation of apoptotic process
GO:0030818 IGI:MGI P negative regulation of cAMP biosynthetic process
GO:0014032 IMP:MGI P neural crest cell development
GO:0001569 IGI:MGI P patterning of blood vessels
GO:0043084 IEA:Ensembl P penile erection
GO:0070374 IEA:Ensembl P positive regulation of ERK1 and ERK2 cascade
GO:0008284 IEA:Ensembl P positive regulation of cell proliferation
GO:0051482 IEA:Ensembl P positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
GO:0050729 IEA:Ensembl P positive regulation of inflammatory response
GO:0090184 IEA:Ensembl P positive regulation of kidney development
GO:0090023 IEA:Ensembl P positive regulation of neutrophil chemotaxis
GO:0042482 IEA:Ensembl P positive regulation of odontogenesis
GO:0001934 IEA:Ensembl P positive regulation of protein phosphorylation
GO:0051281 IEA:Ensembl P positive regulation of release of sequestered calcium ion into cytosol
GO:0007205 IEA:Ensembl P protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0008217 IEA:InterPro P regulation of blood pressure
GO:0050678 IEA:Ensembl P regulation of epithelial cell proliferation
GO:0007585 IMP:MGI P respiratory gaseous exchange
GO:0001666 IMP:MGI P response to hypoxia
GO:0032496 IEA:Ensembl P response to lipopolysaccharide
GO:0043278 IEA:Ensembl P response to morphine
GO:0019233 IEA:Ensembl P sensory perception of pain
GO:0048659 IEA:Ensembl P smooth muscle cell proliferation
GO:0042310 IMP:MGI P vasoconstriction

KEGG Pathway Links

KEGG Pathway ID Description
mmu04020 Calcium signaling pathway
mmu04270 Vascular smooth muscle contraction
mmu04024 cAMP signaling pathway
mmu04022 cGMP-PKG signaling pathway

Domain Information

InterPro Annotations

Accession Description
IPR002175 Endothelin receptor A
IPR000499 Endothelin receptor family
IPR000276 G protein-coupled receptor, rhodopsin-like
IPR017452 GPCR, rhodopsin-like, 7TM

UniProt Annotations

Entry Information

Gene Name
endothelin receptor type A
Protein Entry
EDNRA_MOUSE
UniProt ID
Q61614
Species
Mouse

Comments

Comment Type Description
Function Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3 (By similarity). {ECO:0000250}.
Similarity Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRA sub-subfamily. {ECO:0000255|PROSITE-ProRule:PRU00521}.
Subcellular Location Cell membrane; Multi-pass membrane protein.
Subunit Interacts with HDAC7 and KAT5. {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP000155 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
45383740 RefSeq NP_034462 427 endothelin-1 receptor precursor

Identical Sequences to LMP000155 proteins

Reference Database Accession Length Protein Name
GI:45383740 DBBJ BAC31493.1 427 unnamed protein product [Mus musculus]
GI:45383740 GenBank AAH08277.1 427 Ednra protein [Mus musculus]
GI:45383740 GenBank EDL10851.1 427 endothelin receptor type A, isoform CRA_b [Mus musculus]
GI:45383740 SwissProt Q61614.3 427 RecName: Full=Endothelin-1 receptor; AltName: Full=Endothelin A receptor; Short=ET-A; Short=ET-AR; Flags: Precursor [Mus musculus]

Related Sequences to LMP000155 proteins

Reference Database Accession Length Protein Name
GI:45383740 GenBank AAA41114.1 426 endothelin receptor [Rattus norvegicus]
GI:45383740 GenBank AAB21848.1 426 endothelin receptor ETA, ETR ETA [Rattus sp.]
GI:45383740 RefSeq NP_036682.1 426 endothelin-1 receptor precursor [Rattus norvegicus]
GI:45383740 RefSeq XP_006255482.1 426 PREDICTED: endothelin-1 receptor isoform X1 [Rattus norvegicus]
GI:45383740 RefSeq XP_008770693.1 426 PREDICTED: endothelin-1 receptor isoform X1 [Rattus norvegicus]
GI:45383740 SwissProt P26684.2 426 RecName: Full=Endothelin-1 receptor; AltName: Full=Endothelin A receptor; Short=ET-A; Short=ET-AR; Flags: Precursor [Rattus norvegicus]