Gene/Proteome Database (LMPD)

LMPD ID
LMP000169
Gene ID
15212
Species
Mus musculus (Mouse)
Gene Name
hexosaminidase B
Gene Symbol
Hexb
Synonyms
-
Alternate Names
beta-hexosaminidase subunit beta; hexosaminidase subunit B; beta-N-acetylhexosaminidase subunit beta; N-acetyl-beta-glucosaminidase subunit beta
Chromosome
13
Map Location
13 D1|13 50.66 cM
EC Number
3.2.1.52

Proteins

beta-hexosaminidase subunit beta precursor
Refseq ID NP_034552
Protein GI 6754186
UniProt ID P20060
mRNA ID NM_010422
Length 536
RefSeq Status VALIDATED
MPQSPRSAPGLLLLQALVSLVSLALVAPARLQPALWPFPRSVQMFPRLLYISAEDFSIDHSPNSTAGPSCSLLQEAFRRYYNYVFGFYKRHHGPARFRAEPQLQKLLVSITLESECESFPSLSSDETYSLLVQEPVAVLKANSVWGALRGLETFSQLVYQDSFGTFTINESSIADSPRFPHRGILIDTSRHFLPVKTILKTLDAMAFNKFNVLHWHIVDDQSFPYQSTTFPELSNKGSYSLSHVYTPNDVRMVLEYARLRGIRVIPEFDTPGHTQSWGKGQKNLLTPCYNQKTKTQVFGPVDPTVNTTYAFFNTFFKEISSVFPDQFIHLGGDEVEFQCWASNPNIQGFMKRKGFGSDFRRLESFYIKKILEIISSLKKNSIVWQEVFDDKVELQPGTVVEVWKSEHYSYELKQVTGSGFPAILSAPWYLDLISYGQDWKNYYKVEPLNFEGSEKQKQLVIGGEACLWGEFVDATNLTPRLWPRASAVGERLWSPKTVTDLENAYKRLAVHRCRMVSRGIAAQPLYTGYCNYENKI
sig_peptide: 1..31 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 3183 peptide sequence: MPQSPRSAPGLLLLQALVSLVSLALVAPARL mat_peptide: 32..536 product: Beta-hexosaminidase subunit beta experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (P20060.2) calculated_mol_wt: 57951 peptide sequence: QPALWPFPRSVQMFPRLLYISAEDFSIDHSPNSTAGPSCSLLQEAFRRYYNYVFGFYKRHHGPARFRAEPQLQKLLVSITLESECESFPSLSSDETYSLLVQEPVAVLKANSVWGALRGLETFSQLVYQDSFGTFTINESSIADSPRFPHRGILIDTSRHFLPVKTILKTLDAMAFNKFNVLHWHIVDDQSFPYQSTTFPELSNKGSYSLSHVYTPNDVRMVLEYARLRGIRVIPEFDTPGHTQSWGKGQKNLLTPCYNQKTKTQVFGPVDPTVNTTYAFFNTFFKEISSVFPDQFIHLGGDEVEFQCWASNPNIQGFMKRKGFGSDFRRLESFYIKKILEIISSLKKNSIVWQEVFDDKVELQPGTVVEVWKSEHYSYELKQVTGSGFPAILSAPWYLDLISYGQDWKNYYKVEPLNFEGSEKQKQLVIGGEACLWGEFVDATNLTPRLWPRASAVGERLWSPKTVTDLENAYKRLAVHRCRMVSRGIAAQPLYTGYCNYENKI

Gene Information

Entrez Gene ID
15212
Gene Name
hexosaminidase B
Gene Symbol
Hexb
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0001669 IDA:MGI C acrosomal vesicle
GO:0070062 IEA:Ensembl C extracellular vesicular exosome
GO:0005764 IDA:MGI C lysosome
GO:0016020 IDA:MGI C membrane
GO:0004563 IDA:MGI F beta-N-acetylhexosaminidase activity
GO:0042803 IDA:MGI F protein homodimerization activity
GO:0043615 IMP:UniProtKB P astrocyte cell migration
GO:0006874 IMP:MGI P cellular calcium ion homeostasis
GO:0044267 IMP:MGI P cellular protein metabolic process
GO:0006689 IMP:MGI P ganglioside catabolic process
GO:0030203 IGI:MGI P glycosaminoglycan metabolic process
GO:0006687 IMP:MGI P glycosphingolipid metabolic process
GO:0019915 IMP:MGI P lipid storage
GO:0007626 IMP:MGI P locomotory behavior
GO:0007040 IMP:MGI P lysosome organization
GO:0008049 IMP:MGI P male courtship behavior
GO:0042552 IGI:MGI P myelination
GO:0050905 IMP:MGI P neuromuscular process
GO:0050885 IMP:MGI P neuromuscular process controlling balance
GO:0009313 IMP:MGI P oligosaccharide catabolic process
GO:0048477 IMP:MGI P oogenesis
GO:0007341 IMP:MGI P penetration of zona pellucida
GO:0008654 IMP:MGI P phospholipid biosynthetic process
GO:0045944 IMP:UniProtKB P positive regulation of transcription from RNA polymerase II promoter
GO:0008360 IMP:UniProtKB P regulation of cell shape
GO:0031323 IMP:MGI P regulation of cellular metabolic process
GO:0007605 IGI:MGI P sensory perception of sound
GO:0019953 IMP:MGI P sexual reproduction
GO:0007338 IMP:MGI P single fertilization
GO:0001501 IGI:MGI P skeletal system development

KEGG Pathway Links

KEGG Pathway ID Description
mmu00520 Amino sugar and nucleotide sugar metabolism
mmu00603 Glycosphingolipid biosynthesis - globo series
mmu04142 Lysosome

Domain Information

InterPro Annotations

Accession Description
IPR029019 Beta-hexosaminidase, eukaryotic type, N-terminal
IPR025705 Beta_hexosaminidase_sua/sub
IPR029018 Chitobiase/beta-hexosaminidase domain 2-like
IPR015883 Glycoside hydrolase family 20, catalytic core
IPR017853 Glycoside hydrolase superfamily
IPR013781 Glycoside hydrolase, catalytic domain

UniProt Annotations

Entry Information

Gene Name
hexosaminidase B
Protein Entry
HEXB_MOUSE
UniProt ID
P20060
Species
Mouse

Comments

Comment Type Description
Catalytic Activity Hydrolysis of terminal non-reducing N-acetyl- D-hexosamine residues in N-acetyl-beta-D-hexosaminides.
Function Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines, in the brain and other tissues.
Similarity Belongs to the glycosyl hydrolase 20 family. {ECO:0000305}.
Subcellular Location Lysosome.

Identical and Related Proteins

Unique RefSeq proteins for LMP000169 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6754186 RefSeq NP_034552 536 beta-hexosaminidase subunit beta precursor

Identical Sequences to LMP000169 proteins

Reference Database Accession Length Protein Name
GI:6754186 DBBJ BAE30155.1 536 unnamed protein product [Mus musculus]
GI:6754186 DBBJ BAE34846.1 536 unnamed protein product [Mus musculus]
GI:6754186 DBBJ BAE34877.1 536 unnamed protein product [Mus musculus]
GI:6754186 DBBJ BAE40652.1 536 unnamed protein product [Mus musculus]
GI:6754186 GenBank AAI40361.1 536 Hexosaminidase B, partial [synthetic construct]
GI:6754186 GenBank AAI46504.1 536 Hexosaminidase B [synthetic construct]

Related Sequences to LMP000169 proteins

Reference Database Accession Length Protein Name
GI:6754186 GenBank AAH79376.1 537 Hexosaminidase B [Rattus norvegicus]
GI:6754186 GenBank EDL00872.1 511 hexosaminidase B, isoform CRA_a, partial [Mus musculus]
GI:6754186 GenBank EDM10131.1 537 rCG44661, isoform CRA_b [Rattus norvegicus]
GI:6754186 PRF - 539 beta hexosaminidase beta [Mus musculus]
GI:6754186 RefSeq NP_001011946.1 537 beta-hexosaminidase subunit beta precursor [Rattus norvegicus]
GI:6754186 SwissProt Q6AXR4.1 537 RecName: Full=Beta-hexosaminidase subunit beta; AltName: Full=Beta-N-acetylhexosaminidase subunit beta; Short=Hexosaminidase subunit B; AltName: Full=N-acetyl-beta-glucosaminidase subunit beta; Flags: Precursor [Rattus norvegicus]