Gene/Proteome Database (LMPD)

LMPD ID
LMP000183
Gene ID
6257
Species
Homo sapiens (Human)
Gene Name
retinoid X receptor, beta
Gene Symbol
RXRB
Synonyms
DAUDI6; H-2RIIBP; NR2B2; RCoR-1
Chromosome
6
Map Location
6p21.3
Summary
This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the effects of retinoic acid (RA). The encoded protein forms homodimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. This gene lies within the major histocompatibility complex (MHC) class II region on chromosome 6. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
Orthologs
View orthologs and multiple alignments for RXRB

Proteins

retinoic acid receptor RXR-beta isoform 1
Refseq ID NP_001257330
Protein GI 393715097
UniProt ID P28702
mRNA ID NM_001270401
Length 537
RefSeq Status REVIEWED
MSWAARPPFLPQRHAAGQCGPVGVRKEMHCGVASRWRRRRPWLDPAAAAAAAVAGGEQQTPEPEPGEAGRDGMGDSGRDSRSPDSSSPNPLPQGVPPPSPPGPPLPPSTAPSLGGSGAPPPPPMPPPPLGSPFPVISSSMGSPGLPPPAPPGFSGPVSSPQINSTVSLPGGGSGPPEDVKPPVLGVRGLHCPPPPGGPGAGKRLCAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLTYSCRDNKDCTVDKRQRNRCQYCRYQKCLATGMKREAVQEERQRGKDKDGDGEGAGGAPEEMPVDRILEAELAVEQKSDQGVEGPGGTGGSGSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSSLPLDDQVILLRAGWNELLIASFSHRSIDVRDGILLATGLHVHRNSAHSAGVGAIFDRSLSRVLTELVSKMRDMRMDKTELGCLRAIILFNPDAKGLSNPSEVEVLREKVYASLETYCKQKYPEQQGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQLA
retinoic acid receptor RXR-beta isoform 2
Refseq ID NP_068811
Protein GI 11415052
UniProt ID Q5STP9
mRNA ID NM_021976
Length 533
RefSeq Status REVIEWED
MSWAARPPFLPQRHAAGQCGPVGVRKEMHCGVASRWRRRRPWLDPAAAAAAAVAGGEQQTPEPEPGEAGRDGMGDSGRDSRSPDSSSPNPLPQGVPPPSPPGPPLPPSTAPSLGGSGAPPPPPMPPPPLGSPFPVISSSMGSPGLPPPAPPGFSGPVSSPQINSTVSLPGGGSGPPEDVKPPVLGVRGLHCPPPPGGPGAGKRLCAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLTYSCRDNKDCTVDKRQRNRCQYCRYQKCLATGMKREAVQEERQRGKDKDGDGEGAGGAPEEMPVDRILEAELAVEQKSDQGVEGPGGTGGSGSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSSLPLDDQVILLRAGWNELLIASFSHRSIDVRDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDMRMDKTELGCLRAIILFNPDAKGLSNPSEVEVLREKVYASLETYCKQKYPEQQGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQLA
retinoic acid receptor RXR-beta isoform 3
Refseq ID NP_001278918
Protein GI 393715097
UniProt ID B7Z7J5
mRNA ID NM_001291989
Length 537
RefSeq Status REVIEWED
MSWAARPPFLPQRHAAGQCGPVGVRKEMHCGVASRWRRRRPWLDPAAAAAAAVAGGEQQTPEPEPGEAGRDGMGDSGRDSRSPDSSSPNPLPQGVPPPSPPGPPLPPSTAPSLGGSGAPPPPPMPPPPLGSPFPVISSSMGSPGLPPPAPPGFSGPVSSPQINSTVSLPGGGSGPPEDVKPPVLGVRGLHCPPPPGGPGAGKRLCAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLTYSCRDNKDCTVDKRQRNRCQYCRYQKCLATGMKREAVQEERQRGKDKDGDGEGAGGAPEEMPVDRILEAELAVEQKSDQGVEGPGGTGGSGSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSSLPLDDQVILLRAGWNELLIASFSHRSIDVRDGILLATGLHVHRNSAHSAGVGAIFDRSLSRVLTELVSKMRDMRMDKTELGCLRAIILFNPDAKGLSNPSEVEVLREKVYASLETYCKQKYPEQQGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQLA

Gene Information

Entrez Gene ID
6257
Gene Name
retinoid X receptor, beta
Gene Symbol
RXRB
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005654 TAS:Reactome C nucleoplasm
GO:0005634 IDA:HGNC C nucleus
GO:0004886 TAS:ProtInc F 9-cis retinoic acid receptor activity
GO:0000980 IEA:Ensembl F RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0000977 IDA:NTNU_SB F RNA polymerase II regulatory region sequence-specific DNA binding
GO:0001228 IDA:NTNU_SB F RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0004879 IDA:BHF-UCL F ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0003700 NAS:ProtInc F sequence-specific DNA binding transcription factor activity
GO:0003707 IEA:InterPro F steroid hormone receptor activity
GO:0003713 TAS:ProtInc F transcription coactivator activity
GO:0008270 IEA:InterPro F zinc ion binding
GO:0060038 IEA:Ensembl P cardiac muscle cell proliferation
GO:0071300 IEA:Ensembl P cellular response to retinoic acid
GO:0010467 TAS:Reactome P gene expression
GO:0001701 IEA:Ensembl P in utero embryonic development
GO:0001893 IEA:Ensembl P maternal placenta development
GO:0045944 IDA:NTNU_SB P positive regulation of transcription from RNA polymerase II promoter
GO:0006367 TAS:Reactome P transcription initiation from RNA polymerase II promoter
GO:0055012 IEA:Ensembl P ventricular cardiac muscle cell differentiation

KEGG Pathway Links

KEGG Pathway ID Description
hsa04919 Thyroid hormone signaling pathway

Domain Information

InterPro Annotations

Accession Description
IPR008946 Nuclear hormone receptor, ligand-binding
IPR000536 Nuclear hormone receptor, ligand-binding, core
IPR000003 Retinoid X receptor/HNF4
IPR001723 Steroid hormone receptor
IPR013088 Zinc finger, NHR/GATA-type
IPR001628 Zinc finger, nuclear hormone receptor-type

UniProt Annotations

Entry Information

Gene Name
retinoid X receptor, beta
Protein Entry
RXRB_HUMAN
UniProt ID
Q5STP9
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P28702-1; Sequence=Displayed; Name=2; IsoId=P28702-3; Sequence=VSP_045587;
Domain Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
Function Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 (By similarity). Specifically binds 9-cis retinoic acid (9C-RA).
Interaction Q00975:CACNA1B; NbExp=3; IntAct=EBI-748576, EBI-1055161;
Sequence Caution Sequence=BAD92481.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence= ;
Similarity Belongs to the nuclear hormone receptor family. NR2 subfamily.
Similarity Contains 1 nuclear receptor DNA-binding domain.
Subcellular Location Nucleus.
Subunit Homodimer (By similarity). Heterodimer with a RAR molecule. Binds DNA preferentially as a RAR/RXR heterodimer. {ECO
Tissue Specificity Expressed in a variety of tumor cell lines.

Identical and Related Proteins

Unique RefSeq proteins for LMP000183 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
393715097 RefSeq NP_001257330 537 retinoic acid receptor RXR-beta isoform 1
11415052 RefSeq NP_068811 533 retinoic acid receptor RXR-beta isoform 2
393715097 RefSeq NP_001278918 537 retinoic acid receptor RXR-beta isoform 3

Identical Sequences to LMP000183 proteins

Reference Database Accession Length Protein Name
GI:11415052 GenBank JAA08269.1 533 retinoid X receptor, beta [Pan troglodytes]
GI:11415052 GenBank JAA19474.1 533 retinoid X receptor, beta [Pan troglodytes]
GI:11415052 GenBank JAA26362.1 533 retinoid X receptor, beta [Pan troglodytes]
GI:393715097 GenBank JAA26363.1 537 retinoid X receptor, beta [Pan troglodytes]
GI:393715097 GenBank JAA26363.1 537 retinoid X receptor, beta [Pan troglodytes]
GI:11415052 GenBank JAA34131.1 533 retinoid X receptor, beta [Pan troglodytes]
GI:393715097 GenBank JAA34132.1 537 retinoid X receptor, beta [Pan troglodytes]
GI:393715097 GenBank JAA34132.1 537 retinoid X receptor, beta [Pan troglodytes]
GI:11415052 GenBank AIC55078.1 533 RXRB, partial [synthetic construct]
GI:393715097 RefSeq XP_005553390.1 537 PREDICTED: retinoic acid receptor RXR-beta isoform X3 [Macaca fascicularis]
GI:393715097 RefSeq XP_005553390.1 537 PREDICTED: retinoic acid receptor RXR-beta isoform X3 [Macaca fascicularis]
GI:11415052 RefSeq XP_005553391.1 533 PREDICTED: retinoic acid receptor RXR-beta isoform X4 [Macaca fascicularis]
GI:393715097 RefSeq XP_008958903.1 537 PREDICTED: retinoic acid receptor RXR-beta isoform X1 [Pan paniscus]
GI:393715097 RefSeq XP_008958903.1 537 PREDICTED: retinoic acid receptor RXR-beta isoform X1 [Pan paniscus]
GI:393715097 RefSeq XP_009203170.1 537 PREDICTED: retinoic acid receptor RXR-beta isoform X1 [Papio anubis]
GI:393715097 RefSeq XP_009203170.1 537 PREDICTED: retinoic acid receptor RXR-beta isoform X1 [Papio anubis]
GI:393715097 RefSeq XP_009449278.1 537 PREDICTED: retinoic acid receptor RXR-beta isoform X1 [Pan troglodytes]
GI:393715097 RefSeq XP_009449278.1 537 PREDICTED: retinoic acid receptor RXR-beta isoform X1 [Pan troglodytes]

Related Sequences to LMP000183 proteins

Reference Database Accession Length Protein Name
GI:393715097 DBBJ BAD92481.1 577 retinoid X receptor, beta variant, partial [Homo sapiens]
GI:393715097 DBBJ BAD92481.1 577 retinoid X receptor, beta variant, partial [Homo sapiens]
GI:11415052 GenBank AAA60293.1 533 retinoid X receptor beta [Homo sapiens]
GI:11415052 GenBank AAR67360.1 533 Sequence 4 from patent US 6635429
GI:393715097 GenBank ACM86074.1 577 Sequence 11572 from patent US 6812339
GI:393715097 GenBank ACM86074.1 577 Sequence 11572 from patent US 6812339
GI:393715097 GenBank JAB14314.1 536 retinoic acid receptor RXR-beta isoform 1 [Callithrix jacchus]
GI:393715097 GenBank JAB14314.1 536 retinoic acid receptor RXR-beta isoform 1 [Callithrix jacchus]
GI:393715097 GenBank JAB24168.1 536 retinoic acid receptor RXR-beta isoform 1 [Callithrix jacchus]
GI:393715097 GenBank JAB24168.1 536 retinoic acid receptor RXR-beta isoform 1 [Callithrix jacchus]
GI:11415052 RefSeq XP_003272215.1 533 PREDICTED: retinoic acid receptor RXR-beta [Nomascus leucogenys]
GI:11415052 RefSeq XP_004043849.1 533 PREDICTED: retinoic acid receptor RXR-beta [Gorilla gorilla gorilla]
GI:393715097 RefSeq XP_007971153.1 537 PREDICTED: retinoic acid receptor RXR-beta isoform X1 [Chlorocebus sabaeus]
GI:393715097 RefSeq XP_007971153.1 537 PREDICTED: retinoic acid receptor RXR-beta isoform X1 [Chlorocebus sabaeus]
GI:11415052 RefSeq XP_007971154.1 533 PREDICTED: retinoic acid receptor RXR-beta isoform X2 [Chlorocebus sabaeus]
GI:393715097 RefSeq XP_010356170.1 537 PREDICTED: retinoic acid receptor RXR-beta isoform X3 [Rhinopithecus roxellana]
GI:393715097 RefSeq XP_010356170.1 537 PREDICTED: retinoic acid receptor RXR-beta isoform X3 [Rhinopithecus roxellana]
GI:11415052 RefSeq XP_010356171.1 533 PREDICTED: retinoic acid receptor RXR-beta isoform X4 [Rhinopithecus roxellana]