Gene/Proteome Database (LMPD)

LMPD ID
LMP000187
Gene ID
20182
Species
Mus musculus (Mouse)
Gene Name
retinoid X receptor beta
Gene Symbol
Rxrb
Synonyms
AL023085; H-2RIIBP; Nr2b2; RCoR-1; Rub
Alternate Names
retinoic acid receptor RXR-beta; putative retinoid X receptor beta; nuclear receptor subfamily 2 group B member 2; MHC class I regulatory element-binding protein H-2RIIBP
Chromosome
17
Map Location
17 B1|17 17.98 cM

Proteins

retinoic acid receptor RXR-beta isoform 1
Refseq ID NP_001192143
Protein GI 327315356
UniProt ID Q3TWJ1
mRNA ID NM_001205214
Length 524
RefSeq Status VALIDATED
MSWATRPPFLPPRHAAGQCGPVGVRKEMHCGVASRWRRRRPWLDPAAAAAAAGEQQALEPEPGEAGRDGMGDSGRDSRSPDSSSPNPLSQGIRPSSPPGPPLTPSAPPPPMPPPPLGSPFPVISSSMGSPGLPPPAPPGFSGPVSSPQINSTVSLPGGGSGPPEDVKPPVLGVRGLHCPPPPGGPGAGKRLCAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLTYSCRDNKDCTVDKRQRNRCQYCRYQKCLATGMKREAVQEERQRGKDKDGDGDGAGGAPEEMPVDRILEAELAVEQKSDQGVEGPGATGGGGSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSSLPLDDQVILLRAGWNELLIASFSHRSIDVRDGILLATGLHVHRNSAHSAGVGAIFDRSLSRVLTELVSKMRDMRMDKTELGCLRAIILFNPDAKGLSNPGEVEILREKVYASLETYCKQKYPEQQGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQLA
retinoic acid receptor RXR-beta isoform 2
Refseq ID NP_035436
Protein GI 13489062
UniProt ID P28704
mRNA ID NM_011306
Length 520
RefSeq Status VALIDATED
MSWATRPPFLPPRHAAGQCGPVGVRKEMHCGVASRWRRRRPWLDPAAAAAAAGEQQALEPEPGEAGRDGMGDSGRDSRSPDSSSPNPLSQGIRPSSPPGPPLTPSAPPPPMPPPPLGSPFPVISSSMGSPGLPPPAPPGFSGPVSSPQINSTVSLPGGGSGPPEDVKPPVLGVRGLHCPPPPGGPGAGKRLCAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLTYSCRDNKDCTVDKRQRNRCQYCRYQKCLATGMKREAVQEERQRGKDKDGDGDGAGGAPEEMPVDRILEAELAVEQKSDQGVEGPGATGGGGSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSSLPLDDQVILLRAGWNELLIASFSHRSIDVRDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDMRMDKTELGCLRAIILFNPDAKGLSNPGEVEILREKVYASLETYCKQKYPEQQGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQLA
retinoic acid receptor RXR-beta isoform 3
Refseq ID NP_001192144
Protein GI 327315358
UniProt ID Q8VCR0
mRNA ID NM_001205215
Length 414
RefSeq Status VALIDATED
MPPPPLGSPFPVISSSMGSPGLPPPAPPGFSGPVSSPQINSTVSLPGGGSGPPEDVKPPVLGVRGLHCPPPPGGPGAGKRLCAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLTYSCRDNKDCTVDKRQRNRCQYCRYQKCLATGMKREAVQEERQRGKDKDGDGDGAGGAPEEMPVDRILEAELAVEQKSDQGVEGPGATGGGGSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSSLPLDDQVILLRAGWNELLIASFSHRSIDVRDGILLATGLHVHRNSAHSAGVGAIFDRSLSRVLTELVSKMRDMRMDKTELGCLRAIILFNPDAKGLSNPGEVEILREKVYASLETYCKQKYPEQQGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQLA
retinoic acid receptor RXR-beta isoform 4
Refseq ID NP_001192145
Protein GI 327315360
UniProt ID P28704
mRNA ID NM_001205216
Length 410
RefSeq Status VALIDATED
MPPPPLGSPFPVISSSMGSPGLPPPAPPGFSGPVSSPQINSTVSLPGGGSGPPEDVKPPVLGVRGLHCPPPPGGPGAGKRLCAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLTYSCRDNKDCTVDKRQRNRCQYCRYQKCLATGMKREAVQEERQRGKDKDGDGDGAGGAPEEMPVDRILEAELAVEQKSDQGVEGPGATGGGGSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSSLPLDDQVILLRAGWNELLIASFSHRSIDVRDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDMRMDKTELGCLRAIILFNPDAKGLSNPGEVEILREKVYASLETYCKQKYPEQQGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQLA

Gene Information

Entrez Gene ID
20182
Gene Name
retinoid X receptor beta
Gene Symbol
Rxrb
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005634 IEA:UniProtKB-KW C nucleus
GO:0004886 IDA:MGI F 9-cis retinoic acid receptor activity
GO:0000980 IDA:MGI F RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0000977 IDA:MGI F RNA polymerase II regulatory region sequence-specific DNA binding
GO:0042803 IDA:MGI F protein homodimerization activity
GO:0043565 IGI:MGI F sequence-specific DNA binding
GO:0003707 IEA:InterPro F steroid hormone receptor activity
GO:0044212 IDA:UniProtKB F transcription regulatory region DNA binding
GO:0008270 IEA:InterPro F zinc ion binding
GO:0060038 IGI:MGI P cardiac muscle cell proliferation
GO:0071300 IDA:UniProtKB P cellular response to retinoic acid
GO:0001701 IGI:MGI P in utero embryonic development
GO:0001893 IGI:MGI P maternal placenta development
GO:0045944 IGI:MGI P positive regulation of transcription from RNA polymerase II promoter
GO:0048384 IDA:MGI P retinoic acid receptor signaling pathway
GO:0055012 IMP:MGI P ventricular cardiac muscle cell differentiation

KEGG Pathway Links

KEGG Pathway ID Description
mmu05223 Non-small cell lung cancer
mmu04919 Thyroid hormone signaling pathway

Domain Information

InterPro Annotations

Accession Description
IPR008946 Nuclear hormone receptor, ligand-binding
IPR000536 Nuclear hormone receptor, ligand-binding, core
IPR000003 Retinoid X receptor/HNF4
IPR001723 Steroid hormone receptor
IPR013088 Zinc finger, NHR/GATA-type
IPR001628 Zinc finger, nuclear hormone receptor-type

UniProt Annotations

Entry Information

Gene Name
retinoid X receptor beta
Protein Entry
Q8VCR0_MOUSE
UniProt ID
Q8VCR0
Species
Mouse

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Comment=Additional isoforms seem to exist.; Name=Long; IsoId=P28704-1; Sequence=Displayed; Name=Short; IsoId=P28704-2; Sequence=VSP_003678;
Domain Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
Function Nuclear hormone receptor. Involved in the retinoic acid response pathway. Binds 9-cis retinoic acid (9C-RA). Binds to both, class I regulatory element of major histocompatibility class I genes (CRE) and the estrogen response element (ERE).
Similarity Belongs to the nuclear hormone receptor family. NR2 subfamily. {ECO:0000305}.
Similarity Contains 1 nuclear receptor DNA-binding domain. {ECO:0000255|PROSITE-ProRule:PRU00407}.
Subcellular Location Nucleus.
Tissue Specificity In all tissues tested including brain, thymus spleen and liver.

Identical and Related Proteins

Unique RefSeq proteins for LMP000187 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
327315356 RefSeq NP_001192143 524 retinoic acid receptor RXR-beta isoform 1
13489062 RefSeq NP_035436 520 retinoic acid receptor RXR-beta isoform 2
327315358 RefSeq NP_001192144 414 retinoic acid receptor RXR-beta isoform 3
327315360 RefSeq NP_001192145 410 retinoic acid receptor RXR-beta isoform 4

Identical Sequences to LMP000187 proteins

Reference Database Accession Length Protein Name
GI:13489062 DBBJ BAA04858.1 520 RXR-beta1 isoform [Mus musculus]
GI:327315360 DBBJ BAA04859.1 410 RXR-beta2 isoform [Mus musculus]
GI:327315358 DBBJ BAE24359.1 414 unnamed protein product [Mus musculus]
GI:327315356 DBBJ BAE35275.1 524 unnamed protein product [Mus musculus]
GI:327315360 EMBL CAA46963.1 410 retinoid X receptor-beta [Mus musculus]
GI:13489062 GenBank AAC69904.1 520 RXRbeta [Mus musculus]
GI:327315358 GenBank AAH19432.1 414 Rxrb protein [Mus musculus]
GI:13489062 GenBank AAH49773.1 520 Retinoid X receptor beta [Mus musculus]
GI:13489062 GenBank EDL10248.1 520 retinoid X receptor beta, isoform CRA_c [Mus musculus]
GI:327315360 GenBank ACP80944.1 410 Sequence 8 from patent US 7501487
GI:13489062 SwissProt P28704.2 520 RecName: Full=Retinoic acid receptor RXR-beta; AltName: Full=MHC class I regulatory element-binding protein H-2RIIBP; AltName: Full=Nuclear receptor subfamily 2 group B member 2; AltName: Full=Retinoid X receptor beta [Mus musculus]

Related Sequences to LMP000187 proteins

Reference Database Accession Length Protein Name
GI:327315360 DBBJ BAA04858.1 520 RXR-beta1 isoform [Mus musculus]
GI:327315356 DBBJ BAA04858.1 520 RXR-beta1 isoform [Mus musculus]
GI:327315358 DBBJ BAE35275.1 524 unnamed protein product [Mus musculus]
GI:13489062 DBBJ BAE35275.1 524 unnamed protein product [Mus musculus]
GI:327315360 GenBank AAA37772.1 446 MHC class I regulatory element binding protein (H-2RIIBP), partial [Mus musculus]
GI:327315356 GenBank AAC69904.1 520 RXRbeta [Mus musculus]
GI:327315360 GenBank AAC69904.1 520 RXRbeta [Mus musculus]
GI:327315356 GenBank AAH49773.1 520 Retinoid X receptor beta [Mus musculus]
GI:327315358 GenBank EDL10247.1 455 retinoid X receptor beta, isoform CRA_b, partial [Mus musculus]
GI:327315360 GenBank EDL10248.1 520 retinoid X receptor beta, isoform CRA_c [Mus musculus]
GI:327315356 GenBank EDL10248.1 520 retinoid X receptor beta, isoform CRA_c [Mus musculus]
GI:13489062 GenBank EDL96823.1 518 rCG60716 [Rattus norvegicus]
GI:13489062 GenBank AIC84007.1 524 retinoid X receptor beta [Mus musculus]
GI:327315358 GenBank AIC84007.1 524 retinoid X receptor beta [Mus musculus]
GI:13489062 GenBank AIC84027.1 520 putative retinoid X receptor beta isoform 1 [Mus musculus]
GI:327315358 GenBank AIC84028.1 486 putative retinoid X receptor beta isoform 2 [Mus musculus]
GI:327315358 GenBank AIC84030.1 463 putative retinoid X receptor beta isoform 4 [Mus musculus]
GI:327315360 RefSeq NP_035436.1 520 retinoic acid receptor RXR-beta isoform 2 [Mus musculus]
GI:327315356 RefSeq NP_035436.1 520 retinoic acid receptor RXR-beta isoform 2 [Mus musculus]
GI:13489062 RefSeq NP_996731.2 518 retinoic acid receptor RXR-beta [Rattus norvegicus]
GI:327315358 RefSeq NP_001192143.1 524 retinoic acid receptor RXR-beta isoform 1 [Mus musculus]
GI:13489062 RefSeq NP_001192143.1 524 retinoic acid receptor RXR-beta isoform 1 [Mus musculus]
GI:327315356 SwissProt P28704.2 520 RecName: Full=Retinoic acid receptor RXR-beta; AltName: Full=MHC class I regulatory element-binding protein H-2RIIBP; AltName: Full=Nuclear receptor subfamily 2 group B member 2; AltName: Full=Retinoid X receptor beta [Mus musculus]
GI:327315360 SwissProt P49743.1 458 RecName: Full=Retinoic acid receptor RXR-beta; AltName: Full=Nuclear receptor coregulator 1; AltName: Full=Nuclear receptor subfamily 2 group B member 2; AltName: Full=Retinoid X receptor beta, partial [Rattus norvegicus]