Gene/Proteome Database (LMPD)

LMPD ID
LMP000191
Gene ID
15450
Species
Mus musculus (Mouse)
Gene Name
lipase, hepatic
Gene Symbol
Lipc
Synonyms
AI256194; HL; Hpl
Alternate Names
hepatic triacylglycerol lipase; hepatic lipase; lipase member C
Chromosome
9
Map Location
9 D|9 39.57 cM
EC Number
3.1.1.3

Proteins

hepatic triacylglycerol lipase precursor
Refseq ID NP_032306
Protein GI 31982278
UniProt ID P27656
mRNA ID NM_008280
Length 510
RefSeq Status PROVISIONAL
MGNPLQISIFLVFCIFIQSSACGQGVGTEPFGRSLGATEASKPLKKPETRFLLFQDENDRLGCRLRPQHPETLQECGFNSSQPLIMIIHGWSVDGLLENWIWKIVSALKSRQSQPVNVGLVDWISLAYQHYTIAVQNTRIVGQDVAALLLWLEESAKFSRSKVHLIGYSLGAHVSGFAGSSMDGKNKIGRITGLDPAGPMFEGTSPNERLSPDDANFVDAIHTFTREHMGLSVGIKQPIAHYDFYPNGGSFQPGCHFLELYKHIAEHGLNAITQTIKCAHERSVHLFIDSLQHSDLQSIGFQCSDMGSFSQGLCLSCKKGRCNTLGYDIRKDRSGKSKRLFLITRAQSPFKVYHYQFKIQFINQIEKPVEPTFTMSLLGTKEEIKRIPITLGEGITSNKTYSFLITLDKDIGELILLKFKWENSAVWANVWNTVQTIMLWGIEPHHSGLILKTIWVKAGETQQRMTFCPENLDDLQLHPSQEKVFVNCEVKSKRLTESKEQMSQETHAKK
sig_peptide: 1..22 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2432 peptide sequence: MGNPLQISIFLVFCIFIQSSAC mat_peptide: 23..510 product: Hepatic triacylglycerol lipase experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (P27656.2) calculated_mol_wt: 54975 peptide sequence: GQGVGTEPFGRSLGATEASKPLKKPETRFLLFQDENDRLGCRLRPQHPETLQECGFNSSQPLIMIIHGWSVDGLLENWIWKIVSALKSRQSQPVNVGLVDWISLAYQHYTIAVQNTRIVGQDVAALLLWLEESAKFSRSKVHLIGYSLGAHVSGFAGSSMDGKNKIGRITGLDPAGPMFEGTSPNERLSPDDANFVDAIHTFTREHMGLSVGIKQPIAHYDFYPNGGSFQPGCHFLELYKHIAEHGLNAITQTIKCAHERSVHLFIDSLQHSDLQSIGFQCSDMGSFSQGLCLSCKKGRCNTLGYDIRKDRSGKSKRLFLITRAQSPFKVYHYQFKIQFINQIEKPVEPTFTMSLLGTKEEIKRIPITLGEGITSNKTYSFLITLDKDIGELILLKFKWENSAVWANVWNTVQTIMLWGIEPHHSGLILKTIWVKAGETQQRMTFCPENLDDLQLHPSQEKVFVNCEVKSKRLTESKEQMSQETHAKK

Gene Information

Entrez Gene ID
15450
Gene Name
lipase, hepatic
Gene Symbol
Lipc
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005615 IDA:MGI C extracellular space
GO:0034364 IEA:UniProtKB-KW C high-density lipoprotein particle
GO:0008201 IEA:UniProtKB-KW F heparin binding
GO:0016298 IDA:MGI F lipase activity
GO:0004806 IEA:UniProtKB-EC F triglyceride lipase activity
GO:0042632 IGI:MGI P cholesterol homeostasis
GO:0008203 IGI:MGI P cholesterol metabolic process
GO:0030301 IMP:MGI P cholesterol transport
GO:0006633 IEA:Ensembl P fatty acid biosynthetic process
GO:0034375 IEA:Ensembl P high-density lipoprotein particle remodeling
GO:0034374 IEA:Ensembl P low-density lipoprotein particle remodeling
GO:0019433 IEA:Ensembl P triglyceride catabolic process
GO:0070328 IEA:Ensembl P triglyceride homeostasis
GO:0034372 IEA:Ensembl P very-low-density lipoprotein particle remodeling

KEGG Pathway Links

KEGG Pathway ID Description
mmu00561 Glycerolipid metabolism

Domain Information

InterPro Annotations

Accession Description
IPR029058 Alpha/Beta hydrolase fold
IPR002333 Hepatic lipase
IPR013818 Lipase, N-terminal
IPR008976 Lipase/lipooxygenase, PLAT/LH2
IPR016272 Lipoprotein_lipase_LIPH
IPR001024 PLAT/LH2 domain
IPR000734 Triacylglycerol lipase family

UniProt Annotations

Entry Information

Gene Name
lipase, hepatic
Protein Entry
LIPC_MOUSE
UniProt ID
P27656
Species
Mouse

Comments

Comment Type Description
Catalytic Activity Triacylglycerol + H(2)O = diacylglycerol + a carboxylate.
Function Hepatic lipase has the capacity to catalyze hydrolysis of phospholipids, mono-, di-, and triglycerides, and acyl-CoA thioesters. It is an important enzyme in HDL metabolism. Hepatic lipase binds heparin.
Similarity Belongs to the AB hydrolase superfamily. Lipase family. {ECO:0000305}.
Similarity Contains 1 PLAT domain. {ECO:0000255|PROSITE- ProRule:PRU00152}.
Subcellular Location Secreted.

Identical and Related Proteins

Unique RefSeq proteins for LMP000191 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
31982278 RefSeq NP_032306 510 hepatic triacylglycerol lipase precursor

Identical Sequences to LMP000191 proteins

Reference Database Accession Length Protein Name
GI:31982278 GenBank AAH21841.1 510 Lipase, hepatic [Mus musculus]
GI:31982278 GenBank AAO73443.1 510 hepatic lipase [Mus musculus]
GI:31982278 GenBank AAH94050.1 510 Lipase, hepatic [Mus musculus]
GI:31982278 GenBank EDL26212.1 510 lipase, hepatic, isoform CRA_a [Mus musculus]
GI:31982278 SwissProt P27656.2 510 RecName: Full=Hepatic triacylglycerol lipase; Short=HL; Short=Hepatic lipase; AltName: Full=Lipase member C; Flags: Precursor [Mus musculus]

Related Sequences to LMP000191 proteins

Reference Database Accession Length Protein Name
GI:31982278 EMBL CAA41329.1 510 lipoprotein lipase [Mus musculus]
GI:31982278 GenBank AAO67352.1 510 hepatic lipase [Mus spretus]
GI:31982278 RefSeq NP_036729.2 494 hepatic triacylglycerol lipase precursor [Rattus norvegicus]
GI:31982278 RefSeq XP_006243422.1 494 PREDICTED: hepatic triacylglycerol lipase isoform X1 [Rattus norvegicus]
GI:31982278 RefSeq XP_006510878.1 526 PREDICTED: hepatic triacylglycerol lipase isoform X1 [Mus musculus]
GI:31982278 RefSeq XP_006510879.1 526 PREDICTED: hepatic triacylglycerol lipase isoform X2 [Mus musculus]