Gene/Proteome Database (LMPD)

LMPD ID
LMP000194
Gene ID
4759
Species
Homo sapiens (Human)
Gene Name
sialidase 2 (cytosolic sialidase)
Gene Symbol
NEU2
Synonyms
SIAL2
Alternate Names
sialidase-2; neuraminidase 2; cytosolic sialidase; N-acetyl-alpha-neuraminidase 2
Chromosome
2
Map Location
2q37
EC Number
3.2.1.18
Summary
This gene belongs to a family of glycohydrolytic enzymes which remove sialic acid residues from glycoproteins and glycolipids. Expression studies in COS7 cells confirmed that this gene encodes a functional sialidase. Its cytosolic localization was demonstrated by cell fractionation experiments. [provided by RefSeq, Jul 2008]
Orthologs
View orthologs and multiple alignments for NEU2

Proteins

sialidase-2
Refseq ID NP_005374
Protein GI 222352170
UniProt ID Q9Y3R4
mRNA ID NM_005383
Length 380
RefSeq Status REVIEWED
MASLPVLQKESVFQSGAHAYRIPALLYLPGQQSLLAFAEQRASKKDEHAELIVLRRGDYDAPTHQVQWQAQEVVAQARLDGHRSMNPCPLYDAQTGTLFLFFIAIPGQVTEQQQLQTRANVTRLCQVTSTDHGRTWSSPRDLTDAAIGPAYREWSTFAVGPGHCLQLHDRARSLVVPAYAYRKLHPIQRPIPSAFCFLSHDHGRTWARGHFVAQDTLECQVAEVETGEQRVVTLNARSHLRARVQAQSTNDGLDFQESQLVKKLVEPPPQGCQGSVISFPSPRSGPGSPAQWLLYTHPTHSWQRADLGAYLNPRPPAPEAWSEPVLLAKGSCAYSDLQSMGTGPDGSPLFGCLYEANDYEEIVFLMFTLKQAFPAEYLPQ

Gene Information

Entrez Gene ID
4759
Gene Name
sialidase 2 (cytosolic sialidase)
Gene Symbol
NEU2
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 TAS:ProtInc C cytoplasm
GO:0005829 TAS:Reactome C cytosol
GO:0052794 IDA:UniProtKB F exo-alpha-(2->3)-sialidase activity
GO:0052795 IEA:UniProtKB-EC F exo-alpha-(2->6)-sialidase activity
GO:0052796 IEA:UniProtKB-EC F exo-alpha-(2->8)-sialidase activity
GO:0006689 IDA:UniProtKB P ganglioside catabolic process
GO:0006687 TAS:Reactome P glycosphingolipid metabolic process
GO:0009313 IDA:UniProtKB P oligosaccharide catabolic process
GO:0044281 TAS:Reactome P small molecule metabolic process
GO:0006665 TAS:Reactome P sphingolipid metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
hsa00600 Sphingolipid metabolism

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_116105 Glycosphingolipid metabolism
REACT_200874 Sialic acid metabolism
REACT_22387 Synthesis of substrates in N-glycan biosythesis

Domain Information

InterPro Annotations

Accession Description
IPR026856 Sialidase family
IPR026945 Sialidase-2
IPR011040 Sialidases

UniProt Annotations

Entry Information

Gene Name
sialidase 2 (cytosolic sialidase)
Protein Entry
NEUR2_HUMAN
UniProt ID
Q9Y3R4
Species
Human

Comments

Comment Type Description
Catalytic Activity Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates. {ECO
Function Catalyzes the removal of sialic acid (N-acetylneuraminic acid) moities from glycoproteins, oligosaccharides and gangliosides. {ECO
Similarity Belongs to the glycosyl hydrolase 33 family.
Similarity Contains 2 BNR repeats.
Subcellular Location Cytoplasm .
Tissue Specificity Expressed in skeletal muscle, fetal liver and embryonic carcinoma cell line NT2-D1.

Identical and Related Proteins

Unique RefSeq proteins for LMP000194 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
222352170 RefSeq NP_005374 380 sialidase-2

Identical Sequences to LMP000194 proteins

Reference Database Accession Length Protein Name
GI:222352170 GenBank AAH69151.1 380 Sialidase 2 (cytosolic sialidase) [Homo sapiens]
GI:222352170 GenBank AAY24360.1 380 unknown [Homo sapiens]
GI:222352170 GenBank EAW71028.1 380 sialidase 2 (cytosolic sialidase) [Homo sapiens]
GI:222352170 GenBank AEP61118.1 380 Sequence 112 from patent US 8026065
GI:222352170 SwissProt Q9Y3R4.2 380 RecName: Full=Sialidase-2; AltName: Full=Cytosolic sialidase; AltName: Full=N-acetyl-alpha-neuraminidase 2 [Homo sapiens]

Related Sequences to LMP000194 proteins

Reference Database Accession Length Protein Name
GI:222352170 EMBL CAB41449.1 380 neuraminidase [Homo sapiens]
GI:222352170 GenBank AAI07054.1 380 Sialidase 2 (cytosolic sialidase) [Homo sapiens]
GI:222352170 GenBank AIC54808.1 380 NEU2, partial [synthetic construct]
GI:222352170 PDB 1SO7 382 Chain A, Maltose-Induced Structure Of The Human Cytolsolic Sialidase Neu2
GI:222352170 PDB 1VCU 382 Chain A, Structure Of The Human Cytosolic Sialidase Neu2 In Complex With The Inhibitor Dana
GI:222352170 PDB 1VCU 382 Chain B, Structure Of The Human Cytosolic Sialidase Neu2 In Complex With The Inhibitor Dana