Gene/Proteome Database (LMPD)
LMPD ID
LMP000196
Gene ID
Species
Mus musculus (Mouse)
Gene Name
sphingosine-1-phosphate receptor 3
Gene Symbol
Synonyms
AI132464; Edg3; Lpb3; S1p3
Alternate Names
sphingosine 1-phosphate receptor 3; S1p receptor 3; S1P receptor Edg-3; lysophospholipid receptor B3; sphingosine 1-phosphate receptor Edg-3; endothelial differentiation G-protein coupled receptor 3; endothelial differentiation sphingolipid G-protein-coupled receptor 3
Chromosome
13
Map Location
13|13 B1
Summary
This gene encodes a member of the G-protein coupled receptor 1 family. The encoded protein is a receptor for the lysophospholipid sphingosine 1-phosphate. The gene product functions in endothelial cells and is involved in vascular and heart development. The gene product mediates HDL and HDL-associated lysophospholipid-induced vasorelaxation, and it coordinates with other lysophospholipid receptors in the process of angiogenesis. [provided by RefSeq, Jan 2010]
Orthologs
Proteins
| sphingosine 1-phosphate receptor 3 | |
|---|---|
| Refseq ID | NP_034231 |
| Protein GI | 6753716 |
| UniProt ID | Q9Z0U9 |
| mRNA ID | NM_010101 |
| Length | 378 |
| RefSeq Status | REVIEWED |
| MATTHAQGHQPVLGNDTLREHYDYVGKLAGRLRDPPEGGTLITTILFLVTCSFIVLENLMVLIAIWKNNKFHNRMYFFIGNLALCDLLAGIAYKVNILMSGRKTFSLSPTVWFLREGSMFVALGASTCSLLAIAIERHLTMIKMRPYDANKKHRVFLLIGMCWLIAFSLGALPILGWNCLENFPDCSTILPLYSKKYIAFLISIFTAILVTIVILYARIYCLVKSSSRRVANHNSERSMALLRTVVIVVSVFIACWSPLFILFLIDVACRAKECSILFKSQWFIMLAVLNSAMNPVIYTLASKEMRRAFFRLVCGCLVKGKGTQASPMQPALDPSRSKSSSSNNSSHSPKVKEDLPRVATSSCIIDKNRSFQNGVLCK | |
Gene Information
Entrez Gene ID
Gene Name
sphingosine-1-phosphate receptor 3
Gene Symbol
Species
Mus musculus
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005887 | TAS:MGI | C | integral component of plasma membrane |
| GO:0004930 | TAS:MGI | F | G-protein coupled receptor activity |
| GO:0038036 | IEA:InterPro | F | sphingosine-1-phosphate receptor activity |
| GO:0007193 | IDA:MGI | P | adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway |
| GO:0001816 | IMP:MGI | P | cytokine production |
| GO:0006954 | IMP:MGI | P | inflammatory response |
| GO:0032651 | IMP:MGI | P | regulation of interleukin-1 beta production |
REACTOME Pathway Links
Domain Information
UniProt Annotations
Entry Information
Gene Name
sphingosine-1-phosphate receptor 3
Protein Entry
S1PR3_MOUSE
UniProt ID
Species
Mouse
Comments
| Comment Type | Description |
|---|---|
| Function | Receptor for the lysosphingolipid sphingosine 1- phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. |
| Similarity | Belongs to the G-protein coupled receptor 1 family. {ECO:0000255|PROSITE-ProRule:PRU00521}. |
| Subcellular Location | Cell membrane; Multi-pass membrane protein. |
| Tissue Specificity | Most abundant in heart, lung, kidney and spleen; low but detectable in brain, thymus, muscle and testis; and nearly undetectable in liver, stomach, and intestine. Expressed in embryonic lung from embryonic day 14-18. Also abundantly detected in embryonic nasal cartilage, sphenoid bone, vena cava, Meckel's cartilage/incisor teeth, genital tubercle and bladder. {ECO:0000269|PubMed:9931453}. |
Identical and Related Proteins
Unique RefSeq proteins for LMP000196 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 6753716 | RefSeq | NP_034231 | 378 | sphingosine 1-phosphate receptor 3 |
Identical Sequences to LMP000196 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:6753716 | DBBJ | BAC39316.1 | 378 | unnamed protein product [Mus musculus] |
| GI:6753716 | DBBJ | BAC39383.1 | 378 | unnamed protein product [Mus musculus] |
| GI:6753716 | DBBJ | BAC25715.1 | 378 | unnamed protein product [Mus musculus] |
| GI:6753716 | GenBank | AAH64007.1 | 378 | Sphingosine-1-phosphate receptor 3 [Mus musculus] |
| GI:6753716 | GenBank | AAH68176.1 | 378 | Sphingosine-1-phosphate receptor 3 [Mus musculus] |
| GI:6753716 | SwissProt | Q9Z0U9.1 | 378 | RecName: Full=Sphingosine 1-phosphate receptor 3; Short=S1P receptor 3; Short=S1P3; AltName: Full=Endothelial differentiation G-protein coupled receptor 3; AltName: Full=Lysophospholipid receptor B3; AltName: Full=Sphingosine 1-phosphate receptor Edg-3; Short=S1P receptor Edg-3 [Mus musculus] |
Related Sequences to LMP000196 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:6753716 | DBBJ | BAC37277.1 | 378 | unnamed protein product [Mus musculus] |
| GI:6753716 | GenBank | ABP12357.1 | 379 | Sequence 29 from patent US 7183105 |
| GI:6753716 | GenBank | EDL41098.1 | 380 | endothelial differentiation, sphingolipid G-protein-coupled receptor, 3, partial [Mus musculus] |
| GI:6753716 | GenBank | AED03609.1 | 379 | Sequence 29 from patent US 7871815 |
| GI:6753716 | GenBank | AFA68024.1 | 379 | Sequence 29 from patent US 8101396 |
| GI:6753716 | RefSeq | XP_006253740.1 | 379 | PREDICTED: sphingosine 1-phosphate receptor 3 isoform X1 [Rattus norvegicus] |