Gene/Proteome Database (LMPD)

LMPD ID
LMP000202
Gene ID
71780
Species
Mus musculus (Mouse)
Gene Name
myo-inositol 1-phosphate synthase A1
Gene Symbol
Isyna1
Synonyms
1300017C10Rik; AU018670
Alternate Names
inositol-3-phosphate synthase 1; IPS 1; MIP synthase; MI-1-P synthase; myo-inositol-1-phosphate synthase
Chromosome
8
Map Location
8 B3.3|8
EC Number
5.5.1.4

Proteins

inositol-3-phosphate synthase 1
Refseq ID NP_076116
Protein GI 12963757
UniProt ID Q9JHU9
mRNA ID NM_023627
Length 557
RefSeq Status PROVISIONAL
MEPAAEILVDSPDVVYSPETIEARYEYRTTRVSREGGVLRVQPRATRFTFRTARQVPRLGVMLVGWGGNNGSTLTAAVLANRLRLTWPTRTGRKEANYYGSLTQAGTVNLGLDENGREVFVPFSALLPMVAPNDLVFDGWDISSLNLAEAMRRAQVLDCGLQEQLWPHMESLRPRPSVYIPEFIAANQTARADNLIPGTRAQQLEQIRKDIRDFRSSAGLDKVIVLWTANTERFCEVVPGRNDTAENLLHTIQLGLEVSPSTLFAVASILEDCAFLNGSPQNTLVPGALELASQRHVFVGGDDFKSGQTKVKSVLVDFLIGSGLKTMSIVSYNHLGNNDGQNLSAPLQFRSKEVTKSSVVDDMVHSNHVLYAPGERPDHCVVIKYVPYVGDSKRALDEYTSELMLGGTNTLVLHNTCEDSLLAAPIMLDLVLLTELCQRVSFCTDSDPEPQGFHTVLSLLSFLFKAPLVPPGSPVVNALFRQRSCIENIFRACVGLPPQNHMLLEHKMERPGPGIKPGEVVATSPLPCKKEPTPATNGCTGDANGHPQAPTPKLSTA

Gene Information

Entrez Gene ID
71780
Gene Name
myo-inositol 1-phosphate synthase A1
Gene Symbol
Isyna1
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IEA:UniProtKB-KW C cytoplasm
GO:0004512 IEA:UniProtKB-EC F inositol-3-phosphate synthase activity
GO:0006021 IEA:UniProtKB-UniPathway P inositol biosynthetic process
GO:0008654 IEA:UniProtKB-KW P phospholipid biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
mmu00562 Inositol phosphate metabolism
mmu01100 Metabolic pathways

REACTOME Pathway Links

REACTOME Pathway ID Description
5894026 Inositol phosphate metabolism
5894027 Synthesis of IP2, IP, and Ins in the cytosol

Domain Information

InterPro Annotations

Accession Description
IPR002587 Myo-inositol-1-phosphate synthase
IPR013021 Myo-inositol-1-phosphate synthase, GAPDH-like
IPR016040 NAD(P)-binding domain

UniProt Annotations

Entry Information

Gene Name
myo-inositol 1-phosphate synthase A1
Protein Entry
INO1_MOUSE
UniProt ID
Q9JHU9
Species
Mouse

Comments

Comment Type Description
Catalytic Activity D-glucose 6-phosphate = 1D-myo-inositol 3- phosphate.
Cofactor Name=NAD(+); Xref=ChEBI:CHEBI:57540; Evidence={ECO:0000250};
Function Key enzyme in myo-inositol biosynthesis pathway that catalyzes the conversion of glucose 6-phosphate to 1-myo-inositol 1-phosphate in a NAD-dependent manner. Rate-limiting enzyme in the synthesis of all inositol-containing compounds (By similarity). {ECO:0000250}.
Pathway Polyol metabolism; myo-inositol biosynthesis; myo- inositol from D-glucose 6-phosphate: step 1/2.
Similarity Belongs to the myo-inositol 1-phosphate synthase family. {ECO:0000305}.
Subcellular Location Cytoplasm {ECO:0000250}.
Tissue Specificity In testis, it is expressed in Sertoli cells. Highly expressed in 2 types of germ cells, pachytene spermatocytes and round spermatids. {ECO:0000269|PubMed:14613899}.

Identical and Related Proteins

Unique RefSeq proteins for LMP000202 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
12963757 RefSeq NP_076116 557 inositol-3-phosphate synthase 1

Identical Sequences to LMP000202 proteins

Reference Database Accession Length Protein Name
GI:12963757 DBBJ BAB23756.1 557 unnamed protein product [Mus musculus]
GI:12963757 DBBJ BAC37607.1 557 unnamed protein product [Mus musculus]
GI:12963757 GenBank AAF90201.1 557 myo-inositol 1-phosphate synthase A1 [Mus musculus]
GI:12963757 GenBank AAH03458.1 557 Myo-inositol 1-phosphate synthase A1 [Mus musculus]
GI:12963757 GenBank EDL28844.1 557 myo-inositol 1-phosphate synthase A1 [Mus musculus]
GI:12963757 SwissProt Q9JHU9.1 557 RecName: Full=Inositol-3-phosphate synthase 1; Short=IPS 1; AltName: Full=Myo-inositol 1-phosphate synthase; Short=MI-1-P synthase; Short=MIP synthase [Mus musculus]

Related Sequences to LMP000202 proteins

Reference Database Accession Length Protein Name
GI:12963757 GenBank EDL90710.1 557 similar to myo-inositol 1-phosphate synthase A1 [Rattus norvegicus]
GI:12963757 RefSeq NP_001013902.2 557 inositol-3-phosphate synthase 1 [Rattus norvegicus]
GI:12963757 RefSeq XP_005086181.1 558 PREDICTED: inositol-3-phosphate synthase 1 [Mesocricetus auratus]
GI:12963757 RefSeq XP_005370626.1 558 PREDICTED: inositol-3-phosphate synthase 1 [Microtus ochrogaster]
GI:12963757 RefSeq XP_006989215.1 558 PREDICTED: inositol-3-phosphate synthase 1 [Peromyscus maniculatus bairdii]
GI:12963757 SwissProt Q6AYK3.2 557 RecName: Full=Inositol-3-phosphate synthase 1; Short=IPS 1; AltName: Full=Myo-inositol 1-phosphate synthase; Short=MI-1-P synthase; Short=MIP synthase [Rattus norvegicus]