Gene/Proteome Database (LMPD)

LMPD ID
LMP000210
Gene ID
253782
Species
Homo sapiens (Human)
Gene Name
ceramide synthase 6
Gene Symbol
CERS6
Synonyms
CERS5; LASS6
Alternate Names
ceramide synthase 6; longevity assurance homolog 6; LAG1 homolog, ceramide synthase 6
Chromosome
2
Map Location
2q24.3

Proteins

ceramide synthase 6 isoform 1
Refseq ID NP_001243055
Protein GI 371122599
UniProt ID Q6ZMG9
mRNA ID NM_001256126
Length 392
RefSeq Status VALIDATED
MAGILAWFWNERFWLPHNVTWADLKNTEEATFPQAEDLYLAFPLAFCIFMVRLIFERFVAKPCAIALNIQANGPQIAPPNAILEKVFTAITKHPDEKRLEGLSKQLDWDVRSIQRWFRQRRNQEKPSTLTRFCESMWRFSFYLYVFTYGVRFLKKTPWLWNTRHCWYNYPYQPLTTDLHYYYILELSFYWSLMFSQFTDIKRKDFGIMFLHHLVSIFLITFSYVNNMARVGTLVLCLHDSADALLEAAKMANYAKFQKMCDLLFVMFAVVFITTRLGIFPLWVLNTTLFESWEIVGPYPSWWVFNLLLLLVQGLNCFWSYLIVKIACKAVSRGKAGKWNPLHVSKDDRSDIESSSDEEDSEPPGKNPHTATTTNGTSGTNGYLLTGSCSMDD
ceramide synthase 6 isoform 2
Refseq ID NP_982288
Protein GI 45007002
UniProt ID Q6ZMG9
mRNA ID NM_203463
Length 384
RefSeq Status VALIDATED
MAGILAWFWNERFWLPHNVTWADLKNTEEATFPQAEDLYLAFPLAFCIFMVRLIFERFVAKPCAIALNIQANGPQIAPPNAILEKVFTAITKHPDEKRLEGLSKQLDWDVRSIQRWFRQRRNQEKPSTLTRFCESMWRFSFYLYVFTYGVRFLKKTPWLWNTRHCWYNYPYQPLTTDLHYYYILELSFYWSLMFSQFTDIKRKDFGIMFLHHLVSIFLITFSYVNNMARVGTLVLCLHDSADALLEAAKMANYAKFQKMCDLLFVMFAVVFITTRLGIFPLWVLNTTLFESWEIVGPYPSWWVFNLLLLLVQGLNCFWSYLIVKIACKAVSRGKVSKDDRSDIESSSDEEDSEPPGKNPHTATTTNGTSGTNGYLLTGSCSMDD

Gene Information

Entrez Gene ID
253782
Gene Name
ceramide synthase 6
Gene Symbol
CERS6
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005789 TAS:Reactome C endoplasmic reticulum membrane
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0016020 IDA:UniProtKB C membrane
GO:0005634 IEA:UniProtKB-KW C nucleus
GO:0003677 IEA:UniProtKB-KW F DNA binding
GO:0050291 IEA:Ensembl F sphingosine N-acyltransferase activity
GO:0046513 IEA:Ensembl P ceramide biosynthetic process
GO:0044281 TAS:Reactome P small molecule metabolic process
GO:0030148 TAS:Reactome P sphingolipid biosynthetic process
GO:0006665 TAS:Reactome P sphingolipid metabolic process

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_115810 Sphingolipid de novo biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR001356 Homeobox domain
IPR009057 Homeodomain-like
IPR016439 Longevity assurance, LAG1/LAC1
IPR006634 TRAM/LAG1/CLN8 homology domain

UniProt Annotations

Entry Information

Gene Name
ceramide synthase 6
Protein Entry
CERS6_HUMAN
UniProt ID
Q6ZMG9
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6ZMG9-1; Sequence=Displayed; Name=2; IsoId=Q6ZMG9-2; Sequence=VSP_045162;
Function May be involved in sphingolipid synthesis or its regulation.
Ptm Glycosylation on Asn-18 is not necessary for function.
Sequence Caution Sequence=AAH30800.2; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence= ;
Similarity Contains 1 TLC (TRAM/LAG1/CLN8) domain.
Similarity Contains 1 homeobox DNA-binding domain.
Subcellular Location Nucleus membrane {ECO

Identical and Related Proteins

Unique RefSeq proteins for LMP000210 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
371122599 RefSeq NP_001243055 392 ceramide synthase 6 isoform 1
45007002 RefSeq NP_982288 384 ceramide synthase 6 isoform 2

Identical Sequences to LMP000210 proteins

Reference Database Accession Length Protein Name
GI:371122599 DBBJ BAI46117.1 392 LAG1 homolog, ceramide synthase 6, partial [synthetic construct]
GI:45007002 EMBL CCF77042.1 384 unnamed protein product [Homo sapiens]
GI:371122599 GenBank AAI09286.1 392 LASS6 protein [Homo sapiens]
GI:371122599 GenBank AAI09285.1 392 LASS6 protein [Homo sapiens]
GI:45007002 GenBank JAA10078.1 384 LAG1 homolog, ceramide synthase 6 [Pan troglodytes]
GI:45007002 GenBank JAA18946.1 384 LAG1 homolog, ceramide synthase 6 [Pan troglodytes]
GI:45007002 GenBank JAA38407.1 384 LAG1 homolog, ceramide synthase 6 [Pan troglodytes]
GI:45007002 GenBank AHD75787.1 384 Sequence 18170 from patent US 8586006
GI:371122599 GenBank AIC61580.1 392 CERS6, partial [synthetic construct]
GI:371122599 RefSeq XP_001154789.1 392 PREDICTED: ceramide synthase 6 [Pan troglodytes]
GI:45007002 RefSeq XP_003824357.1 384 PREDICTED: ceramide synthase 6 isoform X2 [Pan paniscus]
GI:371122599 RefSeq XP_003824358.1 392 PREDICTED: ceramide synthase 6 isoform X1 [Pan paniscus]

Related Sequences to LMP000210 proteins

Reference Database Accession Length Protein Name
GI:371122599 GenBank EHH54919.1 392 hypothetical protein EGM_04026 [Macaca fascicularis]
GI:45007002 GenBank AFH31830.1 384 LAG1 longevity assurance homolog 6 [Macaca mulatta]
GI:45007002 GenBank JAB22343.1 384 ceramide synthase 6 isoform 2 [Callithrix jacchus]
GI:371122599 GenBank JAB22344.1 392 ceramide synthase 6 isoform 1 [Callithrix jacchus]
GI:371122599 GenBank JAB32422.1 392 ceramide synthase 6 isoform 1 [Callithrix jacchus]
GI:45007002 RefSeq XP_003254264.1 384 PREDICTED: ceramide synthase 6 isoform 1 [Nomascus leucogenys]
GI:45007002 RefSeq NP_001253052.1 384 ceramide synthase 6 [Macaca mulatta]
GI:371122599 RefSeq XP_004092010.1 392 PREDICTED: ceramide synthase 6 isoform 2 [Nomascus leucogenys]
GI:371122599 RefSeq XP_005573443.1 392 PREDICTED: ceramide synthase 6 isoform X1 [Macaca fascicularis]
GI:45007002 RefSeq XP_005573444.1 384 PREDICTED: ceramide synthase 6 isoform X2 [Macaca fascicularis]
GI:371122599 RefSeq XP_007963450.1 392 PREDICTED: ceramide synthase 6 isoform X1 [Chlorocebus sabaeus]
GI:45007002 RefSeq XP_007963451.1 384 PREDICTED: ceramide synthase 6 isoform X2 [Chlorocebus sabaeus]