Gene/Proteome Database (LMPD)

LMPD ID
LMP000219
Gene ID
19411
Species
Mus musculus (Mouse)
Gene Name
retinoic acid receptor, gamma
Gene Symbol
Rarg
Synonyms
Nr1b3; RAR-gamma; RARD; RARgamma2
Alternate Names
retinoic acid receptor gamma; RAR gamma 2; nuclear receptor subfamily 1 group B member 3
Chromosome
15
Map Location
15 E-F3|15 57.4 cM

Proteins

retinoic acid receptor gamma isoform 1
Refseq ID NP_035374
Protein GI 112181202
UniProt ID P18911
mRNA ID NM_011244
Length 458
RefSeq Status VALIDATED
MATNKERLFAPGALGPGSGYPGAGFPFAFPGALRGSPPFEMLSPSFRGLGQPDLPKEMASLSVETQSTSSEEMVPSSPSPPPPPRVYKPCFVCNDKSSGYHYGVSSCEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKEAVRNDRNKKKKEVKEEGSPDSYELSPQLEELITKVSKAHQETFPSLCQLGKYTTNSSADHRVQLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLSIADQITLLKAACLDILMLRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFAGQLLPLEMDDTETGLLSAICLICGDRMDLEEPEKVDKLQEPLLEALRLYARRRRPSQPYMFPRMLMKITDLRGISTKGAERAITLKMEIPGPMPPLIREMLENPEMFEDDSSKPGPHPKASSEDEAPGGQGKRGQSPQPDQGP
retinoic acid receptor gamma isoform 2
Refseq ID NP_001036192
Protein GI 112181196
UniProt ID P18911
mRNA ID NM_001042727
Length 447
RefSeq Status VALIDATED
MYDCMESFVPGPRRLYGAAGPGAGLLRRATGSSCFAGLESFAWAQPASLQSVETQSTSSEEMVPSSPSPPPPPRVYKPCFVCNDKSSGYHYGVSSCEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKEAVRNDRNKKKKEVKEEGSPDSYELSPQLEELITKVSKAHQETFPSLCQLGKYTTNSSADHRVQLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLSIADQITLLKAACLDILMLRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFAGQLLPLEMDDTETGLLSAICLICGDRMDLEEPEKVDKLQEPLLEALRLYARRRRPSQPYMFPRMLMKITDLRGISTKGAERAITLKMEIPGPMPPLIREMLENPEMFEDDSSKPGPHPKASSEDEAPGGQGKRGQSPQPDQGP

Gene Information

Entrez Gene ID
19411
Gene Name
retinoic acid receptor, gamma
Gene Symbol
Rarg
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005634 IDA:MGI C nucleus
GO:0005667 IDA:BHF-UCL C transcription factor complex
GO:0003677 IC:BHF-UCL F DNA binding
GO:0000977 IDA:MGI F RNA polymerase II regulatory region sequence-specific DNA binding
GO:0003708 IEA:Ensembl F retinoic acid receptor activity
GO:0046965 IMP:BHF-UCL F retinoid X receptor binding
GO:0003700 IDA:BHF-UCL F sequence-specific DNA binding transcription factor activity
GO:0003707 IEA:InterPro F steroid hormone receptor activity
GO:0008270 IEA:InterPro F zinc ion binding
GO:0070384 IMP:MGI P Harderian gland development
GO:0009952 IMP:MGI P anterior/posterior pattern specification
GO:0060348 IMP:UniProtKB P bone development
GO:0060349 IMP:MGI P bone morphogenesis
GO:0043010 IGI:MGI P camera-type eye development
GO:0071300 IDA:MGI P cellular response to retinoic acid
GO:0002063 IMP:UniProtKB P chondrocyte development
GO:0031076 IGI:MGI P embryonic camera-type eye development
GO:0048048 IGI:MGI P embryonic eye morphogenesis
GO:0035116 IGI:MGI P embryonic hindlimb morphogenesis
GO:0060429 IMP:MGI P epithelium development
GO:0060324 IGI:MGI P face development
GO:0048732 IMP:MGI P gland development
GO:0002068 IGI:MGI P glandular epithelial cell development
GO:0003430 IMP:UniProtKB P growth plate cartilage chondrocyte growth
GO:0003417 IGI:MGI P growth plate cartilage development
GO:0060173 IMP:UniProtKB P limb development
GO:0035264 IGI:MGI P multicellular organism growth
GO:0043066 IGI:MGI P negative regulation of apoptotic process
GO:0061037 IMP:MGI P negative regulation of cartilage development
GO:0045596 IMP:MGI P negative regulation of cell differentiation
GO:0008285 IGI:MGI P negative regulation of cell proliferation
GO:0032331 IMP:MGI P negative regulation of chondrocyte differentiation
GO:0000122 IDA:MGI P negative regulation of transcription from RNA polymerase II promoter
GO:0001843 IGI:MGI P neural tube closure
GO:0043065 IGI:MGI P positive regulation of apoptotic process
GO:0008284 IGI:MGI P positive regulation of cell proliferation
GO:0010628 IDA:MGI P positive regulation of gene expression
GO:0043068 IGI:MGI P positive regulation of programmed cell death
GO:0045944 IC:BHF-UCL P positive regulation of transcription from RNA polymerase II promoter
GO:0060740 IMP:MGI P prostate gland epithelium morphogenesis
GO:0010468 IGI:MGI P regulation of gene expression
GO:0031641 IEA:Ensembl P regulation of myelination
GO:0048608 IMP:MGI P reproductive structure development
GO:0060041 IGI:MGI P retina development in camera-type eye
GO:0003406 IGI:MGI P retinal pigment epithelium development
GO:0048384 IMP:MGI P retinoic acid receptor signaling pathway
GO:0060534 IMP:MGI P trachea cartilage development

REACTOME Pathway Links

REACTOME Pathway ID Description
5893658 Nuclear Receptor transcription pathway

Domain Information

InterPro Annotations

Accession Description
IPR008946 Nuclear hormone receptor, ligand-binding
IPR000536 Nuclear hormone receptor, ligand-binding, core
IPR003078 Retinoic acid receptor
IPR001723 Steroid hormone receptor
IPR013088 Zinc finger, NHR/GATA-type
IPR001628 Zinc finger, nuclear hormone receptor-type

UniProt Annotations

Entry Information

Gene Name
retinoic acid receptor, gamma
Protein Entry
RARG_MOUSE
UniProt ID
P18911
Species
Mouse

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=A; IsoId=P18911-1; Sequence=Displayed; Name=2; Synonyms=B; IsoId=P18911-2, P20787-1; Sequence=VSP_031082; Name=3; IsoId=P18911-3; Sequence=VSP_031081;
Developmental Stage In E9.5-E12.5 embryos, expression throughout limb bud mesenchyme. This expression overlaps with that of CYP26B1. Also strongly expressed in the caudal and craniofacial regions. {ECO:0000269|PubMed:20043900}.
Disruption Phenotype Rarg and Rarb double null mice exhibit growth retardation 3 weeks after birth. Defects are found in the growth plates with deficiency in cartilage. Growth retardation was noticable in limb sketal elements such as femurs. Early lethality and male sterility due to squamous metaplasia of the seminal vesicles and prostate are also observed. Isoform 2 mutants appear normal. The Rarg and Cyp26b1 double null mutation is able to partially rescue limb skeletal morphology without restoring normal expression of proximo-distal patterning genes. {ECO:0000269|PubMed:19389355, ECO:0000269|PubMed:20043900, ECO:0000269|PubMed:8388780}.
Domain Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
Function Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, acts mainly as an activator of gene expression due to weak binding to corepressors (By similarity). Required for limb bud development. In concert with RARA or RARB, required for skeletal growth, matrix homeostasis and growth plate function. {ECO:0000250, ECO:0000269|PubMed:19389355, ECO:0000269|PubMed:8388780}.
Similarity Belongs to the nuclear hormone receptor family. NR1 subfamily. {ECO:0000305}.
Similarity Contains 1 nuclear receptor DNA-binding domain. {ECO:0000255|PROSITE-ProRule:PRU00407}.
Subcellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00407, ECO:0000269|PubMed:15327771}.
Subunit Homodimer (By similarity). Heterodimer with a RXR molecule (By similarity). Binds DNA preferentially as a RAR/RXR heterodimer (By similarity). Forms a complex with PUS1 and the SRA1 RNA in the nucleus. {ECO:0000250, ECO:0000269|PubMed:15327771}.

Identical and Related Proteins

Unique RefSeq proteins for LMP000219 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
112181202 RefSeq NP_035374 458 retinoic acid receptor gamma isoform 1
112181196 RefSeq NP_001036192 447 retinoic acid receptor gamma isoform 2

Identical Sequences to LMP000219 proteins

Reference Database Accession Length Protein Name
GI:112181202 EMBL CAA33845.1 458 Retinoic acid receptor gamma [Mus musculus]
GI:112181202 GenBank AAH12923.1 458 Retinoic acid receptor, gamma [Mus musculus]
GI:112181202 GenBank EDL03996.1 458 retinoic acid receptor, gamma [Mus musculus]
GI:112181202 RefSeq XP_006520712.1 458 PREDICTED: retinoic acid receptor gamma isoform X1 [Mus musculus]
GI:112181202 RefSeq XP_006520713.1 458 PREDICTED: retinoic acid receptor gamma isoform X2 [Mus musculus]
GI:112181202 SwissProt P18911.3 458 RecName: Full=Retinoic acid receptor gamma; Short=RAR-gamma; AltName: Full=Nuclear receptor subfamily 1 group B member 3 [Mus musculus]

Related Sequences to LMP000219 proteins

Reference Database Accession Length Protein Name
GI:112181202 DBBJ BAE28323.1 458 unnamed protein product [Mus musculus]
GI:112181202 GenBank AAA40035.1 458 retinoic acid receptor gamma [Mus musculus]
GI:112181196 GenBank AAA40036.1 447 retinoic acid receptor gamma [Mus musculus]
GI:112181202 GenBank AAH13709.1 458 Retinoic acid receptor, gamma [Mus musculus]
GI:112181202 GenBank EDL86852.1 458 rCG50849 [Rattus norvegicus]
GI:112181196 GenBank ERE83635.1 447 retinoic acid receptor gamma isoform 2 [Cricetulus griseus]
GI:112181202 PRF - 458 retinoic acid receptor gamma [Mus musculus]
GI:112181196 RefSeq XP_003507258.1 485 PREDICTED: retinoic acid receptor gamma isoform X1 [Cricetulus griseus]
GI:112181196 RefSeq XP_007614454.1 447 PREDICTED: retinoic acid receptor gamma isoform X4 [Cricetulus griseus]
GI:112181196 RefSeq XP_007614455.1 447 PREDICTED: retinoic acid receptor gamma isoform X5 [Cricetulus griseus]
GI:112181196 RefSeq XP_008764006.1 471 PREDICTED: retinoic acid receptor gamma isoform X2 [Rattus norvegicus]
GI:112181202 RefSeq XP_008764007.1 458 PREDICTED: retinoic acid receptor gamma isoform X1 [Rattus norvegicus]