Gene/Proteome Database (LMPD)

LMPD ID
LMP000221
Gene ID
311
Species
Homo sapiens (Human)
Gene Name
annexin A11
Gene Symbol
ANXA11
Synonyms
ANX11; CAP50
Alternate Names
annexin A11; CAP-50; annexin XI; annexin-11; 56 kDa autoantigen; autoantigen, 56-kD; calcyclin-associated annexin 50
Chromosome
10
Map Location
10q23
Summary
This gene encodes a member of the annexin family, a group of calcium-dependent phospholipid-binding proteins. Annexins have unique N-terminal domains and conserved C-terminal domains, which contain the calcium-dependent phospholipid-binding sites. The encoded protein is a 56-kD antigen recognized by sera from patients with various autoimmune diseases. Several transcript variants encoding two different isoforms have been identified. [provided by RefSeq, May 2013]
Orthologs
View orthologs and multiple alignments for ANXA11

Proteins

annexin A11 isoform 1
Refseq ID NP_665875
Protein GI 22165431
UniProt ID P50995
mRNA ID NM_145868
Length 505
RefSeq Status REVIEWED
MSYPGYPPPPGGYPPAAPGGGPWGGAAYPPPPSMPPIGLDNVATYAGQFNQDYLSGMAANMSGTFGGANMPNLYPGAPGAGYPPVPPGGFGQPPSAQQPVPPYGMYPPPGGNPPSRMPSYPPYPGAPVPGQPMPPPGQQPPGAYPGQPPVTYPGQPPVPLPGQQQPVPSYPGYPGSGTVTPAVPPTQFGSRGTITDAPGFDPLRDAEVLRKAMKGFGTDEQAIIDCLGSRSNKQRQQILLSFKTAYGKDLIKDLKSELSGNFEKTILALMKTPVLFDIYEIKEAIKGVGTDEACLIEILASRSNEHIRELNRAYKAEFKKTLEEAIRSDTSGHFQRLLISLSQGNRDESTNVDMSLAQRDAQELYAAGENRLGTDESKFNAVLCSRSRAHLVAVFNEYQRMTGRDIEKSICREMSGDLEEGMLAVVKCLKNTPAFFAERLNKAMRGAGTKDRTLIRIMVSRSETDLLDIRSEYKRMYGKSLYHDISGDTSGDYRKILLKICGGND
annexin A11 isoform 1
Refseq ID NP_001265337
Protein GI 508772597
UniProt ID P50995
mRNA ID NM_001278408
Length 505
RefSeq Status REVIEWED
Protein sequence is identical to GI:22165431 (mRNA isoform)
annexin A11 isoform 1
Refseq ID NP_001148
Protein GI 4557317
UniProt ID P50995
mRNA ID NM_001157
Length 505
RefSeq Status REVIEWED
Protein sequence is identical to GI:22165431 (mRNA isoform)
annexin A11 isoform 1
Refseq ID NP_001265336
Protein GI 508772595
UniProt ID P50995
mRNA ID NM_001278407
Length 505
RefSeq Status REVIEWED
Protein sequence is identical to GI:22165431 (mRNA isoform)
annexin A11 isoform 1
Refseq ID NP_665876
Protein GI 22165433
UniProt ID P50995
mRNA ID NM_145869
Length 505
RefSeq Status REVIEWED
Protein sequence is identical to GI:22165431 (mRNA isoform)
annexin A11 isoform 2
Refseq ID NP_001265338
Protein GI 508772599
UniProt ID P50995
mRNA ID NM_001278409
Length 472
RefSeq Status REVIEWED
MPPIGLDNVATYAGQFNQDYLSGMAANMSGTFGGANMPNLYPGAPGAGYPPVPPGGFGQPPSAQQPVPPYGMYPPPGGNPPSRMPSYPPYPGAPVPGQPMPPPGQQPPGAYPGQPPVTYPGQPPVPLPGQQQPVPSYPGYPGSGTVTPAVPPTQFGSRGTITDAPGFDPLRDAEVLRKAMKGFGTDEQAIIDCLGSRSNKQRQQILLSFKTAYGKDLIKDLKSELSGNFEKTILALMKTPVLFDIYEIKEAIKGVGTDEACLIEILASRSNEHIRELNRAYKAEFKKTLEEAIRSDTSGHFQRLLISLSQGNRDESTNVDMSLAQRDAQELYAAGENRLGTDESKFNAVLCSRSRAHLVAVFNEYQRMTGRDIEKSICREMSGDLEEGMLAVVKCLKNTPAFFAERLNKAMRGAGTKDRTLIRIMVSRSETDLLDIRSEYKRMYGKSLYHDISGDTSGDYRKILLKICGGND

Gene Information

Entrez Gene ID
311
Gene Name
annexin A11
Gene Symbol
ANXA11
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0042582 IDA:UniProtKB C azurophil granule
GO:0005737 IDA:UniProtKB C cytoplasm
GO:0070062 IDA:UniProtKB C extracellular vesicular exosome
GO:0016020 IDA:UniProtKB C membrane
GO:0030496 IDA:UniProtKB C midbody
GO:0005635 IDA:UniProtKB C nuclear envelope
GO:0005654 IDA:UniProtKB C nucleoplasm
GO:0005634 IDA:HPA C nucleus
GO:0045335 IDA:UniProtKB C phagocytic vesicle
GO:0042581 IDA:UniProtKB C specific granule
GO:0005819 IDA:UniProtKB C spindle
GO:0023026 IDA:UniProt F MHC class II protein complex binding
GO:0044548 IPI:UniProtKB F S100 protein binding
GO:0005509 IEA:Ensembl F calcium ion binding
GO:0005544 IEA:UniProtKB-KW F calcium-dependent phospholipid binding
GO:0048306 IPI:UniProtKB F calcium-dependent protein binding
GO:0008429 IEA:Ensembl F phosphatidylethanolamine binding
GO:0044822 IDA:UniProtKB F poly(A) RNA binding
GO:0007109 IMP:UniProtKB P cytokinesis, completion of separation
GO:0006909 IEP:UniProtKB P phagocytosis
GO:0051592 IDA:UniProtKB P response to calcium ion

Domain Information

InterPro Annotations

Accession Description
IPR001464 Annexin
IPR018252 Annexin repeat, conserved site
IPR008157 Annexin, type XI
IPR018502 Annexin_repeat

UniProt Annotations

Entry Information

Gene Name
annexin A11
Protein Entry
ANX11_HUMAN
UniProt ID
P50995
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P50995-1; Sequence=Displayed; Name=2; IsoId=P50995-2; Sequence=VSP_054553; Note=No experimental confirmation available.;
Domain A pair of annexin repeats may form one binding site for calcium and phospholipid.
Function Binds specifically to calcyclin in a calcium-dependent manner (By similarity). Required for midbody formation and completion of the terminal phase of cytokinesis. {ECO
Similarity Belongs to the annexin family.
Similarity Contains 4 annexin repeats.
Subcellular Location Cytoplasm. Melanosome. Nucleus envelope. Nucleus, nucleoplasm. Cytoplasm, cytoskeleton, spindle. Note=Found throughout the nucleoplasm at interphase and during mitosis concentrates around the mitotic apparatus (By similarity). Elevation of intracellular calcium causes relocalization from the nucleoplasm to the nuclear envelope, with little effect on the cytoplasmic pool. Localization to the nuclear envelope is cell- cycle dependent.
Subunit Interacts with S100A6 (By similarity). Interacts with PDCD6 in a calcium-dependent manner. Interacts with KIF23 during cytokinesis. {ECO

Identical and Related Proteins

Unique RefSeq proteins for LMP000221 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
22165431 RefSeq NP_665875 505 annexin A11 isoform 1
508772599 RefSeq NP_001265338 472 annexin A11 isoform 2

Identical Sequences to LMP000221 proteins

Reference Database Accession Length Protein Name
GI:508772599 DBBJ BAG62659.1 472 unnamed protein product [Homo sapiens]
GI:22165431 GenBank JAA21950.1 505 annexin A11 [Pan troglodytes]
GI:22165431 GenBank AFX11683.1 505 Sequence 15 from patent US 8293522
GI:22165431 GenBank AIC48270.1 505 ANXA11, partial [synthetic construct]
GI:22165431 RefSeq NP_001265336.1 505 annexin A11 isoform 1 [Homo sapiens]
GI:22165431 RefSeq NP_001265337.1 505 annexin A11 isoform 1 [Homo sapiens]
GI:22165431 RefSeq XP_009457060.1 505 PREDICTED: annexin A11 [Pan troglodytes]

Related Sequences to LMP000221 proteins

Reference Database Accession Length Protein Name
GI:22165431 GenBank AAX41290.1 505 annexin A11 [synthetic construct]
GI:22165431 GenBank ACM82123.1 557 Sequence 7621 from patent US 6812339
GI:508772599 GenBank ADA20858.1 505 Sequence 2682 from patent US 7608413
GI:508772599 GenBank ADA20859.1 505 Sequence 2683 from patent US 7608413
GI:508772599 GenBank ADA20860.1 505 Sequence 2684 from patent US 7608413
GI:508772599 GenBank ADA20861.1 505 Sequence 2685 from patent US 7608413
GI:508772599 GenBank ADA20862.1 505 Sequence 2686 from patent US 7608413
GI:508772599 GenBank ADA20863.1 505 Sequence 2687 from patent US 7608413
GI:22165431 GenBank ADT50377.1 1075 Sequence 2394 from patent US 7842467
GI:22165431 GenBank ADT50378.1 837 Sequence 2395 from patent US 7842467
GI:22165431 GenBank ADT50379.1 853 Sequence 2396 from patent US 7842467
GI:22165431 GenBank ADT50384.1 1049 Sequence 2401 from patent US 7842467