Gene/Proteome Database (LMPD)

LMPD ID
LMP000239
Gene ID
26922
Species
Mus musculus (Mouse)
Gene Name
mitochondrial trans-2-enoyl-CoA reductase
Gene Symbol
Mecr
Synonyms
AI195831; Nrbf1
Alternate Names
trans-2-enoyl-CoA reductase, mitochondrial; nuclear receptor binding factor 1
Chromosome
4
Map Location
4 D2.3|4
EC Number
1.3.1.38

Proteins

trans-2-enoyl-CoA reductase, mitochondrial precursor
Refseq ID NP_079573
Protein GI 227116358
UniProt ID Q9DCS3
mRNA ID NM_025297
Length 373
RefSeq Status VALIDATED
MLVSQRVTGARARAPQLAGLLEAWYRHGRTTSSYSALSEPSRVRALVYGNHGDPAKVVQLKNLELTAVEGSDVHVRMLAAPINPSDINMIQGNYGLLPKLPAVGGNEGVGQVIAVGSSVSALKPGDWVIPANAGLGTWRTEAVFSEEALIGIPKDIPLQSAATLGVNPCTAYRMLVDFEQLQPGDSVIQNASNSGVGQAVIQIASALRLKTINVVRDRPDIKKLTDRLKDLGADYVLTEEELRMPETKTIFKDLPLPRLALNCVGGKSSTELLRHLAPGGTMVTYGGMAKQPVTASVSLLIFKDLKLRGFWLSQWKKNHSPDEFKELILTLCNLIRQGRLTAPSCSEVPLQGYQQALEASMKPFVSSKQILTM
transit_peptide: 1..53 inference: non-experimental evidence, no additional details recorded note: Mitochondrion (Potential); propagated from UniProtKB/Swiss-Prot (Q9DCS3.2) calculated_mol_wt: 5815 peptide sequence: MLVSQRVTGARARAPQLAGLLEAWYRHGRTTSSYSALSEPSRVRALVYGNHGD mat_peptide: 54..373 product: Trans-2-enoyl-CoA reductase, mitochondrial experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q9DCS3.2) calculated_mol_wt: 34546 peptide sequence: PAKVVQLKNLELTAVEGSDVHVRMLAAPINPSDINMIQGNYGLLPKLPAVGGNEGVGQVIAVGSSVSALKPGDWVIPANAGLGTWRTEAVFSEEALIGIPKDIPLQSAATLGVNPCTAYRMLVDFEQLQPGDSVIQNASNSGVGQAVIQIASALRLKTINVVRDRPDIKKLTDRLKDLGADYVLTEEELRMPETKTIFKDLPLPRLALNCVGGKSSTELLRHLAPGGTMVTYGGMAKQPVTASVSLLIFKDLKLRGFWLSQWKKNHSPDEFKELILTLCNLIRQGRLTAPSCSEVPLQGYQQALEASMKPFVSSKQILTM

Gene Information

Entrez Gene ID
26922
Gene Name
mitochondrial trans-2-enoyl-CoA reductase
Gene Symbol
Mecr
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005829 ISO:MGI C cytosol
GO:0005739 IDA:MGI C mitochondrion
GO:0005634 ISO:MGI C nucleus
GO:0016922 ISO:MGI F ligand-dependent nuclear receptor binding
GO:0019166 IEA:UniProtKB-EC F trans-2-enoyl-CoA reductase (NADPH) activity
GO:0008270 IEA:InterPro F zinc ion binding
GO:0006633 IEA:UniProtKB-KW P fatty acid biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
mmu00062 Fatty acid elongation
mmu01212 Fatty acid metabolism

Domain Information

InterPro Annotations

Accession Description
IPR013149 Alcohol dehydrogenase, C-terminal
IPR013154 Alcohol dehydrogenase GroES-like
IPR002085 Alcohol dehydrogenase superfamily, zinc-type
IPR011032 GroES (chaperonin 10)-like
IPR016040 NAD(P)-binding domain

UniProt Annotations

Entry Information

Gene Name
mitochondrial trans-2-enoyl-CoA reductase
Protein Entry
MECR_MOUSE
UniProt ID
Q9DCS3
Species
Mouse

Comments

Comment Type Description
Catalytic Activity Acyl-CoA + NADP(+) = trans-2,3-dehydroacyl-CoA + NADPH.
Function Oxidoreductase with a preference for short and medium chain substrates, including trans-2-hexenoyl-CoA (C6), trans-2- decenoyl-CoA (C10), and trans-2-hexadecenoyl-CoA (C16). May play a role in mitochondrial fatty acid synthesis (By similarity). {ECO:0000250}.
Similarity Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily. {ECO:0000305}.
Subcellular Location Mitochondrion {ECO:0000250}.
Subunit Homodimer. {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP000239 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
227116358 RefSeq NP_079573 373 trans-2-enoyl-CoA reductase, mitochondrial precursor

Identical Sequences to LMP000239 proteins

Reference Database Accession Length Protein Name
GI:227116358 GenBank AAH03864.1 373 Mitochondrial trans-2-enoyl-CoA reductase [Mus musculus]
GI:227116358 GenBank EDL30126.1 373 mitochondrial trans-2-enoyl-CoA reductase [Mus musculus]
GI:227116358 SwissProt Q9DCS3.2 373 RecName: Full=Trans-2-enoyl-CoA reductase, mitochondrial; Flags: Precursor [Mus musculus]

Related Sequences to LMP000239 proteins

Reference Database Accession Length Protein Name
GI:227116358 DBBJ BAA34804.1 373 nuclear receptor binding factor-1 [Rattus norvegicus]
GI:227116358 DBBJ BAB22169.1 373 unnamed protein product [Mus musculus]
GI:227116358 GenBank EDL80610.1 373 mitochondrial trans-2-enoyl-CoA reductase, isoform CRA_b [Rattus norvegicus]
GI:227116358 RefSeq NP_058905.1 373 trans-2-enoyl-CoA reductase, mitochondrial precursor [Rattus norvegicus]
GI:227116358 RefSeq XP_006538948.1 407 PREDICTED: trans-2-enoyl-CoA reductase, mitochondrial isoform X1 [Mus musculus]
GI:227116358 SwissProt Q9Z311.1 373 RecName: Full=Trans-2-enoyl-CoA reductase, mitochondrial; AltName: Full=Nuclear receptor-binding factor 1; Short=NRBF-1; Flags: Precursor [Rattus norvegicus]