Gene/Proteome Database (LMPD)
LMPD ID
LMP000242
Gene ID
Species
Mus musculus (Mouse)
Gene Name
acyl-CoA thioesterase 5
Gene Symbol
Synonyms
BC016076; PTE-Ic
Alternate Names
acyl-coenzyme A thioesterase 5; peroxisomal acyl-CoA thioesterase Ic; peroxisomal acyl-coenzyme A thioester hydrolase Ic
Chromosome
12
Map Location
12 D1|12
EC Number
3.1.2.2
Proteins
| acyl-coenzyme A thioesterase 5 | |
|---|---|
| Refseq ID | NP_663419 |
| Protein GI | 238550185 |
| UniProt ID | Q6Q2Z6 |
| mRNA ID | NM_145444 |
| Length | 421 |
| RefSeq Status | VALIDATED |
| MVPTVSLEPTGHSCWDEPLSIAVRGLAPEQPVTLRTALRDEKGALFRAHARYRADSHGELDLARTPALGGSFSGLEPMGLLWAMEPDRPFWRLIKRDVQTPFVVELEVLDGHEPDGGRLLARAVHERHFMAPGVRRVPVREGRVRATLFLPPGTGPFPGIIDLFGVGGGLLEYRASLLAGKGFAVMALAYYKYDDLPKVIDILHLEYFEEAVTYLLSHPQVKGPGVGLLGISKGAELSLSMASFLKGITAAVVINGATVNVISTLYYKEESLPGLGMHLERIKVTKDGFKDIIDILNVPLEAPDQKSLIPLERSDTAFLFLVGQDDHNWKSEFYAREASKRLQAHGKEKPQIVCYPKTGHHIEPPYIPWSIAAPHSYFDKPILLGGEPRAHAMAQVDAWQRLQTFFHKHLSGDKRPSPAKL | |
Gene Information
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005829 | IDA:MGI | C | cytosol |
| GO:0005777 | TAS:HGNC | C | peroxisome |
| GO:0047617 | IDA:HGNC | F | acyl-CoA hydrolase activity |
| GO:0052689 | IEA:UniProtKB-KW | F | carboxylic ester hydrolase activity |
| GO:0016290 | IEA:UniProtKB-EC | F | palmitoyl-CoA hydrolase activity |
| GO:0006637 | IDA:HGNC | P | acyl-CoA metabolic process |
| GO:0001676 | IDA:HGNC | P | long-chain fatty acid metabolic process |
| GO:0032788 | IDA:HGNC | P | saturated monocarboxylic acid metabolic process |
| GO:0032789 | IDA:HGNC | P | unsaturated monocarboxylic acid metabolic process |
| GO:0000038 | IDA:HGNC | P | very long-chain fatty acid metabolic process |
KEGG Pathway Links
| KEGG Pathway ID | Description |
|---|---|
| mmu01040 | Biosynthesis of unsaturated fatty acids |
| mmu00062 | Fatty acid elongation |
| mmu01100 | Metabolic pathways |
BIOCYC Pathway Links
| BIOCYC Pathway ID | Description |
|---|---|
| PWY-5148 | acyl-CoA hydrolysis |
Domain Information
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Catalytic Activity | Palmitoyl-CoA + H(2)O = CoA + palmitate. |
| Function | Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Seems to be involved in intraperoxisomal regulation of acyl-CoA levels, but not CoASH levels. Mainly active on medium-chain acyl- CoAs. May have a function in termination of beta-oxidation of fatty acids. {ECO:0000269|PubMed:15007068}. |
| Induction | In the liver and kidney, by peroxisome proliferator, via the peroxisome proliferator-activated receptors (PPARs) and by fasting. |
| Similarity | Belongs to the C/M/P thioester hydrolase family. {ECO:0000305}. |
| Subcellular Location | Peroxisome. |
| Tissue Specificity | Highly expressed in spleen, brain, testis and proximal and distal intestine; expressed at low level in the liver. {ECO:0000269|PubMed:15007068}. |
Identical and Related Proteins
Unique RefSeq proteins for LMP000242 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 238550185 | RefSeq | NP_663419 | 421 | acyl-coenzyme A thioesterase 5 |
Identical Sequences to LMP000242 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:238550185 | GenBank | AHA90858.1 | 421 | acyl-CoA thioesterase 5 [synthetic construct] |
| GI:238550185 | SwissProt | Q6Q2Z6.2 | 421 | RecName: Full=Acyl-coenzyme A thioesterase 5; Short=Acyl-CoA thioesterase 5; AltName: Full=Peroxisomal acyl-coenzyme A thioester hydrolase Ic; Short=Peroxisomal acyl-CoA thioesterase Ic [Mus musculus] |
Related Sequences to LMP000242 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:238550185 | GenBank | AAS75455.1 | 432 | peroxisomal acyl-CoA thioesterase Ia splice variant 5':1 [Mus musculus] |
| GI:238550185 | GenBank | AAS75457.1 | 421 | peroxisomal acyl-CoA thioesterase Ic [Mus musculus] |
| GI:238550185 | GenBank | AAI28771.1 | 421 | Acyl-CoA thioesterase 5 [Rattus norvegicus] |
| GI:238550185 | RefSeq | NP_001073177.1 | 421 | acyl-coenzyme A thioesterase 5 [Rattus norvegicus] |
| GI:238550185 | RefSeq | XP_005086456.1 | 421 | PREDICTED: acyl-coenzyme A thioesterase 5-like [Mesocricetus auratus] |
| GI:238550185 | RefSeq | XP_006515756.1 | 434 | PREDICTED: acyl-coenzyme A thioesterase 5 isoform X1 [Mus musculus] |