Gene/Proteome Database (LMPD)

LMPD ID
LMP000249
Gene ID
2529
Species
Homo sapiens (Human)
Gene Name
fucosyltransferase 7 (alpha (1,3) fucosyltransferase)
Gene Symbol
FUT7
Synonyms
FucT-VII
Alternate Names
alpha-(1,3)-fucosyltransferase 7; fuc-TVII; fucosyltransferase VII; selectin ligand synthase; selectin-ligand synthase; galactoside 3-L-fucosyltransferase
Chromosome
9
Map Location
9q34.3
EC Number
2.4.1.-
Summary
The protein encoded by this gene is a Golgi stack membrane protein that is involved in the creation of sialyl-Lewis X antigens. The encoded protein can direct the synthesis of the E-selectin-binding sialyl-Lewis X moiety. [provided by RefSeq, Jul 2008]
Orthologs
View orthologs and multiple alignments for FUT7

Proteins

alpha-(1,3)-fucosyltransferase 7
Refseq ID NP_004470
Protein GI 4758406
UniProt ID Q11130
mRNA ID NM_004479
Length 342
RefSeq Status REVIEWED
MNNAGHGPTRRLRGLGVLAGVALLAALWLLWLLGSAPRGTPAPQPTITILVWHWPFTDQPPELPSDTCTRYGIARCHLSANRSLLASADAVVFHHRELQTRRSHLPLAQRPRGQPWVWASMESPSHTHGLSHLRGIFNWVLSYRRDSDIFVPYGRLEPHWGPSPPLPAKSRVAAWVVSNFQERQLRARLYRQLAPHLRVDVFGRANGRPLCASCLVPTVAQYRFYLSFENSQHRDYITEKFWRNALVAGTVPVVLGPPRATYEAFVPADAFVHVDDFGSARELAAFLTGMNESRYQRFFAWRDRLRVRLFTDWRERFCAICDRYPHLPRSQVYEDLEGWFQA

Gene Information

Entrez Gene ID
2529
Gene Name
fucosyltransferase 7 (alpha (1,3) fucosyltransferase)
Gene Symbol
FUT7
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005794 TAS:UniProtKB C Golgi apparatus
GO:0016021 TAS:ProtInc C integral component of membrane
GO:0016020 IDA:UniProtKB C membrane
GO:0046920 TAS:UniProtKB F alpha-(1->3)-fucosyltransferase activity
GO:0008417 TAS:ProtInc F fucosyltransferase activity
GO:0002361 IEA:Ensembl P CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
GO:0042355 NAS:UniProtKB P L-fucose catabolic process
GO:0036065 TAS:GOC P fucosylation
GO:0002522 IEA:Ensembl P leukocyte migration involved in immune response
GO:0006486 TAS:UniProtKB P protein glycosylation

KEGG Pathway Links

KEGG Pathway ID Description
hsa00601 Glycosphingolipid biosynthesis - lacto and neolacto series
hsa01100 Metabolic pathways
hsa00514 Other types of O-glycan biosynthesis
ko00514 Other types of O-glycan biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR001503 Glycosyl transferase, family 10

UniProt Annotations

Entry Information

Gene Name
fucosyltransferase 7 (alpha (1,3) fucosyltransferase)
Protein Entry
FUT7_HUMAN
UniProt ID
Q11130
Species
Human

Comments

Comment Type Description
Catalytic Activity GDP-L-fucose + alpha-2,3-Neu-N-acetyl-1,4- beta-D-galactosyl-N-acetyl-D-glucosaminyl-R = GDP + alpha-2,3-Neu- N-acetyl-1,4-beta-D-galactosyl-(alpha-1,3-L-fucosyl)-N-acetyl-D- glucosaminyl-R.
Function May catalyze alpha-1,3 glycosidic linkages involved in the expression of sialyl Lewis X antigens.
Pathway Protein modification; protein glycosylation.
Similarity Belongs to the glycosyltransferase 10 family.
Subcellular Location Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Membrane-bound form in trans cisternae of Golgi.
Tissue Specificity Leukocytic/myeloid lineage cells.
Web Resource Name=Functional Glycomics Gateway - GTase; Note=Fucosyltransferase 7; URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_604";
Web Resource Name=GGDB; Note=GlycoGene database; URL="http://jcggdb.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=FUT7";

Identical and Related Proteins

Unique RefSeq proteins for LMP000249 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
4758406 RefSeq NP_004470 342 alpha-(1,3)-fucosyltransferase 7

Identical Sequences to LMP000249 proteins

Reference Database Accession Length Protein Name
GI:4758406 DBBJ BAG35944.1 342 unnamed protein product [Homo sapiens]
GI:4758406 GenBank ACW32146.1 342 Sequence 4 from patent US 7569376
GI:4758406 GenBank ADL90916.1 342 Sequence 2 from patent US 7709234
GI:4758406 GenBank AFG79848.1 342 Sequence 107 from patent US 8137928
GI:4758406 GenBank AHE02343.1 342 Sequence 61148 from patent US 8586006
GI:4758406 GenBank AIC48795.1 342 FUT7, partial [synthetic construct]

Related Sequences to LMP000249 proteins

Reference Database Accession Length Protein Name
GI:4758406 GenBank AAA56869.1 341 alpha(1,3)fucosyltransferase [Homo sapiens]
GI:4758406 RefSeq XP_003279849.1 342 PREDICTED: alpha-(1,3)-fucosyltransferase [Nomascus leucogenys]
GI:4758406 RefSeq XP_003777550.1 342 PREDICTED: alpha-(1,3)-fucosyltransferase 7 [Pongo abelii]
GI:4758406 RefSeq XP_003817033.1 342 PREDICTED: alpha-(1,3)-fucosyltransferase 7 [Pan paniscus]
GI:4758406 RefSeq XP_003911094.1 342 PREDICTED: alpha-(1,3)-fucosyltransferase 7 [Papio anubis]
GI:4758406 RefSeq XP_004048961.1 342 PREDICTED: alpha-(1,3)-fucosyltransferase-like [Gorilla gorilla gorilla]