Gene/Proteome Database (LMPD)

LMPD ID
LMP000277
Gene ID
10555
Species
Homo sapiens (Human)
Gene Name
1-acylglycerol-3-phosphate O-acyltransferase 2
Gene Symbol
AGPAT2
Synonyms
1-AGPAT2; BSCL; BSCL1; LPAAB; LPAAT-beta
Alternate Names
1-acyl-sn-glycerol-3-phosphate acyltransferase beta; 1-AGPAT 2; 1-AGP acyltransferase 2; lysophosphatidic acid acyltransferase beta; lysophosphatidic acid acyltransferase-beta; 1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta)
Chromosome
9
Map Location
9q34.3
EC Number
2.3.1.51
Summary
This gene encodes a member of the 1-acylglycerol-3-phosphate O-acyltransferase family. The protein is located within the endoplasmic reticulum membrane and converts lysophosphatidic acid to phosphatidic acid, the second step in de novo phospholipid biosynthesis. Mutations in this gene have been associated with congenital generalized lipodystrophy (CGL), or Berardinelli-Seip syndrome, a disease characterized by a near absence of adipose tissue and severe insulin resistance. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Orthologs
View orthologs and multiple alignments for AGPAT2

Proteins

1-acyl-sn-glycerol-3-phosphate acyltransferase beta isoform a precursor
Refseq ID NP_006403
Protein GI 6041665
UniProt ID O15120
mRNA ID NM_006412
Length 278
RefSeq Status REVIEWED
MELWPCLAAALLLLLLLVQLSRAAEFYAKVALYCALCFTVSAVASLVCLLRHGGRTVENMSIIGWFVRSFKYFYGLRFEVRDPRRLQEARPCVIVSNHQSILDMMGLMEVLPERCVQIAKRELLFLGPVGLIMYLGGVFFINRQRSSTAMTVMADLGERMVRENLKVWIYPEGTRNDNGDLLPFKKGAFYLAVQAQVPIVPVVYSSFSSFYNTKKKFFTSGTVTVQVLEAIPTSGLTAADVPALVDTCHRAMRTTFLHISKTPQENGATAGSGVQPAQ
sig_peptide: 1..23 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2551 peptide sequence: MELWPCLAAALLLLLLLVQLSRA sig_peptide: 1..23 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2551 peptide sequence: MELWPCLAAALLLLLLLVQLSRA
1-acyl-sn-glycerol-3-phosphate acyltransferase beta isoform b precursor
Refseq ID NP_001012745
Protein GI 69122971
UniProt ID O15120
mRNA ID NM_001012727
Length 246
RefSeq Status REVIEWED
MELWPCLAAALLLLLLLVQLSRAAEFYAKVALYCALCFTVSAVASLVCLLRHGGRTVENMSIIGWFVRSFKYFYGLRFEVRDPRRLQEARPCVIVSNHQSILDMMGLMEVLPERCVQIAKRELLFLGPVGLIMYLGGVFFINRQRSSTAMTVMADLGERMVRENVPIVPVVYSSFSSFYNTKKKFFTSGTVTVQVLEAIPTSGLTAADVPALVDTCHRAMRTTFLHISKTPQENGATAGSGVQPAQ

Gene Information

Entrez Gene ID
10555
Gene Name
1-acylglycerol-3-phosphate O-acyltransferase 2
Gene Symbol
AGPAT2
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 ISS:UniProtKB C endoplasmic reticulum
GO:0005789 TAS:Reactome C endoplasmic reticulum membrane
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0003841 NAS:UniProtKB F 1-acylglycerol-3-phosphate O-acyltransferase activity
GO:0016024 IEA:UniProtKB-UniPathway P CDP-diacylglycerol biosynthetic process
GO:0044255 TAS:Reactome P cellular lipid metabolic process
GO:0008544 IEA:Ensembl P epidermis development
GO:0046474 TAS:Reactome P glycerophospholipid biosynthetic process
GO:0006654 IGI:BHF-UCL P phosphatidic acid biosynthetic process
GO:0006644 NAS:UniProtKB P phospholipid metabolic process
GO:0001819 IMP:BHF-UCL P positive regulation of cytokine production
GO:0001961 IC:BHF-UCL P positive regulation of cytokine-mediated signaling pathway
GO:0044281 TAS:Reactome P small molecule metabolic process
GO:0019432 TAS:Reactome P triglyceride biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
hsa04975 Fat digestion and absorption

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_120906 Synthesis of PA

Domain Information

InterPro Annotations

Accession Description
IPR004552 1-acyl-sn-glycerol-3-phosphate acyltransferase
IPR002123 Phospholipid/glycerol acyltransferase

UniProt Annotations

Entry Information

Gene Name
1-acylglycerol-3-phosphate O-acyltransferase 2
Protein Entry
PLCB_HUMAN
UniProt ID
O15120
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O15120-1; Sequence=Displayed; Name=2; IsoId=O15120-2; Sequence=VSP_005071; Note=No experimental confirmation available.;
Catalytic Activity Acyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate. {ECO
Disease Congenital generalized lipodystrophy 1 (CGL1) [MIM
Domain The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.
Function Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. {ECO
Pathway Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 2/3.
Similarity Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
Subcellular Location Endoplasmic reticulum membrane ; Multi-pass membrane protein .
Tissue Specificity Expressed predominantly in adipose tissue, pancreas and liver.

Identical and Related Proteins

Unique RefSeq proteins for LMP000277 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6041665 RefSeq NP_006403 278 1-acyl-sn-glycerol-3-phosphate acyltransferase beta isoform a precursor
69122971 RefSeq NP_001012745 246 1-acyl-sn-glycerol-3-phosphate acyltransferase beta isoform b precursor

Identical Sequences to LMP000277 proteins

Reference Database Accession Length Protein Name
GI:6041665 GenBank AAC51649.1 278 lysophosphatidic acid acyltransferase [Homo sapiens]
GI:69122971 GenBank AAH04529.1 246 1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta) [Homo sapiens]
GI:6041665 GenBank AAB58776.2 278 lysophosphatidic acid acyltransferase-beta [Homo sapiens]
GI:6041665 GenBank EAW88249.1 278 1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta), isoform CRA_a [Homo sapiens]
GI:6041665 GenBank EAW88250.1 278 1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta), isoform CRA_a [Homo sapiens]
GI:69122971 GenBank EAW88251.1 246 1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta), isoform CRA_b [Homo sapiens]
GI:69122971 GenBank EAW88252.1 246 1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta), isoform CRA_b [Homo sapiens]
GI:6041665 GenBank ACM81228.1 278 Sequence 6726 from patent US 6812339
GI:69122971 GenBank AIC63298.1 246 AGPAT2, partial [synthetic construct]
GI:6041665 SwissProt O15120.1 278 RecName: Full=1-acyl-sn-glycerol-3-phosphate acyltransferase beta; AltName: Full=1-acylglycerol-3-phosphate O-acyltransferase 2; Short=1-AGP acyltransferase 2; Short=1-AGPAT 2; AltName: Full=Lysophosphatidic acid acyltransferase beta; Short=LPAAT-beta; Flags: Precursor [Homo sapiens]

Related Sequences to LMP000277 proteins

Reference Database Accession Length Protein Name
GI:69122971 GenBank AAC51649.1 278 lysophosphatidic acid acyltransferase [Homo sapiens]
GI:6041665 GenBank AAB64299.1 278 lysophosphatidic acid acyltransferase [Homo sapiens]
GI:6041665 GenBank AAH00026.1 278 1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta) [Homo sapiens]
GI:69122971 GenBank AAB58776.2 278 lysophosphatidic acid acyltransferase-beta [Homo sapiens]
GI:6041665 GenBank ABH82016.1 278 Sequence 7 from patent US 7045327
GI:69122971 GenBank EAW88249.1 278 1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta), isoform CRA_a [Homo sapiens]
GI:6041665 GenBank ABM83072.1 278 1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta) [synthetic construct]
GI:6041665 GenBank ABM86268.1 278 1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta), partial [synthetic construct]
GI:69122971 GenBank ACM81228.1 278 Sequence 6726 from patent US 6812339
GI:6041665 GenBank AIC55803.1 278 AGPAT2, partial [synthetic construct]
GI:69122971 RefSeq NP_006403.2 278 1-acyl-sn-glycerol-3-phosphate acyltransferase beta isoform a precursor [Homo sapiens]
GI:69122971 SwissProt O15120.1 278 RecName: Full=1-acyl-sn-glycerol-3-phosphate acyltransferase beta; AltName: Full=1-acylglycerol-3-phosphate O-acyltransferase 2; Short=1-AGP acyltransferase 2; Short=1-AGPAT 2; AltName: Full=Lysophosphatidic acid acyltransferase beta; Short=LPAAT-beta; Flags: Precursor [Homo sapiens]