Gene/Proteome Database (LMPD)

LMPD ID
LMP000278
Gene ID
18105
Species
Mus musculus (Mouse)
Gene Name
NAD(P)H dehydrogenase, quinone 2
Gene Symbol
Nqo2
Synonyms
NMO2; Nmor2; Ox2
Chromosome
13
Map Location
13 A4|13 14.01 cM

Proteins

ribosyldihydronicotinamide dehydrogenase [quinone] isoform 1
Refseq ID NP_001156713
Protein GI 253795453
UniProt ID Q9JI75
mRNA ID NM_001163241
Length 231
RefSeq Status VALIDATED
MAGKKVLIVYAHQEPKSFNGSLKKVAVEELSKQGCTVTVSDLYSMNFEPRATRNDITGAPSNPDVFSYGIETHEAYKKKALTSDIFEEQRKVQEADLVIFQFPLYWFSVPAILKGWMDRVLCRGFAFDIPGFYDSGFLKGKLALLSLTTGGTAEMYTKDGVSGDFRYFLWPLQHGTLHFCGFKVLAPQISFGLDVSSEEERKVMLASWAQRLKSIWKEEPIHCTPPWYFQE
ribosyldihydronicotinamide dehydrogenase [quinone] isoform 1
Refseq ID NP_001156714
Protein GI 253795455
UniProt ID Q9JI75
mRNA ID NM_001163242
Length 231
RefSeq Status VALIDATED
Protein sequence is identical to GI:253795453 (mRNA isoform)
ribosyldihydronicotinamide dehydrogenase [quinone] isoform 1
Refseq ID NP_064678
Protein GI 9937970
UniProt ID Q9JI75
mRNA ID NM_020282
Length 231
RefSeq Status VALIDATED
Protein sequence is identical to GI:253795453 (mRNA isoform)
ribosyldihydronicotinamide dehydrogenase [quinone] isoform 2
Refseq ID NP_001156711
Protein GI 253795451
UniProt ID Q9CVF5
mRNA ID NM_001163239
Length 187
RefSeq Status VALIDATED
MNFEPRATRNDITGAPSNPDVFSYGIETHEAYKKKALTSDIFEEQRKVQEADLVIFQFPLYWFSVPAILKGWMDRVLCRGFAFDIPGFYDSGFLKGKLALLSLTTGGTAEMYTKDGVSGDFRYFLWPLQHGTLHFCGFKVLAPQISFGLDVSSEEERKVMLASWAQRLKSIWKEEPIHCTPPWYFQE

Gene Information

Entrez Gene ID
18105
Gene Name
NAD(P)H dehydrogenase, quinone 2
Gene Symbol
Nqo2
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IEA:UniProtKB-KW C cytoplasm
GO:0070062 IEA:Ensembl C extracellular vesicular exosome
GO:0005634 IEA:Ensembl C nucleus
GO:0001512 IEA:UniProtKB-EC F dihydronicotinamide riboside quinone reductase activity
GO:0046872 IEA:UniProtKB-KW F metal ion binding
GO:0007613 IEA:Ensembl P memory

Domain Information

InterPro Annotations

Accession Description
IPR003680 Flavodoxin-like fold
IPR029039 Flavoprotein-like

UniProt Annotations

Entry Information

Gene Name
NAD(P)H dehydrogenase, quinone 2
Protein Entry
NQO2_MOUSE
UniProt ID
Q9JI75
Species
Mouse

Comments

Comment Type Description
Catalytic Activity 1-(beta-D-ribofuranosyl)-1,4- dihydronicotinamide + a quinone = 1-(beta-D- ribofuranosyl)nicotinamide + a hydroquinone.
Cofactor Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000250};
Cofactor Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000250}; Note=Binds 1 zinc ion per subunit. {ECO:0000250};
Function The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.
Miscellaneous Uses dihydronicotinamide riboside (NRH) rather than NAD(P)H as an electron donor.
Similarity Belongs to the NAD(P)H dehydrogenase (quinone) family. {ECO:0000305}.
Subcellular Location Cytoplasm {ECO:0000250}.
Subunit Homodimer. {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP000278 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
253795453 RefSeq NP_001156713 231 ribosyldihydronicotinamide dehydrogenase [quinone] isoform 1
253795451 RefSeq NP_001156711 187 ribosyldihydronicotinamide dehydrogenase [quinone] isoform 2

Identical Sequences to LMP000278 proteins

Reference Database Accession Length Protein Name
GI:253795453 GenBank EDL40874.1 231 NAD(P)H dehydrogenase, quinone 2, isoform CRA_a [Mus musculus]
GI:253795453 GenBank EDL40875.1 231 NAD(P)H dehydrogenase, quinone 2, isoform CRA_a [Mus musculus]
GI:253795451 GenBank EDL40876.1 187 NAD(P)H dehydrogenase, quinone 2, isoform CRA_b [Mus musculus]
GI:253795453 GenBank EDL40878.1 231 NAD(P)H dehydrogenase, quinone 2, isoform CRA_a [Mus musculus]
GI:253795453 RefSeq NP_001156714.1 231 ribosyldihydronicotinamide dehydrogenase [quinone] isoform 1 [Mus musculus]
GI:253795453 RefSeq XP_006516637.1 231 PREDICTED: ribosyldihydronicotinamide dehydrogenase [quinone] isoform X1 [Mus musculus]
GI:253795453 SwissProt Q9JI75.3 231 RecName: Full=Ribosyldihydronicotinamide dehydrogenase [quinone]; AltName: Full=NRH dehydrogenase [quinone] 2; AltName: Full=NRH:quinone oxidoreductase 2; AltName: Full=Quinone reductase 2; Short=QR2 [Mus musculus]

Related Sequences to LMP000278 proteins

Reference Database Accession Length Protein Name
GI:253795451 DBBJ BAB25486.1 266 unnamed protein product, partial [Mus musculus]
GI:253795453 DBBJ BAB25486.1 266 unnamed protein product, partial [Mus musculus]
GI:253795451 DBBJ BAB25683.1 267 unnamed protein product, partial [Mus musculus]
GI:253795453 DBBJ BAB25683.1 267 unnamed protein product, partial [Mus musculus]
GI:253795451 GenBank AAH27629.1 231 NAD(P)H dehydrogenase, quinone 2 [Mus musculus]
GI:253795451 RefSeq NP_001156713.1 231 ribosyldihydronicotinamide dehydrogenase [quinone] isoform 1 [Mus musculus]
GI:253795451 RefSeq NP_001156714.1 231 ribosyldihydronicotinamide dehydrogenase [quinone] isoform 1 [Mus musculus]
GI:253795453 RefSeq XP_003513239.1 231 PREDICTED: ribosyldihydronicotinamide dehydrogenase [quinone] [Cricetulus griseus]
GI:253795451 RefSeq XP_006516637.1 231 PREDICTED: ribosyldihydronicotinamide dehydrogenase [quinone] isoform X1 [Mus musculus]
GI:253795453 RefSeq XP_006983570.1 231 PREDICTED: ribosyldihydronicotinamide dehydrogenase [quinone] [Peromyscus maniculatus bairdii]
GI:253795453 RefSeq XP_007651692.1 231 PREDICTED: ribosyldihydronicotinamide dehydrogenase [quinone] [Cricetulus griseus]
GI:253795453 RefSeq XP_007651693.1 231 PREDICTED: ribosyldihydronicotinamide dehydrogenase [quinone] [Cricetulus griseus]