Gene/Proteome Database (LMPD)
LMPD ID
LMP000282
Gene ID
Species
Homo sapiens (Human)
Gene Name
phospholipase A2, group IID
Gene Symbol
Synonyms
PLA2IID; SPLASH; sPLA2-IID; sPLA2S
Alternate Names
group IID secretory phospholipase A2; GIID sPLA2; secretory phospholipase A2s; phosphatidylcholine 2-acylhydrolase 2D; secretory-type PLA, stroma-associated homolog
Chromosome
1
Map Location
1p36.12
EC Number
3.1.1.4
Summary
This gene encodes a secreted member of the phospholipase A2 family, and is found in a cluster of related family members on chromosome 1. Phospholipase A2 family members hydrolyze the sn-2 fatty acid ester bond of glycerophospholipids to produce lysophospholipids and free fatty acid. This gene may be involved in inflammation and immune response, and in weight loss associated with chronic obstructive pulmonary disease. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2012]
Orthologs
Proteins
| group IID secretory phospholipase A2 isoform 1 precursor | |
|---|---|
| Refseq ID | NP_036532 |
| Protein GI | 6912596 |
| UniProt ID | Q9UNK4 |
| mRNA ID | NM_012400 |
| Length | 145 |
| RefSeq Status | REVIEWED |
| MELALLCGLVVMAGVIPIQGGILNLNKMVKQVTGKMPILSYWPYGCHCGLGGRGQPKDATDWCCQTHDCCYDHLKTQGCSIYKDYYRYNFSQGNIHCSDKGSWCEQQLCACDKEVAFCLKRNLDTYQKRLRFYWRPHCRGQTPGC | |
| sig_peptide: 1..20 inference: non-experimental evidence, no additional details recorded note: Potential; propagated from UniProtKB/Swiss-Prot (Q9UNK4.2) calculated_mol_wt: 2028 peptide sequence: MELALLCGLVVMAGVIPIQG mat_peptide: 21..62 product: group IID secretory phospholipase A2 isoform 2 calculated_mol_wt: 4551 peptide sequence: GILNLNKMVKQVTGKMPILSYWPYGCHCGLGGRGQPKDATDC sig_peptide: 1..20 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2028 peptide sequence: MELALLCGLVVMAGVIPIQG mat_peptide: 21..145 product: Group IID secretory phospholipase A2 experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q9UNK4.2) calculated_mol_wt: 14537 peptide sequence: GILNLNKMVKQVTGKMPILSYWPYGCHCGLGGRGQPKDATDWCCQTHDCCYDHLKTQGCSIYKDYYRYNFSQGNIHCSDKGSWCEQQLCACDKEVAFCLKRNLDTYQKRLRFYWRPHCRGQTPGC | |
| group IID secretory phospholipase A2 isoform 2 precursor | |
|---|---|
| Refseq ID | NP_001258743 |
| Protein GI | 425854812 |
| UniProt ID | Q9UNK4 |
| mRNA ID | NM_001271814 |
| Length | 62 |
| RefSeq Status | REVIEWED |
| MELALLCGLVVMAGVIPIQGGILNLNKMVKQVTGKMPILSYWPYGCHCGLGGRGQPKDATDC | |
Gene Information
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005576 | TAS:Reactome | C | extracellular region |
| GO:0005509 | IEA:InterPro | F | calcium ion binding |
| GO:0004623 | TAS:ProtInc | F | phospholipase A2 activity |
| GO:0046474 | TAS:Reactome | P | glycerophospholipid biosynthetic process |
| GO:0006954 | TAS:ProtInc | P | inflammatory response |
| GO:0016042 | IEA:UniProtKB-KW | P | lipid catabolic process |
| GO:0006654 | TAS:Reactome | P | phosphatidic acid biosynthetic process |
| GO:0036151 | TAS:Reactome | P | phosphatidylcholine acyl-chain remodeling |
| GO:0036152 | TAS:Reactome | P | phosphatidylethanolamine acyl-chain remodeling |
| GO:0036148 | TAS:Reactome | P | phosphatidylglycerol acyl-chain remodeling |
| GO:0036149 | TAS:Reactome | P | phosphatidylinositol acyl-chain remodeling |
| GO:0036150 | TAS:Reactome | P | phosphatidylserine acyl-chain remodeling |
| GO:0006644 | TAS:Reactome | P | phospholipid metabolic process |
| GO:0044281 | TAS:Reactome | P | small molecule metabolic process |
KEGG Pathway Links
Domain Information
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Biophysicochemical Properties | pH dependence: Optimally active at neutral to alkaline pHs with 2 mM Ca(2+).; |
| Catalytic Activity | Phosphatidylcholine + H(2)O = 1- acylglycerophosphocholine + a carboxylate. {ECO |
| Cofactor | Name=Ca(2+); Xref=ChEBI |
| Function | PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. L-alpha-1-palmitoyl-2- linoleoyl phosphatidylethanolamine is more efficiently hydrolyzed than the other phospholipids examined. |
| Similarity | Belongs to the phospholipase A2 family. |
| Subcellular Location | Secreted . |
| Tissue Specificity | Broadly expressed. |
| Web Resource | Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/pla2g2d/"; |
Identical and Related Proteins
Unique RefSeq proteins for LMP000282 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 6912596 | RefSeq | NP_036532 | 145 | group IID secretory phospholipase A2 isoform 1 precursor |
| 425854812 | RefSeq | NP_001258743 | 62 | group IID secretory phospholipase A2 isoform 2 precursor |
Identical Sequences to LMP000282 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:6912596 | DBBJ | BAJ20250.1 | 145 | phospholipase A2, group IID, partial [synthetic construct] |
| GI:6912596 | GenBank | EAW94915.1 | 145 | phospholipase A2, group IID [Homo sapiens] |
| GI:6912596 | GenBank | AEU43348.1 | 145 | Sequence 97 from patent US 8052970 |
| GI:6912596 | GenBank | AGF22440.1 | 145 | Sequence 6 from patent US 8372594 |
| GI:6912596 | GenBank | AHD78604.1 | 145 | Sequence 26602 from patent US 8586006 |
| GI:6912596 | GenBank | AIC51141.1 | 145 | PLA2G2D, partial [synthetic construct] |
Related Sequences to LMP000282 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:6912596 | DBBJ | BAF83095.1 | 145 | unnamed protein product [Homo sapiens] |
| GI:425854812 | DBBJ | BAF83095.1 | 145 | unnamed protein product [Homo sapiens] |
| GI:6912596 | GenBank | AAD51390.1 | 145 | group IID secretory phospholipase A2 [Homo sapiens] |
| GI:425854812 | GenBank | AAD51390.1 | 145 | group IID secretory phospholipase A2 [Homo sapiens] |
| GI:425854812 | GenBank | AAV21489.1 | 145 | Sequence 27 from patent US 6756219 |
| GI:6912596 | GenBank | AAV21489.1 | 145 | Sequence 27 from patent US 6756219 |
| GI:6912596 | GenBank | AAX36145.1 | 146 | phospholipase A2 group IID, partial [synthetic construct] |
| GI:6912596 | GenBank | AAY75611.1 | 157 | Sequence 514 from patent US 6900016 |
| GI:6912596 | GenBank | AEX18374.1 | 145 | Sequence 38 from patent US 8084200 |
| GI:425854812 | GenBank | AEX18374.1 | 145 | Sequence 38 from patent US 8084200 |
| GI:425854812 | RefSeq | XP_008965324.1 | 78 | PREDICTED: group IID secretory phospholipase A2 isoform X2 [Pan paniscus] |
| GI:425854812 | RefSeq | XP_009448074.1 | 78 | PREDICTED: group IID secretory phospholipase A2 isoform X2 [Pan troglodytes] |