Gene/Proteome Database (LMPD)

LMPD ID
LMP000287
Gene ID
232174
Species
Mus musculus (Mouse)
Gene Name
cytochrome P450, family 26, subfamily b, polypeptide 1
Gene Symbol
Cyp26b1
Synonyms
CP26; P450RAI-2
Alternate Names
cytochrome P450 26B1; retinoic acid B1; cytochrome P450RAI-2; retinoic acid hydroxylase; cytochrome P450, 26, retinoic acid B1; cytochrome P450 retinoic acid-inactivating 2
Chromosome
6
Map Location
6 C3|6
EC Number
1.14.-.-

Proteins

cytochrome P450 26B1
Refseq ID NP_780684
Protein GI 28202045
UniProt ID Q811W2
mRNA ID NM_175475
Length 512
RefSeq Status VALIDATED
MLFEGLELVSALATLAACLVSVTLLLAVSQQLWQLRWAATRDKSCKLPIPKGSMGFPLIGETGHWLLQGSGFQSSRREKYGNVFKTHLLGRPLIRVTGAENVRKILLGEHQLVSTEWPRSARVLLGPNTVANSIGDIHRNKRKVFSKIFSHEALESYLPKIQLVIQDTLRAWSSQPEAINVYQEAQRLTFRMAVRVLLGFSIPEEDLGHLFEVYQQFVENVFSLPVDLPFSGYRRGIQARQILQKGLEKAIREKLQCTQGKDYSDALDILIESSKEHGKEMTMQELKDGTLELIFAAYATTASASTSLIMQLLKHPAVLEKLREELRAQGLLHGGGCPCEGTLRLDTLSSLRYLDCVIKEVMRLFTPVSGGYRTVLQTFELDGFQIPKGWSVMYSIRDTHDTAPVFKDVNVFDPDRFSQARSEDKDGRFHYLPFGGGVRTCLGKHLAKLFLKVLAVELASTSRFELATRTFPRITLVPVLHPVDGLSVKFFGLDSNQNEILPETEAMLSATV
cytochrome P450 26B1
Refseq ID NP_001171184
Protein GI 295148144
UniProt ID Q811W2
mRNA ID NM_001177713
Length 512
RefSeq Status VALIDATED
Protein sequence is identical to GI:28202045 (mRNA isoform)

Gene Information

Entrez Gene ID
232174
Gene Name
cytochrome P450, family 26, subfamily b, polypeptide 1
Gene Symbol
Cyp26b1
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IEA:UniProtKB-KW C endoplasmic reticulum
GO:0016020 IEA:UniProtKB-KW C membrane
GO:0020037 IEA:InterPro F heme binding
GO:0005506 IEA:InterPro F iron ion binding
GO:0008401 IEA:Ensembl F retinoic acid 4-hydroxylase activity
GO:0001972 IEA:Ensembl F retinoic acid binding
GO:0060349 IEA:Ensembl P bone morphogenesis
GO:0001709 IMP:MGI P cell fate determination
GO:0071300 IEP:UniProtKB P cellular response to retinoic acid
GO:0070268 IMP:MGI P cornification
GO:0030326 IMP:MGI P embryonic limb morphogenesis
GO:0061436 IMP:MGI P establishment of skin barrier
GO:0007140 IMP:MGI P male meiosis
GO:0048387 IMP:MGI P negative regulation of retinoic acid receptor signaling pathway
GO:0010628 IMP:UniProtKB P positive regulation of gene expression
GO:2001037 IMP:UniProtKB P positive regulation of tongue muscle cell differentiation
GO:0009954 IMP:MGI P proximal/distal pattern formation
GO:0034653 IC:MGI P retinoic acid catabolic process
GO:0042573 IC:MGI P retinoic acid metabolic process
GO:0048384 IMP:UniProtKB P retinoic acid receptor signaling pathway
GO:0007283 IMP:MGI P spermatogenesis
GO:0043587 IMP:UniProtKB P tongue morphogenesis

KEGG Pathway Links

KEGG Pathway ID Description
mmu00830 Retinol metabolism

Domain Information

InterPro Annotations

Accession Description
IPR001128 Cytochrome P450
IPR002403 Cytochrome P450, E-class, group IV
IPR017972 Cytochrome P450, conserved site

UniProt Annotations

Entry Information

Gene Name
cytochrome P450, family 26, subfamily b, polypeptide 1
Protein Entry
CP26B_MOUSE
UniProt ID
Q811W2
Species
Mouse

Comments

Comment Type Description
Cofactor Name=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000250};
Developmental Stage In the embryonic male gonad, expressed in somatic cells as early as E11.5 and persist throughout development. Expression is detected in peritubular myoepithelial cells in the postnatal testis, while expression is absent in developing and adult ovaries. {ECO:0000269|PubMed:16461896, ECO:0000269|PubMed:16574820}.
Disruption Phenotype Germ cells enter meiosis precociously in embryonic testes, due to strong-up-regulation of Stra8. {ECO:0000269|PubMed:16574820}.
Function Involved in the metabolism of retinoic acid (RA), rendering this classical morphogen inactive through oxidation. Involved in the specific inactivation of all-trans-retinoic acid (all-trans-RA), with a preference for the following substrates: all-trans-RA > 9-cis-RA > 13-cis-RA. Generates several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA, and 18-OH- RA. Esential for postnatal survival. Plays a central role in germ cell development: acts by degrading RA in the developing testis, preventing STRA8 expression, thereby leading to delay of meiosis. Required for the maintenance of the undifferentiated state of male germ cells during embryonic development in Sertoli cells, inducing arrest in G0 phase of the cell cycle and preventing meiotic entry. Plays a role in skeletal development, both at the level of patterning and in the ossification of bone and the establishment of some synovial joints. {ECO:0000269|PubMed:16461896, ECO:0000269|PubMed:16574820, ECO:0000269|PubMed:19838304, ECO:0000269|PubMed:22019272}.
Similarity Belongs to the cytochrome P450 family. {ECO:0000305}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Microsome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP000287 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
28202045 RefSeq NP_780684 512 cytochrome P450 26B1

Identical Sequences to LMP000287 proteins

Reference Database Accession Length Protein Name
GI:28202045 DBBJ BAE23242.1 512 unnamed protein product [Mus musculus]
GI:28202045 GenBank AAN08613.1 512 cytochrome p450 26B1 [Mus musculus]
GI:28202045 GenBank AAH59246.1 512 Cyp26b1 protein [Mus musculus]
GI:28202045 GenBank EDK99117.1 512 cytochrome P450, family 26, subfamily b, polypeptide 1, isoform CRA_a [Mus musculus]
GI:28202045 RefSeq NP_001171184.1 512 cytochrome P450 26B1 [Mus musculus]
GI:28202045 SwissProt Q811W2.1 512 RecName: Full=Cytochrome P450 26B1; AltName: Full=Cytochrome P450 retinoic acid-inactivating 2; Short=Cytochrome P450RAI-2 [Mus musculus]

Related Sequences to LMP000287 proteins

Reference Database Accession Length Protein Name
GI:28202045 GenBank EDK99118.1 614 cytochrome P450, family 26, subfamily b, polypeptide 1, isoform CRA_b, partial [Mus musculus]
GI:28202045 GenBank EDL91177.1 512 cytochrome P450, family 26, subfamily b, polypeptide 1 [Rattus norvegicus]
GI:28202045 RefSeq XP_005071132.1 512 PREDICTED: cytochrome P450 26B1-like isoform X1 [Mesocricetus auratus]
GI:28202045 RefSeq XP_005071133.1 512 PREDICTED: cytochrome P450 26B1-like isoform X2 [Mesocricetus auratus]
GI:28202045 RefSeq XP_006991603.1 512 PREDICTED: cytochrome P450 26B1-like isoform X1 [Peromyscus maniculatus bairdii]
GI:28202045 SwissProt G3V7X8.1 512 RecName: Full=Cytochrome P450 26B1 [Rattus norvegicus]