Gene/Proteome Database (LMPD)
LMPD ID
LMP000298
Gene ID
Species
Homo sapiens (Human)
Gene Name
inositol polyphosphate multikinase
Gene Symbol
Synonyms
-
Alternate Names
inositol polyphosphate multikinase; inositol 1,3,4,6-tetrakisphosphate 5-kinase
Chromosome
10
Map Location
10q21.1
EC Number
2.7.1.151
Summary
This gene encodes a member of the inositol phosphokinase family. The encoded protein has 3-kinase, 5-kinase and 6-kinase activities on phosphorylated inositol substrates. The encoded protein plays an important role in the biosynthesis of inositol 1,3,4,5,6-pentakisphosphate, and has a preferred 5-kinase activity. This gene may play a role in nuclear mRNA export. Pseudogenes of this gene are located on the long arm of chromosome 13 and the short arm of chromosome 19. [provided by RefSeq, Dec 2010]
Orthologs
Proteins
| inositol polyphosphate multikinase | |
|---|---|
| Refseq ID | NP_689416 |
| Protein GI | 22726201 |
| UniProt ID | Q8NFU5 |
| mRNA ID | NM_152230 |
| Length | 416 |
| RefSeq Status | REVIEWED |
| MATEPPSPLRVEAPGPPEMRTSPAIESTPEGTPQPAGGRLRFLNGCVPLSHQVAGHMYGKDKVGILQHPDGTVLKQLQPPPRGPRELEFYNMVYAADCFDGVLLELRKYLPKYYGIWSPPTAPNDLYLKLEDVTHKFNKPCIMDVKIGQKSYDPFASSEKIQQQVSKYPLMEEIGFLVLGMRVYHVHSDSYETENQHYGRSLTKETIKDGVSRFFHNGYCLRKDAVAASIQKIEKILQWFENQKQLNFYASSLLFVYEGSSQPTTTKLNDRTLAEKFLSKGQLSDTEVLEYNNNFHVLSSTANGKIESSVGKSLSKMYARHRKIYTKKHHSQTSLKVENLEQDNGWKSMSQEHLNGNVLSQLEKVFYHLPTGCQEIAEVEVRMIDFAHVFPSNTIDEGYVYGLKHLISVLRSILDN | |
Gene Information
Entrez Gene ID
Gene Name
inositol polyphosphate multikinase
Gene Symbol
Species
Homo sapiens
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005654 | TAS:Reactome | C | nucleoplasm |
| GO:0005634 | IDA:HPA | C | nucleus |
| GO:0005524 | IEA:UniProtKB-KW | F | ATP binding |
| GO:0000824 | IEA:Ensembl | F | inositol tetrakisphosphate 3-kinase activity |
| GO:0008440 | IEA:Ensembl | F | inositol-1,4,5-trisphosphate 3-kinase activity |
| GO:0000823 | IEA:UniProtKB-EC | F | inositol-1,4,5-trisphosphate 6-kinase activity |
| GO:0032958 | IEA:Ensembl | P | inositol phosphate biosynthetic process |
| GO:0043647 | TAS:Reactome | P | inositol phosphate metabolic process |
| GO:0001841 | IEA:Ensembl | P | neural tube formation |
| GO:0044281 | TAS:Reactome | P | small molecule metabolic process |
BIOCYC Pathway Links
| BIOCYC Pathway ID | Description |
|---|---|
| PWY-6362 | 1D-myo-inositol hexakisphosphate biosynthesis II (mammalian) |
| PWY-6366 | D-myo-inositol (1,4,5,6)-tetrakisphosphate biosynthesis |
| PWY-6369 | inositol pyrophosphates biosynthesis |
REACTOME Pathway Links
| REACTOME Pathway ID | Description |
|---|---|
| REACT_150275 | Synthesis of IPs in the nucleus |
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR005522 | Inositol polyphosphate kinase |
UniProt Annotations
Entry Information
Gene Name
inositol polyphosphate multikinase
Protein Entry
IPMK_HUMAN
UniProt ID
Species
Human
Comments
| Comment Type | Description |
|---|---|
| Catalytic Activity | 2 ATP + 1D-myo-inositol 1,4,5-trisphosphate = 2 ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate. |
| Function | Inositol phosphate kinase with a broad substrate specificity. Has a preference for inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) and inositol 1,3,4,6-tetrakisphosphate (Ins(1,3,4,6)P4). {ECO |
| Similarity | Belongs to the inositol phosphokinase (IPK) family. |
| Subcellular Location | Nucleus . |
| Tissue Specificity | Ubiquitous, with the highest expression in skeletal muscle, liver, placenta, lung, peripheral blood leukocytes, kidney, spleen and colon. |
Identical and Related Proteins
Unique RefSeq proteins for LMP000298 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 22726201 | RefSeq | NP_689416 | 416 | inositol polyphosphate multikinase |
Identical Sequences to LMP000298 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:22726201 | GenBank | AAH65709.1 | 416 | Inositol polyphosphate multikinase [Homo sapiens] |
| GI:22726201 | GenBank | EAW54161.1 | 416 | inositol polyphosphate multikinase [Homo sapiens] |
| GI:22726201 | GenBank | AHD72911.1 | 416 | Sequence 9979 from patent US 8586006 |
| GI:22726201 | GenBank | AIC62907.1 | 416 | IPMK, partial [synthetic construct] |
| GI:22726201 | SwissProt | Q8NFU5.1 | 416 | RecName: Full=Inositol polyphosphate multikinase; AltName: Full=Inositol 1,3,4,6-tetrakisphosphate 5-kinase [Homo sapiens] |
| GI:22726201 | Third Party Genbank | DAA01362.1 | 416 | TPA_exp: inositol 1,3,4,6-tetrakisphosphate 5-kinase [Homo sapiens] |
Related Sequences to LMP000298 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:22726201 | GenBank | JAA08382.1 | 416 | inositol polyphosphate multikinase [Pan troglodytes] |
| GI:22726201 | GenBank | JAA19525.1 | 416 | inositol polyphosphate multikinase [Pan troglodytes] |
| GI:22726201 | GenBank | JAA30219.1 | 416 | inositol polyphosphate multikinase [Pan troglodytes] |
| GI:22726201 | RefSeq | XP_507801.2 | 416 | PREDICTED: inositol polyphosphate multikinase isoform X2 [Pan troglodytes] |
| GI:22726201 | RefSeq | XP_002820968.1 | 416 | PREDICTED: inositol polyphosphate multikinase isoform X2 [Pongo abelii] |
| GI:22726201 | RefSeq | XP_003821218.1 | 416 | PREDICTED: inositol polyphosphate multikinase isoform X2 [Pan paniscus] |