Gene/Proteome Database (LMPD)

LMPD ID
LMP000309
Gene ID
228550
Species
Mus musculus (Mouse)
Gene Name
inositol 1,4,5-trisphosphate 3-kinase A
Gene Symbol
Itpka
Synonyms
-
Alternate Names
inositol-trisphosphate 3-kinase A; IP3K A; IP3-kinase A; IP3 3-kinase A; insP 3-kinase A
Chromosome
2
Map Location
2 E5|2
EC Number
2.7.1.127

Proteins

inositol-trisphosphate 3-kinase A
Refseq ID NP_666237
Protein GI 22122643
UniProt ID Q8R071
mRNA ID NM_146125
Length 459
RefSeq Status PROVISIONAL
MTLPGRPTGMARPRGAGPCSPGLERAPRRSVGELRLLFEARCAAVAAAAAAGEPRARGAKRRGGQVPNGLPRAAPAPVIPQLTVTSEEDVTPASPGPPDQEGNWLPAAGSHLQQPRRLSTSSLSSTGSSSLLEDSEDDLLSDSESRSRGNVQLETSEDVGQKSHWQKIRTMVNLPVMSPFRKRYSWVQLAGHTGSFKAAGTSGLILKRSSEPEHYCLVRLMADVLRGCVPAFHGIVERDGESYLQLQDLLDGFDGPCVLDCKMGVRTYLEEELTKARERPKLRKDMYKKMLAVDPEAPTEEEHAQRAVTKPRYMQWREGISSSTTLGFRIEGIKKADGSCSTDFKTTRSREQVTRVFEEFMQGDAEVLRRYLNRLQQIRDTLEISDFFRRHEVIGSSLLFVHDHCHRAGVWLIDFGKTTPLPDGQILDHRRPWEEGNREDGYLLGLDNLIGILASLAER

Gene Information

Entrez Gene ID
228550
Gene Name
inositol 1,4,5-trisphosphate 3-kinase A
Gene Symbol
Itpka
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0043197 IEA:Ensembl C dendritic spine
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0004683 IEA:Ensembl F calmodulin-dependent protein kinase activity
GO:0008440 IEA:UniProtKB-EC F inositol-1,4,5-trisphosphate 3-kinase activity
GO:0030036 IEA:Ensembl P actin cytoskeleton organization
GO:0097062 IEA:Ensembl P dendritic spine maintenance
GO:0006020 IMP:MGI P inositol metabolic process
GO:0061003 IEA:Ensembl P positive regulation of dendritic spine morphogenesis
GO:0048167 IMP:MGI P regulation of synaptic plasticity

KEGG Pathway Links

KEGG Pathway ID Description
mmu04020 Calcium signaling pathway
mmu00562 Inositol phosphate metabolism

REACTOME Pathway Links

REACTOME Pathway ID Description
5894025 Synthesis of IP3 and IP4 in the cytosol

Domain Information

InterPro Annotations

Accession Description
IPR005522 Inositol polyphosphate kinase

UniProt Annotations

Entry Information

Gene Name
inositol 1,4,5-trisphosphate 3-kinase A
Protein Entry
IP3KA_MOUSE
UniProt ID
Q8R071
Species
Mouse

Comments

Comment Type Description
Catalytic Activity ATP + 1D-myo-inositol 1,4,5-trisphosphate = ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate.
Enzyme Regulation IP3K is activated by calmodulin. {ECO:0000250}.
Similarity Belongs to the inositol phosphokinase (IPK) family. {ECO:0000305}.

Identical and Related Proteins

Unique RefSeq proteins for LMP000309 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
22122643 RefSeq NP_666237 459 inositol-trisphosphate 3-kinase A

Identical Sequences to LMP000309 proteins

Reference Database Accession Length Protein Name
GI:22122643 GenBank AAH27291.1 459 Inositol 1,4,5-trisphosphate 3-kinase A [Mus musculus]
GI:22122643 SwissProt Q8R071.1 459 RecName: Full=Inositol-trisphosphate 3-kinase A; AltName: Full=Inositol 1,4,5-trisphosphate 3-kinase A; Short=IP3 3-kinase A; Short=IP3K A; Short=InsP 3-kinase A [Mus musculus]

Related Sequences to LMP000309 proteins

Reference Database Accession Length Protein Name
GI:22122643 EMBL CAA40248.1 459 inositol 1,4,5-triphosphate 3-kinase [Rattus norvegicus]
GI:22122643 GenBank EDL79924.1 459 inositol 1,4,5-trisphosphate 3-kinase A, isoform CRA_b [Rattus norvegicus]
GI:22122643 RefSeq NP_112307.2 459 inositol-trisphosphate 3-kinase A [Rattus norvegicus]
GI:22122643 RefSeq XP_005064772.1 459 PREDICTED: inositol-trisphosphate 3-kinase A [Mesocricetus auratus]
GI:22122643 RefSeq XP_005364339.1 459 PREDICTED: inositol-trisphosphate 3-kinase A [Microtus ochrogaster]
GI:22122643 SwissProt P17105.3 459 RecName: Full=Inositol-trisphosphate 3-kinase A; AltName: Full=Inositol 1,4,5-trisphosphate 3-kinase A; Short=IP3 3-kinase A; Short=IP3K A; Short=InsP 3-kinase A [Rattus norvegicus]