Gene/Proteome Database (LMPD)
LMPD ID
LMP000317
Gene ID
Species
Mus musculus (Mouse)
Gene Name
synaptotagmin XIV
Gene Symbol
Synonyms
B230320I09Rik; sytXIV
Alternate Names
synaptotagmin-14
Chromosome
1
Map Location
1 H6|1
Summary
This gene encodes a member of the synaptotagmin family. The encoded protein may be involved in membrane trafficking. Disruption of a similar gene in human has been associated with autosomal recessive spinocerebellar ataxia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]
Orthologs
Proteins
| synaptotagmin-14 isoform 1 | |
|---|---|
| Refseq ID | NP_001288299 |
| Protein GI | 672590373 |
| UniProt ID | Q8BL96 |
| mRNA ID | NM_001301370 |
| Length | 574 |
| RefSeq Status | REVIEWED |
| MAIEGGERTCGVHELICIRKVSPEAVGFLSAVGVFIVLMLLLFLYINKKFCFENVGGFPDLGSGYNTRTNSQDKMYNSYMDRDEPGSSSESEDEALGKYHEALSRTHNSRWPLVDSRQKSYAWETRQKYSPLSAEYDGYSTEASMEDGNCIQRMRRTPPLDELQPPPYQDDSGSPHLSCTPSEIGDAKCEISHCSNSPRCSFNKCPSEGSTGHEAESYHNKGYEDDVPSDSTAVLSPEDMSAQGSSSQLPKPFDPEPEAKYGTLDVTFDYDSERQKLLVTVTAVTDIPTYNRTGGNSWQVHLVLLPIKKQRAKTSIQRGPCPVFTETFKFNHVESEMIGNYAVRFRLYGVHRMKKEKIVGEKIFYLTKLNLQGKMSLPVILEPSYNPSGCDSQVSLSEASCGDSTSSCQSLQHGSVPEILIGLLYNATTGRLSAEVIKGSHFKNLAANRPPNGLFCCLKHLIGGQVYIIRDTYVKLTLLNSMGQEMSKCKTSTRRGQPNPVYKETFVFQVALFQLSDVTLILSVYNRRSMKRKEMIGWISLGLNSSGEEELRHWTAMKESKGQQVCRWHALLES | |
| synaptotagmin-14 isoform 2 | |
|---|---|
| Refseq ID | NP_853524 |
| Protein GI | 31559805 |
| UniProt ID | Q8BL96 |
| mRNA ID | NM_181546 |
| Length | 555 |
| RefSeq Status | REVIEWED |
| MAIEGGERTCGVHELICIRKVSPEAVGFLSAVGVFIVLMLLLFLYINKKFCFENVGGFPDLGSGYNTRTNSQDKMYNSYMDRDEPGSSSESEDEALGKYHEALSRTHNSRWPLVDSRQKSYAWETRQKYSPLSAEYDGYSTEASMEDGNCIQRMRRTPPLDELQPPPYQDDSGSPHLSCTPSEIGDAKCEISHCSNSPRCSFNKCPSEGSTGHEAESYHNKGYEDDVPSDSTAVLSPEDMSAQGSSSQLPKPFDPEPEAKYGTLDVTFDYDSERQKLLVTVTAVTDIPTYNRTGGNSWQVHLVLLPIKKQRAKTSIQRGPCPVFTETFKFNHVESEMIGNYAVRFRLYGVHRMKKEKIVGEKIFYLTKLNLQGKMSLPVILEPSYNPSGCDSQVSLSEASCGDSTSSCQSLQHGSVPEILIGLLYNATTGRLSAEVIKGSHFKNLAANRPPNTYVKLTLLNSMGQEMSKCKTSTRRGQPNPVYKETFVFQVALFQLSDVTLILSVYNRRSMKRKEMIGWISLGLNSSGEEELRHWTAMKESKGQQVCRWHALLES | |
Gene Information
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0016021 | ISS:MGI | C | integral component of membrane |
| GO:0005543 | IDA:MGI | F | phospholipid binding |
| GO:0046982 | IPI:MGI | F | protein heterodimerization activity |
| GO:0042803 | IDA:MGI | F | protein homodimerization activity |
Domain Information
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Function | May be involved in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues. Is Ca(2+)-independent. |
| Similarity | Belongs to the synaptotagmin family. {ECO:0000305}. |
| Similarity | Contains 2 C2 domains. {ECO:0000255|PROSITE- ProRule:PRU00041}. |
| Subcellular Location | Membrane {ECO:0000305}; Single-pass type III membrane protein {ECO:0000305}. |
| Subunit | Homodimer. Can also form heterodimers (By similarity). {ECO:0000250}. |
| Tissue Specificity | Expressed in heart and testis. Expressed in brain (especially in the cerebellum). {ECO:0000269|PubMed:12801916, ECO:0000269|PubMed:21835308}. |
Identical and Related Proteins
Unique RefSeq proteins for LMP000317 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 672590373 | RefSeq | NP_001288299 | 574 | synaptotagmin-14 isoform 1 |
| 31559805 | RefSeq | NP_853524 | 555 | synaptotagmin-14 isoform 2 |
Identical Sequences to LMP000317 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:31559805 | DBBJ | BAC76808.1 | 555 | synaptotagmin XIV [Mus musculus] |
| GI:31559805 | GenBank | AAI60355.1 | 555 | Synaptotagmin XIV [synthetic construct] |
| GI:31559805 | SwissProt | Q7TN84.1 | 555 | RecName: Full=Synaptotagmin-14; AltName: Full=Synaptotagmin XIV; Short=SytXIV [Mus musculus] |
Related Sequences to LMP000317 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:31559805 | GenBank | EDL12960.1 | 576 | synaptotagmin XIV, isoform CRA_b, partial [Mus musculus] |
| GI:31559805 | GenBank | AAI45603.1 | 574 | Syt14 protein [Mus musculus] |
| GI:31559805 | GenBank | AAI41263.1 | 574 | Syt14 protein [Mus musculus] |
| GI:31559805 | RefSeq | XP_003751344.1 | 555 | PREDICTED: synaptotagmin-14 isoform X3 [Rattus norvegicus] |
| GI:31559805 | RefSeq | XP_008762169.1 | 555 | PREDICTED: synaptotagmin-14 isoform X3 [Rattus norvegicus] |
| GI:31559805 | RefSeq | NP_001288299.1 | 574 | synaptotagmin-14 isoform 1 [Mus musculus] |