Gene/Proteome Database (LMPD)
LMPD ID
LMP000323
Gene ID
Species
Homo sapiens (Human)
Gene Name
prostaglandin E receptor 1 (subtype EP1), 42kDa
Gene Symbol
Synonyms
EP1
Alternate Names
prostaglandin E2 receptor EP1 subtype; prostanoid EP1 receptor; PGE receptor EP1 subtype; PGE receptor, EP1 subtype; PGE2 receptor EP1 subtype; prostaglandin E receptor 1, subtype EP1; prostaglandin E receptor 1 (subtype EP1), 42kD
Chromosome
19
Map Location
19p13.1
Summary
The protein encoded by this gene is a member of the G protein-coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). Through a phosphatidylinositol-calcium second messenger system, G-Q proteins mediate this receptor's activity. Knockout studies in mice suggested a role of this receptor in mediating algesia and in regulation of blood pressure. Studies in mice also suggested that this gene may mediate adrenocorticotropic hormone response to bacterial endotoxin. [provided by RefSeq, Jul 2008]
Orthologs
Proteins
| prostaglandin E2 receptor EP1 subtype | |
|---|---|
| Refseq ID | NP_000946 |
| Protein GI | 38505194 |
| UniProt ID | P34995 |
| mRNA ID | NM_000955 |
| Length | 402 |
| RefSeq Status | REVIEWED |
| MSPCGPLNLSLAGEATTCAAPWVPNTSAVPPSGASPALPIFSMTLGAVSNLLALALLAQAAGRLRRRRSAATFLLFVASLLATDLAGHVIPGALVLRLYTAGRAPAGGACHFLGGCMVFFGLCPLLLGCGMAVERCVGVTRPLLHAARVSVARARLALAAVAAVALAVALLPLARVGRYELQYPGTWCFIGLGPPGGWRQALLAGLFASLGLVALLAALVCNTLSGLALLRARWRRRSRRPPPASGPDSRRRWGAHGPRSASASSASSIASASTFFGGSRSSGSARRARAHDVEMVGQLVGIMVVSCICWSPMLVLVALAVGGWSSTSLQRPLFLAVRLASWNQILDPWVYILLRQAVLRQLLRLLPPRAGAKGGPAGLGLTPSAWEASSLRSSRHSGLSHF | |
Gene Information
Entrez Gene ID
Gene Name
prostaglandin E receptor 1 (subtype EP1), 42kDa
Gene Symbol
Species
Homo sapiens
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005887 | TAS:ProtInc | C | integral component of plasma membrane |
| GO:0005886 | TAS:Reactome | C | plasma membrane |
| GO:0004957 | TAS:ProtInc | F | prostaglandin E receptor activity |
| GO:0007186 | TAS:ProtInc | P | G-protein coupled receptor signaling pathway |
| GO:0032496 | IEA:Ensembl | P | response to lipopolysaccharide |
KEGG Pathway Links
| KEGG Pathway ID | Description |
|---|---|
| hsa04020 | Calcium signaling pathway |
REACTOME Pathway Links
| REACTOME Pathway ID | Description |
|---|---|
| REACT_18425 | Prostanoid ligand receptors |
Domain Information
UniProt Annotations
Entry Information
Gene Name
prostaglandin E receptor 1 (subtype EP1), 42kDa
Protein Entry
PE2R1_HUMAN
UniProt ID
Species
Human
Comments
| Comment Type | Description |
|---|---|
| Function | Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(q) proteins which activate a phosphatidylinositol-calcium second messenger system. May play a role as an important modulator of renal function. Implicated the smooth muscle contractile response to PGE2 in various tissues. |
| Ptm | Phosphorylated. |
| Sequence Caution | Sequence=BAC05723.1; Type=Erroneous gene model prediction; Evidence= ; |
| Similarity | Belongs to the G-protein coupled receptor 1 family. |
| Subcellular Location | Cell membrane; Multi-pass membrane protein. |
| Tissue Specificity | Abundant in kidney. Lower level expression in lung, skeletal muscle and spleen, lowest expression in testis and not detected in liver brain and heart. |
Identical and Related Proteins
Unique RefSeq proteins for LMP000323 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 38505194 | RefSeq | NP_000946 | 402 | prostaglandin E2 receptor EP1 subtype |
Identical Sequences to LMP000323 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:38505194 | GenBank | AAH51286.1 | 402 | Prostaglandin E receptor 1 (subtype EP1), 42kDa [Homo sapiens] |
| GI:38505194 | GenBank | AAH39034.1 | 402 | Prostaglandin E receptor 1 (subtype EP1), 42kDa [Homo sapiens] |
| GI:38505194 | GenBank | EAW84422.1 | 402 | prostaglandin E receptor 1 (subtype EP1), 42kDa [Homo sapiens] |
| GI:38505194 | GenBank | ADA18176.1 | 402 | Sequence 1 from patent US 7608411 |
| GI:38505194 | SwissProt | P34995.3 | 402 | RecName: Full=Prostaglandin E2 receptor EP1 subtype; Short=PGE receptor EP1 subtype; Short=PGE2 receptor EP1 subtype; AltName: Full=Prostanoid EP1 receptor [Homo sapiens] |
Related Sequences to LMP000323 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:38505194 | GenBank | AAB27654.1 | 402 | putative prostanoid receptor [Homo sapiens] |
| GI:38505194 | GenBank | AAC37539.1 | 402 | prostaglandin receptor ep1 subtype [Homo sapiens] |
| GI:38505194 | GenBank | AAE36323.1 | 402 | Sequence 4 from patent US 5985597 |
| GI:38505194 | GenBank | AAN27284.1 | 402 | Sequence 4 from patent US 6440680 |
| GI:38505194 | GenBank | AAP32302.1 | 402 | prostaglandin E receptor 1 subtype EP1 [Homo sapiens] |
| GI:38505194 | RefSeq | XP_004060215.1 | 402 | PREDICTED: prostaglandin E2 receptor EP1 subtype [Gorilla gorilla gorilla] |