Gene/Proteome Database (LMPD)

LMPD ID
LMP000333
Gene ID
301
Species
Homo sapiens (Human)
Gene Name
annexin A1
Gene Symbol
ANXA1
Synonyms
ANX1; LPC1
Alternate Names
annexin A1; p35; annexin-1; calpactin-2; calpactin II; lipocortin I; chromobindin-9; annexin I (lipocortin I); phospholipase A2 inhibitory protein
Chromosome
9
Map Location
9q21.13
Summary
Annexin I belongs to a family of Ca(2+)-dependent phospholipid binding proteins which have a molecular weight of approximately 35,000 to 40,000 and are preferentially located on the cytosolic face of the plasma membrane. Annexin I protein has an apparent relative molecular mass of 40 kDa, with phospholipase A2 inhibitory activity. Since phospholipase A2 is required for the biosynthesis of the potent mediators of inflammation, prostaglandins and leukotrienes, annexin I may have potential anti-inflammatory activity. [provided by RefSeq, Jul 2008]
Orthologs
View orthologs and multiple alignments for ANXA1

Proteins

annexin A1
Refseq ID NP_000691
Protein GI 4502101
UniProt ID P04083
mRNA ID NM_000700
Length 346
RefSeq Status REVIEWED
MAMVSEFLKQAWFIENEEQEYVQTVKSSKGGPGSAVSPYPTFNPSSDVAALHKAIMVKGVDEATIIDILTKRNNAQRQQIKAAYLQETGKPLDETLKKALTGHLEEVVLALLKTPAQFDADELRAAMKGLGTDEDTLIEILASRTNKEIRDINRVYREELKRDLAKDITSDTSGDFRNALLSLAKGDRSEDFGVNEDLADSDARALYEAGERRKGTDVNVFNTILTTRSYPQLRRVFQKYTKYSKHDMNKVLDLELKGDIEKCLTAIVKCATSKPAFFAEKLHQAMKGVGTRHKALIRIMVSRSEIDMNDIKAFYQKMYGISLCQAILDETKGDYEKILVALCGGN

Gene Information

Entrez Gene ID
301
Gene Name
annexin A1
Gene Symbol
ANXA1
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0009986 IDA:BHF-UCL C cell surface
GO:0005929 IEA:UniProtKB-KW C cilium
GO:0001533 IDA:UniProtKB C cornified envelope
GO:0005737 TAS:UniProtKB C cytoplasm
GO:0005768 IDA:UniProtKB C endosome
GO:0005576 TAS:Reactome C extracellular region
GO:0005615 IDA:UniProt C extracellular space
GO:0070062 IDA:UniProtKB C extracellular vesicular exosome
GO:0005925 IDA:UniProtKB C focal adhesion
GO:0031966 IEA:Ensembl C mitochondrial membrane
GO:0005634 IDA:BHF-UCL C nucleus
GO:0005886 IDA:HPA C plasma membrane
GO:0043234 IEA:Ensembl C protein complex
GO:0042383 IEA:Ensembl C sarcolemma
GO:0031982 IDA:UniProtKB C vesicle
GO:0005509 TAS:ProtInc F calcium ion binding
GO:0005544 IDA:UniProtKB F calcium-dependent phospholipid binding
GO:0048306 IPI:AgBase F calcium-dependent protein binding
GO:0019834 IDA:UniProtKB F phospholipase A2 inhibitor activity
GO:0005543 TAS:ProtInc F phospholipid binding
GO:0030674 IDA:UniProtKB F protein binding, bridging
GO:0005102 TAS:ProtInc F receptor binding
GO:0005198 IDA:UniProtKB F structural molecule activity
GO:0046632 ISS:BHF-UCL P alpha-beta T cell differentiation
GO:0050482 IEA:Ensembl P arachidonic acid secretion
GO:0007166 TAS:ProtInc P cell surface receptor signaling pathway
GO:0006928 TAS:ProtInc P cellular component movement
GO:0071385 IDA:BHF-UCL P cellular response to glucocorticoid stimulus
GO:0070301 IEA:Ensembl P cellular response to hydrogen peroxide
GO:0031018 IEA:Ensembl P endocrine pancreas development
GO:0060206 IEA:Ensembl P estrous cycle phase
GO:0042063 IEA:Ensembl P gliogenesis
GO:0070365 IEA:Ensembl P hepatocyte differentiation
GO:0006954 TAS:ProtInc P inflammatory response
GO:0030073 IEA:Ensembl P insulin secretion
GO:0030216 IDA:UniProtKB P keratinocyte differentiation
GO:0002674 IEA:Ensembl P negative regulation of acute inflammatory response
GO:0043066 TAS:UniProtKB P negative regulation of apoptotic process
GO:0043086 IDA:GOC P negative regulation of catalytic activity
GO:2000483 IMP:BHF-UCL P negative regulation of interleukin-8 secretion
GO:0097350 IMP:BHF-UCL P neutrophil clearance
GO:0001780 IMP:BHF-UCL P neutrophil homeostasis
GO:0018149 IDA:UniProtKB P peptide cross-linking
GO:1900087 IEA:Ensembl P positive regulation of G1/S transition of mitotic cell cycle
GO:0033031 IEA:Ensembl P positive regulation of neutrophil apoptotic process
GO:0031394 IEA:Ensembl P positive regulation of prostaglandin biosynthetic process
GO:0031340 IDA:UniProtKB P positive regulation of vesicle fusion
GO:0042127 IEA:Ensembl P regulation of cell proliferation
GO:0010165 IEA:Ensembl P response to X-ray
GO:0042493 IEA:Ensembl P response to drug
GO:0032355 IEA:Ensembl P response to estradiol
GO:0070555 IEA:Ensembl P response to interleukin-1
GO:0043434 IEA:Ensembl P response to peptide hormone
GO:0007165 TAS:UniProtKB P signal transduction

Domain Information

InterPro Annotations

Accession Description
IPR001464 Annexin
IPR018252 Annexin repeat, conserved site
IPR002388 Annexin, type I
IPR018502 Annexin_repeat

UniProt Annotations

Entry Information

Gene Name
annexin A1
Protein Entry
ANXA1_HUMAN
UniProt ID
P04083
Species
Human

Comments

Comment Type Description
Domain A pair of annexin repeats may form one binding site for calcium and phospholipid.
Function Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. This protein regulates phospholipase A2 activity. It seems to bind from two to four calcium ions with high affinity.
Interaction Q9Y6K9:IKBKG; NbExp=6; IntAct=EBI-354007, EBI-81279; Q13546:RIPK1; NbExp=5; IntAct=EBI-354007, EBI-358507;
Ptm Phosphorylated by protein kinase C, epidermal growth factor receptor/kinase and TRPM7. Phosphorylation results in loss of the inhibitory activity. {ECO
Similarity Belongs to the annexin family.
Similarity Contains 4 annexin repeats.
Subcellular Location Nucleus . Cytoplasm {ECO
Subunit Homodimer in placenta (20%); linked by transglutamylation. Interacts with DYSF (By similarity).
Web Resource Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/ANXA1ID653ch9q21.html";

Identical and Related Proteins

Unique RefSeq proteins for LMP000333 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
4502101 RefSeq NP_000691 346 annexin A1

Identical Sequences to LMP000333 proteins

Reference Database Accession Length Protein Name
GI:4502101 GenBank AFX11675.1 346 Sequence 7 from patent US 8293522
GI:4502101 GenBank AGU04121.1 346 Sequence 12 from patent US 8476008
GI:4502101 GenBank AHD70318.1 346 Sequence 2993 from patent US 8586006
GI:4502101 GenBank AIC54004.1 346 ANXA1, partial [synthetic construct]
GI:4502101 GenBank AIC54005.1 346 ANXA1, partial [synthetic construct]
GI:4502101 RefSeq XP_009454957.1 346 PREDICTED: annexin A1 isoform X1 [Pan troglodytes]

Related Sequences to LMP000333 proteins

Reference Database Accession Length Protein Name
GI:4502101 GenBank AAX42867.1 347 annexin A1, partial [synthetic construct]
GI:4502101 GenBank AAX42869.1 347 annexin A1, partial [synthetic construct]
GI:4502101 GenBank AAX43650.1 347 annexin A1, partial [synthetic construct]
GI:4502101 GenBank ACM86036.1 370 Sequence 11534 from patent US 6812339
GI:4502101 pat US 363 Sequence 4 from Patent US 4874743
GI:4502101 pat WO 363 Sequence 2 from Patent WO 8604094