Gene/Proteome Database (LMPD)
LMPD ID
LMP000336
Gene ID
Species
Homo sapiens (Human)
Gene Name
annexin A3
Gene Symbol
Synonyms
ANX3
Alternate Names
annexin A3; PAP-III; annexin-3; lipocortin III; 35-alpha calcimedin; calcimedin 35-alpha; Annexin III (lipocortin III); placental anticoagulant protein III; inositol 1,2-cyclic phosphate 2-phosphohydrolase; annexin III (lipocortin III, 1,2-cyclic-inositol-phosphate phosphodiesterase, placental anticoagulant protein III, calcimedin 35-alpha)
Chromosome
4
Map Location
4q21.21
Summary
This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions in the inhibition of phopholipase A2 and cleavage of inositol 1,2-cyclic phosphate to form inositol 1-phosphate. This protein may also play a role in anti-coagulation. [provided by RefSeq, Jul 2008]
Orthologs
Proteins
| annexin A3 | |
|---|---|
| Refseq ID | NP_005130 |
| Protein GI | 4826643 |
| UniProt ID | P12429 |
| mRNA ID | NM_005139 |
| Length | 323 |
| RefSeq Status | REVIEWED |
| MASIWVGHRGTVRDYPDFSPSVDAEAIQKAIRGIGTDEKMLISILTERSNAQRQLIVKEYQAAYGKELKDDLKGDLSGHFEHLMVALVTPPAVFDAKQLKKSMKGAGTNEDALIEILTTRTSRQMKDISQAYYTVYKKSLGDDISSETSGDFRKALLTLADGRRDESLKVDEHLAKQDAQILYKAGENRWGTDEDKFTEILCLRSFPQLKLTFDEYRNISQKDIVDSIKGELSGHFEDLLLAIVNCVRNTPAFLAERLHRALKGIGTDEFTLNRIMVSRSEIDLLDIRTEFKKHYGYSLYSAIKSDTSGDYEITLLKICGGDD | |
Gene Information
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005737 | IDA:UniProtKB | C | cytoplasm |
| GO:0070062 | IDA:UniProtKB | C | extracellular vesicular exosome |
| GO:0016020 | IDA:UniProtKB | C | membrane |
| GO:0030670 | IDA:UniProtKB | C | phagocytic vesicle membrane |
| GO:0005886 | IDA:UniProtKB | C | plasma membrane |
| GO:0042581 | IDA:UniProtKB | C | specific granule |
| GO:0005509 | IEA:InterPro | F | calcium ion binding |
| GO:0005544 | IDA:UniProtKB | F | calcium-dependent phospholipid binding |
| GO:0048306 | IPI:AgBase | F | calcium-dependent protein binding |
| GO:0019834 | IEA:UniProtKB-KW | F | phospholipase A2 inhibitor activity |
| GO:0042742 | IDA:UniProtKB | P | defense response to bacterium |
| GO:0043312 | IDA:UniProtKB | P | neutrophil degranulation |
| GO:0006909 | IDA:UniProtKB | P | phagocytosis |
| GO:0045766 | IDA:UniProtKB | P | positive regulation of angiogenesis |
| GO:0010595 | IDA:UniProtKB | P | positive regulation of endothelial cell migration |
| GO:0051091 | IDA:UniProtKB | P | positive regulation of sequence-specific DNA binding transcription factor activity |
Domain Information
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Domain | A pair of annexin repeats may form one binding site for calcium and phospholipid. |
| Function | Inhibitor of phospholipase A2, also possesses anti- coagulant properties. Also cleaves the cyclic bond of inositol 1,2-cyclic phosphate to form inositol 1-phosphate. |
| Similarity | Belongs to the annexin family. |
| Similarity | Contains 4 annexin repeats. |
Identical and Related Proteins
Unique RefSeq proteins for LMP000336 (as displayed in Record Overview)
Identical Sequences to LMP000336 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:4826643 | GenBank | AEN36348.1 | 323 | Sequence 2276 from patent US 7998689 |
| GI:4826643 | GenBank | AEN36349.1 | 323 | Sequence 2277 from patent US 7998689 |
| GI:4826643 | GenBank | AFX11684.1 | 323 | Sequence 16 from patent US 8293522 |
| GI:4826643 | GenBank | AGU04118.1 | 323 | Sequence 9 from patent US 8476008 |
| GI:4826643 | GenBank | AHD78298.1 | 323 | Sequence 26296 from patent US 8586006 |
| GI:4826643 | RefSeq | XP_005263030.1 | 323 | PREDICTED: annexin A3 isoform X1 [Homo sapiens] |
Related Sequences to LMP000336 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:4826643 | EMBL | CAG28576.1 | 323 | ANXA3, partial [Homo sapiens] |
| GI:4826643 | GenBank | AAO99127.1 | 323 | Sequence 5 from patent US 6511829 |
| GI:4826643 | GenBank | ACM82454.1 | 334 | Sequence 7952 from patent US 6812339 |
| GI:4826643 | GenBank | ADQ32626.1 | 323 | annexin A3, partial [synthetic construct] |
| GI:4826643 | PDB | 1AXN | 323 | Chain A, The High Resolution Structure Of Annexin Iii Shows Differences With Annexin V |
| GI:4826643 | RefSeq | XP_004038920.1 | 323 | PREDICTED: annexin A3 [Gorilla gorilla gorilla] |