Gene/Proteome Database (LMPD)

LMPD ID
LMP000338
Gene ID
14933
Species
Mus musculus (Mouse)
Gene Name
glycerol kinase
Gene Symbol
Gyk
Synonyms
D930012N15Rik; GK
Chromosome
X
Map Location
X C-D|X 39.32 cM

Proteins

glycerol kinase isoform 1
Refseq ID NP_032220
Protein GI 6680139
UniProt ID Q64516
mRNA ID NM_008194
Length 524
RefSeq Status VALIDATED
MAAAKKAVLGPLVGAVDQGTSSTRFLVFNSKTAELLSHHQVEIKQEFPREGWVEQDPKEILQSVYECIEKTCEKLGQLNIDISNIKAIGVSNQRETTVVWDKVTGEPLYNAVVWLDLRTQSTVENLSKRIPGNNNFVKSKTGLPLSTYFSAVKLRWLLDNVKKVQEAVEENRALFGTIDSWLIWSLTGGIHGGVHCTDVTNASRTMLFNIHSLEWDKELCEFFGIPMEILPNVRSSSEIYGLMKAGALEGVPISGCLGDQSAALVGQMCFQDGQAKNTYGTGCFLLCNTGHKCVFSEHGLLTTVAYKLGRDKPVYYALEGSVAIAGAVIRWLRDNLGIIKSSEEIEKLAKEVGTSYGCYFVPAFSGLYAPYWEPSARGIICGLTQFTNKCHIAFAALEAVCFQTREILDAMNRDCGIPLSHLQVDGGMTSNKILMQLQADILYIPVVKPSMPETTALGAAMAAGAAEGVGVWSLEPEDLSAVTMERFEPQINAEESEIRYSTWKKAVMKSIGWVTTQSPESGIP
glycerol kinase isoform 2
Refseq ID NP_997609
Protein GI 46909579
UniProt ID Q64516
mRNA ID NM_212444
Length 553
RefSeq Status VALIDATED
MAAAKKAVLGPLVGAVDQGTSSTRFLVFNSKTAELLSHHQVEIKQEFPREGWVEQDPKEILQSVYECIEKTCEKLGQLNIDISNIKAIGVSNQRETTVVWDKVTGEPLYNAVVWLDLRTQSTVENLSKRIPGNNNFVKSKTGLPLSTYFSAVKLRWLLDNVKKVQEAVEENRALFGTIDSWLIWSLTGGIHGGVHCTDVTNASRTMLFNIHSLEWDKELCEFFGIPMEILPNVRSSSEIYGLMKAGALEGVPISGCLGDQSAALVGQMCFQDGQAKNTYGTGCFLLCNTGHKCVFSEHGLLTTVAYKLGRDKPVYYALEGSVAIAGAVIRWLRDNLGIIKSSEEIEKLAKEVGTSYGCYFVPAFSGLYAPYWEPSARGIICGLTQFTNKCHIAFAALEAVCFQTREILDAMNRDCGIPLSHLQVDGGMTSNKILMQLQADILYIPVVKPSMPETTALGAAMAAGAAEGVGVWSLEPEDLSAVTMERFEPQINAEESEIRYSTWKKAVMKSIGWVTTQSPESGDPSIFCSLPLGFFIVSSMVMLIGARYISGIP
glycerol kinase isoform 3
Refseq ID NP_001281067
Protein GI 659066186
UniProt ID Q3TET2
mRNA ID NM_001294138
Length 552
RefSeq Status VALIDATED
MAAAKKAVLGPLVGAVDQGTSSTRFLVFNSKTAELLSHHQVEIKQEFPREGWVEQDPKEILQSVYECIEKTCEKLGQLNIDISNIKAIGVSNQRETTVVWDKVTGEPLYNAVAAPVSPGSSVPVAVVPSGSSVPAAGASSVWLDLRTQSTVENLSKRIPGNNNFVKSKTGLPLSTYFSAVKLRWLLDNVKKVQEAVEENRALFGTIDSWLIWSLTGGIHGGVHCTDVTNASRTMLFNIHSLEWDKELCEFFGIPMEILPNVRSSSEIYGLMKAGALEGVPISGCLGDQSAALVGQMCFQDGQAKNTYGTGCFLLCNTGHKCVFSEHGLLTTVAYKLGRDKPVYYALEGSVAIAGAVIRWLRDNLGIIKSSEEIEKLAKEVGTSYGCYFVPAFSGLYAPYWEPSARGIICGLTQFTNKCHIAFAALEAVCFQTREILDAMNRDCGIPLSHLQVDGGMTSNKILMQLQADILYIPVVKPSMPETTALGAAMAAGAAEGVGVWSLEPEDLSAVTMERFEPQINAEESEIRYSTWKKAVMKSIGWVTTQSPESGIP
glycerol kinase isoform 4
Refseq ID NP_001281069
Protein GI 659066190
UniProt ID Q64516
mRNA ID NM_001294140
Length 559
RefSeq Status VALIDATED
MAAAKKAVLGPLVGAVDQGTSSTRFLVFNSKTAELLSHHQVEIKQEFPREGWVEQDPKEILQSVYECIEKTCEKLGQLNIDISNIKAIGVSNQRETTVVWDKVTGEPLYNAVVWLDLRTQSTVENLSKRIPGNNNFVKSKTGLPLSTYFSAVKLRWLLDNVKKVQEAVEENRALFGTIDSWLIWSLTGGIHGGVHCTDVTNASRTMLFNIHSLEWDKELCEFFGIPMEILPNVRSSSEIYGLMKISHSLKAGALEGVPISGCLGDQSAALVGQMCFQDGQAKNTYGTGCFLLCNTGHKCVFSEHGLLTTVAYKLGRDKPVYYALEGSVAIAGAVIRWLRDNLGIIKSSEEIEKLAKEVGTSYGCYFVPAFSGLYAPYWEPSARGIICGLTQFTNKCHIAFAALEAVCFQTREILDAMNRDCGIPLSHLQVDGGMTSNKILMQLQADILYIPVVKPSMPETTALGAAMAAGAAEGVGVWSLEPEDLSAVTMERFEPQINAEESEIRYSTWKKAVMKSIGWVTTQSPESGDPSIFCSLPLGFFIVSSMVMLIGARYISGIP

Gene Information

Entrez Gene ID
14933
Gene Name
glycerol kinase
Gene Symbol
Gyk
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005829 IDA:MGI C cytosol
GO:0070062 IEA:Ensembl C extracellular vesicular exosome
GO:0005741 IEA:UniProtKB-KW C mitochondrial outer membrane
GO:0005739 IDA:MGI C mitochondrion
GO:0005634 IDA:MGI C nucleus
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0004370 IDA:MGI F glycerol kinase activity
GO:0042593 IMP:MGI P glucose homeostasis
GO:0019563 IEA:UniProtKB-UniPathway P glycerol catabolic process
GO:0006071 IMP:MGI P glycerol metabolic process
GO:0046167 IEA:Ensembl P glycerol-3-phosphate biosynthetic process
GO:0006641 IEA:Ensembl P triglyceride metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
ko00561 Glycerolipid metabolism
mmu00561 Glycerolipid metabolism
mmu01100 Metabolic pathways
ko03320 PPAR signaling pathway
mmu03320 PPAR signaling pathway

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY-4261 glycerol degradation IV

REACTOME Pathway Links

REACTOME Pathway ID Description
5892798 Fatty acid, triacylglycerol, and ketone body metabolism
5892760 Metabolism
5892799 Metabolism of lipids and lipoproteins
5892974 Triglyceride Biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR018485 Carbohydrate kinase, FGGY, C-terminal
IPR018484 Carbohydrate kinase, FGGY, N-terminal
IPR018483 Carbohydrate kinase, FGGY, conserved site
IPR005999 Glycerol kinase

UniProt Annotations

Entry Information

Gene Name
glycerol kinase
Protein Entry
GLPK_MOUSE
UniProt ID
Q64516
Species
Mouse

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=3; Name=3; IsoId=Q64516-3; Sequence=Displayed; Name=2; IsoId=Q64516-2; Sequence=VSP_034650; Name=1; IsoId=Q64516-1; Sequence=VSP_034650, VSP_034651;
Catalytic Activity ATP + glycerol = ADP + sn-glycerol 3- phosphate.
Function Key enzyme in the regulation of glycerol uptake and metabolism. {ECO:0000250}.
Pathway Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.
Similarity Belongs to the FGGY kinase family. {ECO:0000305}.
Subcellular Location Mitochondrion outer membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Bound to the mitochondrial surface or cytoplasmic. {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP000338 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6680139 RefSeq NP_032220 524 glycerol kinase isoform 1
46909579 RefSeq NP_997609 553 glycerol kinase isoform 2
659066186 RefSeq NP_001281067 552 glycerol kinase isoform 3
659066190 RefSeq NP_001281069 559 glycerol kinase isoform 4

Identical Sequences to LMP000338 proteins

Reference Database Accession Length Protein Name
GI:46909579 EMBL CBG09943.1 553 unnamed protein product [Mus musculus]
GI:46909579 EMBL CBG03254.1 553 unnamed protein product [Mus musculus]
GI:46909579 EMBL CBV16774.1 553 unnamed protein product [Mus musculus]
GI:46909579 EMBL CBV23465.1 553 unnamed protein product [Mus musculus]
GI:6680139 GenBank AAC52824.1 524 glycerol kinase [Mus musculus]
GI:6680139 GenBank AAH03767.1 524 Glycerol kinase [Mus musculus]
GI:6680139 GenBank EDL29155.1 524 glycerol kinase, isoform CRA_b [Mus musculus]
GI:46909579 GenBank AGX94619.1 553 Sequence 69507 from patent US 8541208
GI:46909579 GenBank AGY01486.1 553 Sequence 83186 from patent US 8541208
GI:659066190 SwissProt Q64516.2 559 RecName: Full=Glycerol kinase; Short=GK; Short=Glycerokinase; AltName: Full=ATP:glycerol 3-phosphotransferase [Mus musculus]

Related Sequences to LMP000338 proteins

Reference Database Accession Length Protein Name
GI:659066190 DBBJ BAC31861.1 559 unnamed protein product [Mus musculus]
GI:6680139 DBBJ BAC40312.1 553 unnamed protein product [Mus musculus]
GI:659066186 DBBJ BAE41166.1 552 unnamed protein product [Mus musculus]
GI:6680139 EMBL CBG09943.1 553 unnamed protein product [Mus musculus]
GI:6680139 EMBL CBG03254.1 553 unnamed protein product [Mus musculus]
GI:46909579 GenBank EDL29154.1 556 glycerol kinase, isoform CRA_a, partial [Mus musculus]
GI:6680139 GenBank AGX94619.1 553 Sequence 69507 from patent US 8541208
GI:6680139 GenBank AGY01486.1 553 Sequence 83186 from patent US 8541208
GI:6680139 RefSeq NP_997609.1 553 glycerol kinase isoform 2 [Mus musculus]
GI:659066190 RefSeq XP_005080112.1 559 PREDICTED: glycerol kinase isoform X1 [Mesocricetus auratus]
GI:46909579 RefSeq XP_005080113.1 553 PREDICTED: glycerol kinase isoform X2 [Mesocricetus auratus]
GI:659066186 RefSeq XP_005080114.1 552 PREDICTED: glycerol kinase isoform X3 [Mesocricetus auratus]
GI:659066190 RefSeq XP_006257049.1 559 PREDICTED: glycerol kinase isoform X4 [Rattus norvegicus]
GI:46909579 RefSeq XP_006257050.1 553 PREDICTED: glycerol kinase isoform X6 [Rattus norvegicus]
GI:659066186 RefSeq XP_006527892.1 587 PREDICTED: glycerol kinase isoform X1 [Mus musculus]
GI:659066186 RefSeq XP_006527893.1 585 PREDICTED: glycerol kinase isoform X2 [Mus musculus]
GI:659066186 RefSeq XP_006527894.1 581 PREDICTED: glycerol kinase isoform X3 [Mus musculus]
GI:659066186 RefSeq XP_006527896.1 558 PREDICTED: glycerol kinase isoform X5 [Mus musculus]
GI:659066190 RefSeq XP_007646699.1 559 PREDICTED: glycerol kinase isoform X1 [Cricetulus griseus]
GI:46909579 RefSeq XP_007646700.1 553 PREDICTED: glycerol kinase isoform X2 [Cricetulus griseus]
GI:659066190 RefSeq XP_007621135.1 559 PREDICTED: glycerol kinase isoform X1 [Cricetulus griseus]
GI:46909579 RefSeq XP_007621136.1 553 PREDICTED: glycerol kinase isoform X2 [Cricetulus griseus]
GI:659066190 RefSeq XP_008820950.1 559 PREDICTED: glycerol kinase [Nannospalax galili]
GI:46909579 SwissProt Q64516.2 559 RecName: Full=Glycerol kinase; Short=GK; Short=Glycerokinase; AltName: Full=ATP:glycerol 3-phosphotransferase [Mus musculus]