Gene/Proteome Database (LMPD)
LMPD ID
LMP000362
Gene ID
Species
Homo sapiens (Human)
Gene Name
glycerol-3-phosphate acyltransferase, mitochondrial
Gene Symbol
Synonyms
GPAT; GPAT1
Chromosome
10
Map Location
10q25.2
Summary
This gene encodes a mitochondrial enzyme which prefers saturated fatty acids as its substrate for the synthesis of glycerolipids. This metabolic pathway's first step is catalyzed by the encoded enzyme. Two forms for this enzyme exist, one in the mitochondria and one in the endoplasmic reticulum. Two alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Oct 2011]
Orthologs
Proteins
| glycerol-3-phosphate acyltransferase 1, mitochondrial precursor | |
|---|---|
| Refseq ID | NP_065969 |
| Protein GI | 190358539 |
| UniProt ID | Q86T70 |
| mRNA ID | NM_020918 |
| Length | 828 |
| RefSeq Status | REVIEWED |
| MDESALTLGTIDVSYLPHSSEYSVGRCKHTSEEWGECGFRPTIFRSATLKWKESLMSRKRPFVGRCCYSCTPQSWDKFFNPSIPSLGLRNVIYINETHTRHRGWLARRLSYVLFIQERDVHKGMFATNVTENVLNSSRVQEAIAEVAAELNPDGSAQQQSKAVNKVKKKAKRILQEMVATVSPAMIRLTGWVLLKLFNSFFWNIQIHKGQLEMVKAATETNLPLLFLPVHRSHIDYLLLTFILFCHNIKAPYIASGNNLNIPIFSTLIHKLGGFFIRRRLDETPDGRKDVLYRALLHGHIVELLRQQQFLEIFLEGTRSRSGKTSCARAGLLSVVVDTLSTNVIPDILIIPVGISYDRIIEGHYNGEQLGKPKKNESLWSVARGVIRMLRKNYGCVRVDFAQPFSLKEYLESQSQKPVSALLSLEQALLPAILPSRPSDAADEGRDTSINESRNATDESLRRRLIANLAEHILFTASKSCAIMSTHIVACLLLYRHRQGIDLSTLVEDFFVMKEEVLARDFDLGFSGNSEDVVMHAIQLLGNCVTITHTSRNDEFFITPSTTVPSVFELNFYSNGVLHVFIMEAIIACSLYAVLNKRGLGGPTSTPPNLISQEQLVRKAASLCYLLSNEGTISLPCQTFYQVCHETVGKFIQYGILTVAEHDDQEDISPSLAEQQWDKKLPEPLSWRSDEEDEDSDFGEEQRDCYLKVSQSKEHQQFITFLQRLLGPLLEAYSSAAIFVHNFSGPVPEPEYLQKLHKYLITRTERNVAVYAESATYCLVKNAVKMFKDIGVFKETKQKRVSVLELSSTFLPQCNRQKLLEYILSFVVL | |
| glycerol-3-phosphate acyltransferase 1, mitochondrial precursor | |
|---|---|
| Refseq ID | NP_001231878 |
| Protein GI | 350276140 |
| UniProt ID | Q86T70 |
| mRNA ID | NM_001244949 |
| Length | 828 |
| RefSeq Status | REVIEWED |
| Protein sequence is identical to GI:190358539 (mRNA isoform) | |
Gene Information
Entrez Gene ID
Gene Name
glycerol-3-phosphate acyltransferase, mitochondrial
Gene Symbol
Species
Homo sapiens
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005886 | IEA:InterPro | C | plasma membrane |
| GO:0004366 | IEA:InterPro | F | glycerol-3-phosphate O-acyltransferase activity |
| GO:0008654 | IEA:InterPro | P | phospholipid biosynthetic process |
REACTOME Pathway Links
| REACTOME Pathway ID | Description |
|---|---|
| REACT_147904 | Activation of gene expression by SREBF (SREBP) |
| REACT_120906 | Synthesis of PA |
Domain Information
UniProt Annotations
Entry Information
Gene Name
glycerol-3-phosphate acyltransferase, mitochondrial
Protein Entry
GPAT1_HUMAN
UniProt ID
Species
Human
Identical and Related Proteins
Unique RefSeq proteins for LMP000362 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 190358539 | RefSeq | NP_065969 | 828 | glycerol-3-phosphate acyltransferase 1, mitochondrial precursor |
Identical Sequences to LMP000362 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:190358539 | GenBank | EAW49544.1 | 828 | glycerol-3-phosphate acyltransferase, mitochondrial, isoform CRA_b [Homo sapiens] |
| GI:190358539 | RefSeq | NP_001231878.1 | 828 | glycerol-3-phosphate acyltransferase 1, mitochondrial precursor [Homo sapiens] |
| GI:190358539 | RefSeq | XP_005270055.1 | 828 | PREDICTED: glycerol-3-phosphate acyltransferase 1, mitochondrial isoform X1 [Homo sapiens] |
| GI:190358539 | SwissProt | Q9HCL2.3 | 828 | RecName: Full=Glycerol-3-phosphate acyltransferase 1, mitochondrial; Short=GPAT-1; Flags: Precursor [Homo sapiens] |
Related Sequences to LMP000362 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:190358539 | DBBJ | BAD18772.1 | 828 | unnamed protein product [Homo sapiens] |
| GI:190358539 | EMBL | CAD35486.1 | 828 | unnamed protein product [Homo sapiens] |
| GI:190358539 | EMBL | CAD89932.1 | 828 | hypothetical protein [Homo sapiens] |
| GI:190358539 | GenBank | ABH86318.1 | 828 | Sequence 2 from patent US 7052888 |
| GI:190358539 | GenBank | ACH30243.1 | 828 | Sequence 2 from patent US 7410785 |
| GI:190358539 | GenBank | ADS79856.1 | 828 | Sequence 2 from patent US 7820403 |