Gene/Proteome Database (LMPD)
LMPD ID
LMP000363
Gene ID
Species
Mus musculus (Mouse)
Gene Name
glycerol phosphate dehydrogenase 2, mitochondrial
Gene Symbol
Synonyms
AA408484; AI448216; AU021455; AW494132; GPDH; Gdm1; Gpd-m; Gpdh-m; TISP38
Alternate Names
glycerol-3-phosphate dehydrogenase, mitochondrial; FAD-linked glycerol-3-phosphate dehydrogenase; glycerol phosphate dehydrogenase 1, mitochondrial; glycerol-3-phosphate dehydrogenase 2, mitochondrial
Chromosome
2
Map Location
2 C1.1|2 31.66 cM
EC Number
1.1.5.3
Proteins
| glycerol-3-phosphate dehydrogenase, mitochondrial precursor | |
|---|---|
| Refseq ID | NP_034404 |
| Protein GI | 224922803 |
| UniProt ID | Q64521 |
| mRNA ID | NM_010274 |
| Length | 727 |
| RefSeq Status | VALIDATED |
| MAFQKAVKGTILVGGGALATVLGLSPFAHYRRKQVSLAYVEAAGYLTEPVNREPPSREAQLMTLKNTPEFDILVIGGGATGCGCALDAVTRGLKTALVERDDFSSGTSSRSTKLIHGGVRYLQKAIMNLDVEQYRMVKEALHERANLLEIAPHLSAPLPIMLPLYKWWQLPYYWVGIKMYDLVAGSQCLKSSYVLSKSRALEHFPMLQKDKLVGAIVYYDGQHNDARMNLAIALTAARYGAATANYMEVVSLLKKTDPETGKERVSGARCKDVLTGQEFDVRAKCVINASGPFTDSVRKMDDKNVVPICQPSAGVHIVMPGYYSPENMGLLDPATSDGRVIFFLPWEKMTIAGTTDTPTDVTHHPIPSEEDINFILNEVRNYLSSDVEVRRGDVLAAWSGIRPLVTDPKSADTQSISRNHVVDISDSGLITIAGGKWTTYRSMAEDTVDAAVKFHNLNAGPSRTVGLFLQGGKDWSPTLYIRLVQDYGLESEVAQHLAKTYGDKAFEVAKMASVTGKRWPVVGVRLVSEFPYIEAEVKYGIKEYACTAVDMISRRTRLAFLNVQAAEEALPRIVELMGRELNWSELRKQEELETATRFLYYEMGYKSRTEQLTDSTEISLLPSDIDRYKKRFHKFDEDEKGFITIVDVQRVLESINVQMDENTLHEILCEVDLNKNGQVELHEFLQLMSAVQKGRVSGSRLAILMKTAEENLDRRVPIPVDRSCGGL | |
| transit_peptide: 1..42 inference: non-experimental evidence, no additional details recorded note: Mitochondrion (By similarity); propagated from UniProtKB/Swiss-Prot (Q64521.2) calculated_mol_wt: 4420 peptide sequence: MAFQKAVKGTILVGGGALATVLGLSPFAHYRRKQVSLAYVEA mat_peptide: 43..727 product: Glycerol-3-phosphate dehydrogenase, mitochondrial experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q64521.2) calculated_mol_wt: 76552 peptide sequence: AGYLTEPVNREPPSREAQLMTLKNTPEFDILVIGGGATGCGCALDAVTRGLKTALVERDDFSSGTSSRSTKLIHGGVRYLQKAIMNLDVEQYRMVKEALHERANLLEIAPHLSAPLPIMLPLYKWWQLPYYWVGIKMYDLVAGSQCLKSSYVLSKSRALEHFPMLQKDKLVGAIVYYDGQHNDARMNLAIALTAARYGAATANYMEVVSLLKKTDPETGKERVSGARCKDVLTGQEFDVRAKCVINASGPFTDSVRKMDDKNVVPICQPSAGVHIVMPGYYSPENMGLLDPATSDGRVIFFLPWEKMTIAGTTDTPTDVTHHPIPSEEDINFILNEVRNYLSSDVEVRRGDVLAAWSGIRPLVTDPKSADTQSISRNHVVDISDSGLITIAGGKWTTYRSMAEDTVDAAVKFHNLNAGPSRTVGLFLQGGKDWSPTLYIRLVQDYGLESEVAQHLAKTYGDKAFEVAKMASVTGKRWPVVGVRLVSEFPYIEAEVKYGIKEYACTAVDMISRRTRLAFLNVQAAEEALPRIVELMGRELNWSELRKQEELETATRFLYYEMGYKSRTEQLTDSTEISLLPSDIDRYKKRFHKFDEDEKGFITIVDVQRVLESINVQMDENTLHEILCEVDLNKNGQVELHEFLQLMSAVQKGRVSGSRLAILMKTAEENLDRRVPIPVDRSCGGL transit_peptide: 1..42 inference: non-experimental evidence, no additional details recorded note: Mitochondrion (By similarity); propagated from UniProtKB/Swiss-Prot (Q64521.2) calculated_mol_wt: 4420 peptide sequence: MAFQKAVKGTILVGGGALATVLGLSPFAHYRRKQVSLAYVEA mat_peptide: 43..727 product: Glycerol-3-phosphate dehydrogenase, mitochondrial experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q64521.2) calculated_mol_wt: 76552 peptide sequence: AGYLTEPVNREPPSREAQLMTLKNTPEFDILVIGGGATGCGCALDAVTRGLKTALVERDDFSSGTSSRSTKLIHGGVRYLQKAIMNLDVEQYRMVKEALHERANLLEIAPHLSAPLPIMLPLYKWWQLPYYWVGIKMYDLVAGSQCLKSSYVLSKSRALEHFPMLQKDKLVGAIVYYDGQHNDARMNLAIALTAARYGAATANYMEVVSLLKKTDPETGKERVSGARCKDVLTGQEFDVRAKCVINASGPFTDSVRKMDDKNVVPICQPSAGVHIVMPGYYSPENMGLLDPATSDGRVIFFLPWEKMTIAGTTDTPTDVTHHPIPSEEDINFILNEVRNYLSSDVEVRRGDVLAAWSGIRPLVTDPKSADTQSISRNHVVDISDSGLITIAGGKWTTYRSMAEDTVDAAVKFHNLNAGPSRTVGLFLQGGKDWSPTLYIRLVQDYGLESEVAQHLAKTYGDKAFEVAKMASVTGKRWPVVGVRLVSEFPYIEAEVKYGIKEYACTAVDMISRRTRLAFLNVQAAEEALPRIVELMGRELNWSELRKQEELETATRFLYYEMGYKSRTEQLTDSTEISLLPSDIDRYKKRFHKFDEDEKGFITIVDVQRVLESINVQMDENTLHEILCEVDLNKNGQVELHEFLQLMSAVQKGRVSGSRLAILMKTAEENLDRRVPIPVDRSCGGL | |
| glycerol-3-phosphate dehydrogenase, mitochondrial precursor | |
|---|---|
| Refseq ID | NP_034404 |
| Protein GI | 224922803 |
| UniProt ID | Q64521 |
| mRNA ID | NM_010274 |
| Length | 727 |
| RefSeq Status | VALIDATED |
| MAFQKAVKGTILVGGGALATVLGLSPFAHYRRKQVSLAYVEAAGYLTEPVNREPPSREAQLMTLKNTPEFDILVIGGGATGCGCALDAVTRGLKTALVERDDFSSGTSSRSTKLIHGGVRYLQKAIMNLDVEQYRMVKEALHERANLLEIAPHLSAPLPIMLPLYKWWQLPYYWVGIKMYDLVAGSQCLKSSYVLSKSRALEHFPMLQKDKLVGAIVYYDGQHNDARMNLAIALTAARYGAATANYMEVVSLLKKTDPETGKERVSGARCKDVLTGQEFDVRAKCVINASGPFTDSVRKMDDKNVVPICQPSAGVHIVMPGYYSPENMGLLDPATSDGRVIFFLPWEKMTIAGTTDTPTDVTHHPIPSEEDINFILNEVRNYLSSDVEVRRGDVLAAWSGIRPLVTDPKSADTQSISRNHVVDISDSGLITIAGGKWTTYRSMAEDTVDAAVKFHNLNAGPSRTVGLFLQGGKDWSPTLYIRLVQDYGLESEVAQHLAKTYGDKAFEVAKMASVTGKRWPVVGVRLVSEFPYIEAEVKYGIKEYACTAVDMISRRTRLAFLNVQAAEEALPRIVELMGRELNWSELRKQEELETATRFLYYEMGYKSRTEQLTDSTEISLLPSDIDRYKKRFHKFDEDEKGFITIVDVQRVLESINVQMDENTLHEILCEVDLNKNGQVELHEFLQLMSAVQKGRVSGSRLAILMKTAEENLDRRVPIPVDRSCGGL | |
| transit_peptide: 1..42 inference: non-experimental evidence, no additional details recorded note: Mitochondrion (By similarity); propagated from UniProtKB/Swiss-Prot (Q64521.2) calculated_mol_wt: 4420 peptide sequence: MAFQKAVKGTILVGGGALATVLGLSPFAHYRRKQVSLAYVEA mat_peptide: 43..727 product: Glycerol-3-phosphate dehydrogenase, mitochondrial experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q64521.2) calculated_mol_wt: 76552 peptide sequence: AGYLTEPVNREPPSREAQLMTLKNTPEFDILVIGGGATGCGCALDAVTRGLKTALVERDDFSSGTSSRSTKLIHGGVRYLQKAIMNLDVEQYRMVKEALHERANLLEIAPHLSAPLPIMLPLYKWWQLPYYWVGIKMYDLVAGSQCLKSSYVLSKSRALEHFPMLQKDKLVGAIVYYDGQHNDARMNLAIALTAARYGAATANYMEVVSLLKKTDPETGKERVSGARCKDVLTGQEFDVRAKCVINASGPFTDSVRKMDDKNVVPICQPSAGVHIVMPGYYSPENMGLLDPATSDGRVIFFLPWEKMTIAGTTDTPTDVTHHPIPSEEDINFILNEVRNYLSSDVEVRRGDVLAAWSGIRPLVTDPKSADTQSISRNHVVDISDSGLITIAGGKWTTYRSMAEDTVDAAVKFHNLNAGPSRTVGLFLQGGKDWSPTLYIRLVQDYGLESEVAQHLAKTYGDKAFEVAKMASVTGKRWPVVGVRLVSEFPYIEAEVKYGIKEYACTAVDMISRRTRLAFLNVQAAEEALPRIVELMGRELNWSELRKQEELETATRFLYYEMGYKSRTEQLTDSTEISLLPSDIDRYKKRFHKFDEDEKGFITIVDVQRVLESINVQMDENTLHEILCEVDLNKNGQVELHEFLQLMSAVQKGRVSGSRLAILMKTAEENLDRRVPIPVDRSCGGL transit_peptide: 1..42 inference: non-experimental evidence, no additional details recorded note: Mitochondrion (By similarity); propagated from UniProtKB/Swiss-Prot (Q64521.2) calculated_mol_wt: 4420 peptide sequence: MAFQKAVKGTILVGGGALATVLGLSPFAHYRRKQVSLAYVEA mat_peptide: 43..727 product: Glycerol-3-phosphate dehydrogenase, mitochondrial experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q64521.2) calculated_mol_wt: 76552 peptide sequence: AGYLTEPVNREPPSREAQLMTLKNTPEFDILVIGGGATGCGCALDAVTRGLKTALVERDDFSSGTSSRSTKLIHGGVRYLQKAIMNLDVEQYRMVKEALHERANLLEIAPHLSAPLPIMLPLYKWWQLPYYWVGIKMYDLVAGSQCLKSSYVLSKSRALEHFPMLQKDKLVGAIVYYDGQHNDARMNLAIALTAARYGAATANYMEVVSLLKKTDPETGKERVSGARCKDVLTGQEFDVRAKCVINASGPFTDSVRKMDDKNVVPICQPSAGVHIVMPGYYSPENMGLLDPATSDGRVIFFLPWEKMTIAGTTDTPTDVTHHPIPSEEDINFILNEVRNYLSSDVEVRRGDVLAAWSGIRPLVTDPKSADTQSISRNHVVDISDSGLITIAGGKWTTYRSMAEDTVDAAVKFHNLNAGPSRTVGLFLQGGKDWSPTLYIRLVQDYGLESEVAQHLAKTYGDKAFEVAKMASVTGKRWPVVGVRLVSEFPYIEAEVKYGIKEYACTAVDMISRRTRLAFLNVQAAEEALPRIVELMGRELNWSELRKQEELETATRFLYYEMGYKSRTEQLTDSTEISLLPSDIDRYKKRFHKFDEDEKGFITIVDVQRVLESINVQMDENTLHEILCEVDLNKNGQVELHEFLQLMSAVQKGRVSGSRLAILMKTAEENLDRRVPIPVDRSCGGL | |
| glycerol-3-phosphate dehydrogenase, mitochondrial precursor | |
|---|---|
| Refseq ID | NP_001139292 |
| Protein GI | 224922806 |
| UniProt ID | Q64521 |
| mRNA ID | NM_001145820 |
| Length | 727 |
| RefSeq Status | VALIDATED |
| Protein sequence is identical to GI:224922803 (mRNA isoform) | |
| glycerol-3-phosphate dehydrogenase, mitochondrial precursor | |
|---|---|
| Refseq ID | NP_001139292 |
| Protein GI | 224922806 |
| UniProt ID | Q64521 |
| mRNA ID | NM_001145820 |
| Length | 727 |
| RefSeq Status | VALIDATED |
| Protein sequence is identical to GI:224922803 (mRNA isoform) | |
Gene Information
Entrez Gene ID
Gene Name
glycerol phosphate dehydrogenase 2, mitochondrial
Gene Symbol
Species
Mus musculus
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0009331 | TAS:MGI | C | glycerol-3-phosphate dehydrogenase complex |
| GO:0005743 | IDA:MGI | C | mitochondrial inner membrane |
| GO:0005739 | IDA:MGI | C | mitochondrion |
| GO:0005509 | IEA:InterPro | F | calcium ion binding |
| GO:0052591 | IEA:UniProtKB-EC | F | sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity |
| GO:0043010 | IGI:MGI | P | camera-type eye development |
| GO:0006094 | IMP:MGI | P | gluconeogenesis |
| GO:0019563 | IEA:UniProtKB-UniPathway | P | glycerol catabolic process |
| GO:0006072 | IMP:MGI | P | glycerol-3-phosphate metabolic process |
| GO:0035264 | IGI:MGI | P | multicellular organism growth |
KEGG Pathway Links
| KEGG Pathway ID | Description |
|---|---|
| mmu00564 | Glycerophospholipid metabolism |
BIOCYC Pathway Links
| BIOCYC Pathway ID | Description |
|---|---|
| AERESPDON-PWY | aerobic respiration -- electron donors reaction list |
| PWY-6118 | glycerol-3-phosphate shuttle |
Domain Information
UniProt Annotations
Entry Information
Gene Name
glycerol phosphate dehydrogenase 2, mitochondrial
Protein Entry
GPDM_MOUSE
UniProt ID
Species
Mouse
Comments
| Comment Type | Description |
|---|---|
| Catalytic Activity | sn-glycerol 3-phosphate + a quinone = glycerone phosphate + a quinol. |
| Cofactor | Name=FAD; Xref=ChEBI:CHEBI:57692; |
| Enzyme Regulation | Calcium-binding enhance the activity of the enzyme. |
| Pathway | Polyol metabolism; glycerol degradation via glycerol kinase pathway; glycerone phosphate from sn-glycerol 3-phosphate (anaerobic route): step 1/1. |
| Similarity | Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family. {ECO:0000305}. |
| Similarity | Contains 2 EF-hand domains. {ECO:0000255|PROSITE- ProRule:PRU00448}. |
| Subcellular Location | Mitochondrion inner membrane. |
Identical and Related Proteins
Unique RefSeq proteins for LMP000363 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 224922803 | RefSeq | NP_034404 | 727 | glycerol-3-phosphate dehydrogenase, mitochondrial precursor |
| 224922803 | RefSeq | NP_034404 | 727 | glycerol-3-phosphate dehydrogenase, mitochondrial precursor |
| 224922803 | RefSeq | NP_034404 | 727 | glycerol-3-phosphate dehydrogenase, mitochondrial precursor |
| 224922803 | RefSeq | NP_034404 | 727 | glycerol-3-phosphate dehydrogenase, mitochondrial precursor |
Identical Sequences to LMP000363 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:224922803 | DBBJ | BAE39294.1 | 727 | unnamed protein product [Mus musculus] |
| GI:224922803 | DBBJ | BAE39294.1 | 727 | unnamed protein product [Mus musculus] |
| GI:224922803 | DBBJ | BAE39294.1 | 727 | unnamed protein product [Mus musculus] |
| GI:224922803 | DBBJ | BAE39294.1 | 727 | unnamed protein product [Mus musculus] |
| GI:224922803 | DBBJ | BAE26028.1 | 727 | unnamed protein product [Mus musculus] |
| GI:224922803 | DBBJ | BAE26028.1 | 727 | unnamed protein product [Mus musculus] |
| GI:224922803 | DBBJ | BAE26028.1 | 727 | unnamed protein product [Mus musculus] |
| GI:224922803 | DBBJ | BAE26028.1 | 727 | unnamed protein product [Mus musculus] |
| GI:224922803 | RefSeq | NP_001139292.1 | 727 | glycerol-3-phosphate dehydrogenase, mitochondrial precursor [Mus musculus] |
| GI:224922803 | RefSeq | NP_001139292.1 | 727 | glycerol-3-phosphate dehydrogenase, mitochondrial precursor [Mus musculus] |
| GI:224922803 | RefSeq | NP_001139292.1 | 727 | glycerol-3-phosphate dehydrogenase, mitochondrial precursor [Mus musculus] |
| GI:224922803 | RefSeq | NP_001139292.1 | 727 | glycerol-3-phosphate dehydrogenase, mitochondrial precursor [Mus musculus] |
| GI:224922803 | SwissProt | Q64521.2 | 727 | RecName: Full=Glycerol-3-phosphate dehydrogenase, mitochondrial; Short=GPD-M; Short=GPDH-M; AltName: Full=Protein TISP38; Flags: Precursor [Mus musculus] |
| GI:224922803 | SwissProt | Q64521.2 | 727 | RecName: Full=Glycerol-3-phosphate dehydrogenase, mitochondrial; Short=GPD-M; Short=GPDH-M; AltName: Full=Protein TISP38; Flags: Precursor [Mus musculus] |
| GI:224922803 | SwissProt | Q64521.2 | 727 | RecName: Full=Glycerol-3-phosphate dehydrogenase, mitochondrial; Short=GPD-M; Short=GPDH-M; AltName: Full=Protein TISP38; Flags: Precursor [Mus musculus] |
| GI:224922803 | SwissProt | Q64521.2 | 727 | RecName: Full=Glycerol-3-phosphate dehydrogenase, mitochondrial; Short=GPD-M; Short=GPDH-M; AltName: Full=Protein TISP38; Flags: Precursor [Mus musculus] |
Related Sequences to LMP000363 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:224922803 | DBBJ | BAA08926.1 | 727 | glycerol-3-phosphate dehydrogenase [Mus musculus] |
| GI:224922803 | DBBJ | BAA08926.1 | 727 | glycerol-3-phosphate dehydrogenase [Mus musculus] |
| GI:224922803 | DBBJ | BAA08926.1 | 727 | glycerol-3-phosphate dehydrogenase [Mus musculus] |
| GI:224922803 | DBBJ | BAA08926.1 | 727 | glycerol-3-phosphate dehydrogenase [Mus musculus] |
| GI:224922803 | DBBJ | BAC28685.1 | 726 | unnamed protein product [Mus musculus] |
| GI:224922803 | DBBJ | BAC28685.1 | 726 | unnamed protein product [Mus musculus] |
| GI:224922803 | DBBJ | BAC28685.1 | 726 | unnamed protein product [Mus musculus] |
| GI:224922803 | DBBJ | BAC28685.1 | 726 | unnamed protein product [Mus musculus] |
| GI:224922803 | GenBank | AAB50545.1 | 727 | FAD-linked glycerol-3-phosphate dehydrogenase [Mus musculus] |
| GI:224922803 | GenBank | AAB50545.1 | 727 | FAD-linked glycerol-3-phosphate dehydrogenase [Mus musculus] |
| GI:224922803 | GenBank | AAB50545.1 | 727 | FAD-linked glycerol-3-phosphate dehydrogenase [Mus musculus] |
| GI:224922803 | GenBank | AAB50545.1 | 727 | FAD-linked glycerol-3-phosphate dehydrogenase [Mus musculus] |
| GI:224922803 | GenBank | AAH21359.1 | 727 | Glycerol phosphate dehydrogenase 2, mitochondrial [Mus musculus] |
| GI:224922803 | GenBank | AAH21359.1 | 727 | Glycerol phosphate dehydrogenase 2, mitochondrial [Mus musculus] |
| GI:224922803 | GenBank | AAH21359.1 | 727 | Glycerol phosphate dehydrogenase 2, mitochondrial [Mus musculus] |
| GI:224922803 | GenBank | AAH21359.1 | 727 | Glycerol phosphate dehydrogenase 2, mitochondrial [Mus musculus] |
| GI:224922803 | GenBank | EDL26931.1 | 727 | glycerol phosphate dehydrogenase 2, mitochondrial [Mus musculus] |
| GI:224922803 | GenBank | EDL26931.1 | 727 | glycerol phosphate dehydrogenase 2, mitochondrial [Mus musculus] |
| GI:224922803 | GenBank | EDL26931.1 | 727 | glycerol phosphate dehydrogenase 2, mitochondrial [Mus musculus] |
| GI:224922803 | GenBank | EDL26931.1 | 727 | glycerol phosphate dehydrogenase 2, mitochondrial [Mus musculus] |
| GI:224922803 | GenBank | ADT54649.1 | 727 | Sequence 127 from patent US 7842783 |
| GI:224922803 | GenBank | ADT54649.1 | 727 | Sequence 127 from patent US 7842783 |
| GI:224922803 | GenBank | ADT54649.1 | 727 | Sequence 127 from patent US 7842783 |
| GI:224922803 | GenBank | ADT54649.1 | 727 | Sequence 127 from patent US 7842783 |