Gene/Proteome Database (LMPD)

LMPD ID
LMP000367
Gene ID
51366
Species
Homo sapiens (Human)
Gene Name
ubiquitin protein ligase E3 component n-recognin 5
Gene Symbol
UBR5
Synonyms
DD5; EDD; EDD1; HYD
Alternate Names
E3 ubiquitin-protein ligase UBR5; ubiquitin-protein ligase; progestin induced protein; progestin-induced protein; hyperplastic discs protein homolog; E3 identified by differential display; E3 ubiquitin-protein ligase, HECT domain-containing 1; E3 ubiquitin protein ligase, HECT domain containing, 1
Chromosome
8
Map Location
8q22
EC Number
6.3.2.-
Summary
This gene encodes a progestin-induced protein, which belongs to the HECT (homology to E6-AP carboxyl terminus) family. The HECT family proteins function as E3 ubiquitin-protein ligases, targeting specific proteins for ubiquitin-mediated proteolysis. This gene is localized to chromosome 8q22 which is disrupted in a variety of cancers. This gene potentially has a role in regulation of cell proliferation or differentiation. [provided by RefSeq, Jul 2008]
Orthologs
View orthologs and multiple alignments for UBR5

Proteins

E3 ubiquitin-protein ligase UBR5 isoform 1
Refseq ID NP_056986
Protein GI 15147337
UniProt ID O95071
mRNA ID NM_015902
Length 2799
RefSeq Status REVIEWED
MTSIHFVVHPLPGTEDQLNDRLREVSEKLNKYNLNSHPPLNVLEQATIKQCVVGPNHAAFLLEDGRVCRIGFSVQPDRLELGKPDNNDGSKLNSNSGAGRTSRPGRTSDSPWFLSGSETLGRLAGNTLGSRWSSGVGGSGGGSSGRSSAGARDSRRQTRVIRTGRDRGSGLLGSQPQPVIPASVIPEELISQAQVVLQGKSRSVIIRELQRTNLDVNLAVNNLLSRDDEDGDDGDDTASESYLPGEDLMSLLDADIHSAHPSVIIDADAMFSEDISYFGYPSFRRSSLSRLGSSRVLLLPLERDSELLRERESVLRLRERRWLDGASFDNERGSTSKEGEPNLDKKNTPVQSPVSLGEDLQWWPDKDGTKFICIGALYSELLAVSSKGELYQWKWSESEPYRNAQNPSLHHPRATFLGLTNEKIVLLSANSIRATVATENNKVATWVDETLSSVASKLEHTAQTYSELQGERIVSLHCCALYTCAQLENSLYWWGVVPFSQRKKMLEKARAKNKKPKSSAGISSMPNITVGTQVCLRNNPLYHAGAVAFSISAGIPKVGVLMESVWNMNDSCRFQLRSPESLKNMEKASKTTEAKPESKQEPVKTEMGPPPSPASTCSDASSIASSASMPYKRRRSTPAPKEEEKVNEEQWSLREVVFVEDVKNVPVGKVLKVDGAYVAVKFPGTSSNTNCQNSSGPDADPSSLLQDCRLLRIDELQVVKTGGTPKVPDCFQRTPKKLCIPEKTEILAVNVDSKGVHAVLKTGNWVRYCIFDLATGKAEQENNFPTSSIAFLGQNERNVAIFTAGQESPIILRDGNGTIYPMAKDCMGGIRDPDWLDLPPISSLGMGVHSLINLPANSTIKKKAAVIIMAVEKQTLMQHILRCDYEACRQYLMNLEQAVVLEQNLQMLQTFISHRCDGNRNILHACVSVCFPTSNKETKEEEEAERSERNTFAERLSAVEAIANAISVVSSNGPGNRAGSSSSRSLRLREMMRRSLRAAGLGRHEAGASSSDHQDPVSPPIAPPSWVPDPPAMDPDGDIDFILAPAVGSLTTAATGTGQGPSTSTIPGPSTEPSVVESKDRKANAHFILKLLCDSVVLQPYLRELLSAKDARGMTPFMSAVSGRAYPAAITILETAQKIAKAEISSSEKEEDVFMGMVCPSGTNPDDSPLYVLCCNDTCSFTWTGAEHINQDIFECRTCGLLESLCCCTECARVCHKGHDCKLKRTSPTAYCDCWEKCKCKTLIAGQKSARLDLLYRLLTATNLVTLPNSRGEHLLLFLVQTVARQTVEHCQYRPPRIREDRNRKTASPEDSDMPDHDLEPPRFAQLALERVLQDWNALKSMIMFGSQENKDPLSASSRIGHLLPEEQVYLNQQSGTIRLDCFTHCLIVKCTADILLLDTLLGTLVKELQNKYTPGRREEAIAVTMRFLRSVARVFVILSVEMASSKKKNNFIPQPIGKCKRVFQALLPYAVEELCNVAESLIVPVRMGIARPTAPFTLASTSIDAMQGSEELFSVEPLPPRPSSDQSSSSSQSQSSYIIRNPQQRRISQSQPVRGRDEEQDDIVSADVEEVEVVEGVAGEEDHHDEQEEHGEENAEAEGQHDEHDEDGSDMELDLLAAAETESDSESNHSNQDNASGRRSVVTAATAGSEAGASSVPAFFSEDDSQSNDSSDSDSSSSQSDDIEQETFMLDEPLERTTNSSHANGAAQAPRSMQWAVRNTQHQRAASTAPSSTSTPAASSAGLIYIDPSNLRRSGTISTSAAAAAAALEASNASSYLTSASSLARAYSIVIRQISDLMGLIPKYNHLVYSQIPAAVKLTYQDAVNLQNYVEEKLIPTWNWMVSIMDSTEAQLRYGSALASAGDPGHPNHPLHASQNSARRERMTAREEASLRTLEGRRRATLLSARQGMMSARGDFLNYALSLMRSHNDEHSDVLPVLDVCSLKHVAYVFQALIYWIKAMNQQTTLDTPQLERKRTRELLELGIDNEDSEHENDDDTNQSATLNDKDDDSLPAETGQNHPFFRRSDSMTFLGCIPPNPFEVPLAEAIPLADQPHLLQPNARKEDLFGRPSQGLYSSSASSGKCLMEVTVDRNCLEVLPTKMSYAANLKNVMNMQNRQKKEGEEQPVLPEETESSKPGPSAHDLAAQLKSSLLAEIGLTESEGPPLTSFRPQCSFMGMVISHDMLLGRWRLSLELFGRVFMEDVGAEPGSILTELGGFEVKESKFRREMEKLRNQQSRDLSLEVDRDRDLLIQQTMRQLNNHFGRRCATTPMAVHRVKVTFKDEPGEGSGVARSFYTAIAQAFLSNEKLPNLECIQNANKGTHTSLMQRLRNRGERDREREREREMRRSSGLRAGSRRDRDRDFRRQLSIDTRPFRPASEGNPSDDPEPLPAHRQALGERLYPRVQAMQPAFASKITGMLLELSPAQLLLLLASEDSLRARVDEAMELIIAHGRENGADSILDLGLVDSSEKVQQENRKRHGSSRSVVDMDLDDTDDGDDNAPLFYQPGKRGFYTPRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYESLRQLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQVELIPNGVNIPVTPQNVYEYVRKYAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLPASEEGFQPMPSITIRPPDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAIKTKNFGFV
E3 ubiquitin-protein ligase UBR5 isoform 2
Refseq ID NP_001269802
Protein GI 544583486
UniProt ID O95071
mRNA ID NM_001282873
Length 2798
RefSeq Status REVIEWED
MTSIHFVVHPLPGTEDQLNDRLREVSEKLNKYNLNSHPPLNVLEQATIKQCVVGPNHAAFLLEDGRVCRIGFSVQPDRLELGKPDNNDGSKLNSNSGAGRTSRPGRTSDSPWFLSGSETLGRLAGNTLGSRWSSGVGGSGGGSSGRSSAGARDSRRQTRVIRTGRDRGSGLLGSQPQPVIPASVIPEELISQAQVVLQGKSRSVIIRELQRTNLDVNLAVNNLLSRDDEDGDDGDDTASESYLPGEDLMSLLDADIHSAHPSVIIDADAMFSEDISYFGYPSFRRSSLSRLGSSRVLLLPLERDSELLRERESVLRLRERRWLDGASFDNERGSTSKEGEPNLDKKNTPVQSPVSLGEDLQWWPDKDGTKFICIGALYSELLAVSSKGELYQWKWSESEPYRNAQNPSLHHPRATFLGLTNEKIVLLSANSIRATVATENNKVATWVDETLSSVASKLEHTAQTYSELQGERIVSLHCCALYTCAQLENSLYWWGVVPFSQRKKMLEKARAKNKKPKSSAGISSMPNITVGTQVCLRNNPLYHAGAVAFSISAGIPKVGVLMESVWNMNDSCRFQLRSPESLKNMEKASKTTEAKPESKQEPVKTEMGPPPSPASTCSDASSIASSASMPYKRRRSTPAPKEEEKVNEEQWSLREVVFVEDVKNVPVGKVLKVDGAYVAVKFPGTSSNTNCQNSSGPDADPSSLLQDCRLLRIDELQVVKTGGTPKVPDCFQRTPKKLCIPEKTEILAVNVDSKGVHAVLKTGNWVRYCIFDLATGKAEQENNFPTSSIAFLGQNERNVAIFTAGQESPIILRDGNGTIYPMAKDCMGGIRDPDWLDLPPISSLGMGVHSLINLPANSTIKKKAAVIIMAVEKQTLMQHILRCDYEACRQYLMNLEQAVVLEQNLQMLQTFISHRCDGNRNILHACVSVCFPTSNKETKEEEEAERSERNTFAERLSAVEAIANAISVVSSNGPGNRAGSSSSRSLRLREMMRRSLRAAGLGRHEAGASSSDHQDPVSPPIAPPSWVPDPPAMDPDGDIDFILAPAVGSLTTAATGTGQGPSTSTIPGPSTEPSVVESKDRKANAHFILKLLCDSVVLQPYLRELLSAKDARGMTPFMSAVSGRAYPAAITILETAQKIAKAEISSSEKEEDVFMGMVCPSGTNPDDSPLYVLCCNDTCSFTWTGAEHINQDIFECRTCGLLESLCCCTECARVCHKGHDCKLKRTSPTAYCDCWEKCKCKTLIAGQKSARLDLLYRLLTATNLVTLPNSRGEHLLLFLVQTVARQTVEHCQYRPPRIREDRNRKTASPEDSDMPDHDLEPPRFAQLALERVLQDWNALKSMIMFGSQENKDPLSASSRIGHLLPEEQVYLNQQSGTIRLDCFTHCLIVKCTADILLLDTLLGTLVKELQNKYTPGRREEAIAVTMRFLRSVARVFVILSVEMASSKKKNNFIPQPIGKCKRVFQALLPYAVEELCNVAESLIVPVRMGIARPTAPFTLASTSIDAMQGSEELFSVEPLPPRPSSDQSSSSSQSQSSYIIRNPQQRRISQSQPVRGRDEEQDDIVSADVEEVEVVEGVAGEEDHHDEQEEHGEENAEAEGQHDEHDEDGSDMELDLLAAAETESDSESNHSNQDNASGRRSVVTAATAGSEAGASSVPAFFSEDDSQSNDSSDSDSSSSQSDDIEQETFMLDEPLERTTNSSHANGAAQAPRSMQWAVRNTQHQRAASTAPSSTSTPAASSAGLIYIDPSNLRRSGTISTSAAAAAAALEASNASSYLTSASSLARAYSIVIRQISDLMGLIPKYNHLVYSQIPAAVKLTYQDAVNLQNYVEEKLIPTWNWMVSIMDSTEAQLRYGSALASAGDPGHPNHPLHASQNSARRERMTAREEASLRTLEGRRRATLLSARQGMMSARGDFLNYALSLMRSHNDEHSDVLPVLDVCSLKHVAYVFQALIYWIKAMNQQTTLDTPQLERKRTRELLELGIDNEDSEHENDDDTNQSATLNDKDDDSLPAETGQNHPFFRRSDSMTFLGCIPPNPFEVPLAEAIPLADQPHLLQPNARKEDLFGRPSQGLYSSSASSGKCLMEVTVDRNCLEVLPTKMSYAANLKNVMNMQNRQKKEGEEQPVLPEETESSKPGPSAHDLAAQLKSSLLAEIGLTESEGPPLTSFRPQCSFMGMVISHDMLLGRWRLSLELFGRVFMEDVGAEPGSILTELGGFEVKESKFRREMEKLRNQQSRDLSLEVDRDRDLLIQQTMRQLNNHFGRRCATTPMAVHRVKVTFKDEPGEGSGVARSFYTAIAQAFLSNEKLPNLECIQNANKGTHTSLMQRLRNRGERDREREREREMRRSSGLRAGSRRDRDRDFRRQLSIDTRPFRPASEGNPSDDPEPLPAHRQALGERLYPRVQAMQPAFASKITGMLLELSPAQLLLLLASEDSLRARVDEAMELIIAHGRENGADSILDLGLVDSSEKVQENRKRHGSSRSVVDMDLDDTDDGDDNAPLFYQPGKRGFYTPRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYESLRQLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQVELIPNGVNIPVTPQNVYEYVRKYAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLPASEEGFQPMPSITIRPPDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAIKTKNFGFV

Gene Information

Entrez Gene ID
51366
Gene Name
ubiquitin protein ligase E3 component n-recognin 5
Gene Symbol
UBR5
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IDA:HPA C cytoplasm
GO:0016020 IDA:UniProtKB C membrane
GO:0005634 IDA:BHF-UCL C nucleus
GO:0003723 IEA:InterPro F RNA binding
GO:0016874 IEA:UniProtKB-KW F ligase activity
GO:0004842 TAS:ProtInc F ubiquitin-protein transferase activity
GO:0034450 IDA:BHF-UCL F ubiquitin-ubiquitin ligase activity
GO:0008270 IEA:InterPro F zinc ion binding
GO:0006281 IEA:UniProtKB-KW P DNA repair
GO:0008283 TAS:ProtInc P cell proliferation
GO:0006974 IMP:UniProtKB P cellular response to DNA damage stimulus
GO:2000780 IMP:UniProtKB P negative regulation of double-strand break repair
GO:1901315 IMP:UniProtKB P negative regulation of histone H2A K63-linked ubiquitination
GO:0090263 IMP:BHF-UCL P positive regulation of canonical Wnt signaling pathway
GO:0035413 IMP:BHF-UCL P positive regulation of catenin import into nucleus
GO:0033160 IMP:BHF-UCL P positive regulation of protein import into nucleus, translocation
GO:0050847 IDA:HGNC P progesterone receptor signaling pathway
GO:0000209 IDA:BHF-UCL P protein polyubiquitination
GO:0042787 IBA:RefGenome P protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0006511 TAS:ProtInc P ubiquitin-dependent protein catabolic process

KEGG Pathway Links

KEGG Pathway ID Description
hsa04120 Ubiquitin mediated proteolysis
ko04120 Ubiquitin mediated proteolysis

Domain Information

InterPro Annotations

Accession Description
IPR024725 E3 ubiquitin ligase EDD, ubiquitin-associated domain
IPR000569 HECT
IPR002004 Polyadenylate-binding protein/Hyperplastic disc protein
IPR009091 Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II
IPR003126 Zinc finger, N-recognin
IPR013993 Zinc finger, N-recognin, metazoa

UniProt Annotations

Entry Information

Gene Name
ubiquitin protein ligase E3 component n-recognin 5
Protein Entry
UBR5_HUMAN
UniProt ID
O95071
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O95071-1; Sequence=Displayed; Name=2; IsoId=O95071-2; Sequence=VSP_054399; Note=No experimental confirmation available.;
Function E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation (By similarity). Involved in maturation and/or transcriptional regulation of mRNA by activating CDK9 by polyubiquitination. May play a role in control of cell cycle progression. May have tumor suppressor function. Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response. Plays an essential role in extraembryonic development. Ubiquitinates acetylated PCK1. Also acts as a regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'- linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes. {ECO
Interaction P35222:CTNNB1; NbExp=6; IntAct=EBI-358329, EBI-491549; P49841:GSK3B; NbExp=8; IntAct=EBI-358329, EBI-373586; Q9BPZ3:PAIP2; NbExp=5; IntAct=EBI-358329, EBI-2957445;
Miscellaneous A cysteine residue is required for ubiquitin- thioester formation.
Pathway Protein modification; protein ubiquitination.
Sequence Caution Sequence=BAA74919.3; Type=Erroneous initiation; Evidence= ;
Similarity Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain.
Similarity Contains 1 PABC domain. {ECO
Similarity Contains 1 UBR-type zinc finger. {ECO
Subcellular Location Nucleus.
Subunit Binds TOPBP1. Associates with CDK9 and TFIIS/TCEA1 and forms a transcription regulatory complex made of CDK9, RNAP II, UBR5 and TFIIS/TCEA1 that can stimulate target gene transcription (e.g. gamma fibrinogen/FGG) by recruiting their promoters. Associates with the E3 ligase complex containing DYRK2, EDD/UBR5, DDB1 and VPRBP proteins (EDVP complex). Interacts directly with DYRK2. {ECO
Tissue Specificity Widely expressed. Most abundant in testis and expressed at high levels in brain, pituitary and kidney.

Identical and Related Proteins

Unique RefSeq proteins for LMP000367 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
15147337 RefSeq NP_056986 2799 E3 ubiquitin-protein ligase UBR5 isoform 1
544583486 RefSeq NP_001269802 2798 E3 ubiquitin-protein ligase UBR5 isoform 2

Identical Sequences to LMP000367 proteins

Reference Database Accession Length Protein Name
GI:544583486 DBBJ BAG10396.1 2798 E3 ubiquitin-protein ligase EDD1, partial [synthetic construct]
GI:15147337 GenBank AAD01259.2 2799 progestin induced protein [Homo sapiens]
GI:15147337 GenBank AAI37235.1 2799 Ubiquitin protein ligase E3 component n-recognin 5 [Homo sapiens]
GI:15147337 GenBank AHD69797.1 2799 Sequence 1386 from patent US 8586006
GI:15147337 SwissProt O95071.2 2799 RecName: Full=E3 ubiquitin-protein ligase UBR5; AltName: Full=E3 ubiquitin-protein ligase, HECT domain-containing 1; AltName: Full=Hyperplastic discs protein homolog; Short=hHYD; AltName: Full=Progestin-induced protein [Homo sapiens]

Related Sequences to LMP000367 proteins

Reference Database Accession Length Protein Name
GI:544583486 DBBJ BAA74919.3 2820 KIAA0896 protein, partial [Homo sapiens]
GI:544583486 GenBank AAD01259.2 2799 progestin induced protein [Homo sapiens]
GI:544583486 GenBank EAW91843.1 2798 E3 ubiquitin protein ligase, HECT domain containing, 1, isoform CRA_a [Homo sapiens]
GI:15147337 GenBank EAW91846.1 2799 E3 ubiquitin protein ligase, HECT domain containing, 1, isoform CRA_d [Homo sapiens]
GI:544583486 GenBank AAI37235.1 2799 Ubiquitin protein ligase E3 component n-recognin 5 [Homo sapiens]
GI:15147337 GenBank JAA09536.1 2799 ubiquitin protein ligase E3 component n-recognin 5 [Pan troglodytes]
GI:15147337 GenBank JAA19192.1 2799 ubiquitin protein ligase E3 component n-recognin 5 [Pan troglodytes]
GI:15147337 GenBank JAA32152.1 2799 ubiquitin protein ligase E3 component n-recognin 5 [Pan troglodytes]
GI:15147337 GenBank JAA44706.1 2799 ubiquitin protein ligase E3 component n-recognin 5 [Pan troglodytes]
GI:544583486 RefSeq NP_056986.2 2799 E3 ubiquitin-protein ligase UBR5 isoform 1 [Homo sapiens]
GI:15147337 RefSeq XP_008973447.1 2799 PREDICTED: LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase UBR5 [Pan paniscus]
GI:544583486 SwissProt O95071.2 2799 RecName: Full=E3 ubiquitin-protein ligase UBR5; AltName: Full=E3 ubiquitin-protein ligase, HECT domain-containing 1; AltName: Full=Hyperplastic discs protein homolog; Short=hHYD; AltName: Full=Progestin-induced protein [Homo sapiens]